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An evaluation of the clinical and cost-effectiveness of alternative care locations for critically ill adult patients with acute traumatic brain injury.
R Grieve, Z Sadique, M Gomes, M Smith, FE Lecky, PJA Hutchinson, DK Menon, KM Rowan, DA Harrison, Risk Adjustment In Neurocritical care (RAIN) Study Investigators
Jun 25, 2018
BACKGROUND: For critically ill adult patients with acute traumatic brain injury (TBI), we assessed the clinical and cost-effectiveness of: (a) Management in dedicated neurocritical care units versus combined neuro/general...
Consensus summary statement of the International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care
Peter Le Roux, David K Menon, Giuseppe Citerio, Paul Vespa, Mary Kay Bader, Gretchen M Brophy, Michael N Diringer, Nino Stocchetti, Walter Videtta, Rocco Armonda, Neeraj Badjatia, Julian Böesel, Randall Chesnut, Sherry Chou, Jan Claassen, Marek Czosnyka, Michael De Georgia, Anthony Figaji, Jennifer Fugate, Raimund Helbok, David Horowitz, Peter Hutchinson, Monisha Kumar, Molly McNett, Chad Miller, Andrew Naidech, Mauro Oddo, DaiWai Olson, Kristine O'Phelan, J Javier Provencio, Corinna Puppo, Richard Riker, Claudia Robertson, Michael Schmidt, Fabio Taccone, Neurocritical Care Society, European Society of Intensive Care Medicine
Jan 09, 2019
Neurocritical care depends, in part, on careful patient monitoring but as yet there are little data on what processes are the most important to monitor, how these should be monitored, and whether monitoring these processes is...
Diffuse Intracranial Injury Patterns Are Associated with Impaired Cerebrovascular Reactivity in Adult Traumatic Brain Injury
Frederick A Zeiler, François Mathieu, Miguel Monteiro, Ben Glocker, Ari Ercole, Erta Beqiri, Manuel Cabeleira, Nino Stocchetti, Peter Smielewski, Marek Czosnyka, Virginia Newcombe, David K Menon, the CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Feb 28, 2020
Recent single-center retrospective analysis displayed the association between admission computed tomography (CT) markers of diffuse intracranial injury and worse cerebrovascular reactivity. The goal of this study was to further...
Differences in access to Emergency Paediatric Intensive Care and care during Transport (DEPICT)
Padmanabhan Ramnarayan, Ruth Evans, Elizabeth S Draper, Sarah E Seaton, Jo Wray, Stephen Morris, Christina Pagel, DEPICT Study Investigators
Nov 17, 2020
INTRODUCTION: Following centralisation of UK paediatric intensive care, specialist retrieval teams were established who travel to general hospitals to stabilise and transport sick children to regional paediatric intensive care...
The United Kingdom Childhood Cancer Study
UK Childhood Cancer Study Investigators
Feb 21, 2020
An investigation into the possible causes of childhood cancer has been carried out throughout England, Scotland and Wales over the period 1991-1998. All children known to be suffering from one or other type of the disease over...
Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection
Hugh S Markus, Christopher Levi, Alice King, Jeremy Madigan, John Norris, Cervical Artery Dissection in Stroke Study (CADISS) Investigators
Mar 19, 2019
IMPORTANCE: Extracranial carotid and vertebral artery dissection is an important cause of stroke, particularly in younger individuals. In some but not all observational studies, it has been associated with a high risk of...
Adolescent Adult Aged Aged 80 and over Anticoagulants Aspirin Carotid Artery Internal Dissection Clopidogrel Dipyridamole Female Hemorrhage Heparin Humans Male Middle Aged Mortality Platelet Aggregation Inhibitors Recurrence Secondary Prevention stroke Treatment Outcome Vertebral Artery Dissection Warfarin Young Adult
Rain Garden Maintenance Guide
Hannah Blanco
Jan 01, 0001
Gardens, while serving an aesthetic purpose, also have practical and ecological importance. They provide food and habitat for local pollinators and wildlife, and, in the case of the rain garden, perform the important task of...
Published by: Ursinus College
SCORE2-OP risk prediction algorithms
AIMS: The aim of this study was to derive and validate the SCORE2-Older Persons (SCORE2-OP) risk model to estimate 5- and 10-year risk of cardiovascular disease (CVD) in individuals aged over 70 years in four geographical risk...
APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up
HAD Keage, FE Matthews, A Yip, L Gao, C McCracken, IG McKeith, DC Rubinsztein, C Brayne, MRC Cognitive Function and Ageing Study
Jul 10, 2018
BACKGROUND: dementia risk conferred by apolipoprotein-E (APOE) and angiotensin-1-converting enzyme (ACE) polymorphisms have been reported for the MRC Cognitive Function and Ageing Study (CFAS) at 6-year follow-up. We concentrate...
Psychological impact of family history risk assessment in primary care
BACKGROUND: Routine family history risk assessment for chronic diseases could enable primary care practitioners to efficiently identify at-risk patients and promote preventive management strategies. OBJECTIVES: To investigate...
Treatment targets based on autoregulation parameters in neurocritical care patients.
PURPOSE OF REVIEW: This review summarizes the physiological basis of autoregulation-oriented therapy in critically ill patients, with a particular emphasis on individual targets based on parameters that describe autoregulation...
Risk-return relationships and asymmetric adjustment in the UK housing market
This study employs an EGARCH-M model to determine whether regional house prices in the UK share any of the properties associated with assets such as equities. The results suggest there is some evidence of a positive risk-return...
What are the optimum components in a care bundle aimed at reducing post-operative pulmonary complications in high-risk patients?
Sophie V Griffiths, Daniel H Conway, POPC-CB Investigators, Michael Sander, Ib Jammer, Michael PW Grocott, Ben C Creagh-Brown
Apr 28, 2020
BACKGROUND: Post-operative pulmonary complications (POPC) are common, predictable and associated with increased morbidity and mortality, independent of pre-operative risk. Interventions to reduce the incidence of POPC have been...
Social work support and unmet social needs in life after stroke
Sophie Lehnerer, Benjamin Hotter, Inken Padberg, Petra Knispel, Dike Remstedt, Andrea Liebenau, Ulrike Grittner, Ian Wellwood, Andreas Meisel, BSA Long Term Care Study Group
Sep 05, 2020
BACKGROUND: Stroke patients are often affected by long-term disabilities with needs concerning social issues. There is relatively little consideration of social recovery of patients and the support required to return to work...
Assessment tools Long-Term Care Screening social work Social situation stroke Unmet social needs Aged Aged 80 and over Caregivers Cross-Sectional Studies Disabled Persons Female Humans Long-Term Care Male Middle Aged Patient Discharge Quality of life Retrospective Studies social support Social Work stroke Stroke Rehabilitation Surveys and Questionnaires Survivors
Risk-return relationships and asymmetric adjustment in the UK housing market
This study employs an EGARCH-M model to determine whether regional house prices in the UK share any of the properties associated with assets such as equities. The results suggest there is some evidence of a positive risk-return...
Ten false beliefs in neurocritical care.
In acute brain injury, the need for specific expertise on central nervous pathophysiology is evident. However, even when the primary reason for ICU admission is extracranial, the brain may be affected too, through inadequate...
Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017
GBD 2017 Risk Factor Collaborators
Sep 18, 2019
BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising...
Adolescent Adult Age Distribution Aged Aged 80 and over Child Child Preschool Disabled Persons Environmental Exposure Female Global Burden of Disease Global Health Health Risk Behaviors Humans Infant Infant Newborn Life Expectancy Male Metabolic Diseases Middle Aged Occupational Diseases occupational exposure Quality-Adjusted Life Years Risk Assessment Sex Distribution Socioeconomic Factors Young Adult
Influenza-associated mortality in hospital care
Mark Reacher, Ben Warne, Lucy Reeve, Neville Q Verlander, Nicholas K Jones, Kyriaki Ranellou, Silvana Christou, Callum Wright, Saher Choudhry, Maria Zambon, Clare Sander, Hongyi Zhang, Hamid Jalal
Jan 03, 2020
BackgroundEvidence of an oseltamivir treatment effect on influenza A(H3N2) virus infections in hospitalised patients is incomplete.AimsThis cohort study aimed to evaluate risk factors for death among PCR-confirmed hospitalised...
Historic Cohort Study In-patient Mortality Influenza logistic regression Multivariable Logistic Regression Risk Factors Adolescent Adult Age Distribution Aged Aged 80 and over Antiviral Agents Child Child Preschool Female Guideline Adherence Hospital Mortality Hospitals Teaching Humans Infant Infant Newborn Influenza A virus H3N2 Subtype Influenza Human Inpatients Male Middle Aged Oseltamivir Polymerase Chain Reaction Retrospective Studies Young Adult
Hospital-level evaluation of the effect of a national quality improvement programme
Timothy J Stephens, Carol J Peden, Ryan Haines, Mike PW Grocott, Dave Murray, David Cromwell, Carolyn Johnston, Sarah Hare, Jose Lourtie, Sharon Drake, Graham P Martin, Rupert M Pearse, Enhanced Perioperative Care for High-risk patients (EPOCH) trial group
Oct 31, 2019
BACKGROUND AND OBJECTIVES: A clinical trial in 93 National Health Service hospitals evaluated a quality improvement programme for emergency abdominal surgery, designed to improve mortality by improving the patient care pathway....
Is loneliness associated with increased health and social care utilisation in the oldest old? Findings from a population-based longitudinal study.
Hanyuying Wang, Emily Zhao, Jane Fleming, Tom Dening, Kay-Tee Khaw, Carol Brayne, CC75C Study Collaboration
Apr 17, 2019
OBJECTIVES: The present study aimed to examine the impact of loneliness on health and social care service use in the oldest old over a 7-year follow-up. DESIGN: Prospective study. SETTING: UK population-based cohort....
Variation in Structure and Process of Care in Traumatic Brain Injury
Maryse C Cnossen, Suzanne Polinder, Hester F Lingsma, Andrew IR Maas, David Menon, Ewout W Steyerberg, CENTER-TBI Investigators and Participants
Jun 19, 2018
INTRODUCTION: The strength of evidence underpinning care and treatment recommendations in traumatic brain injury (TBI) is low. Comparative effectiveness research (CER) has been proposed as a framework to provide evidence for...
The effect of care provided by paediatric critical care transport teams on mortality of children transported to paediatric intensive care units in England and Wales
Sarah E Seaton, Elizabeth S Draper, Christina Pagel, Fatemah Rajah, Jo Wray, Padmanabhan Ramnarayan, DEPICT Study Team
Jul 12, 2021
BACKGROUND: Centralisation of paediatric intensive care units (PICUs) has the increased the need for specialist paediatric critical care transport teams (PCCT) to transport critically ill children to PICU. We investigated the...
Alemtuzumab CARE-MS II 5-year follow-up
Alasdair J Coles, Jeffrey A Cohen, Edward J Fox, Gavin Giovannoni, Hans-Peter Hartung, Eva Havrdova, Sven Schippling, Krzysztof W Selmaj, Anthony Traboulsee, D Alastair S Compston, David H Margolin, Karthinathan Thangavelu, Madalina C Chirieac, Darlene Jody, Panos Xenopoulos, Richard J Hogan, Michael A Panzara, Douglas L Arnold, CARE-MS II and CAMMS03409 Investigators
Dec 11, 2017
OBJECTIVE: To evaluate 5-year efficacy and safety of alemtuzumab in patients with active relapsing-remitting multiple sclerosis and inadequate response to prior therapy. METHODS: In the 2-year Comparison of Alemtuzumab and Rebif...
Affordable monsoon rain mitigation measures in the World Heritage site of Moenjodaro, Pakistan
The paper provides an overview of environmental monitoring, monsoon
rain deterioration effects, and affordable monitoring measures
implemented in the 52km of exposed walls of the Bronze Age
archaeological site of...
rain deterioration effects, and affordable monitoring measures
implemented in the 52km of exposed walls of the Bronze Age
archaeological site of...
Predicting risk of cardiovascular events 1 to 3 years post-myocardial infarction using a global registry.
Stuart J Pocock, David Brieger, John Gregson, Ji Y Chen, Mauricio G Cohen, Shaun G Goodman, Christopher B Granger, Richard Grieve, Jose C Nicolau, Tabassome Simon, Dirk Westermann, Satoshi Yasuda, Katarina Hedman, Kirsten L Rennie, Karolina Andersson Sundell, TIGRIS Study Investigators
Jan 16, 2020
BACKGROUND: Risk prediction tools are lacking for patients with stable disease some years after myocardial infarction (MI). HYPOTHESIS: A practical long-term cardiovascular risk index can be developed. METHODS: The long-Term...
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