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The CHEK2 Variant C.349A>G Is Associated with Prostate Cancer Risk and Carriers Share a Common Ancestor.
Andreia Brandão, Paula Paulo, Sofia Maia, Manuela Pinheiro, Ana Peixoto, Marta Cardoso, Maria P Silva, Catarina Santos, Rosalind A Eeles, Zsofia Kote-Jarai, Kenneth Muir, UKGPCS collaborators, Johanna Schleutker, Ying Wang, Nora Pashayan, Jyotsna Batra, APCB BioResource, Henrik Grönberg, David E Neal, Børge G Nordestgaard, Catherine M Tangen, Melissa C Southey, Alicja Wolk, Demetrius Albanes, Christopher A Haiman, Ruth C Travis, Janet L Stanford, Lorelei A Mucci, Catharine ML West, Sune F Nielsen, Adam S Kibel, Olivier Cussenot, Sonja I Berndt, Stella Koutros, Karina Dalsgaard Sørensen, Cezary Cybulski, Eli Marie Grindedal, Jong Y Park, Sue A Ingles, Christiane Maier, Robert J Hamilton, Barry S Rosenstein, Ana Vega, The Impact Study Steering Committee And Collaborators, Manolis Kogevinas, Fredrik Wiklund, Kathryn L Penney, Hermann Brenner, Esther M John, Radka Kaneva, Christopher J Logothetis, Susan L Neuhausen, Kim De Ruyck, Azad Razack, Lisa F Newcomb, Canary PASS Investigators, Davor Lessel, Nawaid Usmani, Frank Claessens, Manuela Gago-Dominguez, Paul A Townsend, Monique J Roobol, The Profile Study Steering Committee, the PRACTICAL consortium, Manuel R Teixeira
Nov 09, 2020
The identification of recurrent founder variants in cancer predisposing genes may have important implications for implementing cost-effective targeted genetic screening strategies. In this study, we evaluated the prevalence and...
Rectal cancer management during the COVID-19 pandemic (ReCaP)
RE Clifford, D Harji, L Poynter, R Jackson, R Adams, NS Fearnhead, D Vimalachandran, ReCaP Steering Committee and Collaborators
Jun 07, 2021
Concerns over unacceptable high mortality in patients with rectal cancer undergoing surgery or systemic therapy who contract COVID-19 have led to widespread adoption of alternative treatment strategies.The ReCaP study aimed to...
Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations.
Elizabeth K Bancroft, Sibel Saya, Elizabeth C Page, Kathryn Myhill, Sarah Thomas, Jennifer Pope, Anthony Chamberlain, Rachel Hart, Wayne Glover, Jackie Cook, Derek J Rosario, Brian T Helfand, Christina Hutten Selkirk, Rosemarie Davidson, Mark Longmuir, Diana M Eccles, Neus Gadea, Carole Brewer, Julian Barwell, Monica Salinas, Lynn Greenhalgh, Marc Tischkowitz, Alex Henderson, David Gareth Evans, Saundra S Buys, IMPACT Study Steering Committee, IMPACT Collaborators, Rosalind A Eeles, Neil K Aaronson
Feb 07, 2020
OBJECTIVES: To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic...
BRCA1 BRCA2 #ProstateCancer #PCSM Psychosocial Quality of life Adult Anxiety Case-Control Studies Depression Early Detection of Cancer Genes BRCA1 Genes BRCA2 Health Knowledge Attitudes practice Humans Longitudinal Studies Male Middle Aged Mutation Perception Prostatic Neoplasms Psychiatric Status Rating Scales Quality of life Risk Factors Surveys and Questionnaires
External validation and recalibration of an incidental meningioma prognostic model - IMPACT
Abdurrahman I Islim, Christopher P Millward, Rory J Piper, Daniel M Fountain, Shaveta Mehta, Ruwanthi Kolamunnage-Dona, Usama Ali, Shelli Diane Koszdin, Theo Georgious, Samantha J Mills, Andrew R Brodbelt, Ryan K Mathew, Thomas Santarius, Michael D Jenkinson, International Consortium on Meningioma (ICOM) and British Neurosurgical Trainee Research Collaborative (BNTRC) IMPACT Study Investigators
Feb 19, 2022
INTRODUCTION: Due to the increased use of CT and MRI, the prevalence of incidental findings on brain scans is increasing. Meningioma, the most common primary brain tumour, is a frequently encountered incidental finding, with an...
External validation and recalibration of an incidental meningioma prognostic model - IMPACT
Abdurrahman I Islim, Christopher P Millward, Rory J Piper, Daniel M Fountain, Shaveta Mehta, Ruwanthi Kolamunnage-Dona, Usama Ali, Shelli Diane Koszdin, Theo Georgious, Samantha J Mills, Andrew R Brodbelt, Ryan K Mathew, Thomas Santarius, Michael D Jenkinson, International Consortium on Meningioma (ICOM) and British Neurosurgical Trainee Research Collaborative (BNTRC) IMPACT Study Investigators
Jan 28, 2022
INTRODUCTION: Due to the increased use of CT and MRI, the prevalence of incidental findings on brain scans is increasing. Meningioma, the most common primary brain tumour, is a frequently encountered incidental finding, with an...
External data required timely response by the Trial Steering-Data Monitoring Committee for the NALoxone InVEstigation (N-ALIVE) pilot trial
The prison-based N-ALIVE pilot trial had undertaken to notify the Research Ethics Committee and participants if we had reason to believe that the N-ALIVE pilot trial would not proceed to the main trial. In this paper, we...
Diffuse Intracranial Injury Patterns Are Associated with Impaired Cerebrovascular Reactivity in Adult Traumatic Brain Injury
Frederick A Zeiler, François Mathieu, Miguel Monteiro, Ben Glocker, Ari Ercole, Erta Beqiri, Manuel Cabeleira, Nino Stocchetti, Peter Smielewski, Marek Czosnyka, Virginia Newcombe, David K Menon, the CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Feb 28, 2020
Recent single-center retrospective analysis displayed the association between admission computed tomography (CT) markers of diffuse intracranial injury and worse cerebrovascular reactivity. The goal of this study was to further...
Report of the Library Committee
The Rockefeller University
Jan 01, 0001
Report of the Library Committee by Purnell W. Choppin, June 18th, 1971
Published by: Rockefeller University
The National Institute for Health Research
V Goh, National Institute for Health Research Clinical Research Network Imaging Network Steering Group, Royal College of Radiologists' Academic Committee
Oct 01, 2019
Since the inception of the National Institute for Health Research (NIHR) in 2006, the landscape for the delivery of clinical research within the National Health Service (NHS) has been transformed. Clinical radiology has...
Comment on Herring et al. The Use of "Retardation" in FRAXA, FMRP, FMR1 and Other Designations. Cells 2022, 11, 1044.
This commentary is written in response to the recent article from Herring et al., discussing the eradication of the offensive term "retardation" from gene nomenclature. We discuss the work of the HUGO (Human Genome Organisation)...
COVID-19 trajectories among 57 million adults in England
Johan H Thygesen, Christopher Tomlinson, Sam Hollings, Mehrdad A Mizani, Alex Handy, Ashley Akbari, Amitava Banerjee, Jennifer Cooper, Alvina G Lai, Kezhi Li, Bilal A Mateen, Naveed Sattar, Reecha Sofat, Ana Torralbo, Honghan Wu, Angela Wood, Jonathan AC Sterne, Christina Pagel, William N Whiteley, Cathie Sudlow, Harry Hemingway, Spiros Denaxas, Longitudinal Health and Wellbeing COVID-19 National Core Study and the CVD-COVID-UK/COVID-IMPACT Consortium
Jul 14, 2022
BACKGROUND: Updatable estimates of COVID-19 onset, progression, and trajectories underpin pandemic mitigation efforts. To identify and characterise disease trajectories, we aimed to define and validate ten COVID-19 phenotypes...
Supervising projects you don’t (fully) understand
Strategically important projects involve high stakes, uncertainty, and stakeholder complexity, with contingencies and risks typically surfacing repeatedly as the project evolves. This is challenging not only for the project...
Baseline results from the UK SIGNIFY study
S Saya, E Killick, S Thomas, N Taylor, EK Bancroft, J Rothwell, S Benafif, A Dias, C Mikropoulos, J Pope, A Chamberlain, R Gunapala, SIGNIFY Study Steering Committee, L Izatt, L Side, L Walker, S Tomkins, J Cook, J Barwell, V Wiles, L Limb, D Eccles, MO Leach, S Shanley, FJ Gilbert, H Hanson, D Gallagher, B Rajashanker, RW Whitehouse, D-M Koh, SA Sohaib, DG Evans, RA Eeles
Mar 08, 2017
Impact of duration and magnitude of raised intracranial pressure on outcome after severe traumatic brain injury
Cecilia AI Åkerlund, Joseph Donnelly, Frederick A. Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W. Nelson, the CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators
Dec 22, 2020
Magnitude of intracranial pressure (ICP) elevations and their duration have been associated with worse outcomes in patients with traumatic brain injuries (TBI), however published thresholds for injury vary and uncertainty about...
Polygenic hazard score is associated with prostate cancer in multi-ethnic populations.
Minh-Phuong Huynh-Le, Chun Chieh Fan, Roshan Karunamuni, Wesley K Thompson, Maria Elena Martinez, Rosalind A Eeles, Zsofia Kote-Jarai, Kenneth Muir, Johanna Schleutker, Nora Pashayan, Jyotsna Batra, Henrik Grönberg, David E Neal, Jenny L Donovan, Freddie C Hamdy, Richard M Martin, Sune F Nielsen, Børge G Nordestgaard, Fredrik Wiklund, Catherine M Tangen, Graham G Giles, Alicja Wolk, Demetrius Albanes, Ruth C Travis, William J Blot, Wei Zheng, Maureen Sanderson, Janet L Stanford, Lorelei A Mucci, Catharine ML West, Adam S Kibel, Olivier Cussenot, Sonja I Berndt, Stella Koutros, Karina Dalsgaard Sørensen, Cezary Cybulski, Eli Marie Grindedal, Florence Menegaux, Kay-Tee Khaw, Jong Y Park, Sue A Ingles, Christiane Maier, Robert J Hamilton, Stephen N Thibodeau, Barry S Rosenstein, Yong-Jie Lu, Stephen Watya, Ana Vega, Manolis Kogevinas, Kathryn L Penney, Chad Huff, Manuel R Teixeira, Luc Multigner, Robin J Leach, Lisa Cannon-Albright, Hermann Brenner, Esther M John, Radka Kaneva, Christopher J Logothetis, Susan L Neuhausen, Kim De Ruyck, Hardev Pandha, Azad Razack, Lisa F Newcomb, Jay H Fowke, Marija Gamulin, Nawaid Usmani, Frank Claessens, Manuela Gago-Dominguez, Paul A Townsend, William S Bush, Monique J Roobol, Marie-Élise Parent, Jennifer J Hu, Ian G Mills, Ole A Andreassen, Anders M Dale, Tyler M Seibert, UKGPCS collaborators, APCB (Australian Prostate Cancer BioResource), NC-LA PCaP Investigators, IMPACT Study Steering Committee and Collaborators, Canary PASS Investigators, Profile Study Steering Committee, PRACTICAL Consortium
Feb 23, 2021
Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves...
Combined steering and direct tilt control for the enhancement of narrow tilting vehicle stability
Narrow tilting vehicles offer an opportunity to reduce both traffic congestion and carbon emissions by having a small road footprint, a low weight and a small frontal area. Their narrow track requires that they tilt into corners...
The STRATAA study protocol
Thomas C Darton, James E Meiring, Susan Tonks, Md Arifuzzaman Khan, Farhana Khanam, Mila Shakya, Deus Thindwa, Stephen Baker, Buddha Basnyat, John D Clemens, Gordon Dougan, Christiane Dolecek, Sarah J Dunstan, Melita A Gordon, Robert S Heyderman, Kathryn E Holt, Virginia E Pitzer, Firdausi Qadri, K Zaman, Andrew J Pollard, STRATAA Study Consortium
Apr 10, 2019
INTRODUCTION: Invasive infections caused by Salmonella enterica serovar Typhi and Paratyphi A are estimated to account for 12-27 million febrile illness episodes worldwide annually. Determining the true burden of typhoidal...
Africa Asia Diagnosis enteric fever febrile illness healthcare utilisation infection transmission resource-limited setting Salmonella paratyphi A Salmonella typhi seroepidemiology serosurveillance vaccination programme Adolescent Bangladesh Carrier State Censuses Child Child Preschool Cost of Illness Female Health Resources Humans Incidence Infant Infant Newborn Malawi Male Models Theoretical Nepal Patient Acceptance of Health Care Population Surveillance Research Design Seroepidemiologic Studies Surveys and Questionnaires Typhoid Fever
Phonotactic steering and representation of directional information in the ascending auditory pathway of a cricket.
Directional hearing is crucial for animals depending on acoustic signals to locate a mate. We focused on crickets to explore the reliability of directional information forwarded to the brain by the ascending auditory interneuron...
Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015
BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from...
COngenital heart disease and the Diagnostic yield with Exome sequencing (CODE) study
F Mone, RY Eberhardt, RK Morris, ME Hurles, DJ McMullan, ER Maher, J Lord, LS Chitty, JL Giordano, RJ Wapner, MD Kilby, CODE Study Collaborators
Sep 10, 2020
OBJECTIVE: To determine the incremental yield of antenatal exome sequencing (ES) over chromosomal microarray analysis (CMA) or conventional karyotyping in prenatally diagnosed congenital heart disease (CHD). METHODS: A...
The global burden of typhoid and paratyphoid fevers
GBD 2017 Typhoid and Paratyphoid Collaborators
Apr 18, 2019
BACKGROUND: Efforts to quantify the global burden of enteric fever are valuable for understanding the health lost and the large-scale spatial distribution of the disease. We present the estimates of typhoid and paratyphoid fever...
Adolescent Adult Aged Aged 80 and over Cause of Death Child Child Preschool Disabled Persons Female Global Burden of Disease Humans Incidence Infant Life Expectancy Male Mass Vaccination Middle Aged Paratyphoid Fever Quality-Adjusted Life Years Risk Factors Salmonella enterica Sanitation Typhoid Fever Typhoid-Paratyphoid Vaccines Young Adult
Combined steering and direct tilt control for the enhancement of narrow tilting vehicle stability
Narrow tilting vehicles offer an opportunity to reduce both traffic congestion and carbon emissions by having a small road footprint, a low weight and a small frontal area. Their narrow track requires that they tilt into corners...
'Be on the TEAM' Study (Teenagers Against Meningitis)
Jeremy Carr, Emma Plested, Parvinder Aley, Susana Camara, Kimberly Davis, Jenny M MacLennan, Steve Gray, Saul N Faust, Ray Borrow, Hannah Christensen, Caroline Trotter, Martin CJ Maiden, Adam Finn, Matthew D Snape, ‘Be on the TEAM’ investigators
Oct 27, 2020
INTRODUCTION: Capsular group B Neisseria meningitidis (MenB) is the most common cause of invasive meningococcal disease (IMD) in many parts of the world. A MenB vaccine directed against the polysaccharide capsule remains elusive...
Paediatric infectious disease and immunisation paediatric intensive and critical care Infectious Diseases Paediatrics Adolescent Adult Humans Meningitis Meningococcal Infections Meningococcal Vaccines Neisseria meningitidis Neisseria meningitidis Serogroup B Randomized Controlled Trials as Topic State Medicine Vaccination Young Adult
Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017
BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and...
Adolescent Adult Age Distribution Aged Aged 80 and over Child Child Preschool Disabled Persons Female Global Burden of Disease Global Health Humans Incidence Infant Infant Newborn Life Expectancy Male Middle Aged Morbidity prevalence Sex Distribution Socioeconomic Factors Wounds and Injuries Young Adult
Population and fertility by age and sex for 195 countries and territories, 1950-2017
GBD 2017 Population and Fertility Collaborators
Sep 18, 2019
BACKGROUND: Population estimates underpin demographic and epidemiological research and are used to track progress on numerous international indicators of health and development. To date, internationally available estimates of...
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