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Applications of Mechatronics in Textiles and Clothing Industries
This article focuses on the transformative potential of mechatronics in up-to-date textiles and clothing industries, with a special focus on its implications for automation, efficiency in production, and product quality....
Published by: IGI Global Scientific Publishing
Microglia and the aging brain
The single largest risk factor for etiology of neurodegenerative diseases like Alzheimer's disease is increased age. Therefore, understanding the changes that occur as a result of aging is central to any possible prevention...
Altered Processing of β-Amyloid in SH-SY5Y Cells Induced by Model Senescent Microglia
The single greatest risk factor for neurodegenerative diseases is aging. Aging of cells such as microglia in the nervous system has an impact not only on the ability of those cells to function but also on cells they interact...
APP ER stress Autophagy insulin degrading enzyme Microglia β-amyloid /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/1300/1314 name=Physiology /dk/atira/pure/subjectarea/asjc/2800/2805 name=Cognitive Neuroscience /dk/atira/pure/subjectarea/asjc/1300/1307 name=Cell Biology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Microglia and the aging brain
The single largest risk factor for etiology of neurodegenerative diseases like Alzheimer's disease is increased age. Therefore, understanding the changes that occur as a result of aging is central to any possible prevention...
Altered Processing of β-Amyloid in SH-SY5Y Cells Induced by Model Senescent Microglia
The single greatest risk factor for neurodegenerative diseases is aging. Aging of cells such as microglia in the nervous system has an impact not only on the ability of those cells to function but also on cells they interact...
APP ER stress Autophagy insulin degrading enzyme Microglia β-amyloid /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/1300/1314 name=Physiology /dk/atira/pure/subjectarea/asjc/2800/2805 name=Cognitive Neuroscience /dk/atira/pure/subjectarea/asjc/1300/1307 name=Cell Biology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Levels of α- and β-synuclein regulate cellular susceptibility to toxicity from α-synuclein oligomers
α-Synuclein (α-syn) is associated with a range of diseases, including Parkinson disease. In disease, α-syn is known to aggregate and has the potential to be neurotoxic. The association between copper and α-syn results inthe...
Levels of α- and β-synuclein regulate cellular susceptibility to toxicity from α-synuclein oligomers
α-Synuclein (α-syn) is associated with a range of diseases, including Parkinson disease. In disease, α-syn is known to aggregate and has the potential to be neurotoxic. The association between copper and α-syn results inthe...
ArcHives—combined palynological, genomic and lipid analysis of medieval wax seals
Abstract Beeswax is a product of honeybees (Apis mellifera ) and has been used extensively through time, especially as the primary component in medieval sealing wax for...
TM Kasso, R Enevold, S Johns, G Rangel-Piñeros, AJ Taurozzi, A Sutherland, M Ramsøe, LV Angelova, M Roffet-Salque, MJ Collins, C Carøe
Jan 19, 2023
Alpha synuclein aggregation drives ferroptosis
Plamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S. Dolt, Tilo Kunath, Michael J. Devine, Paul Gissen, Mikhail S. Shchepinov, Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Sep 16, 2020
Abstract: Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death...
Alpha synuclein aggregation drives ferroptosis
Plamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S. Dolt, Tilo Kunath, Michael J. Devine, Paul Gissen, Mikhail S. Shchepinov, Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Oct 12, 2020
Abstract: Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death...
Alpha synuclein aggregation drives ferroptosis
Plamena R Angelova, Minee L Choi, Alexey V Berezhnov, Mathew H Horrocks, Craig D Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S Dolt, Tilo Kunath, Michael J Devine, Paul Gissen, Mikhail S Shchepinov, Sergiy Sylantyev, Evgeny V Pavlov, David Klenerman, Andrey Y Abramov, Sonia Gandhi
Apr 27, 2021
Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death called...
Alpha synuclein aggregation drives ferroptosis
Plamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S. Dolt, Tilo Kunath, Michael J. Devine, Paul Gissen, Mikhail S. Shchepinov, Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Feb 09, 2021
Abstract: Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death...
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.
Marthe HR Ludtmann, Plamena R Angelova, Mathew H Horrocks, Minee L Choi, Margarida Rodrigues, Artyom Y Baev, Alexey V Berezhnov, Zhi Yao, Daniel Little, Blerida Banushi, Afnan Saleh Al-Menhali, Rohan T Ranasinghe, Daniel R Whiten, Ratsuda Yapom, Karamjit Singh Dolt, Michael J Devine, Paul Gissen, Tilo Kunath, Morana Jaganjac, Evgeny V Pavlov, David Klenerman, Andrey Y Abramov, Sonia Gandhi
Oct 10, 2018
Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP synthase efficiency. Here, we report that...
Animals Coculture Techniques Embryonic Stem Cells Humans Induced Pluripotent Stem Cells Lipid Peroxidation Mitochondria Mitochondrial Membrane Transport Proteins Mitochondrial Permeability Transition Pore Mitochondrial Proton-Translocating ATPases Neurons Oxidation-Reduction Parkinson Disease Patch-Clamp Techniques Permeability Proteomics Rats Rats Sprague-Dawley Reactive Oxygen Species ALPHA-SYNUCLEIN
Alpha synuclein aggregation drives ferroptosis
Plamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S. Dolt, Tilo Kunath, Michael J. Devine, Paul Gissen, Mikhail S. Shchepinov, Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Oct 02, 2020
Abstract: Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death...
Why Gamification is Malarkey
Amy Todd
Mar 17, 2017
Within education, gamification is described as an emerging trend, a tool, and possibly the holistic approach of a new pedagogy (Biro, 2013; Dicheva, Dichev, Agre, & Angelova, 2015). Supporters of gamification state that, if...
Published by: The Morning Watch: Educational and Social Analysis
Why Gamification is Malarkey
Amy Todd
Mar 17, 2017
Within education, gamification is described as an emerging trend, a tool, and possibly the holistic approach of a new pedagogy (Biro, 2013; Dicheva, Dichev, Agre, & Angelova, 2015). Supporters of gamification state that, if...
Published by: The Morning Watch: Educational and Social Analysis
Clonal somatic copy number altered driver events inform drug sensitivity in high-grade serous ovarian cancer.
Filipe Correia Martins, Dominique-Laurent Couturier, Ines de Santiago, Carolin Margarethe Sauer, Maria Vias, Mihaela Angelova, Deborah Sanders, Anna Piskorz, James Hall, Karen Hosking, Anumithra Amirthanayagam, Sabina Cosulich, Larissa Carnevalli, Barry Davies, Thomas BK Watkins, Ionut G Funingana, Helen Bolton, Krishnayan Haldar, John Latimer, Peter Baldwin, Robin Crawford, Matthew Eldridge, Bristi Basu, Mercedes Jimenez-Linan, Andrew W Mcpherson, Nicholas McGranahan, Kevin Litchfield, Sohrab P Shah, Iain McNeish, Carlos Caldas, Gerard Evan, Charles Swanton, James D Brenton
Nov 26, 2022
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.
Minee L Choi, Alexandre Chappard, Bhanu P Singh, Catherine Maclachlan, Margarida Rodrigues, Evgeniya I Fedotova, Alexey V Berezhnov, Suman De, Christopher J Peddie, Dilan Athauda, Gurvir S Virdi, Weijia Zhang, James R Evans, Anna I Wernick, Zeinab Shadman Zanjani, Plamena R Angelova, Noemi Esteras, Andrey Y Vinokurov, Katie Morris, Kiani Jeacock, Laura Tosatto, Daniel Little, Paul Gissen, David J Clarke, Tilo Kunath, Lucy Collinson, David Klenerman, Andrey Y Abramov, Mathew H Horrocks, Sonia Gandhi
Oct 24, 2022
Aggregation of alpha-synuclein (α-Syn) drives Parkinson's disease (PD), although the initial stages of self-assembly and structural conversion have not been directly observed inside neurons. In this study, we tracked the...
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.
Minee L Choi, Alexandre Chappard, Bhanu P Singh, Catherine Maclachlan, Margarida Rodrigues, Evgeniya I Fedotova, Alexey V Berezhnov, Suman De, Christopher J Peddie, Dilan Athauda, Gurvir S Virdi, Weijia Zhang, James R Evans, Anna I Wernick, Zeinab Shadman Zanjani, Plamena R Angelova, Noemi Esteras, Andrey Y Vinokurov, Katie Morris, Kiani Jeacock, Laura Tosatto, Daniel Little, Paul Gissen, David J Clarke, Tilo Kunath, Lucy Collinson, David Klenerman, Andrey Y Abramov, Mathew H Horrocks, Sonia Gandhi
Sep 07, 2022
Aggregation of alpha-synuclein (α-Syn) drives Parkinson's disease (PD), although the initial stages of self-assembly and structural conversion have not been directly observed inside neurons. In this study, we tracked the...
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.
Minee L Choi, Alexandre Chappard, Bhanu P Singh, Catherine Maclachlan, Margarida Rodrigues, Evgeniya I Fedotova, Alexey V Berezhnov, Suman De, Christopher J Peddie, Dilan Athauda, Gurvir S Virdi, Weijia Zhang, James R Evans, Anna I Wernick, Zeinab Shadman Zanjani, Plamena R Angelova, Noemi Esteras, Andrey Y Vinokurov, Katie Morris, Kiani Jeacock, Laura Tosatto, Daniel Little, Paul Gissen, David J Clarke, Tilo Kunath, Lucy Collinson, David Klenerman, Andrey Y Abramov, Mathew H Horrocks, Sonia Gandhi
Sep 30, 2022
Aggregation of alpha-synuclein (α-Syn) drives Parkinson's disease (PD), although the initial stages of self-assembly and structural conversion have not been directly observed inside neurons. In this study, we tracked the...
Published by: Nature neuroscience
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Minee L. Choi, Alexandre Chappard, Bhanu P. Singh, Catherine Maclachlan, Margarida Rodrigues, Evgeniya I. Fedotova, Alexey V. Berezhnov, Suman De, Christopher J. Peddie, Dilan Athauda, Gurvir S. Virdi, Weijia Zhang, James R. Evans, Anna I. Wernick, Zeinab Shadman Zanjani, Plamena R. Angelova, Noemi Esteras, Andrey Y. Vinokurov, Katie Morris, Kiani Jeacock, Laura Tosatto, Daniel Little, Paul Gissen, David J. Clarke, Tilo Kunath, Lucy Collinson, David Klenerman, Andrey Y. Abramov, Mathew H. Horrocks, Sonia Gandhi
Oct 24, 2022
Abstract: Aggregation of alpha-synuclein (α-Syn) drives Parkinson’s disease (PD), although the initial stages of self-assembly and structural conversion have not been directly observed inside neurons. In this study, we tracked...
Clonal somatic copy number altered driver events inform drug sensitivity in high-grade serous ovarian cancer
Abstract Chromosomal instability is a major challenge to patient stratification and targeted drug development for high-grade serous ovarian carcinoma (HGSOC). Here we show that somatic copy number...
Filipe Correia Martins, Dominique-Laurent Couturier, Ines de Santiago, Carolin Margarethe Sauer, Maria Vias, Mihaela Angelova, Deborah Sanders, Anna Piskorz, James Hall, Karen Hosking, Anumithra Amirthanayagam, Sabina Cosulich, Larissa Carnevalli, Barry Davies, Thomas BK Watkins, Ionut G Funingana, Helen Bolton, Krishnayan Haldar, John Latimer, Peter Baldwin, Robin Crawford, Matthew Eldridge, Bristi Basu, Mercedes Jimenez-Linan, Andrew W Mcpherson, Nicholas McGranahan, Kevin Litchfield, Sohrab P Shah, Iain McNeish, Carlos Caldas, Gerard Evan, Charles Swanton, James D Brenton
Oct 26, 2022
Observation of Gravitational Waves from Two Neutron Star-Black Hole Coalescences
R Abbott, TD Abbott, S Abraham, F Acernese, K Ackley, A Adams, C Adams, RX Adhikari, VB Adya, C Affeldt, D Agarwal, M Agathos, K Agatsuma, N Aggarwal, OD Aguiar, L Aiello, A Ain, P Ajith, T Akutsu, KM Aleman, G Allen, A Allocca, PA Altin, A Amato, S Anand, A Ananyeva, SB Anderson, WG Anderson, M Ando, SV Angelova, S Ansoldi, JM Antelis, S Antier, S Appert, K Arai, K Arai, Y Arai, S Araki, A Araya, MC Araya, JS Areeda, M Arène, N Aritomi, N Arnaud, SM Aronson, KG Arun, H Asada, Y Asali, G Ashton, Y Aso, SM Aston, P Astone, F Aubin, P Aufmuth, K AultONeal, C Austin, S Babak, F Badaracco, MKM Bader, S Bae, Y Bae, AM Baer, S Bagnasco, Y Bai, L Baiotti, J Baird, R Bajpai, M Ball, G Ballardin, SW Ballmer, M Bals, A Balsamo, G Baltus, S Banagiri, D Bankar, RS Bankar, JC Barayoga, C Barbieri, BC Barish, D Barker, P Barneo, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, J Bartlett, MA Barton, I Bartos, R Bassiri, A Basti, M Bawaj, JC Bayley, AC Baylor, M Bazzan, B Bécsy, VM Bedakihale, M Bejger, I Belahcene, V Benedetto
Jul 07, 2021
We report the observation of gravitational waves from two compact binary
coalescences in LIGO's and Virgo's third observing run with properties
consistent with neutron star-black hole (NSBH) binaries. The two events are
named...
Narrowband Searches for Continuous and Long-duration Transient Gravitational Waves from Known Pulsars in the LIGO-Virgo Third Observing Run
R Abbott, TD Abbott, F Acernese, K Ackley, C Adams, N Adhikari, RX Adhikari, VB Adya, C Affeldt, D Agarwal, M Agathos, K Agatsuma, N Aggarwal, OD Aguiar, L Aiello, A Ain, P Ajith, T Akutsu, S Albanesi, A Allocca, PA Altin, A Amato, C Anand, S Anand, A Ananyeva, SB Anderson, WG Anderson, M Ando, T Andrade, N Andres, T Andrić, SV Angelova, S Ansoldi, JM Antelis, S Antier, S Appert, K Arai, K Arai, Y Arai, S Araki, A Araya, MC Araya, JS Areeda, M Arène, N Aritomi, N Arnaud, SM Aronson, KG Arun, H Asada, Y Asali, G Ashton, Y Aso, M Assiduo, SM Aston, P Astone, F Aubin, C Austin, S Babak, F Badaracco, MKM Bader, C Badger, S Bae, Y Bae, AM Baer, S Bagnasco, Y Bai, M Bailes, L Baiotti, J Baird, R Bajpai, M Ball, G Ballardin, SW Ballmer, A Balsamo, G Baltus, S Banagiri, D Bankar, JC Barayoga, C Barbieri, BC Barish, D Barker, P Barneo, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, J Bartlett, MA Barton, I Bartos, R Bassiri, A Basti, M Bawaj, JC Bayley, AC Baylor, M Bazzan, B Bécsy, VM Bedakihale, M Bejger, I Belahcene
Jun 29, 2022
Isolated neutron stars that are asymmetric with respect to their spin axis
are possible sources of detectable continuous gravitational waves. This paper
presents a fully-coherent search for such signals from eighteen pulsars in...
Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift during the LIGO-Virgo Run O3b
R Abbott, TD Abbott, F Acernese, K Ackley, C Adams, N Adhikari, RX Adhikari, VB Adya, C Affeldt, D Agarwal, M Agathos, K Agatsuma, N Aggarwal, OD Aguiar, L Aiello, A Ain, P Ajith, T Akutsu, S Albanesi, A Allocca, PA Altin, A Amato, C Anand, S Anand, A Ananyeva, SB Anderson, WG Anderson, M Ando, T Andrade, N Andres, T Andrić, SV Angelova, S Ansoldi, JM Antelis, S Antier, S Appert, K Arai, K Arai, Y Arai, S Araki, A Araya, MC Araya, JS Areeda, M Arène, N Aritomi, N Arnaud, SM Aronson, KG Arun, H Asada, Y Asali, G Ashton, Y Aso, M Assiduo, SM Aston, P Astone, F Aubin, C Austin, S Babak, F Badaracco, MKM Bader, C Badger, S Bae, Y Bae, AM Baer, S Bagnasco, Y Bai, L Baiotti, J Baird, R Bajpai, M Ball, G Ballardin, SW Ballmer, A Balsamo, G Baltus, S Banagiri, D Bankar, JC Barayoga, C Barbieri, BC Barish, D Barker, P Barneo, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, J Bartlett, MA Barton, I Bartos, R Bassiri, A Basti, M Bawaj, JC Bayley, AC Baylor, M Bazzan, B Bécsy, VM Bedakihale, M Bejger, I Belahcene, V Benedetto
Apr 13, 2022
We search for gravitational-wave signals associated with gamma-ray bursts
detected by the Fermi and Swift satellites during the second half of the third
observing run of Advanced LIGO and Advanced Virgo (1 November 2019 15:00...
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