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Results: 4373
Pharmacokinetics of TKM-130803 in Sierra Leonean patients with Ebola virus disease
Janet T Scott, Raman Sharma, Luke W Meredith, Jake Dunning, Catrin E Moore, Foday Sahr, Steve Ward, Ian Goodfellow, Peter Horby, RAPIDE-TKM trial team
Feb 19, 2020
BACKGROUND: TKM-130803 is a specific anti-EBOV therapeutic comprised of two small interfering RNAs (siRNA) siLpol-2 and siVP35-2. The pharmacokinetics (PK) of these siRNAs was defined in Ebola virus disease (EVD) patients, with...
Experimental Treatment of Ebola Virus Disease with TKM-130803
Jake Dunning, Foday Sahr, Amanda Rojek, Fiona Gannon, Gail Carson, Baimba Idriss, Thomas Massaquoi, Regina Gandi, Sebatu Joseph, Hassan K Osman, Timothy JG Brooks, Andrew JH Simpson, Ian Goodfellow, Lucy Thorne, Armando Arias, Laura Merson, Lyndsey Castle, Rebecca Howell-Jones, Raul Pardinaz-Solis, Benjamin Hope-Gill, Mauricio Ferri, Jennifer Grove, Mark Kowalski, Kasia Stepniewska, Trudie Lang, John Whitehead, Piero Olliaro, Mohammed Samai, Peter W Horby, RAPIDE-TKM trial team
Jun 13, 2018
BACKGROUND: TKM-130803, a small interfering RNA lipid nanoparticle product, has been developed for the treatment of Ebola virus disease (EVD), but its efficacy and safety in humans has not been evaluated. METHODS AND FINDINGS...
Adult Aged Aged 80 and over Antiviral Agents Ebolavirus Female Hemorrhagic Fever Ebola Host-Pathogen Interactions Humans Infusions Intravenous Male Middle Aged Nanoparticles RNA Small Interfering RNA Viral RNAi Therapeutics Sierra Leone Survival Analysis Time Factors Treatment Outcome Viral Load Young Adult
Challenges and opportunities for conducting a vaccine trial during the COVID-19 pandemic in the United Kingdom.
M Estée Török, Benjamin R Underwood, Mark Toshner, Claire Waddington, Emad Sidhom, Katherine Sharrocks, Rachel Bousfield, Charlotte Summers, Caroline Saunders, Zoe McIntyre, Helen Morris, Jo Piper, Gloria Calderon, Sarah Dennis, Tracy Assari, Anita Marguerie de Rotrou, Ashley Shaw, John Bradley, John O'Brien, Robert C Rintoul, Ian Smith, Ed Bullmore, Krishna Chatterjee, Cambridge COVID Vaccine Trial Team
Aug 19, 2021
The COVID-19 pandemic has resulted in unprecedented challenges for healthcare systems worldwide. It has also stimulated research in a wide range of areas including rapid diagnostics, novel therapeutics, use of technology to...
Creating inclusive teams through perceptions of supplementary and complementary person-team fit
Using a multi-wave, multi-level design, this study unravels the impact of subjective (dis)similarities in teams on team effectiveness. Based on optimal distinctiveness theory and the social inclusion model, we assume combined...
Effectiveness and cost-effectiveness of a very brief physical activity intervention delivered in NHS Health Checks (VBI Trial)
Joanna Mitchell, Wendy Hardeman, Sally Pears, Joana C Vasconcelos, A Toby Prevost, Ed Wilson, Stephen Sutton, VBI Research Team
Jun 13, 2018
BACKGROUND: Physical activity interventions that are targeted at individuals can be effective in encouraging people to be more physically active. However, most such interventions are too long or complex and not scalable to the...
Accelerometry Cost-effectiveness analysis Pedometer physical activity Primary Health Care randomised controlled trial Very brief intervention Actigraphy Cardiovascular Diseases Clinical Protocols Cost-Benefit Analysis England Exercise Fitness Trackers Health Behavior Health Care Costs health status Humans Patient Education as Topic Primary Health Care Primary Prevention Research Design Risk Reduction Behavior Self Care State Medicine Time Factors Treatment Outcome
Creating inclusive teams through perceptions of supplementary and complementary person-team fit
Using a multi-wave, multi-level design, this study unravels the impact of subjective (dis)similarities in teams on team effectiveness. Based on optimal distinctiveness theory and the social inclusion model, we assume combined...
Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial
Angelos G Kolias, Ellie Edlmann, Eric P Thelin, Diederik Bulters, Patrick Holton, Nigel Suttner, Kevin Owusu-Agyemang, Yahia Z Al-Tamimi, Daniel Gatt, Simon Thomson, Ian A Anderson, Oliver Richards, Peter Whitfield, Monica Gherle, Karen Caldwell, Carol Davis-Wilkie, Silvia Tarantino, Garry Barton, Hani J Marcus, Aswin Chari, Paul Brennan, Antonio Belli, Simon Bond, Carole Turner, Lynne Whitehead, Ian Wilkinson, Peter J Hutchinson, British Neurosurgical Trainee Research Collaborative (BNTRC) and Dex-CSDH Trial Collaborators
Feb 07, 2019
BACKGROUND: Chronic subdural haematoma (CSDH) is a common neurosurgical condition, typically treated with surgical drainage of the haematoma. However, surgery is associated with mortality and morbidity, including up to 20%...
chronic subdural haematoma Dexamethasone Neurology Neurosurgery Randomised control trial Cost-Benefit Analysis Dexamethasone Double-Blind Method Drug Administration Schedule Drug Costs Glucocorticoids Hematoma Subdural Chronic Humans Multicenter Studies as Topic Randomized Controlled Trials as Topic Time Factors Treatment Outcome United Kingdom
Endovascular versus open repair of abdominal aortic aneurysm in 15-years' follow-up of the UK endovascular aneurysm repair trial 1 (EVAR trial 1)
Barrett's oESophagus trial 3 (BEST3)
Judith Offman, Beth Muldrew, Maria O'Donovan, Irene Debiram-Beecham, Francesca Pesola, Irene Kaimi, Samuel G Smith, Ashley Wilson, Zohrah Khan, Pierre Lao-Sirieix, Benoit Aigret, Fiona M Walter, Greg Rubin, Steve Morris, Christopher Jackson, Peter Sasieni, Rebecca C Fitzgerald, BEST3 Trial team
Sep 29, 2018
Acceptability Acid reflux biomarker cost effectiveness Early detection endoscopy Heartburn Medical device OESOPHAGEAL CANCER Quality of life Barrett Esophagus Chronic Disease Disease Progression Early Detection of Cancer endoscopy Digestive System Equipment Design Esophageal Neoplasms Female Gastroesophageal Reflux Humans Male Middle Aged Primary Health Care
'Be on the TEAM' Study (Teenagers Against Meningitis)
Jeremy Carr, Emma Plested, Parvinder Aley, Susana Camara, Kimberly Davis, Jenny M MacLennan, Steve Gray, Saul N Faust, Ray Borrow, Hannah Christensen, Caroline Trotter, Martin CJ Maiden, Adam Finn, Matthew D Snape, ‘Be on the TEAM’ investigators
Oct 27, 2020
INTRODUCTION: Capsular group B Neisseria meningitidis (MenB) is the most common cause of invasive meningococcal disease (IMD) in many parts of the world. A MenB vaccine directed against the polysaccharide capsule remains elusive...
Paediatric infectious disease and immunisation paediatric intensive and critical care Infectious Diseases Paediatrics Adolescent Adult Humans Meningitis Meningococcal Infections Meningococcal Vaccines Neisseria meningitidis Neisseria meningitidis Serogroup B Randomized Controlled Trials as Topic State Medicine Vaccination Young Adult
Bridging Brain and Cognition
Ivan L. Simpson-Kent, Eiko I. Fried, Danyal Akarca, Silvana Mareva, Edward T. Bullmore, the CALM Team the CALM Team, Rogier A. Kievit
Jun 17, 2021
Network analytic methods that are ubiquitous in other areas, such as systems neuroscience, have recently been used to test network theories in psychology, including intelligence research. The network or mutualism theory of...
Team building
Team building has been identified as an important method of improving the psychological climate in which teams operate, as well as overall team functioning. Within the context of sports, team building interventions have...
Study within a trial (SWAT) protocol. Participants' perspectives and preferences on clinical trial result dissemination
Emmy Racine, Caroline Hurley, Aoife Cheung, Carol Sinnott, Karen Matvienko-Sikar, William H Smithson, Patricia M Kearney
Jan 18, 2018
INTRODUCTION: Dissemination of results of randomised controlled trials is traditionally limited to academic and professional groups rather than clinical trial participants. While there is increasing consensus that results should...
Multiple behaviour change intervention and outcomes in recently diagnosed type 2 diabetes
Simon J Griffin, Rebecca K Simmons, A Toby Prevost, Kate M Williams, Wendy Hardeman, Stephen Sutton, Søren Brage, Ulf Ekelund, Richard A Parker, Nicholas J Wareham, Ann Louise Kinmonth, ADDITION-Plus study team
Jun 13, 2018
AIMS/HYPOTHESIS: The aim of this study was to assess whether or not a theory-based behaviour change intervention delivered by trained and quality-assured lifestyle facilitators can achieve and maintain improvements in physical...
Team building
Team building has been identified as an important method of improving the psychological climate in which teams operate, as well as overall team functioning. Within the context of sports, team building interventions have...
Surveillance arterioveNous fistulAs using ultRasound (SONAR) trial in haemodialysis patients
James Richards, Mohammed Hossain, Dominic Summers, Matthew Slater, Matthew Bartlett, Vasilis Kosmoliaptsis, Edward Cf Wilson, Regin Lagaac, Anna Sidders, Claire Foley, Emma Laing, Valerie Hopkins, Chloe Fitzpatrick-Creamer, Cara Hudson, Helen Thomas, Sam Turner, Andrew Tambyraja, Subash Somalanka, James Hunter, Sam Dutta, Sarah Lawman, Tracey Salter, Mohammed Aslam, Atul Bagul, Rajesh Sivaprakasam, George Smith, Zia Moinuddin, Simon Knight, Paul Gibbs, Reza Motallebzadeh, Nicholas Barnett, Gavin Pettigrew, SONAR trial group
Oct 21, 2019
INTRODUCTION: Arteriovenous fistulas (AVFs) are considered the best and safest modality for providing haemodialysis in patients with end-stage renal disease. Only 20% of UK centres achieve the recommended 80% target for...
The AuTOMATIC trial
Grace E Currie, James Totterdell, Grahame Bowland, Alan Leeb, Ian Peters, Chris C Blyth, Claire Waddington, Julie A Marsh, Thomas L Snelling
Mar 13, 2023
Background
While most Australian children are vaccinated, delays in vaccination can put them at risk from preventable infections. Widespread mobile phone ownership in Australia could allow automated short message service...
Vaccination Reminder Systems SMS mHealth Text Messaging Childhood immunisation Humans Bayes Theorem Child Australia Randomized Controlled Trials as Topic Vaccination Coverage Cell Phone
Published by: Trials
The HARMONIC trial
TI Dalgleish, Melissa Black, Caitlin Hitchcock, Anna Bevan, Cliodhna O'Leary, James Clarke, Rachel Elliot, Peter Watson, Louise Lafortune, Sarah Rae, Simon Gilbody, Willem Kuyken, David Johnston, Jill Newby, Timothy Dalgleish
Dec 14, 2018
Axiety, mood and trauma-related disorders are common, affecting up to 20% of adults. Many of these individuals will experience symptoms of more than one disorder as diagnostically defined. However, most psychological treatments...
Anxiety common mental health problems Depression Posttraumatic stress disorder transdiagnostic Adult Anxiety Disorders Feasibility Studies Humans Mood Disorders Obsessive-Compulsive Disorder Patient Acceptance of Health Care Patient Reported Outcome Measures Randomized Controlled Trials as Topic Research Design Stress Disorders Traumatic Symptom Assessment
“The Team Behind The Team”
Rachel Arnold, Samuel Collington, Hannah Manley, Samuel Rees, James Soanes, Matthew Williams
Jan 01, 0001
This study explored the organizational stressors encountered by the “team behind the team” (viz., those operating in sport science and management roles) in elite sport and the consequences these can have. Forty support...
“The Team Behind The Team”
Rachel Arnold, Samuel Collington, Hannah Manley, Samuel Rees, James Soanes, Matthew Williams
Jan 01, 0001
This study explored the organizational stressors encountered by the “team behind the team” (viz., those operating in sport science and management roles) in elite sport and the consequences these can have. Forty support...
Factors Influencing Team Behaviors in Surgery
Emma-Louise Aveling, Juliana Stone, Thoralf Sundt, Cameron Wright, Francesca Gino, Sara Singer
Jun 15, 2018
BACKGROUND: Surgical excellence demands teamwork. Poor team behaviors negatively affect team performance and are associated with adverse events and worse outcomes. Interventions to improve surgical teamwork focusing on frontline...
Attitude of Health Personnel Clinical Competence Cooperative Behavior Female Hospitals Teaching Humans Interprofessional Relations Interviews as Topic leadership Male Medical Errors Operating Rooms Organizational Culture Patient Care Team qualitative research Risk Factors Task Performance and Analysis Thoracic Surgery United States
The AuTOMATIC trial
Grace E Currie, James Totterdell, Grahame Bowland, Alan Leeb, Ian Peters, Chris C Blyth, Claire Waddington, Julie A Marsh, Thomas L Snelling
Feb 09, 2023
BACKGROUND: While most Australian children are vaccinated, delays in vaccination can put them at risk from preventable infections. Widespread mobile phone ownership in Australia could allow automated short message service (SMS)...
Participants' perspectives and preferences on clinical trial result dissemination
Emmy Racine, Caroline Hurley, Aoife Cheung, Carol Sinnott, Karen Matvienko-Sikar, Christine Baumgartner, Nicolas Rodondi, William H Smithson, Patricia M Kearney
Mar 02, 2020
Background: While there is an increasing consensus that clinical trial results should be shared with trial participants, there is a lack of evidence on the most appropriate methods. The aim of this study is to use a patient and...
patient and public involvement Research Dissemination SWAT Study Results Study within a trial Clinical trial result dissemination Patient Involvement In Clinical Trials Trial Results.
Published by: HRB Open Research
Update to the effectiveness and cost-effectiveness of a mindfulness training programme in schools compared with normal school provision (MYRIAD)
Jesus Montero-Marin, Elizabeth Nuthall, Sarah Byford, Catherine Crane, Tim Dalgleish, Tamsin Ford, Poushali Ganguli, Mark T Greenberg, Obioha C Ukoumunne, Russell M Viner, J Mark G Williams, MYRIAD team, Willem Kuyken
Apr 12, 2021
BACKGROUND: MYRIAD (My Resilience in Adolescence) is a superiority, parallel group, cluster randomised controlled trial designed to examine the effectiveness and cost-effectiveness of a mindfulness training (MT) programme...
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