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Mapping the human genetic architecture of COVID-19.
COVID-19 Host Genetics Initiative
Jan 05, 2022
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of...
Autoimmunity Body Mass Index covid-19 Critical Illness Female Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Geographic Mapping Hospitalization Host-Pathogen Interactions Humans Inflammation Information Dissemination Male Multifactorial Inheritance Racial Groups SARS-CoV-2 Smoking
Demographic, behavioural and occupational risk factors associated with SARS-CoV-2 infection in UK healthcare workers
Daniel James Cooper, Sara Lear, Nyarie Sithole, Ashley Shaw, Hannah Stark, Mark Ferris, CITIID-NIHR BioResource COVID-19 collaboration consortium, John Bradley, Patrick Maxwell, Ian Goodfellow, Michael P Weekes, Shaun Seaman, Stephen Baker
Dec 09, 2022
OBJECTIVE: Healthcare workers (HCWs) are at higher risk of SARS-CoV-2 infection than the general population. This group is pivotal to healthcare system resilience during the COVID-19, and future, pandemics. We investigated...
Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses.
Edward J Needham, Alexander L Ren, Richard J Digby, Emma J Norton, Soraya Ebrahimi, Joanne G Outtrim, Doris A Chatfield, Anne E Manktelow, Maya M Leibowitz, Virginia FJ Newcombe, Rainer Doffinger, Gabriela Barcenas-Morales, Claudia Fonseca, Michael J Taussig, Rowan M Burnstein, Romit J Samanta, Cordelia Dunai, Nyarie Sithole, Nicholas J Ashton, Henrik Zetterberg, Magnus Gisslén, Arden Edén, Emelie Marklund, Peter JM Openshaw, Jake Dunning, Michael J Griffiths, Jonathan Cavanagh, Gerome Breen, Sarosh R Irani, Anne Elmer, Nathalie Kingston, Charlotte Summers, John R Bradley, Leonie S Taams, Benedict D Michael, Edward T Bullmore, Kenneth GC Smith, Paul A Lyons, Alasdair J Coles, David K Menon, Cambridge NeuroCOVID Group, CITIID-NIHR COVID-19 BioResource Collaboration, Cambridge NIHR Clinical Research Facility
Oct 06, 2022
COVID-19 is associated with neurological complications including stroke, delirium and encephalitis. Furthermore, a post-viral syndrome dominated by neuropsychiatric symptoms is common, and is seemingly unrelated to COVID-19...
Demographic, behavioural and occupational risk factors associated with SARS-CoV-2 infection in UK healthcare workers
COVID-19 trajectories among 57 million adults in England
Johan H Thygesen, Christopher Tomlinson, Sam Hollings, Mehrdad A Mizani, Alex Handy, Ashley Akbari, Amitava Banerjee, Jennifer Cooper, Alvina G Lai, Kezhi Li, Bilal A Mateen, Naveed Sattar, Reecha Sofat, Ana Torralbo, Honghan Wu, Angela Wood, Jonathan AC Sterne, Christina Pagel, William N Whiteley, Cathie Sudlow, Harry Hemingway, Spiros Denaxas, Longitudinal Health and Wellbeing COVID-19 National Core Study and the CVD-COVID-UK/COVID-IMPACT Consortium
Jul 14, 2022
BACKGROUND: Updatable estimates of COVID-19 onset, progression, and trajectories underpin pandemic mitigation efforts. To identify and characterise disease trajectories, we aimed to define and validate ten COVID-19 phenotypes...
Ensuring that COVID-19 research is inclusive
Miles D Witham, Eleanor Anderson, Camille B Carroll, Paul M Dark, Kim Down, Alistair S Hall, Joanna Knee, Eamonn R Maher, Rebecca H Maier, Gail A Mountain, Gary Nestor, John T O'Brien, Laurie Oliva, James Wason, Lynn Rochester, NIHR CRN INCLUDE Steering Group
Oct 23, 2020
OBJECTIVE: To provide guidance to researchers, funders, regulators and study delivery teams to ensure that research on COVID-19 is inclusive, particularly of groups disproportionately affected by COVID-19 and who may have been...
Written Reminiscences of Dorothea Jansen
These written responses were completed by Dorothea Jansen as part of Project 2020: A Collaborative Oral History. These recollections provide insight into the COVID-19 pandemic and critical year 2020, notably from the perspective...
Published by: Winthrop University
Reminiscences of Biology 213-214
This collection of written reminiscences includes seven written accounts relating to the COVID-19 pandemic and 2020 experience, notably from the student perspective. Seven college students from a Winthrop Biology course...
Published by: Winthrop University
Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England.
Quentin J Leclerc, Naomi M Fuller, Ruth H Keogh, Karla Diaz-Ordaz, Richard Sekula, Malcolm G Semple, ISARIC4C investigators, CMMID COVID-19 working group, Katherine E Atkins, Simon R Procter, Gwenan M Knight
Aug 02, 2021
BACKGROUND: Predicting bed occupancy for hospitalised patients with COVID-19 requires understanding of length of stay (LoS) in particular bed types. LoS can vary depending on the patient's "bed pathway" - the sequence of...
Evidence of previous SARS-CoV-2 infection in seronegative patients with long COVID.
Benjamin A Krishna, Eleanor Y Lim, Lenette Mactavous, NIHR BioResource Team, Paul A Lyons, Rainer Doffinger, John R Bradley, Kenneth GC Smith, John Sinclair, Nicholas J Matheson, Paul J Lehner, Mark R Wills, Nyaradzai Sithole
Aug 01, 2022
BACKGROUND: There is currently no consensus on the diagnosis, definition, symptoms, or duration of COVID-19 illness. The diagnostic complexity of Long COVID is compounded in many patients who were or might have been infected...
Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19.
Nick K Jones, Lucy Rivett, Dominic Sparkes, Sally Forrest, Sushmita Sridhar, Jamie Young, Joana Pereira-Dias, Claire Cormie, Harmeet Gill, Nicola Reynolds, Michelle Wantoch, Matthew Routledge, Ben Warne, Jack Levy, William David Córdova Jiménez, Fathima Nisha Begum Samad, Chris McNicholas, Mark Ferris, Jane Gray, Michael Gill, CITIID-NIHR COVID-19 BioResource Collaboration, Martin D Curran, Stewart Fuller, Afzal Chaudhry, Ashley Shaw, John R Bradley, Gregory J Hannon, Ian G Goodfellow, Gordon Dougan, Kenneth GC Smith, Paul J Lehner, Giles Wright, Nicholas J Matheson, Stephen Baker, Michael P Weekes
Jun 24, 2020
Previously, we showed that 3% (31/1032)of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020. About 15% (26/169) HCWs with symptoms of coronavirus...
covid-19 SARS-CoV-2 emerging pathogens EPIDEMIOLOGY Global Health human human biology infectious disease Medicine Occupational health Virology Adult Asymptomatic Diseases Betacoronavirus covid-19 COVID-19 Testing Clinical Laboratory Techniques Community-Acquired Infections Contact Tracing Coronavirus Infections Disease Transmission Infectious England Family Characteristics Female Health Personnel Hospital Units Hospitals Teaching Hospitals University Humans infection control Infectious Disease Transmission Patient-to-Professional Male Mass Screening Middle Aged nasopharynx Occupational Diseases Pandemics Patient Admission Pneumonia Viral prevalence Program Evaluation Real-Time Polymerase Chain Reaction SARS-CoV-2 Symptom Assessment
Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission.
Lucy Rivett, Sushmita Sridhar, Dominic Sparkes, Matthew Routledge, Nick K Jones, Sally Forrest, Jamie Young, Joana Pereira-Dias, William L Hamilton, Mark Ferris, M Estee Torok, Luke Meredith, CITIID-NIHR COVID-19 BioResource Collaboration, Martin D Curran, Stewart Fuller, Afzal Chaudhry, Ashley Shaw, Richard J Samworth, John R Bradley, Gordon Dougan, Kenneth GC Smith, Paul J Lehner, Nicholas J Matheson, Giles Wright, Ian G Goodfellow, Stephen Baker, Michael P Weekes
May 11, 2020
covid-19 SARS-CoV-2 emerging pathogens EPIDEMIOLOGY Global Health human human biology infectious disease Medicine Occupational health Virology Virus Asymptomatic Infections Betacoronavirus covid-19 COVID-19 Testing COVID-19 Vaccines Clinical Laboratory Techniques Coronavirus Infections Female Health Personnel Humans infection control Male Pandemics Pneumonia Viral Real-Time Polymerase Chain Reaction SARS-CoV-2 United Kingdom
Awareness and preparedness of healthcare workers against the first wave of the COVID-19 pandemic
Nguyen Tien Huy, R Matthew Chico, Vuong Thanh Huan, Hosam Waleed Shaikhkhalil, Vuong Ngoc Thao Uyen, Ahmad Taysir Atieh Qarawi, Shamael Thabit Mohammed Alhady, Nguyen Lam Vuong, Le Van Truong, Mai Ngoc Luu, Shyam Prakash Dumre, Atsuko Imoto, Peter N Lee, Dao Ngoc Hien Tam, Sze Jia Ng, Mohammad Rashidul Hashan, Mitsuaki Matsui, Nguyen Tran Minh Duc, Sedighe Karimzadeh, Nut Koonrungsesomboon, Chris Smith, Sharon Cox, Kazuhiko Moji, Kenji Hirayama, Le Khac Linh, Kirellos Said Abbas, Tran Nu Thuy Dung, Tareq Mohammed Ali Al-Ahdal, Emmanuel Oluwadare Balogun, Nguyen The Duy, Mennatullah Mohamed Eltaras, Trang Huynh, Nguyen Thi Linh Hue, Bui Diem Khue, Abdelrahman Gad, Gehad Mohamed Tawfik, Kazumi Kubota, Hoang-Minh Nguyen, Dmytro Pavlenko, Vu Thi Thu Trang, Le Thuong Vu, Tran Hai Yen, Nguyen Thi Yen-Xuan, Luong Thi Trang, Vinh Dong, Akash Sharma, Vu Quoc Dat, Mohammed Soliman, Jeza Abdul Aziz, Jaffer Shah, Pham Dinh Long Hung, Yap Siang Jee, Dang Thuy Ha Phuong, Tran Thuy Huong Quynh, Hoang Thi Nam Giang, Vy Thi Nhat Huynh, Nguyen Anh Thi, Nacir Dhouibi, Truc Phan, Vincent Duru, Nguyen Hai Nam, Sherief Ghozy, contributors of the TMGH-Global COVID-19 Collaborative, TMGH-Global COVID-19 Collaborative
Jan 28, 2022
BACKGROUND: Since the COVID-19 pandemic began, there have been concerns related to the preparedness of healthcare workers (HCWs). This study aimed to describe the level of awareness and preparedness of hospital HCWs at the time...
Pneumomediastinum in COVID-19
James Melhorn, Andrew Achaiah, Francesca M Conway, Elizabeth MF Thompson, Erik W Skyllberg, Joseph Durrant, Neda A Hasan, Yasser Madani, Prasheena Naran, Bavithra Vijayakumar, Matthew J Tate, Gareth E Trevelyan, Irfan Zaki, Catherine A Doig, Geraldine Lynch, Gill Warwick, Avinash Aujayeb, Karl A Jackson, Hina Iftikhar, Jonathan H Noble, Anthony YKC Ng, Mark Nugent, Philip J Evans, Robert A Hastings, Harry R Bellenberg, Hannah Lawrence, Rachel L Saville, Nikolas T Johl, Adam N Grey, Huw C Ellis, Cheng Chen, Thomas L Jones, Nadeem Maddekar, Shahul Leyakathali Khan, Ambreen Iqbal Muhammad, Hakim Ghani, Yadee Maung Maung Myint, Cecillia Rafique, Benjamin J Pippard, Benjamin RH Irving, Fawad Ali, Viola H Asimba, Aqeem Azam, Eleanor C Barton, Malvika Bhatnagar, Matthew P Blackburn, Kate J Millington, Nicholas J Budhram, Katherine L Bunclark, Toshit P Sapkal, Giles Dixon, Andrew JE Harries, Mohammad Ijaz, Vijayalakshmi Karunanithi, Samir Naik, Malik Aamaz Khan, Karishma Savlani, Vimal Kumar, Beatriz Lara Gallego, Noor A Mahdi, Caitlin Morgan, Neena Patel, Elen W Rowlands, Matthew S Steward, Richard S Thorley, Rebecca L Wollerton, Sana Ullah, David M Smith, Wojciech Lason, Anthony J Rostron, Najib M Rahman, Rob J Hallifax
Mar 14, 2022
BACKGROUND: There is an emerging understanding that coronavirus disease 2019 (COVID-19) is associated with increased incidence of pneumomediastinum. We aimed to determine its incidence among patients hospitalised with COVID-19...
A thermostable, closed SARS-CoV-2 spike protein trimer.
Xiaoli Xiong, Kun Qu, Katarzyna A Ciazynska, Myra Hosmillo, Andrew P Carter, Soraya Ebrahimi, Zunlong Ke, Sjors HW Scheres, Laura Bergamaschi, Guinevere L Grice, Ying Zhang, CITIID-NIHR COVID-19 BioResource Collaboration, James A Nathan, Stephen Baker, Leo C James, Helen E Baxendale, Ian Goodfellow, Rainer Doffinger, John AG Briggs
Oct 21, 2020
The spike (S) protein of SARS-CoV-2 mediates receptor binding and cell entry and is the dominant target of the immune system. It exhibits substantial conformational flexibility. It transitions from closed to open conformations...
Betacoronavirus COVID-19 Testing Clinical Laboratory Techniques Coronavirus Infections Cryoelectron Microscopy Disulfides Enzyme-Linked Immunosorbent Assay Flow Cytometry Humans Immunoglobulin G Models Molecular Mutation Protein Conformation Protein Engineering Protein Multimerization Protein Stability SARS-CoV-2 Spike Glycoprotein Coronavirus Temperature
The effect of human mobility and control measures on the COVID-19 epidemic in China.
Moritz UG Kraemer, Chia-Hung Yang, Bernardo Gutierrez, Chieh-Hsi Wu, Brennan Klein, David M Pigott, Open COVID-19 Data Working Group, Louis du Plessis, Nuno R Faria, Ruoran Li, William P Hanage, John S Brownstein, Maylis Layan, Alessandro Vespignani, Huaiyu Tian, Christopher Dye, Oliver G Pybus, Samuel V Scarpino
May 26, 2020
The ongoing coronavirus disease 2019 (COVID-19) outbreak expanded rapidly throughout China. Major behavioral, clinical, and state interventions were undertaken to mitigate the epidemic and prevent the persistence of the virus in...
Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs.
Lisa Hurler, Erik JM Toonen, Erika Kajdácsi, Bregje van Bree, Ricardo JMGE Brandwijk, Wieke de Bruin, Paul A Lyons, Laura Bergamaschi, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, György Sinkovits, László Cervenak, Reinhard Würzner, Zoltán Prohászka
Dec 24, 2022
The most commonly used markers to assess complement activation are split products that are produced through activation of all three pathways and are located downstream of C3. In contrast, C4d derives from the cleavage of C4 and...
C1-INH complexes assay development and validation classical pathway activation early complement activation lectin pathway activation Adult Humans Complement C1 Inhibitor Protein Complement System Proteins covid-19 Lectins Mannose-Binding Protein-Associated Serine Proteases Enzyme-Linked Immunosorbent Assay
Large scale clinical trials
Alex R Horsley, Laurence Pearmain, Sean Knight, Nick Schindler, Ran Wang, Miriam Bennett, Rebecca C Robey, Jane C Davies, Ratko Djukanović, Liam G Heaney, Tracy Hussell, Stefan J Marciniak, Lorcan P McGarvey, Joanna Porter, Tom Wilkinson, Chris Brightling, Ling-Pei Ho
Jun 16, 2022
BACKGROUND: The COVID-19 pandemic has presented substantial new challenges to clinical and research teams. Our objective was to analyse the experience of investigators and research delivery staff regarding the research response...
Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients
Dami A Collier, Sonny M Assennato, Ben Warne, Nyarie Sithole, Katherine Sharrocks, Allyson Ritchie, Pooja Ravji, Matthew Routledge, Dominic Sparkes, Jordan Skittrall, Anna Smielewska, Isobel Ramsey, Neha Goel, Martin Curran, David Enoch, Rhys Tassell, Michelle Lineham, Devan Vaghela, Clare Leong, Hoi Ping Mok, John Bradley, Kenneth GC Smith, Vivienne Mendoza, Nikos Demiris, Martin Besser, Gordon Dougan, Paul J Lehner, Mark J Siedner, Hongyi Zhang, Claire S Waddington, Helen Lee, Ravindra K Gupta, CITIID-NIHR COVID BioResource Collaboration
Aug 10, 2020
There is an urgent need for rapid SARS-CoV-2 testing in hospitals to limit nosocomial spread. We report an evaluation of point of care (POC) nucleic acid amplification testing (NAAT) in 149 participants with parallel combined...
A prospective study of risk factors associated with seroprevalence of SARS-CoV-2 antibodies in healthcare workers at a large UK teaching hospital.
Daniel J Cooper, Sara Lear, Laura Watson, Ashley Shaw, Mark Ferris, Rainer Doffinger, Rachel Bousfield, Katherine Sharrocks, Michael P Weekes, Ben Warne, Dominic Sparkes, Nick K Jones, Lucy Rivett, Matthew Routledge, Afzal Chaudhry, Katherine Dempsey, Montgomery Matson, Adil Lakha, George Gathercole, Olivia O'Connor, Emily Wilson, Orthi Shahzad, Kieran Toms, Rachel Thompson, Ian Halsall, David Halsall, Sally Houghton, Sofia Papadia, Nathalie Kingston, Kathleen E Stirrups, Barbara Graves, Paul Townsend, Neil Walker, Hannah Stark, CITIID-NIHR BioResource COVID-19 Collaboration, Daniela De Angelis, Shaun Seaman, Gordon Dougan, John R Bradley, M Estée Török, Ian Goodfellow, Stephen Baker
Oct 05, 2022
OBJECTIVES: To describe the risk factors for SARS-CoV-2 infection in UK healthcare workers (HCWs). METHODS: We conducted a prospective sero-epidemiological study of HCWs at a major UK teaching hospital using a SARS-CoV-2...
The COVID-19 Data Portal
Peter W Harrison, Rodrigo Lopez, Nadim Rahman, Stefan Gutnick Allen, Raheela Aslam, Nicola Buso, Carla Cummins, Yasmin Fathy, Eloy Felix, Mihai Glont, Suran Jayathilaka, Sandeep Kadam, Manish Kumar, Katharina B Lauer, Geetika Malhotra, Abayomi Mosaku, Ossama Edbali, Young Mi Park, Andrew Parton, Matt Pearce, Jose Francisco Estrada Pena, Joseph Rossetto, Craig Russell, Sandeep Selvakumar, Xènia Pérez Sitjà, Alexey Sokolov, Ross Thorne, Marianna Ventouratou, Peter Walter, Galabina Yordanova, Amonida Zadissa, Guy Cochrane, Niklas Blomberg, Rolf Apweiler
Jul 29, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic will be remembered as one of the defining events of the 21st century. The rapid global outbreak has had significant impacts on human society and is...
Treatment of COVID-19 with remdesivir in the absence of humoral immunity
Matthew S Buckland, James B Galloway, Caoimhe Nic Fhogartaigh, Luke Meredith, Nicholas M Provine, Stuart Bloor, Ane Ogbe, Wioleta M Zelek, Anna Smielewska, Anna Yakovleva, Tiffeney Mann, Laura Bergamaschi, Lorinda Turner, Frederica Mescia, Erik JM Toonen, Carl-Philipp Hackstein, Hossain Delowar Akther, Vinicius Adriano Vieira, Lourdes Ceron-Gutierrez, Jimstan Periselneris, Sorena Kiani-Alikhan, Sofia Grigoriadou, Devan Vaghela, Sara E Lear, M Estée Török, William L Hamilton, Joanne Stockton, Josh Quick, Peter Nelson, Michael Hunter, Tanya I Coulter, Lisa Devlin, CITIID-NIHR COVID-19 BioResource Collaboration, MRC-Toxicology Unit COVID-19 Consortium, John R Bradley, Kenneth GC Smith, Willem H Ouwehand, Lise Estcourt, Heli Harvala, David J Roberts, Ian B Wilkinson, Nick Screaton, Nicholas Loman, Rainer Doffinger, Paul A Lyons, B Paul Morgan, Ian G Goodfellow, Paul Klenerman, Paul J Lehner, Nicholas J Matheson, James ED Thaventhiran
Oct 13, 2020
Single-cell multi-omics analysis of the immune response in COVID-19.
Emily Stephenson, Gary Reynolds, Rachel A Botting, Fernando J Calero-Nieto, Michael D Morgan, Zewen Kelvin Tuong, Karsten Bach, Waradon Sungnak, Kaylee B Worlock, Masahiro Yoshida, Natsuhiko Kumasaka, Katarzyna Kania, Justin Engelbert, Bayanne Olabi, Jarmila Stremenova Spegarova, Nicola K Wilson, Nicole Mende, Laura Jardine, Louis CS Gardner, Issac Goh, Dave Horsfall, Jim McGrath, Simone Webb, Michael W Mather, Rik GH Lindeboom, Emma Dann, Ni Huang, Krzysztof Polanski, Elena Prigmore, Florian Gothe, Jonathan Scott, Rebecca P Payne, Kenneth F Baker, Aidan T Hanrath, Ina CD Schim van der Loeff, Andrew S Barr, Amada Sanchez-Gonzalez, Laura Bergamaschi, Federica Mescia, Josephine L Barnes, Eliz Kilich, Angus de Wilton, Anita Saigal, Aarash Saleh, Sam M Janes, Claire M Smith, Nusayhah Gopee, Caroline Wilson, Paul Coupland, Jonathan M Coxhead, Vladimir Yu Kiselev, Stijn van Dongen, Jaume Bacardit, Hamish W King, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID-19 BioResource Collaboration, Anthony J Rostron, A John Simpson, Sophie Hambleton, Elisa Laurenti, Paul A Lyons, Kerstin B Meyer, Marko Z Nikolić, Christopher JA Duncan, Kenneth GC Smith, Sarah A Teichmann, Menna R Clatworthy, John C Marioni, Berthold Göttgens, Muzlifah Haniffa
May 10, 2021
Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). We performed...
Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant.
Petra Mlcochova, Dami Collier, Allyson Ritchie, Sonny M Assennato, Myra Hosmillo, Neha Goel, Bo Meng, Krishna Chatterjee, Vivien Mendoza, Nigel Temperton, Leo Kiss, Leo C James, Katarzyna A Ciazynska, Xiaoli Xiong, John AG Briggs, James A Nathan, Federica Mescia, Laura Bergamaschi, Hongyi Zhang, Petros Barmpounakis, Nikos Demeris, Richard Skells, Paul A Lyons, John Bradley, Steven Baker, Jean Pierre Allain, Kenneth GC Smith, Rachel Bousfield, Michael Wilson, Dominic Sparkes, Glenn Amoroso, Effrosyni Gkrania-Klotsas, Susie Hardwick, Adrian Boyle, Ian Goodfellow, Ravindra K Gupta, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration
Sep 29, 2020
Rapid COVID-19 diagnosis in the hospital is essential, although this is complicated by 30%-50% of nose/throat swabs being negative by SARS-CoV-2 nucleic acid amplification testing (NAAT). Furthermore, the D614G spike mutant...
covid-19 D614G SARS-CoV-2 point of care testing rapid diagnoses Aged Aged 80 and over Antibodies Viral covid-19 COVID-19 Testing Female Humans Immunoassay Male Middle Aged Neutralization Tests Nucleic Acid Amplification Techniques Point-of-care testing SARS-CoV-2 Sensitivity and Specificity Spike Glycoprotein Coronavirus
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