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Results: 160
FORWARDS-1
LM Paterson, D Barker, S Cro, P Mozgunov, R Phillips, C Smith, L Nahar, S Paterson, AR Lingford-Hughes
Oct 24, 2022
BACKGROUND: Treatment of opiate addiction with opiate substitution treatment (e.g. methadone) is beneficial. However, some individuals desire or would benefit from abstinence but there are limited options to attenuate problems...
Optimizing Water Quality Sampling Through Application Of Real Time Ionic Concentration Regression Models
The Water Resources Management Division of the Department of Environment and Conservation performs routine water sampling to measure the physical and chemical parameters of select water bodies in Newfoundland and Labrador. Ionic...
Optimizing Water Quality Sampling Through Application Of Real Time Ionic Concentration Regression Models
The Water Resources Management Division of the Department of Environment and Conservation performs routine water sampling to measure the physical and chemical parameters of select water bodies in Newfoundland and Labrador. Ionic...
FORWARDS-1
LM Paterson, D Barker, S Cro, P Mozgunov, R Phillips, C Smith, L Nahar, S Paterson, AR Lingford-Hughes
Nov 18, 2022
BACKGROUND: Treatment of opiate addiction with opiate substitution treatment (e.g. methadone) is beneficial. However, some individuals desire or would benefit from abstinence but there are limited options to attenuate problems...
Adaptive Addiction Baclofen Bayesian dependence dose escalation GABA-B Methadone opiate phase I Humans Analgesics Opioid Baclofen Bayes Theorem Carbon Dioxide Cholecalciferol GABA-B Receptor Agonists Hypnotics and Sedatives Methadone Nicotine Opiate substitution treatment Opioid-Related Disorders Single-Blind Method vitamin D
The emergence of mecC methicillin-resistant Staphylococcus aureus.
Conquering peaks and illuminating depths
The structural complexity and biological importance of macrolide natural products has inspired the development of innovative strategies for their chemical synthesis. With their dense stereochemical content, high level of...
Total synthesis of the actinoallolides and a designed photoaffinity probe for target identification.
The actinoallolides are a family of polyketide natural products isolated from the bacterium Actinoallomurus fulvus. They show potent biological activity against trypanosomes, the causative agents of the neglected tropical...
Stereocontrolled Synthesis as an Enabling Tool for the Configurational Assignment of Marine Polyketide Natural Products
Through the judicious use of stereocontrolled transformations in combination with detailed experimental and computational NMR studies, this Minireview highlights recent synthetic work on stereochemically ambiguous marine...
Stereocontrolled Synthesis as an Enabling Tool for the Configurational Assignment of Marine Polyketide Natural Products
Through the judicious use of stereocontrolled transformations in combination with detailed experimental and computational NMR studies, this Minireview highlights recent synthetic work on stereochemically ambiguous marine...
A synthesis-enabled relative stereochemical assignment of the C1-C28 region of hemicalide.
Through synthesising both candidate diastereomers of a model C1-C28 fragment of the potent cytotoxic marine polyketide hemicalide, an assignment of the relative configuration between the C1-C15 and C16-C26 regions has been...
Enantioselective Intermolecular C-H Amination Directed by a Chiral Cation.
The enantioselective amination of C(sp3)-H bonds is a powerful synthetic transformation yet highly challenging to achieve in an intermolecular sense. We have developed a family of anionic variants of the...
Published by: Journal of the American Chemical Society
A Unified Total Synthesis of the Actinoallolides, a Family of Potent Anti-Trypanosomal Macrolides.
Trypanosoma protozoan parasites are the causative agents of Chagas disease and sleeping sickness, two neglected tropical diseases where there is an urgent need for improved treatments and the evaluation of promising drug leads...
Role of TFF3 as an adjunct in the diagnosis of Barrett's esophagus using a minimally invasive esophageal sampling device-The CytospongeTM.
The incidence of esophageal carcinoma continues to increase whilst its prognosis remains poor. The most dramatic reduction in mortality is likely to follow early diagnosis of the preinvasive precursor lesion, Barrett's esophagus...
Toward aplyronine payloads for antibody-drug conjugates
The aplyronines are a family of antimitotic marine macrolides that disrupt cytoskeletal dynamics by dual targeting of both actin and tubulin. Given their picomolar cytotoxicity profile and unprecedented mode of action, the...
A counterintuitive stereochemical outcome from a chelation-controlled vinylmetal aldehyde addition leads to the configurational reassignment of phormidolide A.
As part of our ongoing studies towards the total synthesis of phormidolide A (1), we explored the chelation-controlled vinylmetal addition of iodide 2 to aldehyde 3 to install the reported 17S configuration. While the...
Naturally-occurring serotype 3 Streptococcus pneumoniae strains that lack functional pneumolysin and autolysin have attenuated virulence but induce localized protective immune responses.
Ηαnnah E Wong, Panagiotis Tourlomousis, Gavin K Paterson, Steve Webster, Clare E Bryant
Apr 09, 2023
Streptococcus pneumoniae is an important cause of fatal pneumonia in humans. These bacteria express virulence factors, such as the toxins pneumolysin and autolysin, that drive host inflammatory responses. In this study we...
Animals Horses Mice Streptococcus pneumoniae N-Acetylmuramoyl-L-alanine Amidase Tumor Necrosis Factor-alpha Bacterial Proteins Streptolysins Virulence Immunity Serogroup
Published by: PLOS ONE
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