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Results: 70195
Lower plasma insulin levels during overnight closed-loop in school children with type 1 diabetes
Ulrike Schierloh, Malgorzata E Wilinska, Ineke M Pit-Ten Cate, Petra Baumann, Roman Hovorka, Carine de Beaufort, Spidiman Study Group: Single Port Insulin Infusion for Improved Diabetes Management
Mar 11, 2019
BACKGROUND: Studies have shown that overnight closed-loop insulin delivery can improve glucose control and reduce the risk of hypoglycemia and hence may improve metabolic outcomes and reduce burden for children with type 1...
Novel Single-Site Device for Conjoined Glucose Sensing and Insulin Infusion
Mathias Tschaikner, Kevin Powell, Miro Jungklaus, Martin Fritz, Martin Ellmerer, Roman Hovorka, Steve Lane, Thomas R Pieber, Werner Regittnig
Jul 01, 2019
OBJECTIVE: This study evaluated a novel diabetes treatment device that combines commercially available continuous glucose monitoring and insulin infusion technology in such a way as to perform insulin delivery and glucose...
Gestational diabetes
Ponnusamy Saravanan, Diabetes in Pregnancy Working Group, Maternal Medicine Clinical Study Group, UK Royal College of Obstetricians and Gynaecologists
Apr 30, 2021
Gestational diabetes, the most common medical disorder in pregnancy, is defined as glucose intolerance resulting in hyperglycaemia that begins or is first diagnosed in pregnancy. Gestational diabetes is associated with increased...
Changing the name of diabetes insipidus
Working Group for Renaming Diabetes Insipidus, Hiroshi Arima, Timothy Cheetham, Mirjam Christ-Crain, Deborah Cooper, Mark Gurnell, Juliana B Drummond, Miles Levy, Ann I McCormack, Joseph Verbalis, John Newell-Price, John AH Wass
Nov 16, 2022
'What's in a name? That which we call a rose/By any other name would smell as sweet' (Juliet, from Romeo and Juliet by William Shakespeare). Shakespeare's implication is that a name is nothing but a word, and it therefore...
Automated insulin delivery
Jennifer L Sherr, Lutz Heinemann, G Alexander Fleming, Richard M Bergenstal, Daniela Bruttomesso, Hélène Hanaire, Reinhard W Holl, John R Petrie, Anne L Peters, Mark Evans
Nov 05, 2022
A technological solution for the management of diabetes in people who require intensive insulin therapy has been sought for decades. The last 10 years have seen substantial growth in devices that can be integrated into clinical...
A new strategy for vascular complications in young people with type 1 diabetes mellitus.
M Loredana Marcovecchio, R Neil Dalton, Denis Daneman, John Deanfield, Timothy W Jones, H Andrew W Neil, David B Dunger, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group
Apr 16, 2019
Diabetes vascular complications, including cardiovascular disease, diabetic nephropathy and retinopathy, have a negative effect on the long-term prognosis of young people with type 1 diabetes mellitus (T1DM). Poor glycaemic...
The Barbados Insulin Matters (BIM) study
Charles G Taylor, Gordon Taylor, Anique Atherley, Ian Hambleton, Nigel Unwin, O Peter Adams
Jul 25, 2019
AIM: The purpose of this study was to document in people with type 2 diabetes (T2DM) in Barbados, attitudes and beliefs that may result in psychological insulin resistance. METHODS: A representative, population-based, sample of...
Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.
Lourdes Ortiz-Fernández, Francisco David Carmona, Raquel López-Mejías, Maria Francisca González-Escribano, Paul A Lyons, Ann W Morgan, Amr H Sawalha, Peter A Merkel, Kenneth GC Smith, Miguel A González-Gay, Javier Martín, UK GCA Consortium, Turkish Takayasu Study Group, Vasculitis Clinical Research Consortium, IgAV Study Group, AAV Study group Spanish GCA Study Group
Apr 18, 2018
OBJETIVE: Systemic vasculitides represent a heterogeneous group of rare complex diseases of the blood vessels with a poorly understood aetiology. To investigate the shared genetic component underlying their predisposition, we...
Autoantibodies outcomes research systemic sclerosis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Case-Control Studies Epigenesis Genetic Female Genetic Loci Genetic Predisposition to Disease Giant Cell Arteritis HLA-DQ Antigens HLA-DQ beta-Chains Humans Jumonji Domain-Containing Histone Demethylases Linkage Disequilibrium Male Phenotype Polymorphism Single Nucleotide Protein Array Analysis Systemic Vasculitis Takayasu arteritis
Medication Adherence During Adjunct Therapy With Statins and ACE Inhibitors in Adolescents With Type 1 Diabetes.
Elżbieta Niechciał, Carlo L Acerini, Scott T Chiesa, Tracey Stevens, R Neil Dalton, Denis Daneman, John E Deanfield, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, David B Dunger, M Loredana Marcovecchio, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group, Adolescent Type 1 Diabetes Cardio-renal Intervention Trial AdDIT Study Group
Jan 31, 2020
OBJECTIVE: Suboptimal adherence to insulin treatment is a main issue in adolescents with type 1 diabetes. However, to date, there are no available data on adherence to adjunct noninsulin medications in this population. Our aim...
Adolescent Angiotensin-Converting Enzyme Inhibitors Australia Canada Cardiovascular Diseases Chemotherapy Adjuvant Child Diabetes mellitus Type 1 Diabetic Angiopathies Double-Blind Method Drug Therapy Combination Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Insulin Male Medication Adherence United Kingdom
Reduced burden of diabetes and improved quality of life
Gianluca Musolino, Klemen Dovc, Charlotte K Boughton, Martin Tauschmann, Janet M Allen, Katrin Nagl, Maria Fritsch, James Yong, Emily Metcalfe, Dominique Schaeffer, Muriel Fichelle, Ulrike Schierloh, Alena G Thiele, Daniela Abt, Harald Kojzar, Julia K Mader, Sonja Slegtenhorst, Nicole Ashcroft, Malgorzata E Wilinska, Judy Sibayan, Nathan Cohen, Craig Kollman, Sabine E Hofer, Elke Fröhlich-Reiterer, Thomas M Kapellen, Carlo L Acerini, Carine de Beaufort, Fiona Campbell, Birgit Rami-Merhar, Roman Hovorka, KidsAP Consortium
May 29, 2019
OBJECTIVE: To evaluate the experiences of families with very young children aged 1 to 7 years (inclusive) with type 1 diabetes using day-and-night hybrid closed-loop insulin delivery. METHODS: Parents/caregivers of 20 children...
Artificial Pancreas closed-loop insulin delivery type 1 diabetes very young children Blood Glucose Blood Glucose Self-Monitoring Caregivers Child Child Preschool Circadian Rhythm Cost of Illness Cross-Over Studies Diabetes mellitus Type 1 Family Female Humans Infant Insulin Insulin Infusion Systems Male Parents Quality of life Surveys and Questionnaires
Assessing the efficacy, safety and utility of closed-loop insulin delivery compared with sensor-augmented pump therapy in very young children with type 1 diabetes (KidsAP02 study)
Julia Fuchs, Janet M Allen, Charlotte K Boughton, Malgorzata E Wilinska, Ajay Thankamony, Carine de Beaufort, Fiona Campbell, James Yong, Elke Froehlich-Reiterer, Julia K Mader, Sabine E Hofer, Thomas M Kapellen, Birgit Rami-Merhar, Martin Tauschmann, Korey Hood, Barbara Kimbell, Julia Lawton, Stephane Roze, Judy Sibayan, Nathan Cohen, Roman Hovorka, KidsAP Consortium
Jan 12, 2021
INTRODUCTION: Diabetes management in very young children remains challenging. Glycaemic targets are achieved at the expense of high parental diabetes management burden and frequent hypoglycaemia, impacting quality of life for...
DIABETES & ENDOCRINOLOGY general diabetes paediatric endocrinology Paediatrics Austria Blood Glucose Blood Glucose Self-Monitoring Child Child Preschool Cross-Over Studies Diabetes mellitus Type 1 Humans Hypoglycemic Agents Infant Insulin Insulin Infusion Systems Luxembourg Multicenter Studies as Topic Quality of life Randomized Controlled Trials as Topic Treatment Outcome
Technology in the management of type 1 diabetes mellitus - current status and future prospects.
Type 1 diabetes mellitus (T1DM) represents 5-10% of diabetes cases worldwide. The incidence of T1DM is increasing, and there is no immediate prospect of a cure. As such, lifelong management is required, the burden of which is...
Closed-loop insulin delivery in suboptimally controlled type 1 diabetes
Martin Tauschmann, Hood Thabit, Lia Bally, Janet M Allen, Sara Hartnell, Malgorzata E Wilinska, Yue Ruan, Judy Sibayan, Craig Kollman, Peiyao Cheng, Roy W Beck, Carlo L Acerini, Mark L Evans, David B Dunger, Daniela Elleri, Fiona Campbell, Richard M Bergenstal, Amy Criego, Viral N Shah, Lalantha Leelarathna, Roman Hovorka, APCam11 Consortium
Sep 08, 2018
BACKGROUND: The achievement of glycaemic control remains challenging for patients with type 1 diabetes. We assessed the effectiveness of day-and-night hybrid closed-loop insulin delivery compared with sensor-augmented pump...
Day and night closed-loop control in adults with type 1 diabetes
Yoeri M Luijf, J Hans DeVries, Koos Zwinderman, Lalantha Leelarathna, Marianna Nodale, Karen Caldwell, Kavita Kumareswaran, Daniela Elleri, Janet M Allen, Malgorzata E Wilinska, Mark L Evans, Roman Hovorka, Werner Doll, Martin Ellmerer, Julia K Mader, Eric Renard, Jerome Place, Anne Farret, Claudio Cobelli, Simone Del Favero, Chiara Dalla Man, Angelo Avogaro, Daniela Bruttomesso, Alessio Filippi, Rachele Scotton, Lalo Magni, Giordano Lanzola, Federico Di Palma, Paola Soru, Chiara Toffanin, Giuseppe De Nicolao, Sabine Arnolds, Carsten Benesch, Lutz Heinemann, AP@home Consortium
Feb 14, 2020
OBJECTIVE: To compare two validated closed-loop (CL) algorithms versus patient self-control with CSII in terms of glycemic control. RESEARCH DESIGN AND METHODS: This study was a multicenter, randomized, three-way crossover...
A Rule-Based Monitoring System for Accurate Prediction of Diabetes
Diabetes is a chronic disease that can affect the life of people due to high sugar level in their blood. The sugar level is increased due to a lack of production of insulin in the human body. Large numbers of people are affected...
Published by: IGI Global Scientific Publishing
AiDAPT: automated insulin delivery amongst pregnant women with type 1 diabetes
Tara TM Lee, Corinne Collett, Mei-See Man, Matt Hammond, Lee Shepstone, Sara Hartnell, Eleanor Gurnell, Caroline Byrne, Eleanor M Scott, Robert S Lindsay, Damian Morris, Anna Brackenridge, Anna R Dover, Rebecca M Reynolds, Katharine F Hunt, David R McCance, Katharine Barnard-Kelly, David Rankin, Julia Lawton, Laura E Bocchino, Judy Sibayan, Craig Kollman, Malgorzata E Wilinska, Roman Hovorka, Helen R Murphy, AiDAPT Collaborative Group
May 09, 2022
BACKGROUND: Pregnant women with type 1 diabetes strive for tight glucose targets (3.5-7.8 mmol/L) to minimise the risks of obstetric and neonatal complications. Despite using diabetes technologies including continuous glucose...
Digital health interventions for adults with type 2 diabetes:
Kingshuk Pal, Charlotte Dack, Jamie Ross, Susan Michie, Carl May, Fiona Stevenson, Andrew Farmer, Lucy Yardley, Maria Barnard, Elizabeth Murray
Jan 29, 2018
Background: The prevalence of type 2 diabetes is increasing globally, and health services in many countries are struggling with the morbidity, mortality, and costs associated with the complications of this long-term...
AiDAPT: automated insulin delivery amongst pregnant women with type 1 diabetes
Tara TM Lee, Corinne Collett, Mei-See Man, Matt Hammond, Lee Shepstone, Sara Hartnell, Eleanor Gurnell, Caroline Byrne, Eleanor M Scott, Robert S Lindsay, Damian Morris, Anna Brackenridge, Anna R Dover, Rebecca M Reynolds, Katharine F Hunt, David R McCance, Katharine Barnard-Kelly, David Rankin, Julia Lawton, Laura E Bocchino, Judy Sibayan, Craig Kollman, Malgorzata E Wilinska, Roman Hovorka, Helen R Murphy, AiDAPT Collaborative Group
Apr 06, 2022
BACKGROUND: Pregnant women with type 1 diabetes strive for tight glucose targets (3.5-7.8 mmol/L) to minimise the risks of obstetric and neonatal complications. Despite using diabetes technologies including continuous glucose...
Technology in the management of type 2 diabetes
The growing incidence of type 2 diabetes (T2D) is a significant health concern, representing 90% of diabetes cases worldwide. As the disease progresses, resultant insulin deficiency and hyperglycaemia necessitates insulin...
Investigation and Management of Apparently Sporadic Central Nervous System Haemangioblastoma for Evidence of Von Hippel–Lindau Disease
Hugh Furness, Louay Salfity, Johanna Devereux, Dorothy Halliday, Helen Hanson, Deborah M. Ruddy, UK VHL Study Group UK VHL Study Group, Neha Shah, George Sultana, Emma R. Woodward, Richard N. Sandford, Katie M. Snape, Eamonn R. Maher
Sep 17, 2021
Haemangioblastomas are rare, highly vascularised tumours that typically occur in the cerebellum, brain stem and spinal cord. Up to a third of individuals with a haemangioblastoma will have von Hippel–Lindau (VHL) disease....
Assessing the effect of closed-loop insulin delivery from onset of type 1 diabetes in youth on residual beta-cell function compared to standard insulin therapy (CLOuD study)
Charlotte Boughton, Janet M Allen, Martin Tauschmann, Sara Hartnell, Malgorzata E Wilinska, Gianluca Musolino, Carlo L Acerini, Professor David Dunger, Fiona Campbell, Atrayee Ghatak, Tabitha Randell, Rachel Besser, Nicola Trevelyan, Daniela Elleri, Elizabeth Northam, Korey Hood, Eleanor Scott, Julia Lawton, Stephane Roze, Judy Sibayan, Craig Kollman, Nate Cohen, John Todd, Roman Hovorka, CLOuD Consortium
Jan 03, 2020
INTRODUCTION: Management of newly diagnosed type 1 diabetes (T1D) in children and adolescents is challenging for patients, families and healthcare professionals. The objective of this study is to determine whether continued...
Artificial Pancreas Closed-loop type 1 diabetes Adolescent Blood Glucose Self-Monitoring Child Diabetes mellitus Type 1 Glycated Hemoglobin Humans Hypoglycemic Agents Insulin Insulin Infusion Systems Insulin-Secreting Cells Multicenter Studies as Topic Randomized Controlled Trials as Topic Treatment Outcome
Assessing the effect of closed-loop insulin delivery from onset of type 1 diabetes in youth on residual beta-cell function compared to standard insulin therapy (CLOuD study)
Charlotte Boughton, Janet M Allen, Martin Tauschmann, Sara Hartnell, Malgorzata E Wilinska, Gianluca Musolino, Carlo L Acerini, Professor David Dunger, Fiona Campbell, Atrayee Ghatak, Tabitha Randell, Rachel Besser, Nicola Trevelyan, Daniela Elleri, Elizabeth Northam, Korey Hood, Eleanor Scott, Julia Lawton, Stephane Roze, Judy Sibayan, Craig Kollman, Nate Cohen, John Todd, Roman Hovorka
Mar 13, 2020
Introduction: Management of newly diagnosed type 1 diabetes (T1D) in children and adolescents is challenging for patients, families and healthcare professionals. The objective of this study is to determine whether continued...
Assessing the efficacy, safety and utility of 6-month day-and-night automated closed-loop insulin delivery under free-living conditions compared with insulin pump therapy in children and adolescents with type 1 diabetes
Gianluca Musolino, Janet M Allen, Sara Hartnell, Malgorzata E Wilinska, Martin Tauschmann, Charlotte Boughton, Fiona Campbell, Louise Denvir, Nicola Trevelyan, Paul Wadwa, Linda DiMeglio, Bruce A Buckingham, Stuart Weinzimer, Carlo L Acerini, Korey Hood, Steven Fox, Craig Kollman, Judy Sibayan, Sarah Borgman, Peiyao Cheng, Roman Hovorka
Apr 26, 2019
INTRODUCTION: Closed-loop systems titrate insulin based on sensor glucose levels, providing novel means to reduce the risk of hypoglycaemia while improving glycaemic control. We will assess effectiveness of 6-month day-and-night...
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response.
Adebowale A Adeyemo, Norann A Zaghloul, Guanjie Chen, Ayo P Doumatey, Carmen C Leitch, Timothy L Hostelley, Jessica E Nesmith, Jie Zhou, Amy R Bentley, Daniel Shriner, Olufemi Fasanmade, Godfrey Okafor, Benjamin Eghan, Kofi Agyenim-Boateng, Settara Chandrasekharappa, Jokotade Adeleye, William Balogun, Samuel Owusu, Albert Amoah, Joseph Acheampong, Thomas Johnson, Johnnie Oli, Clement Adebamowo, South Africa Zulu Type 2 Diabetes Case-Control Study, Francis Collins, Georgia Dunston, Charles N Rotimi
Aug 19, 2019
Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health impact. Here, we report a genome-wide analysis of type 2 diabetes (T2D) in...
Africa Northern Animals Apoptosis Base Sequence Blood Glucose CRISPR-Cas Systems DNA Helicases Diabetes mellitus Type 2 Disease Models Animal Female Gene Editing Gene Knockout Techniques Genetic Association Studies Genetic Predisposition to Disease Genotype Ghana Glucose Homozygote Humans Insulin Insulin-Secreting Cells Kenya Male Mice Middle Aged Mutation Nigeria Polymorphism Single Nucleotide RNA Small Interfering Transcription Factor 7-Like 2 Protein Transcriptome Zebrafish
Digital health interventions for adults with type 2 diabetes:
Kingshuk Pal, Charlotte Dack, Jamie Ross, Susan Michie, Carl May, Fiona Stevenson, Andrew Farmer, Lucy Yardley, Maria Barnard, Elizabeth Murray
Jan 29, 2018
Background: The prevalence of type 2 diabetes is increasing globally, and health services in many countries are struggling with the morbidity, mortality, and costs associated with the complications of this long-term...
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