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Results: 80381
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
Derek Klarin, Scott M Damrauer, Kelly Cho, Yan V Sun, Tanya M Teslovich, Jacqueline Honerlaw, David R Gagnon, Scott L DuVall, Jin Li, Gina M Peloso, Mark Chaffin, Aeron M Small, Jie Huang, Hua Tang, Julie A Lynch, Yuk-Lam Ho, Dajiang J Liu, Connor A Emdin, Alexander H Li, Jennifer E Huffman, Jennifer S Lee, Pradeep Natarajan, Rajiv Chowdhury, Danish Saleheen, Marijana Vujkovic, Aris Baras, Saiju Pyarajan, Emanuele Di Angelantonio, Benjamin M Neale, Aliya Naheed, Amit V Khera, John Danesh, Kyong-Mi Chang, Gonçalo Abecasis, Cristen Willer, Frederick E Dewey, David J Carey, Global Lipids Genetics Consortium, Myocardial Infarction Genetics (MIGen) Consortium, Geisinger-Regeneron DiscovEHR Collaboration, VA Million Veteran Program, John Concato, J Michael Gaziano, Christopher J O'Donnell, Philip S Tsao, Sekar Kathiresan, Daniel J Rader, Peter WF Wilson, Themistocles L Assimes
Sep 08, 2018
The Million Veteran Program (MVP) was established in 2011 as a national research initiative to determine how genetic variation influences the health of US military veterans. Here we genotyped 312,571 MVP participants using a...
Genetic predisposition to smoking in relation to 14 cardiovascular diseases.
Susanna C Larsson, Amy M Mason, Magnus Bäck, Derek Klarin, Scott M Damrauer, Million Veteran Program, Karl Michaëlsson, Stephen Burgess
May 05, 2020
AIMS: The aim of this study was to use Mendelian randomization (MR) to determine the causality of the association between smoking and 14 different cardiovascular diseases (CVDs). METHODS AND RESULTS: Our primary genetic...
cardiovascular disease lifestyle Mendelian randomization Risk Factors SINGLE-NUCLEOTIDE POLYMORPHISMS Smoking Brain Ischemia Cardiovascular Diseases Genetic Predisposition to Disease Genome-Wide Association Study Humans Mendelian Randomization Analysis Polymorphism Single Nucleotide Risk Factors Smoking stroke
Urate, Blood Pressure, and Cardiovascular Disease
Dipender Gill, Alan C Cameron, Stephen Burgess, Xue Li, Daniel J Doherty, Ville Karhunen, Azmil H Abdul-Rahim, Martin Taylor-Rowan, Verena Zuber, Philip S Tsao, Derek Klarin, VA Million Veteran Program, Evangelos Evangelou, Paul Elliott, Scott M Damrauer, Terence J Quinn, Abbas Dehghan, Evropi Theodoratou, Jesse Dawson, Ioanna Tzoulaki
Nov 26, 2020
Serum urate has been implicated in hypertension and cardiovascular disease, but it is not known whether it is exerting a causal effect. To investigate this, we performed Mendelian randomization analysis using data from UK...
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
Ayush Giri, Jacklyn N Hellwege, Jacob M Keaton, Jihwan Park, Chengxiang Qiu, Helen R Warren, Eric S Torstenson, Csaba P Kovesdy, Yan V Sun, Otis D Wilson, Cassianne Robinson-Cohen, Christianne L Roumie, Cecilia P Chung, Kelly A Birdwell, Scott M Damrauer, Scott L DuVall, Derek Klarin, Kelly Cho, Yu Wang, Evangelos Evangelou, Claudia P Cabrera, Louise V Wain, Rojesh Shrestha, Brian S Mautz, Elvis A Akwo, Muralidharan Sargurupremraj, Stéphanie Debette, Michael Boehnke, Laura J Scott, Jian'an Luan, Jing-Hua Zhao, Sara M Willems, Sébastien Thériault, Nabi Shah, Christopher Oldmeadow, Peter Almgren, Ruifang Li-Gao, Niek Verweij, Thibaud S Boutin, Massimo Mangino, Ioanna Ntalla, Elena Feofanova, Praveen Surendran, James P Cook, Savita Karthikeyan, Najim Lahrouchi, Chunyu Liu, Nuno Sepúlveda, Tom G Richardson, Aldi Kraja, Philippe Amouyel, Martin Farrall, Neil R Poulter, Understanding Society Scientific Group, International Consortium for Blood Pressure, Blood Pressure-International Consortium of Exome Chip Studies, Markku Laakso, Eleftheria Zeggini, Peter Sever, Robert A Scott, Claudia Langenberg, Nicholas J Wareham, David Conen, Colin Neil Alexander Palmer, John Attia, Daniel I Chasman, Paul M Ridker, Olle Melander, Dennis Owen Mook-Kanamori, Pim van der Harst, Francesco Cucca, David Schlessinger, Caroline Hayward, Tim D Spector, Marjo-Riitta Jarvelin, Branwen J Hennig, Nicholas J Timpson, Wei-Qi Wei, Joshua C Smith, Yaomin Xu, Michael E Matheny, Edward E Siew, Cecilia Lindgren, Karl-Heinz Herzig, George Dedoussis, Joshua C Denny, Bruce M Psaty, Joanna MM Howson, Patricia B Munroe, Christopher Newton-Cheh, Mark J Caulfield, Paul Elliott, J Michael Gaziano, John Concato, Peter WF Wilson, Philip S Tsao, Digna R Velez Edwards, Katalin Susztak, Million Veteran Program, Christopher J O'Donnell, Adriana M Hung, Todd L Edwards
Feb 01, 2019
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood...
Winthrop's Largest Estate Gift Totaling $3 Million to Establish Student Service Program
Winthrop University
Jan 01, 0001
Reed's gift will be used to establish the Elizabeth Hope Reed Fellows Program, a service-focused student scholarship program. The $3 million estate gift is the largest estate gift in Winthrop's history.
Published by: Winthrop University
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
W423.7-001 - Summer School Program: Various Records
Summer School Program
Jan 01, 0001
Published by: Winthrop University
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
A Role for RAS in V-CRK Transformation
Heidi Greulich
Jan 01, 0001
The v-Crk oncogene product, while possessing no intrinsic tyrosine kinase activity, causes an elevation in levels of cellular phosphotyrosine as it transforms chicken embryo fibroblasts (CEF). Because of this similarity to v-Src...
Published by: Rockefeller University
W444-001A-01 - New Start Program: Publications: New Start News
New Start Program
Jan 01, 0001
Published by: Winthrop University
President Comstock Announces Dare to Rise Fund Tops $1.1 Million Mark
Winthrop University
Jan 01, 0001
Winthrop University President Jamie Comstock announced that more than $1.1 million has been raised for a fund created just seven weeks ago to support the integration of access and quality at Winthrop. A total of 258 individuals...
Published by: Winthrop University
Military veteran athletes’ experiences of competing at the 2016 Invictus Games
Purpose: Previous research has championed sport as a form of recovery for military veterans. Nevertheless, there is a lack of research on military veterans’ experiences of international sporting competitions. The aim of this...
W444-001 - New Start Program: Advertisement Brochures
New Start Program
Jan 01, 0001
Published by: Winthrop University
Evaluation of Parameter Settings for Training Neural Networks Using Backpropagation Algorithms
Artificial neural networks (ANN) are widely used for classification, and the training algorithm commonly used is the backpropagation (BP) algorithm. The major bottleneck faced in the backpropagation neural network training is in...
Published by: IGI Global Scientific Publishing
Military veteran athletes’ experiences of competing at the 2016 Invictus Games
Purpose: Previous research has championed sport as a form of recovery for military veterans. Nevertheless, there is a lack of research on military veterans’ experiences of international sporting competitions. The aim of this...
Transferability of genetic risk scores in African populations.
Abram B Kamiza, Sounkou M Toure, Marijana Vujkovic, Tafadzwa Machipisa, Opeyemi S Soremekun, Christopher Kintu, Manuel Corpas, Fraser Pirie, Elizabeth Young, Dipender Gill, Manjinder S Sandhu, Pontiano Kaleebu, Moffat Nyirenda, Ayesha A Motala, Tinashe Chikowore, Segun Fatumo
Jun 18, 2022
The poor transferability of genetic risk scores (GRSs) derived from European ancestry data in diverse populations is a cause of concern. We set out to evaluate whether GRSs derived from data of African American individuals and...
Transferability of genetic risk scores in African populations.
Abram B Kamiza, Sounkou M Toure, Marijana Vujkovic, Tafadzwa Machipisa, Opeyemi S Soremekun, Christopher Kintu, Manuel Corpas, Fraser Pirie, Elizabeth Young, Dipender Gill, Manjinder S Sandhu, Pontiano Kaleebu, Moffat Nyirenda, Ayesha A Motala, Tinashe Chikowore, Segun Fatumo
Jul 03, 2022
The poor transferability of genetic risk scores (GRSs) derived from European ancestry data in diverse populations is a cause of concern. We set out to evaluate whether GRSs derived from data of African American individuals and...
Transferability of genetic risk scores in African populations.
Abram B Kamiza, Sounkou M Toure, Marijana Vujkovic, Tafadzwa Machipisa, Opeyemi S Soremekun, Christopher Kintu, Manuel Corpas, Fraser Pirie, Elizabeth Young, Dipender Gill, Manjinder S Sandhu, Pontiano Kaleebu, Moffat Nyirenda, Ayesha A Motala, Tinashe Chikowore, Segun Fatumo
Jun 17, 2022
The poor transferability of genetic risk scores (GRSs) derived from European ancestry data in diverse populations is a cause of concern. We set out to evaluate whether GRSs derived from data of African American individuals and...
Impact of Digital Mammography on Cancer Detection and Recall Rates
Roger G Blanks, Matthew G Wallis, Rupert Alison, Olive Kearins, Jacquie Jenkins, Julietta Patnick, Rosalind M Given-Wilson
Aug 01, 2019
Purpose To report the impact of changing from screen-film mammography to digital mammography (DM) in a large organized national screening program. Materials and Methods A retrospective analysis of prospectively collected annual...
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease.
Connor A Emdin, Mary E Haas, Amit V Khera, Krishna Aragam, Mark Chaffin, Derek Klarin, George Hindy, Lan Jiang, Wei-Qi Wei, Qiping Feng, Juha Karjalainen, Aki Havulinna, Tuomo Kiiskinen, Alexander Bick, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Danish Saleheen, Kyong-Mi Chang, Marijana Vujkovic, Ben Voight, Scott Damrauer, Julie Lynch, David Kaplan, Marina Serper, Philip Tsao, Million Veteran Program, Josep Mercader, Craig Hanis, Mark Daly, Joshua Denny, Stacey Gabriel, Sekar Kathiresan
May 16, 2020
Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we identify a common missense variant in the Mitochondrial Amidoxime Reducing Component 1 gene (MARC1 p.A165T) that associates with protection...
A Text-Messaging and Pedometer Program to Promote Physical Activity in People at High Risk of Type 2 Diabetes
Katie Morton, Stephen Sutton, Wendy Hardeman, Jacqui Troughton, Tom Yates, Simon Griffin, Melanie Davies, Kamlesh Khunti, Helen Eborall
Jun 22, 2018
BACKGROUND: Mobile technologies for health (mHealth) represent a promising strategy for reducing type 2 diabetes (T2DM) risk. The PROPELS trial investigates whether structured group-based education alone or supplemented with a...
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease
Connor A. Emdin, Mary E. Haas, Amit V. Khera, Krishna Aragam, Mark Chaffin, Derek Klarin, George Hindy, Lan Jiang, Wei-Qi Wei, Qiping Feng, Juha Karjalainen, Aki Havulinna, Tuomo Kiiskinen, Alexander Bick, Diego Ardissino, James G. Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J. Bown, Nilesh J. Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Danish Saleheen, Kyong-Mi Chang, Marijana Vujkovic, Ben Voight, Scott Damrauer, Julie Lynch, David Kaplan, Marina Serper, Philip Tsao, Million Veteran Program, Josep Mercader, Craig Hanis, Mark Daly, Joshua Denny, Stacey Gabriel, Sekar Kathiresan
May 05, 2020
Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we identify a common missense variant in the Mitochondrial Amidoxime Reducing Component 1 gene (MARC1 p.A165T) that associates with protection...
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