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Results: 4116
Identifying dementia outcomes in UK Biobank
Tim Wilkinson, Christian Schnier, Kathryn Bush, Kristiina Rannikmäe, David E Henshall, Chris Lerpiniere, Naomi E Allen, Robin Flaig, Tom C Russ, Deborah Bathgate, Suvankar Pal, John T O'Brien, Cathie LM Sudlow, Dementias Platform UK and UK Biobank
Mar 06, 2019
Prospective, population-based studies that recruit participants in mid-life are valuable resources for dementia research. Follow-up in these studies is often through linkage to routinely-collected healthcare datasets. We...
Investigation of associations between retinal microvascular parameters and albuminuria in UK Biobank
Euan N Paterson, Chris Cardwell, Thomas J MacGillivray, Emanuele Trucco, Alexander S Doney, Paul Foster, Alexander P Maxwell, Gareth J McKay, UK Biobank Eye and Vision Consortium
May 10, 2021
BACKGROUND: Associations between microvascular variation and chronic kidney disease (CKD) have been reported previously. Non-invasive retinal fundus imaging enables evaluation of the microvascular network and may offer insight...
Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci.
Previous studies have suggested that naturally occurring genetic variation contributes to the risk of astigmatism. The purpose of this investigation was to identify genetic markers associated with corneal and refractive...
Astigmatism Biological Specimen Banks Cornea Corneal Diseases Female Genetic Predisposition to Disease Genome-Wide Association Study Guanine Nucleotide Exchange Factors Humans Male Middle Aged Myopia Nuclear Proteins Polymorphism Single Nucleotide Ubiquitin-Protein Ligases United Kingdom White People
Associations with photoreceptor thickness measures in the UK Biobank.
Sharon YL Chua, Baljean Dhillon, Tariq Aslam, Konstantinos Balaskas, Qi Yang, Pearse A Keane, Adnan Tufail, Charles Reisman, Paul J Foster, Praveen J Patel, UK Biobank Eye and Vision Consortium
Dec 22, 2020
Using UK Biobank for sexual minority health research
Aim: Despite poorer health and healthcare outcomes experienced by lesbian, gay and bisexual adults, data for research to characterize and address these disparities remain limited. Patients & methods: We describe sexual history...
Using UK Biobank for sexual minority health research
Aim: Despite poorer health and healthcare outcomes experienced by lesbian, gay and bisexual adults, data for research to characterize and address these disparities remain limited. Patients & methods: We describe sexual history...
Using UK Biobank for sexual minority health research.
Aim: Despite poorer health and healthcare outcomes experienced by lesbian, gay and bisexual adults, data for research to characterize and address these disparities remain limited. Patients & methods: We describe sexual history...
Genetic map of regional sulcal morphology in the human brain from UK biobank data.
Benjamin B Sun, Stephanie J Loomis, Fabrizio Pizzagalli, Natalia Shatokhina, Jodie N Painter, Christopher N Foley, Biogen Biobank Team, Megan E Jensen, Donald G McLaren, Sai Spandana Chintapalli, Alyssa H Zhu, Daniel Dixon, Tasfiya Islam, Iyad Ba Gari, Heiko Runz, Sarah E Medland, Paul M Thompson, Neda Jahanshad, Christopher D Whelan
Oct 14, 2022
Genetic associations with macroscopic brain structure can provide insights into brain function and disease. However, specific associations with measures of local brain folding are largely under-explored. Here, we conducted...
Genetic map of regional sulcal morphology in the human brain from UK biobank data.
Benjamin B Sun, Stephanie J Loomis, Fabrizio Pizzagalli, Natalia Shatokhina, Jodie N Painter, Christopher N Foley, Biogen Biobank Team, Megan E Jensen, Donald G McLaren, Sai Spandana Chintapalli, Alyssa H Zhu, Daniel Dixon, Tasfiya Islam, Iyad Ba Gari, Heiko Runz, Sarah E Medland, Paul M Thompson, Neda Jahanshad, Christopher D Whelan
Nov 16, 2022
Genetic associations with macroscopic brain structure can provide insights into brain function and disease. However, specific associations with measures of local brain folding are largely under-explored. Here, we conducted...
Comparison of risk factor associations in UK Biobank against representative, general population based studies with conventional response rates
Abstract: Objective: To compare established associations between risk factors and mortality in UK Biobank, a study with an exceptionally low rate of response to its baseline survey, against those from representative studies that...
Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants.
Scott C Ritchie, Praveen Surendran, Savita Karthikeyan, Samuel A Lambert, Thomas Bolton, Lisa Pennells, John Danesh, Emanuele Di Angelantonio, Adam S Butterworth, Michael Inouye
Mar 03, 2023
Metabolic biomarker data quantified by nuclear magnetic resonance (NMR) spectroscopy in approximately 121,000 UK Biobank participants has recently been released as a community resource, comprising absolute concentrations and...
Stronger Associations Between Sleep and Mental Health in Adults with Autism
This study examined sleep and its cognitive and affective correlates in adults with and without autism spectrum disorder (ASD), utilizing UK Biobank data. There were no group differences in subjective sleep duration [n = 220...
Rare variant contribution to human disease in 281,104 UK Biobank exomes.
Quanli Wang, Ryan S Dhindsa, Keren Carss, Andrew R Harper, Abhishek Nag, Ioanna Tachmazidou, Dimitrios Vitsios, Sri VV Deevi, Alex Mackay, Daniel Muthas, Michael Hühn, Susan Monkley, Henric Olsson, AstraZeneca Genomics Initiative, Sebastian Wasilewski, Katherine R Smith, Ruth March, Adam Platt, Carolina Haefliger, Slavé Petrovski
Oct 26, 2021
Genome-wide association studies have uncovered thousands of common variants associated with human disease, but the contribution of rare variants to common disease remains relatively unexplored. The UK Biobank contains detailed...
Describing a new food group classification system for UK biobank
Carmen Piernas, Aurora Perez-Cornago, Min Gao, Heather Young, Zoe Pollard, Angela Mulligan, Marleen Lentjes, Jennifer Carter, Kathryn Bradbury, Tim J Key, Susan A Jebb
Nov 25, 2021
PURPOSE: The UK Biobank study collected detailed dietary data using a web-based self-administered 24 h assessment tool, the Oxford WebQ. We aimed to describe a comprehensive food grouping system for this questionnaire and to...
The Causal Effects of Health Conditions and Risk Factors on Social and Socioeconomic Outcomes
Sean Harrison, Alisha R Davies, Matt Dickson, Jessica Tyrrell, Michael J Green, Srinivasa Vittal Katikireddi, Desmond Campbell, Marcus Munafó, Padraig Dixon, Hayley E Jones, Frances Rice, Neil M Davies, Laura D Howe
Oct 31, 2020
Background
To estimate the causal effect of health conditions and risk factors on social and socioeconomic outcomes in UK Biobank. Evidence on socioeconomic impacts is important to understand because it can help governments...
To estimate the causal effect of health conditions and risk factors on social and socioeconomic outcomes in UK Biobank. Evidence on socioeconomic impacts is important to understand because it can help governments...
Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction
OBJECTIVE: To determine whether endogenous testosterone has a causal role in thromboembolism, heart failure, and myocardial infarction. DESIGN: Two sample mendelian randomisation study using genetic variants as instrumental...
Adult Aged Biological Specimen Banks Female Genetic Pleiotropy genetic variation Genome-Wide Association Study Heart Failure Humans Male Mendelian Randomization Analysis Middle Aged Myocardial Infarction Odds Ratio Randomized Controlled Trials as Topic Risk Factors Testosterone Thromboembolism United Kingdom White People
Stronger Associations Between Sleep and Mental Health in Adults with Autism
This study examined sleep and its cognitive and affective correlates in adults with and without autism spectrum disorder (ASD), utilizing UK Biobank data. There were no group differences in subjective sleep duration [n = 220...
Estimating physical activity from self-reported behaviours in large-scale population studies using network harmonisation
Matthew Pearce, Tessa Strain, Youngwon Kim, Stephen J. Sharp, Kate Westgate, Katrien Wijndaele, Tomas Gonzales, Nicholas J. Wareham, Søren Brage
Mar 16, 2021
Abstract: Background: UK Biobank is a large prospective cohort study containing accelerometer-based physical activity data with strong validity collected from 100,000 participants approximately 5 years after baseline. In...
A commonly occurring genetic variant within the NPLOC4-TSPAN10-PDE6G gene cluster is associated with the risk of strabismus.
Denis Plotnikov, Rupal L Shah, Jamille N Rodrigues, Phillippa M Cumberland, Jugnoo S Rahi, Pirro G Hysi, Denize Atan, Cathy Williams, Jeremy A Guggenheim, UK Biobank Eye and Vision Consortium
Jul 18, 2019
Strabismus refers to an abnormal alignment of the eyes leading to the loss of central binocular vision. Concomitant strabismus occurs when the angle of deviation is constant in all positions of gaze and often manifests in early...
Adult Aged Animals Case-Control Studies Child Cohort Studies Cyclic Nucleotide Phosphodiesterases Type 6 Female Genome-Wide Association Study Humans Male Mice Middle Aged Multigene Family Mutation Nuclear Proteins Polymorphism Single Nucleotide Retina Risk Factors strabismus Tetraspanins Visual Acuity
Consensus for genes to be included on cancer panel tests offered by UK genetics services
Amy Taylor, Angela F Brady, Ian M Frayling, Helen Hanson, Marc Tischkowitz, Clare Turnbull, Lucy Side, UK Cancer Genetics Group (UK-CGG)
May 18, 2018
Genetic testing for hereditary cancer predisposition has evolved rapidly in recent years with the discovery of new genes, but there is much debate over the clinical utility of testing genes for which there are currently limited...
The Causal Effects of Health Conditions and Risk Factors on Social and Socioeconomic Outcomes
Sean Harrison, Alisha R Davies, Matt Dickson, Jessica Tyrrell, Michael J Green, Srinivasa Vittal Katikireddi, Desmond Campbell, Marcus Munafó, Padraig Dixon, Hayley E Jones, Frances Rice, Neil M Davies, Laura D Howe
Oct 31, 2020
Background
To estimate the causal effect of health conditions and risk factors on social and socioeconomic outcomes in UK Biobank. Evidence on socioeconomic impacts is important to understand because it can help governments...
To estimate the causal effect of health conditions and risk factors on social and socioeconomic outcomes in UK Biobank. Evidence on socioeconomic impacts is important to understand because it can help governments...
Estimating physical activity from self-reported behaviours in large-scale population studies using network harmonisation
Matthew Pearce, Tessa Strain, Youngwon Kim, Stephen J Sharp, Kate Westgate, Katrien Wijndaele, Tomas Gonzales, Nicholas J Wareham, Søren Brage
Apr 17, 2020
BACKGROUND:UK Biobank is a large prospective cohort study containing accelerometer-based physical activity data with strong validity collected from 100,000 participants approximately 5 years after baseline. In contrast, the main...
Best practices for multi-ancestry, meta-analytic transcriptome-wide association studies
Arjun Bhattacharya, Jibril B Hirbo, Dan Zhou, Wei Zhou, Jie Zheng, Masahiro Kanai, Global Biobank Meta-analysis Initiative, Bogdan Pasaniuc, Eric R Gamazon, Nancy J Cox
Dec 08, 2022
The Global Biobank Meta-analysis Initiative (GBMI), through its diversity, provides a valuable opportunity to study population-wide and ancestry-specific genetic associations. However, with multiple ascertainment strategies and...
Estimating physical activity from self-reported behaviours in large-scale population studies using network harmonisation
Matthew Pearce, Tessa Strain, Youngwon Kim, Stephen J. Sharp, Kate Westgate, Katrien Wijndaele, Tomas Gonzales, Nicholas J. Wareham, Søren Brage
Jun 06, 2020
Abstract: Background: UK Biobank is a large prospective cohort study containing accelerometer-based physical activity data with strong validity collected from 100,000 participants approximately 5 years after baseline. In...
Healthy living and cancer
Peter C Elwood, Alex Whitmarsh, John Gallacher, Anthony Bayer, Richard Adams, Luke Heslop, Janet Pickering, Gareth Morgan, Julieta Galante, Sunil Dolwani, Marcus Longley, Zoe E Roberts
Jan 10, 2018
CONTEXT: UK Biobank is a prospective study of half a million subjects, almost all aged 40-69 years, identified in 22 centres across the UK during 2006-2010. OBJECTIVE: A healthy lifestyle has been described as 'better than any...
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