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In India, piles are designed as per IS 2911:2010 (Part 1) for different soil conditions considering all the load criteria. But there is no such provision in Indian Standard Codes for designing piles in potentially liquefiable...

Environmental Engineering Geographic Information Systems Physical Sciences and Engineering

The fundamental role of Accounting Information Systems (AIS) in organizations was a processor of accounting data to produce quality accounting information to support the company's internal activities, which had a significant...

The fundamental role of Accounting Information Systems (AIS) in organizations was a processor of accounting data to produce quality accounting information to support the company's internal activities, which had a significant...

In data mining the task of extracting classification rules from large data is an important task and is gaining considerable attention. This article presents a novel ant miner for classification rule mining. The ant miner is...

Computer Science and Information Technology Artificial Intelligence Machine Learning

Energy efficiency House price Hedonic model Repeat sales model

The detection of underwater objects in a video is a challenging problem particularly when both the camera and the objects are in motion. In this article, this problem has been conceived as an incomplete data problem and hence...

Cognitive Informatics Computer Science and Information Technology Cognitive Informatics

Gene Regulatory Networks (GRNs) are the pioneering methodology for finding new gene interactions getting insights of the biological processes using time series gene expression data. It remains a challenge to study the temporal...

Information Retrieval Library and Information Science Information Retrieval

Renal cell carcinoma (RCC) is the most deadly of urological malignancies. Metastatic disease affects one third of patients at diagnosis with a further third developing metastatic disease after extirpative surgery. Heterogeneity...

Adult Aged Aged 80 and over Biomarkers Tumor Carcinoma Renal Cell Female Fluorescent Antibody Technique Gene Expression Regulation Neoplastic Humans Kaplan-Meier Estimate Male Middle Aged Neoplasm Metastasis Prognosis Proteomics venous thrombosis

Social media has progressively grown in the last century and is now seen as a potential opportunity for various purposes, including the decision-making. The present work explores how social media platforms such as Facebook...

Decision Support Systems Computer Science and Information Technology Decision Support Systems

Background: Although attention deficit hyperactivity disorder (ADHD) is thought to reflect a continuously distributed quantitative trait, it is assessed through binary diagnosis or skewed measures biased towards its high...

Attention Deficit Hyperactivity Disorder Extremes Positive genetics Quantitative Trait TWIN

Background: Although attention deficit hyperactivity disorder (ADHD) is thought to reflect a continuously distributed quantitative trait, it is assessed through binary diagnosis or skewed measures biased towards its high...

Attention Deficit Hyperactivity Disorder Extremes Positive genetics Quantitative Trait TWIN

The rpoB gene encodes the β subunit of RNA polymerase holoenzyme in Mycobacterium leprae (M. leprae). Missense mutations in the rpoB gene were identified as etiological factors for rifampin resistance in leprosy. In the present...

Adolescent Adult Bacterial Proteins DNA Bacterial DNA-Directed RNA Polymerases Drug Resistance Bacterial Female Humans india Leprostatic Agents Leprosy Male Microbial Sensitivity Tests Middle Aged Mutation Mycobacterium leprae Protein Binding Protein Stability Recurrence Rifampin Sequence Analysis DNA Structure-Activity Relationship Treatment Outcome Young Adult

BACKGROUND: Epithelial-to-mesenchymal transition (EMT) has recently been implicated in the initiation and progression of renal cell carcinoma (RCC). Some mRNA gene expression studies have suggested a link between the EMT...

Adult Aged Aged 80 and over Antibodies Neoplasm Automation Carcinoma Renal Cell Cluster Analysis Databases Genetic Disease-Free Survival Epithelial-Mesenchymal Transition Female Fluorescent Antibody Technique Gene Expression Regulation Neoplastic Humans Kidney Neoplasms Male Middle Aged Multivariate Analysis Neoplasm Proteins Oligonucleotide Array Sequence Analysis Phenotype Proportional Hazards Models Reproducibility of Results statistics Nonparametric

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.

Whole-genome-sequencing (WGS) of human tumors has revealed distinct mutation patterns that hint at the causative origins of cancer. We examined mutational signatures in 324 WGS human-induced pluripotent stem cells exposed to 79...

DNA Damage mutational signatures Carcinogens environmental mutagens Mutagenesis Carcinogens environmental DNA Damage DNA Mutational Analysis DNA Repair DNA Replication Genetic profile Genome Human Humans INDEL Mutation Mutagenesis Mutation Neoplasms Pluripotent Stem Cells whole genome sequencing

Orally administrated iron is suspected to increase susceptibility to enteric infections among children in infection endemic regions. Here we investigated the effect of dietary iron on the pathology and local immune responses...

Caenorhabditis elegans gut microbiome Intestinal pathogens iron supplementation Lipocalin-2

Orally administrated iron is suspected to increase susceptibility to enteric infections among children in infection endemic regions. Here we investigated the effect of dietary iron on the pathology and local immune responses...

Caenorhabditis elegans gut microbiome Intestinal pathogens iron supplementation Lipocalin-2

Mutational signatures are imprints of pathophysiological processes arising through tumorigenesis. We generated isogenic CRISPR-Cas9 knockouts (Δ) of 43 genes in human induced pluripotent stem cells, cultured them in the absence...

CRISPR-Cas9 systems Genomic Instability Cancer Cancer genomics Brain Neoplasms Clustered Regularly Interspaced Short Palindromic Repeats Colorectal Neoplasms DNA Damage Humans Induced Pluripotent Stem Cells Mutation Neoplastic Syndromes Hereditary

DSTYK Spastic Paraplegia 23 autosomal-recessive deletion GENE hereditary spastic paraplegia Mutation Pigmentation vitiligo whole-exome sequencing