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Letter from Editor
Connie Shen
Jan 01, 0001
This is the introductory letter from Assistant Editor Connie Shen.
Anthology Winthrop Literary Journal Arts Journal Arts Magazine Literary Magazine Magazine art poetry prose Creative Writing Nonfiction
Published by: Winthrop University
What Factors Affect People's Opinions Toward COVID-19 and Contact Tracing Apps in the United States
Haijing Hao, Garrett Smith, Yunan Chen, Mainack Mondal, Po-Shen Loh, Staci Smith, Xinru Page
Jan 01, 2024
In January 2022, at the peak of COVID-19 in the United States, we administered an online survey on Prolific Academic to 302 participants in the United States, a nationally demographic representative sample based on age, gender...
Published by: IGI Global Scientific Publishing
Structural diversity in the series of lanthanide complexes [Ln(Ph<sub>3</sub>PO)<sub>n</sub>(NCS)<sub>3</sub>] (n = 3, 4)
Lawrence Chan, Simon A. Cotton, Joanna Dickson (nee Harris), Andrew W.G. Platt, Paul R. Raithby, Stefanie Schiffers, Alexander Tait, John E. Warren
Jul 01, 2022
Two unique series of lanthanide complexes [Ln(Ph3PO)4(NCS)3] (Ln = La-Tb, except Pm) and [Ln(Ph3PO)3(NCS)3] (Ln = Sm-Lu, Y) have been structurally...
Structural diversity in the series of lanthanide complexes [Ln(Ph<sub>3</sub>PO)<sub>n</sub>(NCS)<sub>3</sub>] (n = 3, 4)
Lawrence Chan, Simon A. Cotton, Joanna Dickson (nee Harris), Andrew W.G. Platt, Paul R. Raithby, Stefanie Schiffers, Alexander Tait, John E. Warren
Jul 01, 2022
Two unique series of lanthanide complexes [Ln(Ph3PO)4(NCS)3] (Ln = La-Tb, except Pm) and [Ln(Ph3PO)3(NCS)3] (Ln = Sm-Lu, Y) have been structurally...
Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1)
Elizabeth M Swisher, Kevin K Lin, Amit M Oza, Clare L Scott, Heidi Giordano, James Sun, Gottfried E Konecny, Robert L Coleman, Anna V Tinker, David M O'Malley, Rebecca S Kristeleit, Ling Ma, Katherine M Bell-McGuinn, James D Brenton, Janiel M Cragun, Ana Oaknin, Isabelle Ray-Coquard, Maria I Harrell, Elaina Mann, Scott H Kaufmann, Anne Floquet, Alexandra Leary, Thomas C Harding, Sandra Goble, Lara Maloney, Jeff Isaacson, Andrew R Allen, Lindsey Rolfe, Roman Yelensky, Mitch Raponi, Iain A McNeish
Sep 21, 2018
BACKGROUND: Poly(ADP-ribose) polymerase (PARP) inhibitors have activity in ovarian carcinomas with homologous recombination deficiency. Along with BRCA1 and BRCA2 (BRCA) mutations genomic loss of heterozygosity (LOH) might also...
Aged Antineoplastic Agents BRCA1 Protein BRCA2 Protein Carcinoma Ovarian Epithelial Drug Resistance Neoplasm Fallopian Tube Neoplasms Female Follow-Up Studies Germ-Line Mutation Humans Indoles International Agencies Middle Aged Neoplasm Recurrence Local Neoplasm Staging Neoplasms Glandular and Epithelial Ovarian Neoplasms Peritoneal Neoplasms Platinum Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases Prognosis Prospective Studies Salvage therapy Survival Rate
GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
Chikashi Terao, Yukihide Momozawa, Kazuyoshi Ishigaki, Eiryo Kawakami, Masato Akiyama, Po-Ru Loh, Giulio Genovese, Hiroki Sugishita, Tazro Ohta, Makoto Hirata, John R. B. Perry, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani
Oct 16, 2020
Abstract: Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing men. However, the genetic architecture and biological mechanisms underlying mLOY are not fully understood. In a cohort of 95,380...
GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
Chikashi Terao, Yukihide Momozawa, Kazuyoshi Ishigaki, Eiryo Kawakami, Masato Akiyama, Po-Ru Loh, Giulio Genovese, Hiroki Sugishita, Tazro Ohta, Makoto Hirata, John RB Perry, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani
Oct 22, 2019
GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health.
Yajie Zhao, Stasa Stankovic, Mine Koprulu, Eleanor Wheeler, Felix R Day, Hana Lango Allen, Nicola D Kerrison, Maik Pietzner, Po-Ru Loh, Nicholas J Wareham, Claudia Langenberg, Ken K Ong, John R B Perry
Aug 11, 2021
Leukocytes Chromosomes Human Y Humans Diabetes mellitus Type 2 Genetic Predisposition to Disease Insulin Receptor IGF Type 1 Carrier Proteins Case-Control Studies DNA Mutational Analysis Signal Transduction Mosaicism Adult Aged Middle Aged Female Male Genome-Wide Association Study Whole exome sequencing Loss of Function Mutation
Published by: Nature Communications
In Helicobacter pylori auto-inducer-2, but not LuxS/MccAB catalysed reverse transsulphuration, regulates motility through modulation of flagellar gene transcription.
Feifei Shen, Laura Hobley, Neil Doherty, John T Loh, Timothy L Cover, R Elizabeth Sockett, Kim R Hardie, John C Atherton
Jun 16, 2011
BACKGROUND: LuxS may function as a metabolic enzyme or as the synthase of a quorum sensing signalling molecule, auto-inducer-2 (AI-2); hence, the mechanism underlying phenotypic changes upon luxS inactivation is not always...
Flecainide Paradoxically Activates Cardiac Ryanodine Receptor Channels under Low Activity Conditions
Cardiac ryanodine receptor (RyR2) mutations are implicated in the potentially fatal catecholaminergic polymorphic ventricular tachycardia (CPVT) and in atrial fibrillation. CPVT has been successfully treated with flecainide...
Structural and mechanistic insights into fast lithium-ion conduction in Li<sub>4</sub>SiO<sub>4</sub>-Li<sub>3</sub>PO<sub>4 </sub>solid electrolytes
Yue Deng, Christopher Eames, Jean Noël Chotard, Fabien Laleìre, Vincent Seznec, Steffen Emge, Oliver Pecher, Clare P. Grey, Christian Masquelier, M. Saiful Islam
Jul 22, 2015
Solid electrolytes that are chemically stable and have a high ionic conductivity would dramatically enhance the safety and operating lifespan of rechargeable lithium batteries. Here, we apply a multi-technique approach to the...
Reactivity of bis(cyclohexylammonium) 4-nitrophenylphosphate with SnMe<sub>3</sub>Cl. X-ray structure of 4-NO<sub>2 </sub>C<sub>6</sub> H<sub>4</sub> PO<sub>4</sub>(SnMe<sub>3</sub>)<sub>2·</sub>H<sub>2</sub>O
The reaction of bis(cyclohexylammonium) 4-nitrophenylphosphate with Me3 SnCl (1:2) under reflux in ethanol yielded the title compound 4-NO2
C6 H4...
GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health
Yajie Zhao, Stasa Stankovic, Mine Koprulu, Eleanor Wheeler, Felix R. Day, Hana Lango Allen, Nicola D. Kerrison, Maik Pietzner, Po-Ru Loh, Nicholas J. Wareham, Claudia Langenberg, Ken K. Ong, John R. B. Perry
Jul 07, 2021
Abstract: Mosaic loss of chromosome Y (LOY) in leukocytes is the most common form of clonal mosaicism, caused by dysregulation in cell-cycle and DNA damage response pathways. Previous genetic studies have focussed on identifying...
Systematic structural studies on cobalt(II) complexes of tricyclohexylphosphine oxide and related ligands
R Bou-Moreno, S A Cotton, V Hunter, K Leonard, A W G Platt, Paul R Raithby, Stefanie Schiffers
Nov 03, 2011
The new cobalt(II) phosphine oxide complexes Co(Cy(3)PO)(2)Cl(2) (1), Co(Cy(3)PO)(2)Br(2) (2), Co(Cy(3)PO)(2)I(2) (3), Co(Ph(2)CyPO)(2)Cl(2) (4), Co(Ph(2)CyPO)(2)Br(2) (5), Co(Ph(2)CyPO)(2)I(2) (6), Co(Ph(2)EtPO)(2)Br(2) (7)...
Flecainide Paradoxically Activates Cardiac Ryanodine Receptor Channels under Low Activity Conditions
Samantha C Salvage, Esther M Gallant, James A Fraser, Christopher L-H Huang, Angela F Dulhunty
Aug 16, 2021
Cardiac ryanodine receptor (RyR2) mutations are implicated in the potentially fatal catecholaminergic polymorphic ventricular tachycardia (CPVT) and in atrial fibrillation. CPVT has been successfully treated with flecainide...
RyR2 RyR2 activation RyR2 inhibition RyR2-P2328S Atrial fibrillation Catecholaminergic polymorphic ventricular tachycardia flecainide Animals Anti-Arrhythmia Agents Arrhythmias Cardiac Calcium flecainide Ion Channel Gating Lipid Bilayers Membrane Potentials Mice Ryanodine Receptor Calcium Release Channel Sarcoplasmic Reticulum Voltage-Gated Sodium Channel Blockers
Structural and mechanistic insights into fast lithium-ion conduction in Li<sub>4</sub>SiO<sub>4</sub>-Li<sub>3</sub>PO<sub>4 </sub>solid electrolytes
Yue Deng, Christopher Eames, Jean Noël Chotard, Fabien Laleìre, Vincent Seznec, Steffen Emge, Oliver Pecher, Clare P. Grey, Christian Masquelier, M. Saiful Islam
Jul 22, 2015
Solid electrolytes that are chemically stable and have a high ionic conductivity would dramatically enhance the safety and operating lifespan of rechargeable lithium batteries. Here, we apply a multi-technique approach to the...
Reasoning about privacy in mobile application install decisions
Data sharing has become prevalent with the rapid growth of mobile technologies. A lack of awareness and understanding of privacy practices often results in the installation of privacy-invasive applications (apps) which could...
Reactivity of bis(cyclohexylammonium) 4-nitrophenylphosphate with SnMe<sub>3</sub>Cl. X-ray structure of 4-NO<sub>2 </sub>C<sub>6</sub> H<sub>4</sub> PO<sub>4</sub>(SnMe<sub>3</sub>)<sub>2·</sub>H<sub>2</sub>O
The reaction of bis(cyclohexylammonium) 4-nitrophenylphosphate with Me3 SnCl (1:2) under reflux in ethanol yielded the title compound 4-NO2
C6 H4...
GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health.
Yajie Zhao, Stasa Stankovic, Mine Koprulu, Eleanor Wheeler, Felix R Day, Hana Lango Allen, Nicola D Kerrison, Maik Pietzner, Po-Ru Loh, Nicholas J Wareham, Claudia Langenberg, Ken K Ong, John RB Perry
Jun 28, 2021
Adult Aged Carrier Proteins Case-Control Studies Chromosomes Human Y DNA Mutational Analysis Diabetes mellitus Type 2 Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Insulin Leukocytes Loss of Function Mutation Male Middle Aged Mosaicism Receptor IGF Type 1 Signal Transduction Exome Sequencing
HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells.
In solid tumours, cancer cells exist within hypoxic microenvironments, and their metabolic adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a broad range of human cancers. HIF...
Hypoxia Myc Lipid Metabolism Glycolysis cancer metabolism Glutamine metabolism AMP-activated protein kinase (AMPK) 2-Hydroxyglutarate phosphatidylinositol 3-kinase (PI3K) hypoxia-inducible factor-1 (HIF-1) creatine metabolism
Published by: Cells
Systematic structural studies on cobalt(II) complexes of tricyclohexylphosphine oxide and related ligands
R Bou-Moreno, S A Cotton, V Hunter, K Leonard, A W G Platt, Paul R Raithby, Stefanie Schiffers
Nov 03, 2011
The new cobalt(II) phosphine oxide complexes Co(Cy(3)PO)(2)Cl(2) (1), Co(Cy(3)PO)(2)Br(2) (2), Co(Cy(3)PO)(2)I(2) (3), Co(Ph(2)CyPO)(2)Cl(2) (4), Co(Ph(2)CyPO)(2)Br(2) (5), Co(Ph(2)CyPO)(2)I(2) (6), Co(Ph(2)EtPO)(2)Br(2) (7)...
Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios.
Lingli Zhang, Chu-Chung Huang, Yuan Dai, Qiang Luo, Yiting Ji, Kai Wang, Shining Deng, Juehua Yu, Mingyu Xu, Xiujuan Du, Yun Tang, Chun Shen, Jianfeng Feng, Barbara J Sahakian, Ching-Po Lin, Fei Li
Feb 28, 2020
Bumetanide has been reported to alter synaptic excitation-inhibition (E-I) balance by potentiating the action of γ-aminobutyric acid (GABA), thereby attenuating the severity of autism spectrum disorder (ASD) in animal models....
Examining the effect of challenge and threat states on endurance exercise capabilities
This paper presents the first two studies to explore the effect of challenge and threat states on endurance exercise capabilities. In study one, relationships between cardiovascular markers of challenge and threat states...
On the Construction and Application of a Platform-Based Corpus in Tourism Translation Teaching
Current studies indicate that corpus-aided translation teaching may greatly improve teaching efficiency and better fulfill the stated teaching aim. On the basis of those findings, this research looks into the design and...
Published by: IGI Global Scientific Publishing
Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios
Lingli Zhang, Chu-Chung Huang, Yuan Dai, Qiang Luo, Yiting Ji, Kai Wang, Shining Deng, Juehua Yu, Mingyu Xu, Xiujuan Du, Yun Tang, Chun Shen, Jianfeng Feng, Barbara J Sahakian, Ching-Po Lin, Fei Li
Jan 26, 2021
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