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Brain tumor research in the United Kingdom
Kathreena M Kurian, Michael D Jenkinson, Paul M Brennan, Robin Grant, Sarah Jefferies, Alasdair G Rooney, Helen Bulbeck, Sara C Erridge, Samantha Mills, Catherine McBain, Martin G McCabe, Stephen J Price, Silvia Marino, Erica Moyes, Wendy Qian, Adam Waldman, Babar Vaqas, Debbie Keatley, Peter Burchill, Colin Watts
Dec 12, 2017
The National Cancer Research Institute (NCRI) is a partnership of charity and government research funders whose purpose is to improve health and quality of life by accelerating progress in cancer-related research through...
The National Institute for Health Research
V Goh, National Institute for Health Research Clinical Research Network Imaging Network Steering Group, Royal College of Radiologists' Academic Committee
Oct 01, 2019
Since the inception of the National Institute for Health Research (NIHR) in 2006, the landscape for the delivery of clinical research within the National Health Service (NHS) has been transformed. Clinical radiology has...
Clinical trials (and tribulations)
There have been immediate and profound impacts of SARS-CoV-2 and COVID-19 on healthcare services worldwide with major consequences for non-COVID-19 related healthcare. Alongside efforts to reconfigure services and enable...
Surveillance recommendations for DICER1 pathogenic variant carriers
Jette J Bakhuizen, Helen Hanson, Karin van der Tuin, Fiona Lalloo, Marc Tischkowitz, Karin Wadt, Marjolijn CJ Jongmans, SIOPE Host Genome Working Group, CanGene-CanVar Clinical Guideline Working Group, Expert Network Members
Oct 01, 2021
DICER1 syndrome is a rare genetic disorder that predisposes to a wide spectrum of tumors. Developing surveillance protocols for this syndrome is challenging because uncertainty exists about the clinical efficacy of surveillance...
Comparison of Suspected and Confirmed Internal External Ventricular Drain-Related Infections
Sei Yon Sohn, Clark D Russell, Aimun AB Jamjoom, Michael T Poon, Aaron Lawson McLean, Aminul I Ahmed, British Neurosurgical Trainee Research Collaborative
Nov 20, 2022
BACKGROUND: Diagnosis of internal external ventricular drain (EVD)-related infections (iERI) is an area of diagnostic difficulty. Empiric treatment is often initiated on clinical suspicion. There is limited guidance around...
Scope of professional roles for genetic counsellors and clinical geneticists in the United Kingdom
Anna Middleton, Nicola Taverner, Catherine Houghton, Sarah Smithson, Meena Balasubramanian, Frances Elmslie
Jan 07, 2023
This document is written on behalf of the two professional bodies in the United Kingdom that represent genetic counsellors (the Association of Genetic Nurses and Counsellors) and clinical geneticists (the Clinical Genetics...
Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST)
Guy E Thwaites, Matthew Scarborough, Alexander Szubert, Emmanuel Nsutebu, Robert Tilley, Julia Greig, Sarah A Wyllie, Peter Wilson, Cressida Auckland, Janet Cairns, Denise Ward, Pankaj Lal, Achyut Guleri, Neil Jenkins, Julian Sutton, Martin Wiselka, Gonzalez-Ruiz Armando, Clive Graham, Paul R Chadwick, Gavin Barlow, N Claire Gordon, Bernadette Young, Sarah Meisner, Paul McWhinney, David A Price, David Harvey, Deepa Nayar, Dakshika Jeyaratnam, Tim Planche, Jane Minton, Fleur Hudson, Susan Hopkins, John Williams, M Estee Török, Martin J Llewelyn, Jonathan D Edgeworth, A Sarah Walker, United Kingdom Clinical Infection Research Group (UKCIRG)
Jun 27, 2018
BACKGROUND: Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed...
Boundary spanning and identity work in the clinical research delivery workforce
BACKGROUND: Research nurses, midwives and allied health professionals are members of an important emergent profession delivering clinical research and, in the United Kingdom, have been the focus of considerable investment by the...
Boundary spanning and identity work in the clinical research delivery workforce
Background
Research nurses, midwives and allied health professionals are members of an important emergent profession delivering clinical research and, in the United Kingdom, have been the focus of considerable investment...
adjustment Clinical Research United Kingdom qualitative research Professional identity Boundary spanning Research delivery Research nursing
Published by: Health research policy and systems
Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.
Lourdes Ortiz-Fernández, Francisco David Carmona, Raquel López-Mejías, Maria Francisca González-Escribano, Paul A Lyons, Ann W Morgan, Amr H Sawalha, Peter A Merkel, Kenneth GC Smith, Miguel A González-Gay, Javier Martín, UK GCA Consortium, Turkish Takayasu Study Group, Vasculitis Clinical Research Consortium, IgAV Study Group, AAV Study group Spanish GCA Study Group
Apr 18, 2018
OBJETIVE: Systemic vasculitides represent a heterogeneous group of rare complex diseases of the blood vessels with a poorly understood aetiology. To investigate the shared genetic component underlying their predisposition, we...
Autoantibodies outcomes research systemic sclerosis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Case-Control Studies Epigenesis Genetic Female Genetic Loci Genetic Predisposition to Disease Giant Cell Arteritis HLA-DQ Antigens HLA-DQ beta-Chains Humans Jumonji Domain-Containing Histone Demethylases Linkage Disequilibrium Male Phenotype Polymorphism Single Nucleotide Protein Array Analysis Systemic Vasculitis Takayasu arteritis
Histopathological frequency of canine hepatobiliary disease in the United Kingdom.
OBJECTIVES: Canine hepatobiliary disease is common; however, data determining disease frequency and breed predispositions are lacking. The primary objective was to identify the frequency of different hepatobiliary disease in a...
Charity retailing in the United Kingdom
Nonprofit organizations are venturing into commercial activities due to the intense competition for the limited government funds and declining availability of donor funds for third-sector organizations that address social...
Charity retailing in the United Kingdom
Nonprofit organizations are venturing into commercial activities due to the intense competition for the limited government funds and declining availability of donor funds for third-sector organizations that address social...
Delivering genomic medicine in the United Kingdom National Health Service
Caroline Pearce, Emma Goettke, Nina Hallowell, Pauline McCormack, Frances Flinter, Christopher McKevitt
Oct 01, 2020
PURPOSE: We sought to assess the readiness of the United Kingdom (UK) National Health Service to implement a Genomic Medicine Service. We conducted a systematic literature review to identify what is known about factors related...
What outcomes should researchers select, collect and report in pre-eclampsia research? A qualitative study exploring the views of women with lived experience of pre-eclampsia.
Jmn Duffy, T Thompson, L Hinton, M Salinas, RJ McManus, S Ziebland, International Collaboration to Harmonise Outcomes in Pre-eclampsia (iHOPE) Qualitative Research Group
Dec 18, 2020
OBJECTIVE: To identify outcomes relevant to women with lived experience of pre-eclampsia. DESIGN: Qualitative interview study. SETTING: A national study conducted in the United Kingdom. SAMPLE: Purposive sample of women with...
Outcome following surgery to treat septic peritonitis in 95 cats in the United Kingdom.
T Anderson, L Beever, J Hall, A Moores, C Llanos, R Adams, L Meakin, M Coppola, K Bowlt-Blacklock, MA Holmes, D Barnes
May 19, 2021
OBJECTIVES: To review the cause, management and outcome in cats with septic peritonitis within the United Kingdom (2008 to 2018) and to identify if previously identified prognostic factors were associated with survival in this...
Environmental policy in the United Kingdom and Germany
Charles Lees
Jan 01, 0001
The essay examines developments within environmental policy making in the United Kingdom and the Federal Republic of Germany and asks: (i) can we identify patterns of convergence and/or divergence between the two countries?; and...
Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia (ARREST)
Guy Thwaites, Cressida Auckland, Gavin Barlow, Richard Cunningham, Gerry Davies, Jonathan Edgeworth, Julia Greig, Susan Hopkins, Dakshika Jeyaratnam, Neil Jenkins, Martin Llewelyn, Sarah Meisner, Emmanuel Nsutebu, Tim Planche, Robert C Read, Matthew Scarborough, Marta Soares, Robert Tilley, M Estée Török, John Williams, Peter Wilson, Sarah Wyllie, A Sarah Walker, United Kingdom Clinical Infection Research Group
Jan 30, 2013
Challenges and opportunities for conducting a vaccine trial during the COVID-19 pandemic in the United Kingdom.
M Estée Török, Benjamin R Underwood, Mark Toshner, Claire Waddington, Emad Sidhom, Katherine Sharrocks, Rachel Bousfield, Charlotte Summers, Caroline Saunders, Zoe McIntyre, Helen Morris, Jo Piper, Gloria Calderon, Sarah Dennis, Tracy Assari, Anita Marguerie de Rotrou, Ashley Shaw, John Bradley, John O'Brien, Robert C Rintoul, Ian Smith, Ed Bullmore, Krishna Chatterjee, Cambridge COVID Vaccine Trial Team
Aug 19, 2021
The COVID-19 pandemic has resulted in unprecedented challenges for healthcare systems worldwide. It has also stimulated research in a wide range of areas including rapid diagnostics, novel therapeutics, use of technology to...
Florence Nightingale's legacy for clinical academics
Natalie Pattison, Christi Deaton, Candy McCabe, Vivien Coates, Bridget Johnston, Fiona Nolan, Lisa Whiting, Michelle Briggs
Mar 12, 2021
BACKGROUND: Clinical academic nursing roles are rare, and clinical academic leadership positions even more scarce. Amongst the United Kingdom (UK) academia, only 3% of nurses who are employed within universities are clinically...
Florence Nightingale's legacy for clinical academics
Natalie Pattison, Christi Deaton, Candy McCabe, Vivien Coates, Bridget Johnston, Fiona Nolan, Lisa Whiting, Michelle Briggs
Jan 28, 2022
BACKGROUND: Clinical academic nursing roles are rare, and clinical academic leadership positions even more scarce. Amongst the United Kingdom (UK) academia, only 3% of nurses who are employed within universities are clinically...
Challenges and opportunities for conducting a vaccine trial during the COVID-19 pandemic in the United Kingdom
M Estée Török, Benjamin R Underwood, Mark Toshner, Claire Waddington, Emad Sidhom, Katherine Sharrocks, Rachel Bousfield, Charlotte Summers, Caroline Saunders, Zoe McIntyre, Helen Morris, Jo Piper, Gloria Calderon, Sarah Dennis, Tracy Assari, Anita Marguerie de Rotrou, Ashley Shaw, John Bradley, John O’Brien, Robert C Rintoul, Ian Smith, Ed Bullmore, Krishna Chatterjee, Carla Ribeiro, Lorinda Pickup, Ranalie de Jesus, Karen Brookes, Phoebe Vargas, Caroline McMahon, Chiara Macor, Ciro Pasquale, Areti Bermperi, Evgenia Kourampa, Marivic Fabiculcana, Julie Ann Zerudo, Vivien Mendoza, Stewart Fuller, Claire Glemas, Sharon Baker, Greta Lyons, Marina Bishop, Siobhan Coleman, Naomi Thomas, Vince Mlilo, Edward Stanton, Rachel Michel, Julie Philips, Heidi Rice, Lucie Garner, Francesca Rosa, Saji Victor, Julie Zamikula, Sue Mepham, Fatima Hajee, Juan Carlos Quijano-Campos, Laura Watson, Christopher Georgiou, Jieniean Worsley, Djamilla Shamtally-Amode, Ferishta Rahimi, Heather Jones, Isabel Cruz, Gayle Lindsay, Christian Sparke, Anna Chapman, Katie Keating-Fedders, Codie Fahey, Danielle Johnson, Lucy Worboys, Simone Hargreaves, Ashlea Bucke, Lindsay Carr, Jackie Hampshire, Tracy Richardson, Jenny Sharpe, Lynne Whitehead, Naval Vyse, Stephen Kelleher, Mary-Beth Sherwood, Vicki Hughes, Kim Giraud
Oct 01, 2021
The COVID-19 pandemic has resulted in unprecedented challenges for healthcare systems worldwide. It has also stimulated research in a wide range of areas including rapid diagnostics, novel therapeutics, use of technology to...
Environmental policy in the United Kingdom and Germany
Charles Lees
Jan 01, 0001
The essay examines developments within environmental policy making in the United Kingdom and the Federal Republic of Germany and asks: (i) can we identify patterns of convergence and/or divergence between the two countries?; and...
The Governance of Economic Unionism after the United Kingdom Internal Market Act
Kenneth A. Armstrong
Nov 01, 2021
Abstract: With the United Kingdom having finally withdrawn from the European Union, and with a new Trade and Cooperation Agreement in place to begin to manage their economic relationship, it might be thought that the...
article ARTICLES Brexit internal market regulatory state economic unionism regulatory competition devolution
Published by: The Modern Law Review
Longitudinal genomic surveillance of multidrug-resistant Escherichia coli carriage in a long-term care facility in the United Kingdom.
Hayley J Brodrick, Kathy E Raven, Teemu Kallonen, Dorota Jamrozy, Beth Blane, Nicholas M Brown, Veronique Martin, M Estée Török, Julian Parkhill, Sharon J Peacock
Jul 25, 2017
BACKGROUND: Residents of long-term care facilities (LTCF) may have high carriage rates of multidrug-resistant pathogens, but are not currently included in surveillance programmes for antimicrobial resistance or...
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