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Comparison of serum and urinary biomarker panels with albumin/creatinine ratio in the prediction of renal function decline in type 1 diabetes.
Marco Colombo, Stuart J McGurnaghan, Luke AK Blackbourn, R Neil Dalton, David Dunger, Samira Bell, John R Petrie, Fiona Green, Sandra MacRury, John A McKnight, John Chalmers, Andrew Collier, Paul M McKeigue, Helen M Colhoun, Scottish Diabetes Research Network (SDRN) Type 1 Bioresource Investigators
Jan 07, 2021
AIMS/HYPOTHESIS: We examined whether candidate biomarkers in serum or urine can improve the prediction of renal disease progression in type 1 diabetes beyond prior eGFR, comparing their performance with urinary...
Clinical science EPIDEMIOLOGY Metabolomics Nephropathy Proteomics Adult Aged Albumins Albuminuria Biomarkers Blood Chemical Analysis Cohort Studies Creatinine Diabetes mellitus Type 1 Diabetic Nephropathies Diagnostic Techniques Endocrine Enzyme-Linked Immunosorbent Assay Female Humans Kidney Function Tests Male Middle Aged Prognosis Prospective Studies Scotland Serum Albumin Urinalysis
Biomarker panels associated with progression of renal disease in type 1 diabetes.
Marco Colombo, Erkka Valo, Stuart J McGurnaghan, Niina Sandholm, Luke AK Blackbourn, R Neil Dalton, David Dunger, Per-Henrik Groop, Paul M McKeigue, Carol Forsblom, Helen M Colhoun, FinnDiane Study Group and the Scottish Diabetes Research Network (SDRN) Type 1 Bioresource Collaboration
May 03, 2019
Medication Adherence During Adjunct Therapy With Statins and ACE Inhibitors in Adolescents With Type 1 Diabetes.
Elżbieta Niechciał, Carlo L Acerini, Scott T Chiesa, Tracey Stevens, R Neil Dalton, Denis Daneman, John E Deanfield, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, David B Dunger, M Loredana Marcovecchio, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group, Adolescent Type 1 Diabetes Cardio-renal Intervention Trial AdDIT Study Group
Jan 31, 2020
OBJECTIVE: Suboptimal adherence to insulin treatment is a main issue in adolescents with type 1 diabetes. However, to date, there are no available data on adherence to adjunct noninsulin medications in this population. Our aim...
Adolescent Angiotensin-Converting Enzyme Inhibitors Australia Canada Cardiovascular Diseases Chemotherapy Adjuvant Child Diabetes mellitus Type 1 Diabetic Angiopathies Double-Blind Method Drug Therapy Combination Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Insulin Male Medication Adherence United Kingdom
Adolescent type 1 Diabetes Cardio-renal Intervention Trial (AdDIT).
Adolescent Albuminuria Angiotensin-Converting Enzyme Inhibitors Area Under Curve Atorvastatin Biomarkers Cardiomyopathies Diabetes mellitus Type 1 Diabetic Nephropathies Double-Blind Method Drug Therapy Combination Dyslipidemias Female Follow-Up Studies Heptanoic Acids Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Male Multicenter Studies as Topic Puberty Pyrroles Quinapril Randomized Controlled Trials as Topic Research Design risk Tetrahydroisoquinolines
A new strategy for vascular complications in young people with type 1 diabetes mellitus.
M Loredana Marcovecchio, R Neil Dalton, Denis Daneman, John Deanfield, Timothy W Jones, H Andrew W Neil, David B Dunger, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group
Apr 16, 2019
Diabetes vascular complications, including cardiovascular disease, diabetic nephropathy and retinopathy, have a negative effect on the long-term prognosis of young people with type 1 diabetes mellitus (T1DM). Poor glycaemic...
Confirmation of novel type 1 diabetes risk loci in families.
JD Cooper, JMM Howson, D Smyth, NM Walker, H Stevens, JHM Yang, J-X She, GS Eisenbarth, M Rewers, JA Todd, B Akolkar, P Concannon, HA Erlich, C Julier, G Morahan, J Nerup, C Nierras, F Pociot, SS Rich, Type 1 Diabetes Genetics Consortium
Jul 09, 2019
AIMS/HYPOTHESIS: Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were...
Vascular Effects of ACE (Angiotensin-Converting Enzyme) Inhibitors and Statins in Adolescents With Type 1 Diabetes.
Scott T Chiesa, M Loredana Marcovecchio, Paul Benitez-Aguirre, Fergus J Cameron, Maria E Craig, Jennifer J Couper, Elizabeth A Davis, R Neil Dalton, Denis Daneman, Kim C Donaghue, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, David B Dunger, John E Deanfield, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group
Nov 03, 2020
An increased albumin-creatinine ratio within the normal range can identify adolescents at higher risk of developing adverse cardio-renal outcomes as they progress into adulthood. Utilizing a parallel randomized controlled trial...
Adolescent arteries Diabetes Type 1 Puberty Vascular diseases Adolescent Albuminuria Angiotensin-Converting Enzyme Inhibitors C-Reactive Protein Creatinine Diabetes mellitus Type 1 Double-Blind Method Drug Therapy Combination Endothelium Vascular Female Glycated Hemoglobin Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Lipids Male Pulse Wave Analysis Vascular Stiffness
Type 1 Diabetes Prevention
Anette-G Ziegler, Ezio Bonifacio, Alvin C Powers, John A Todd, Leonard C Harrison, Mark A Atkinson
Oct 07, 2016
Type 1 diabetes, a disease defined by absolute insulin deficiency, is considered a chronic autoimmune disorder resulting from the destruction of insulin-producing pancreatic β-cells. The incidence of childhood-onset type 1...
Biomarker panels associated with progression of renal disease in type 1 diabetes
Marco Colombo, Erkka Valo, Stuart J. McGurnaghan, Niina Sandholm, Luke A. K. Blackbourn, R. Neil Dalton, David Dunger, Per-Henrik Groop, Paul M. McKeigue, Carol Forsblom, Helen M. Colhoun
Jun 19, 2020
Abstract: Aims/hypothesis: We aimed to identify a sparse panel of biomarkers for improving the prediction of renal disease progression in type 1 diabetes. Methods: We considered 859 individuals recruited from the Scottish...
Renal and Cardiovascular Risk According to Tertiles of Urinary Albumin-to-Creatinine Ratio
M Loredana Marcovecchio, Scott T Chiesa, Jane Armitage, Denis Daneman, Kim C Donaghue, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, R Neil Dalton, John Deanfield, David B Dunger, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group
Oct 10, 2018
Comparison of serum and urinary biomarker panels with albumin/creatinine ratio in the prediction of renal function decline in type 1 diabetes
Marco Colombo, Stuart J. McGurnaghan, Luke A. K. Blackbourn, R. Neil Dalton, David Dunger, Samira Bell, John R. Petrie, Fiona Green, Sandra MacRury, John A. McKnight, John Chalmers, Andrew Collier, Paul M. McKeigue, Helen M. Colhoun
Jun 06, 2020
Abstract: Aims/hypothesis: We examined whether candidate biomarkers in serum or urine can improve the prediction of renal disease progression in type 1 diabetes beyond prior eGFR, comparing their performance with urinary...
Lower plasma insulin levels during overnight closed-loop in school children with type 1 diabetes
Ulrike Schierloh, Malgorzata E Wilinska, Ineke M Pit-Ten Cate, Petra Baumann, Roman Hovorka, Carine de Beaufort, Spidiman Study Group: Single Port Insulin Infusion for Improved Diabetes Management
Mar 11, 2019
BACKGROUND: Studies have shown that overnight closed-loop insulin delivery can improve glucose control and reduce the risk of hypoglycemia and hence may improve metabolic outcomes and reduce burden for children with type 1...
Relationship between islet autoantibody status and the clinical characteristics of children and adults with incident type 1 diabetes in a UK cohort.
Vassiliki Bravis, Akaal Kaur, Helen C Walkey, Ian F Godsland, Shivani Misra, Polly J Bingley, Alistair JK Williams, David B Dunger, Colin M Dayan, Mark Peakman, Nick S Oliver, Desmond G Johnston, Patient Advocate Group and Investigators ADDRESS-2 Management Committee
Jul 30, 2018
OBJECTIVES: To describe the characteristics of children and adults with incident type 1 diabetes in contemporary, multiethnic UK, focusing on differences between the islet autoantibody negative and positive. DESIGN...
Cardiac autonomic dysfunction is associated with high-risk albumin-to-creatinine ratio in young adolescents with type 1 diabetes in AdDIT (adolescent type 1 diabetes cardio-renal interventional trial).
Yoon Hi Cho, Maria E Craig, Elizabeth A Davis, Andrew M Cotterill, Jennifer J Couper, Fergus J Cameron, Paul Z Benitez-Aguirre, R Neil Dalton, David B Dunger, Timothy W Jones, Kim C Donaghue, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial
Aug 06, 2015
Pregnancy losses in women with type 1 or type 2 diabetes in the UK
Aim: This study aims to investigate pregnancy losses in women with type 1 and type 2 diabetes and compare this with the general population.
Methods: Pregnancies ending between 1993 and 2006 in those with type 1 or type...
Methods: Pregnancies ending between 1993 and 2006 in those with type 1 or type...
The National Institute for Health Research
V Goh, National Institute for Health Research Clinical Research Network Imaging Network Steering Group, Royal College of Radiologists' Academic Committee
Oct 01, 2019
Since the inception of the National Institute for Health Research (NIHR) in 2006, the landscape for the delivery of clinical research within the National Health Service (NHS) has been transformed. Clinical radiology has...
Pregnancy losses in women with type 1 or type 2 diabetes in the UK
Aim: This study aims to investigate pregnancy losses in women with type 1 and type 2 diabetes and compare this with the general population.
Methods: Pregnancies ending between 1993 and 2006 in those with type 1 or type...
Methods: Pregnancies ending between 1993 and 2006 in those with type 1 or type...
ENT audit and research in the era of trainee collaboratives.
Matthew E Smith, John Hardman, Matthew Ellis, Richard J Williams, The UK National ENT Trainee Research Network INTEGRATE
Sep 20, 2018
Large surgical audits and research projects are complex and costly to deliver, but increasingly surgical trainees are delivering these projects within formal collaboratives and research networks. Surgical trainee collaboratives...
Is an artificial pancreas (closed-loop system) for Type 1 diabetes effective?
The artificial pancreas is now a viable treatment option for people with Type 1 diabetes and has demonstrated improved glycaemic outcomes while also reducing the onus of self-management of Type 1 diabetes. Closed-loop...
Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn's disease
Evangelos Stournaras, Wendi Qian, Apostolos Pappas, You Yi Hong, Rasha Shawky, UK IBD BioResource Investigators, Tim Raine, Miles Parkes, UK IBD Bioresource Investigators
Jul 20, 2020
OBJECTIVE: Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date...
Reduced burden of diabetes and improved quality of life
Gianluca Musolino, Klemen Dovc, Charlotte K Boughton, Martin Tauschmann, Janet M Allen, Katrin Nagl, Maria Fritsch, James Yong, Emily Metcalfe, Dominique Schaeffer, Muriel Fichelle, Ulrike Schierloh, Alena G Thiele, Daniela Abt, Harald Kojzar, Julia K Mader, Sonja Slegtenhorst, Nicole Ashcroft, Malgorzata E Wilinska, Judy Sibayan, Nathan Cohen, Craig Kollman, Sabine E Hofer, Elke Fröhlich-Reiterer, Thomas M Kapellen, Carlo L Acerini, Carine de Beaufort, Fiona Campbell, Birgit Rami-Merhar, Roman Hovorka, KidsAP Consortium
May 29, 2019
OBJECTIVE: To evaluate the experiences of families with very young children aged 1 to 7 years (inclusive) with type 1 diabetes using day-and-night hybrid closed-loop insulin delivery. METHODS: Parents/caregivers of 20 children...
Artificial Pancreas closed-loop insulin delivery type 1 diabetes very young children Blood Glucose Blood Glucose Self-Monitoring Caregivers Child Child Preschool Circadian Rhythm Cost of Illness Cross-Over Studies Diabetes mellitus Type 1 Family Female Humans Infant Insulin Insulin Infusion Systems Male Parents Quality of life Surveys and Questionnaires
Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes.
A Vella, N Bouatia-Naji, B Heude, JD Cooper, CE Lowe, C Petry, SM Ring, DB Dunger, JA Todd, KK Ong
Aug 08, 2017
AIMS/HYPOTHESIS: Insulin-like growth factor-1 is a major childhood growth factor and promotes pancreatic islet cell survival and growth in vitro. We hypothesised that genetic variation in IGF1 might be associated with childhood...
Widening health inequalities related to type 1 diabetes care in children and young people in the UK
Abstract: In this recent 2019–2020 audit, 96% (168/173) of paediatric diabetes teams submitted data and included a total of 29,242 children and young people (CYP) up to the age of 24 years, and type 1 diabetes consisted of...
Published by: Diabetic Medicine
Parents’ experiences of caring for a young child with type 1 diabetes
Abstract: Aims: To synthesise the qualitative evidence on parents’ experiences of caring for a child aged ≤8 years with type 1 diabetes to identify: the challenges they encounter; their views about support received; ways in...
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