Search

Results: 94673
Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS.
Frontotemporal dementia (FTD) is a neurodegenerative disorder predominantly affecting the frontal and temporal lobes. Genome-wide association studies (GWAS) on FTD identified only a few risk loci. One of the possible...
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
Sven J van der Lee, Olivia J Conway, Iris Jansen, Minerva M Carrasquillo, Luca Kleineidam, Erik van den Akker, Isabel Hernández, Kristel R van Eijk, Najada Stringa, Jason A Chen, Anna Zettergren, Till FM Andlauer, Monica Diez-Fairen, Javier Simon-Sanchez, Alberto Lleó, Henrik Zetterberg, Marianne Nygaard, Cornelis Blauwendraat, Jeanne E Savage, Jonas Mengel-From, Sonia Moreno-Grau, Michael Wagner, Juan Fortea, Michael J Keogh, Kaj Blennow, Ingmar Skoog, Manuel A Friese, Olga Pletnikova, Miren Zulaica, Carmen Lage, Itziar de Rojas, Steffi Riedel-Heller, Ignacio Illán-Gala, Wei Wei, Bernard Jeune, Adelina Orellana, Florian Then Bergh, Xue Wang, Marc Hulsman, Nina Beker, Niccolo Tesi, Christopher M Morris, Begoña Indakoetxea, Lyduine E Collij, Martin Scherer, Estrella Morenas-Rodríguez, James W Ironside, Bart NM van Berckel, Daniel Alcolea, Heinz Wiendl, Samantha L Strickland, Pau Pastor, Eloy Rodríguez Rodríguez, EADB (Alzheimer Disease European DNA biobank) DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), IPDGC (The International Parkinson Disease Genomics Consortium) IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia), Netherlands Brain Bank (NBB), Bradley F Boeve, Ronald C Petersen, Tanis J Ferman, Jay A van Gerpen, Marcel JT Reinders, Ryan J Uitti, Lluís Tárraga, Wolfgang Maier, Oriol Dols-Icardo, Amit Kawalia, Maria Carolina Dalmasso, Mercè Boada, Uwe K Zettl, Natasja M van Schoor, Marian Beekman, Mariet Allen, Eliezer Masliah, Adolfo López de Munain, Alexander Pantelyat, Zbigniew K Wszolek, Owen A Ross, Dennis W Dickson, Neill R Graff-Radford, David Knopman, Rosa Rademakers, Afina W Lemstra, Yolande AL Pijnenburg, Philip Scheltens, Thomas Gasser, Patrick F Chinnery, Bernhard Hemmer, Martijn A Huisman, Juan Troncoso, Fermin Moreno, Ellen A Nohr, Thorkild IA Sørensen, Peter Heutink, Pascual Sánchez-Juan, Danielle Posthuma, GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, Jordi Clarimón, Kaare Christensen, Nilüfer Ertekin-Taner, Sonja W Scholz, Alfredo Ramirez, Agustín Ruiz, Eline Slagboom, Wiesje M van der Flier, Henne Holstege
Jun 06, 2020
The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other...
Association between midlife dementia risk factors and longitudinal brain atrophy
Background: Increased rates of brain atrophy on serial MRI are frequently used as a surrogate marker of disease progression in Alzheimer’s disease and other dementias. However, the extent to which they are associated with future...
SCORE2-OP risk prediction algorithms
AIMS: The aim of this study was to derive and validate the SCORE2-Older Persons (SCORE2-OP) risk model to estimate 5- and 10-year risk of cardiovascular disease (CVD) in individuals aged over 70 years in four geographical risk...
Mapping behavioural, cognitive and affective transdiagnostic dimensions in frontotemporal dementia.
Two common clinical variants of frontotemporal dementia are the behavioural variant frontotemporal dementia, presenting with behavioural and personality changes attributable to prefrontal atrophy, and semantic dementia...
Trauma and depressive symptomatology in middle-aged persons at high risk of dementia
Objective: Depression and trauma are associated with changes in brain regions implicated in Alzheimer’s disease. The present study examined associations between childhood trauma, depression, adult cognitive functioning and risk...
Published by: BMJ Publishing Group
Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
We examined the role of repeat expansions in the pathogenesis of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) by analyzing whole-genome sequence data from 2,442 FTD/ALS patients, 2,599 Lewy body dementia...

|<

<

1

2

3

4

5

>

>|