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Examining Customer Experience in Using a Chatbot
While the use of artificial intelligence and chatbots is increasing, studies of customer experiences in using chatbots remain rare. This article explores the experience of customers before, during, and after their interaction...
Published by: IGI Global Scientific Publishing
Effects Of Online Promotion And Personal Selling On The Purchase Decision Of The Cisauk Point Apartment During The Pandemic
The COVID-19 pandemic has affected all aspects of life. In the business sector, this COVID-19 pandemic forces millions of workers worldwide to work from home. Based on the phenomena and literature studies, the researcher wants...
Published by: Indonesia Strategic Sustainability
Antigenic cartography of SARS-CoV-2 reveals that Omicron BA.1 and BA.2 are antigenically distinct.
Anna Z Mykytyn, Melanie Rissmann, Adinda Kok, Miruna E Rosu, Debby Schipper, Tim I Breugem, Petra B van den Doel, Felicity Chandler, Theo Bestebroer, Maurice de Wit, Martin E van Royen, Richard Molenkamp, Bas B Oude Munnink, Rory D de Vries, Corine GeurtsvanKessel, Derek J Smith, Marion PG Koopmans, Barry Rockx, Mart M Lamers, Ron AM Fouchier, Bart L Haagmans
Jul 24, 2022
The emergence and rapid spread of SARS-CoV-2 variants may affect vaccine efficacy substantially. The Omicron variant termed BA.2, which differs substantially from BA.1 based on genetic sequence, is currently replacing BA.1 in...
Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer
JooYong Park, Ji-Yeob Choi, Jaesung Choi, Seokang Chung, Nan Song, Sue K Park, Wonshik Han, Dong-Young Noh, Sei-Hyun Ahn, Jong Won Lee, Mi Kyung Kim, Sun Ha Jee, Wanqing Wen, Manjeet K Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Mitul Shah, Don M Conroy, Patricia A Harrington, Rebecca Mayes, Kamila Czene, Per Hall, Lauren R Teras, Alpa V Patel, Fergus J Couch, Janet E Olson, Elinor J Sawyer, Rebecca Roylance, Stig E Bojesen, Henrik Flyger, Diether Lambrechts, Adinda Baten, Keitaro Matsuo, Hidemi Ito, Pascal Guénel, Thérèse Truong, Renske Keeman, Marjanka K Schmidt, Anna H Wu, Chiu-Chen Tseng, Angela Cox, Simon S Cross, kConFab Investigators, Irene L Andrulis, John L Hopper, Melissa C Southey, Pei-Ei Wu, Chen-Yang Shen, Peter A Fasching, Arif B Ekici, Kenneth Muir, Artitaya Lophatananon, Hermann Brenner, Volker Arndt, Michael E Jones, Anthony J Swerdlow, Reiner Hoppe, Yon-Dschun Ko, Mikael Hartman, Jingmei Li, Arto Mannermaa, Jaana M Hartikainen, Javier Benitez, Anna González-Neira, Christopher A Haiman, Thilo Dörk, Natalia V Bogdanova, Soo Hwang Teo, Nur Aishah Mohd Taib, Olivia Fletcher, Nichola Johnson, Mervi Grip, Robert Winqvist, Carl Blomqvist, Heli Nevanlinna, Annika Lindblom, Camilla Wendt, Vessela N Kristensen, NBCS Collaborators, Rob AEM Tollenaar, Bernadette AM Heemskerk-Gerritsen, Paolo Radice, Bernardo Bonanni, Ute Hamann, Mehdi Manoochehri, James V Lacey, Maria Elena Martinez, Alison M Dunning, Paul DP Pharoah, Douglas F Easton, Keun-Young Yoo, Daehee Kang
May 13, 2021
In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast...
Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer
JooYong Park, Ji-Yeob Choi, Jaesung Choi, Seokang Chung, Nan Song, Sue K. Park, Wonshik Han, Dong-Young Noh, Sei-Hyun Ahn, Jong Won Lee, Mi Kyung Kim, Sun Ha Jee, Wanqing Wen, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Mitul Shah, Don M. Conroy, Patricia A. Harrington, Rebecca Mayes, Kamila Czene, Per Hall, Lauren R. Teras, Alpa V. Patel, Fergus J. Couch, Janet E. Olson, Elinor J. Sawyer, Rebecca Roylance, Stig E. Bojesen, Henrik Flyger, Diether Lambrechts, Adinda Baten, Keitaro Matsuo, Hidemi Ito, Pascal Guénel, Thérèse Truong, Renske Keeman, Marjanka K. Schmidt, Anna H. Wu, Chiu-Chen Tseng, Angela Cox, Simon S. Cross, kConFab Investigators kConFab Investigators, Irene L. Andrulis, John L. Hopper, Melissa C. Southey, Pei-Ei Wu, Chen-Yang Shen, Peter A. Fasching, Arif B. Ekici, Kenneth Muir, Artitaya Lophatananon, Hermann Brenner, Volker Arndt, Michael E. Jones, Anthony J. Swerdlow, Reiner Hoppe, Yon-Dschun Ko, Mikael Hartman, Jingmei Li, Arto Mannermaa, Jaana M. Hartikainen, Javier Benitez, Anna González-Neira, Christopher A. Haiman, Thilo Dörk, Natalia V. Bogdanova, Soo Hwang Teo, Nur Aishah Mohd Taib, Olivia Fletcher, Nichola Johnson, Mervi Grip, Robert Winqvist, Carl Blomqvist, Heli Nevanlinna, Annika Lindblom, Camilla Wendt, Vessela N. Kristensen, NBCS Collaborators NBCS Collaborators, Rob A. E. M. Tollenaar, Bernadette A. M. Heemskerk-Gerritsen, Paolo Radice, Bernardo Bonanni, Ute Hamann, Mehdi Manoochehri, James V. Lacey, Maria Elena Martinez, Alison M. Dunning, Paul D. P. Pharoah, Douglas F. Easton, Keun-Young Yoo, Daehee Kang
May 20, 2021
In this study we aim to examine gene–environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast...
Common variants in breast cancer risk loci predispose to distinct tumor subtypes.
Thomas U Ahearn, Haoyu Zhang, Kyriaki Michailidou, Roger L Milne, Manjeet K Bolla, Joe Dennis, Alison M Dunning, Michael Lush, Qin Wang, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J Aronson, Paul L Auer, Annelie Augustinsson, Adinda Baten, Heiko Becher, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Stig E Bojesen, Bernardo Bonanni, Anne-Lise Børresen-Dale, Hiltrud Brauch, Hermann Brenner, Angela Brooks-Wilson, Thomas Brüning, Barbara Burwinkel, Saundra S Buys, Federico Canzian, Jose E Castelao, Jenny Chang-Claude, Stephen J Chanock, Georgia Chenevix-Trench, Christine L Clarke, NBCS Collaborators, J Margriet Collée, Angela Cox, Simon S Cross, Kamila Czene, Mary B Daly, Peter Devilee, Thilo Dörk, Miriam Dwek, Diana M Eccles, D Gareth Evans, Peter A Fasching, Jonine Figueroa, Giuseppe Floris, Manuela Gago-Dominguez, Susan M Gapstur, José A García-Sáenz, Mia M Gaudet, Graham G Giles, Mark S Goldberg, Anna González-Neira, Grethe I Grenaker Alnaes, Mervi Grip, Pascal Guénel, Christopher A Haiman, Per Hall, Ute Hamann, Elaine F Harkness, Bernadette AM Heemskerk-Gerritsen, Bernd Holleczek, Antoinette Hollestelle, Maartje J Hooning, Robert N Hoover, John L Hopper, Anthony Howell, ABCTB Investigators, kConFab/AOCS Investigators, Milena Jakimovska, Anna Jakubowska, Esther M John, Michael E Jones, Audrey Jung, Rudolf Kaaks, Saila Kauppila, Renske Keeman, Elza Khusnutdinova, Cari M Kitahara, Yon-Dschun Ko, Stella Koutros, Vessela N Kristensen, Ute Krüger, Katerina Kubelka-Sabit, Allison W Kurian, Kyriacos Kyriacou, Diether Lambrechts, Derrick G Lee, Annika Lindblom, Martha Linet, Jolanta Lissowska, Ana Llaneza, Wing-Yee Lo, Robert J Macinnis, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Maria Elena Martinez, Catriona Mclean, Alfons Meindl, Usha Menon, Heli Nevanlinna, William G Newman, Jesse Nodora, Kenneth Offit, Håkan Olsson, Nick Orr, Tjoung-Won Park-Simon, Alpa V Patel, Julian Peto, Guillermo Pita, Dijana Plaseska-Karanfilska, Ross Prentice, Kevin Punie, Katri Pylkäs, Paolo Radice, Gad Rennert, Atocha Romero, Thomas Rüdiger, Emmanouil Saloustros, Sarah Sampson, Dale P Sandler, Elinor J Sawyer, Rita K Schmutzler, Minouk J Schoemaker, Ben Schöttker, Mark E Sherman, Xiao-Ou Shu, Snezhana Smichkoska, Melissa C Southey, John J Spinelli, Anthony J Swerdlow, Rulla M Tamimi, William J Tapper, Jack A Taylor, Lauren R Teras, Mary Beth Terry, Diana Torres, Melissa A Troester, Celine M Vachon, Carolien HM van Deurzen, Elke M van Veen, Philippe Wagner, Clarice R Weinberg, Camilla Wendt, Jelle Wesseling, Robert Winqvist, Alicja Wolk, Xiaohong R Yang, Wei Zheng, Fergus J Couch, Jacques Simard, Peter Kraft, Douglas Easton, Paul Pharoah, Marjanka K Schmidt, Montserrat García-Closas, Nilanjan Chatterjee
Jan 10, 2022
Mendelian randomisation study of smoking exposure in relation to breast cancer risk.
Hanla A Park, Sonja Neumeyer, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Annelie Augustinsson, Adinda Baten, Laura E Beane Freeman, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Natalia V Bogdanova, Stig E Bojesen, Hiltrud Brauch, Hermann Brenner, Sara Y Brucker, Barbara Burwinkel, Daniele Campa, Federico Canzian, Jose E Castelao, Stephen J Chanock, Georgia Chenevix-Trench, Christine L Clarke, NBCS Collaborators, Don M Conroy, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Mary B Daly, Peter Devilee, Thilo Dörk, Isabel dos-Santos-Silva, Miriam Dwek, Diana M Eccles, A Heather Eliassen, Christoph Engel, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Henrik Flyger, Lin Fritschi, Montserrat García-Closas, José A García-Sáenz, Mia M Gaudet, Graham G Giles, Gord Glendon, Mark S Goldberg, David E Goldgar, Anna González-Neira, Mervi Grip, Pascal Guénel, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Sileny Han, Elaine F Harkness, Steven N Hart, Wei He, Bernadette AM Heemskerk-Gerritsen, John L Hopper, David J Hunter, ABCTB Investigators, kConFab Investigators, Agnes Jager, Anna Jakubowska, Esther M John, Audrey Jung, Rudolf Kaaks, Pooja Middha Kapoor, Renske Keeman, Elza Khusnutdinova, Cari M Kitahara, Linetta B Koppert, Stella Koutros, Vessela N Kristensen, Allison W Kurian, James Lacey, Diether Lambrechts, Loic Le Marchand, Wing-Yee Lo, Jan Lubiński, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Maria Elena Martinez, Dimitrios Mavroudis, Alfons Meindl, Usha Menon, Roger L Milne, Taru A Muranen, Heli Nevanlinna, William G Newman, Børge G Nordestgaard, Kenneth Offit, Andrew F Olshan, Håkan Olsson, Tjoung-Won Park-Simon, Paolo Peterlongo, Julian Peto, Dijana Plaseska-Karanfilska, Nadege Presneau, Paolo Radice, Gad Rennert, Hedy S Rennert, Atocha Romero, Emmanouil Saloustros, Elinor J Sawyer, Marjanka K Schmidt, Rita K Schmutzler, Minouk J Schoemaker, Lukas Schwentner, Christopher Scott, Mitul Shah, Xiao-Ou Shu, Jacques Simard, Ann Smeets, Melissa C Southey, John J Spinelli, Victoria Stevens, Anthony J Swerdlow, Rulla M Tamimi, William J Tapper, Jack A Taylor, Mary Beth Terry, Ian Tomlinson, Melissa A Troester, Thérèse Truong, Celine M Vachon, Elke M van Veen, Joseph Vijai, Sophia Wang, Camilla Wendt, Robert Winqvist, Alicja Wolk, Argyrios Ziogas, Alison M Dunning, Paul DP Pharoah, Douglas F Easton, Wei Zheng, Peter Kraft, Jenny Chang-Claude
Aug 20, 2021
BACKGROUND: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. METHODS: We...
Common variants in breast cancer risk loci predispose to distinct tumor subtypes.
Thomas U Ahearn, Haoyu Zhang, Kyriaki Michailidou, Roger L Milne, Manjeet K Bolla, Joe Dennis, Alison M Dunning, Michael Lush, Qin Wang, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J Aronson, Paul L Auer, Annelie Augustinsson, Adinda Baten, Heiko Becher, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Stig E Bojesen, Bernardo Bonanni, Anne-Lise Børresen-Dale, Hiltrud Brauch, Hermann Brenner, Angela Brooks-Wilson, Thomas Brüning, Barbara Burwinkel, Saundra S Buys, Federico Canzian, Jose E Castelao, Jenny Chang-Claude, Stephen J Chanock, Georgia Chenevix-Trench, Christine L Clarke, NBCS Collaborators, J Margriet Collée, Angela Cox, Simon S Cross, Kamila Czene, Mary B Daly, Peter Devilee, Thilo Dörk, Miriam Dwek, Diana M Eccles, D Gareth Evans, Peter A Fasching, Jonine Figueroa, Giuseppe Floris, Manuela Gago-Dominguez, Susan M Gapstur, José A García-Sáenz, Mia M Gaudet, Graham G Giles, Mark S Goldberg, Anna González-Neira, Grethe I Grenaker Alnaes, Mervi Grip, Pascal Guénel, Christopher A Haiman, Per Hall, Ute Hamann, Elaine F Harkness, Bernadette AM Heemskerk-Gerritsen, Bernd Holleczek, Antoinette Hollestelle, Maartje J Hooning, Robert N Hoover, John L Hopper, Anthony Howell, ABCTB Investigators, kConFab/AOCS Investigators, Milena Jakimovska, Anna Jakubowska, Esther M John, Michael E Jones, Audrey Jung, Rudolf Kaaks, Saila Kauppila, Renske Keeman, Elza Khusnutdinova, Cari M Kitahara, Yon-Dschun Ko, Stella Koutros, Vessela N Kristensen, Ute Krüger, Katerina Kubelka-Sabit, Allison W Kurian, Kyriacos Kyriacou, Diether Lambrechts, Derrick G Lee, Annika Lindblom, Martha Linet, Jolanta Lissowska, Ana Llaneza, Wing-Yee Lo, Robert J Macinnis, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Maria Elena Martinez, Catriona Mclean, Alfons Meindl, Usha Menon, Heli Nevanlinna, William G Newman, Jesse Nodora, Kenneth Offit, Håkan Olsson, Nick Orr, Tjoung-Won Park-Simon, Alpa V Patel, Julian Peto, Guillermo Pita, Dijana Plaseska-Karanfilska, Ross Prentice, Kevin Punie, Katri Pylkäs, Paolo Radice, Gad Rennert, Atocha Romero, Thomas Rüdiger, Emmanouil Saloustros, Sarah Sampson, Dale P Sandler, Elinor J Sawyer, Rita K Schmutzler, Minouk J Schoemaker, Ben Schöttker, Mark E Sherman, Xiao-Ou Shu, Snezhana Smichkoska, Melissa C Southey, John J Spinelli, Anthony J Swerdlow, Rulla M Tamimi, William J Tapper, Jack A Taylor, Lauren R Teras, Mary Beth Terry, Diana Torres, Melissa A Troester, Celine M Vachon, Carolien HM van Deurzen, Elke M van Veen, Philippe Wagner, Clarice R Weinberg, Camilla Wendt, Jelle Wesseling, Robert Winqvist, Alicja Wolk, Xiaohong R Yang, Wei Zheng, Fergus J Couch, Jacques Simard, Peter Kraft, Douglas F Easton, Paul DP Pharoah, Marjanka K Schmidt, Montserrat García-Closas, Nilanjan Chatterjee
Feb 05, 2022
BACKGROUND: Genome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these...
Mendelian randomisation study of smoking exposure in relation to breast cancer risk
Hanla A. Park, Sonja Neumeyer, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Adinda Baten, Laura E. Beane Freeman, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Natalia V. Bogdanova, Stig E. Bojesen, Hiltrud Brauch, Hermann Brenner, Sara Y. Brucker, Barbara Burwinkel, Daniele Campa, Federico Canzian, Jose E. Castelao, Stephen J. Chanock, Georgia Chenevix-Trench, Christine L. Clarke, Don M. Conroy, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dörk, Isabel dos-Santos-Silva, Miriam Dwek, Diana M. Eccles, A. Heather Eliassen, Christoph Engel, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Henrik Flyger, Lin Fritschi, Montserrat García-Closas, José A. García-Sáenz, Mia M. Gaudet, Graham G. Giles, Gord Glendon, Mark S. Goldberg, David E. Goldgar, Anna González-Neira, Mervi Grip, Pascal Guénel, Eric Hahnen, Christopher A. Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Sileny Han, Elaine F. Harkness, Steven N. Hart, Wei He, Bernadette A. M. Heemskerk-Gerritsen, John L. Hopper, David J. Hunter, Agnes Jager, Anna Jakubowska, Esther M. John, Audrey Jung, Rudolf Kaaks, Pooja Middha Kapoor, Renske Keeman, Elza Khusnutdinova, Cari M. Kitahara, Linetta B. Koppert, Stella Koutros, Vessela N. Kristensen, Allison W. Kurian, James Lacey, Diether Lambrechts, Loic Le Marchand, Wing-Yee Lo, Jan Lubiński, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Maria Elena Martinez, Dimitrios Mavroudis, Alfons Meindl, Usha Menon, Roger L. Milne, Taru A. Muranen, Heli Nevanlinna, William G. Newman, Børge G. Nordestgaard, Kenneth Offit, Andrew F. Olshan, Håkan Olsson, Tjoung-Won Park-Simon, Paolo Peterlongo, Julian Peto, Dijana Plaseska-Karanfilska, Nadege Presneau, Paolo Radice, Gad Rennert, Hedy S. Rennert, Atocha Romero, Emmanouil Saloustros, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Minouk J. Schoemaker, Lukas Schwentner, Christopher Scott, Mitul Shah, Xiao-Ou Shu, Jacques Simard, Ann Smeets, Melissa C. Southey, John J. Spinelli, Victoria Stevens, Anthony J. Swerdlow, Rulla M. Tamimi, William J. Tapper, Jack A. Taylor, Mary Beth Terry, Ian Tomlinson, Melissa A. Troester, Thérèse Truong, Celine M. Vachon, Elke M. van Veen, Joseph Vijai, Sophia Wang, Camilla Wendt, Robert Winqvist, Alicja Wolk, Argyrios Ziogas, Alison M. Dunning, Paul D. P. Pharoah, Douglas F. Easton, Wei Zheng, Peter Kraft, Jenny Chang-Claude, Anne-Lise Børresen-Dale, Grethe I. Grenaker Alnæs, Kristine K. Sahlberg, Lars Ottestad, Rolf Kåresen, Ellen Schlichting, Marit Muri Holmen, Toril Sauer, Vilde Haakensen, Olav Engebråten, Bjørn Naume, Alexander Fosså, Cecile E. Kiserud, Kristin V. Reinertsen, Åslaug Helland, Margit Riis, Jürgen Geisler, Christine Clarke, Deborah Marsh, Rodney Scott, Robert Baxter, Desmond Yip, Jane Carpenter, Alison Davis, Nirmala Pathmanathan, Peter Simpson, Dinny Graham, Mythily Sachchithananthan, David Amor, Lesley Andrews, Yoland Antill, Rosemary Balleine, Jonathan Beesley, Ian Bennett, Michael Bogwitz, Leon Botes, Meagan Brennan, Melissa Brown, Michael Buckley, Jo Burke, Phyllis Butow, Liz Caldon, Ian Campbell, Deepa Chauhan, Manisha Chauhan, Alice Christian, Paul Cohen, Alison Colley, Ashley Crook, James Cui, Margaret Cummings, Sarah-Jane Dawson, Anna DeFazio, Martin Delatycki, Rebecca Dickson, Joanne Dixon, Ted Edkins, Stacey Edwards, Gelareh Farshid, Andrew Fellows, Georgina Fenton, Michael Field, James Flanagan, Peter Fong, Laura Forrest, Stephen Fox, Juliet French, Michael Friedlander, Clara Gaff, Mike Gattas, Peter George, Sian Greening, Marion Harris, Stewart Hart, Nick Hayward, John Hopper, Cass Hoskins, Clare Hunt, Paul James, Mark Jenkins, Alexa Kidd, Judy Kirk, Jessica Koehler, James Kollias, Sunil Lakhani, Mitchell Lawrence, Geoff Lindeman, Lara Lipton, Liz Lobb, Graham Mann, Sue Anne McLachlan, Bettina Meiser, Roger Milne, Sophie Nightingale, Shona O’Connell, Sarah O’Sullivan, David Gallego Ortega, Nick Pachter, Briony Patterson, Amy Pearn, Kelly Phillips, Ellen Pieper, Edwina Rickard, Bridget Robinson, Mona Saleh, Elizabeth Salisbury, Christobel Saunders, Jodi Saunus, Clare Scott, Adrienne Sexton, Andrew Shelling, Melissa Southey, Amanda Spurdle, Jessica Taylor, Renea Taylor, Heather Thorne, Alison Trainer, Kathy Tucker, Jane Visvader, Logan Walker, Rachael Williams, Ingrid Winship, Mary Ann Young
Oct 13, 2021
Abstract: Background: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk....