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Factorial Structure and Validity of Depression (PHQ-9) and Anxiety (GAD-7) Scales after Traumatic Brain Injury
Ali Teymoori, Anastasia Gorbunova, Fardzadeh E. Haghish, Ruben Real, Marina Zeldovich, Yi-Jhen Wu, Suzanne Polinder, Thomas Asendorf, David Menon, CENTER-TBI Investigators and Participants CENTER-TBI Investigators and Participants, Nicole v. Steinbüchel
Mar 25, 2020
Background: The dimensionality of depression and anxiety instruments have recently been a source of controversy. Objectives and Design: In a European-wide sample of patients after Traumatic Brain Injury (TBI), we aim to examine...
Breast cancer risk prediction using a polygenic risk score in the familial setting
Hongyan Li, Bingjian Feng, Alexander Miron, Xiaoqing Chen, Jonathan Beesley, Emmanuella Bimeh, Daniel Barrowdale, Esther M John, Mary B Daly, Irene L Andrulis, Saundra S Buys, Peter Kraft, kConFab Investigators, Heather Thorne, Georgia Chenevix-Trench, Melissa C Southey, Antonis C Antoniou, Paul A James, Mary Beth Terry, Kelly-Anne Phillips, John L Hopper, Gillian Mitchell, David E Goldgar
Jun 03, 2016
The United Kingdom Childhood Cancer Study
UK Childhood Cancer Study Investigators
Feb 21, 2020
An investigation into the possible causes of childhood cancer has been carried out throughout England, Scotland and Wales over the period 1991-1998. All children known to be suffering from one or other type of the disease over...
Diffuse Intracranial Injury Patterns Are Associated with Impaired Cerebrovascular Reactivity in Adult Traumatic Brain Injury
Frederick A Zeiler, François Mathieu, Miguel Monteiro, Ben Glocker, Ari Ercole, Erta Beqiri, Manuel Cabeleira, Nino Stocchetti, Peter Smielewski, Marek Czosnyka, Virginia Newcombe, David K Menon, the CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Feb 28, 2020
Recent single-center retrospective analysis displayed the association between admission computed tomography (CT) markers of diffuse intracranial injury and worse cerebrovascular reactivity. The goal of this study was to further...
Accuracy of Risk Estimates from the iPrevent Breast Cancer Risk Assessment and Management Tool.
Kelly-Anne Phillips, Yuyan Liao, Roger L Milne, Robert J Macinnis, Ian M Collins, Richard Buchsbaum, Prue C Weideman, Adrian Bickerstaffe, Stephanie Nesci, Wendy K Chung, Melissa C Southey, Julia A Knight, Alice S Whittemore, Gillian S Dite, David Goldgar, Graham G Giles, Gord Glendon, Jack Cuzick, Antonis C Antoniou, Irene L Andrulis, Esther M John, Mary B Daly, Saundra S Buys, John L Hopper, Mary Beth Terry, kConFab Investigators
Aug 28, 2020
BACKGROUND: iPrevent is an online breast cancer (BC) risk management decision support tool. It uses an internal switching algorithm, based on a woman's risk factor data, to estimate her absolute BC risk using either the...
Annexin A1 expression in a pooled breast cancer series
Marcelo Sobral-Leite, Jelle Wesseling, Vincent THBM Smit, Heli Nevanlinna, Martine H van Miltenburg, Joyce Sanders, Ingrid Hofland, Fiona M Blows, Penny Coulson, Gazinska Patrycja, Jan HM Schellens, Rainer Fagerholm, Päivi Heikkilä, Kristiina Aittomäki, Carl Blomqvist, Elena Provenzano, Hamid Raza Ali, Jonine Figueroa, Mark Sherman, Jolanta Lissowska, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, Kelly-Anne Phillips, kConFab/AOCS Investigators, Fergus J Couch, Janet E Olson, Celine Vachon, Daniel Visscher, Hermann Brenner, Katja Butterbach, Volker Arndt, Bernd Holleczek, Maartje J Hooning, Antoinette Hollestelle, John WM Martens, Carolien HM van Deurzen, Bob van de Water, Annegien Broeks, Jenny Chang-Claude, Georgia Chenevix-Trench, Douglas F Easton, Paul DP Pharoah, Montserrat García-Closas, Marjo de Graauw, Marjanka K Schmidt
Jun 25, 2015
The predictive ability of the 313 variant-based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant.
Inge MM Lakeman, Alexandra J van den Broek, Juliën AM Vos, Daniel R Barnes, Julian Adlard, Irene L Andrulis, Adalgeir Arason, Norbert Arnold, Banu K Arun, Judith Balmaña, Daniel Barrowdale, Javier Benitez, Ake Borg, Trinidad Caldés, Maria A Caligo, Wendy K Chung, Kathleen BM Claes, GEMO Study Collaborators, EMBRACE Collaborators, J Margriet Collée, Fergus J Couch, Mary B Daly, Joe Dennis, Mallika Dhawan, Susan M Domchek, Ros Eeles, Christoph Engel, D Gareth Evans, Lidia Feliubadaló, Lenka Foretova, Eitan Friedman, Debra Frost, Patricia A Ganz, Judy Garber, Simon A Gayther, Anne-Marie Gerdes, Andrew K Godwin, David E Goldgar, Eric Hahnen, Christopher R Hake, Ute Hamann, Frans BL Hogervorst, Maartje J Hooning, John L Hopper, Peter J Hulick, Evgeny N Imyanitov, OCGN Investigators, HEBON Investigators, kConFab Investigators, Claudine Isaacs, Louise Izatt, Anna Jakubowska, Paul A James, Ramunas Janavicius, Uffe Birk Jensen, Yue Jiao, Esther M John, Vijai Joseph, Beth Y Karlan, Carolien M Kets, Irene Konstantopoulou, Ava Kwong, Clémentine Legrand, Goska Leslie, Fabienne Lesueur, Jennifer T Loud, Jan Lubiński, Siranoush Manoukian, Lesley McGuffog, Austin Miller, Denise Molina Gomes, Marco Montagna, Emmanuelle Mouret-Fourme, Katherine L Nathanson, Susan L Neuhausen, Heli Nevanlinna, Joanne Ngeow Yuen Yie, Edith Olah, Olufunmilayo I Olopade, Sue K Park, Michael T Parsons, Paolo Peterlongo, Marion Piedmonte, Paolo Radice, Johanna Rantala, Gad Rennert, Harvey A Risch, Rita K Schmutzler, Priyanka Sharma, Jacques Simard, Christian F Singer, Zsofia Stadler, Dominique Stoppa-Lyonnet, Christian Sutter, Yen Yen Tan, Manuel R Teixeira, Soo Hwang Teo, Alex Teulé, Mads Thomassen, Darcy L Thull, Marc Tischkowitz, Amanda E Toland, Nadine Tung, Elizabeth J van Rensburg, Ana Vega, Barbara Wappenschmidt, Peter Devilee, Christi J van Asperen, Jonine L Bernstein, Kenneth Offit, Douglas F Easton, Matti A Rookus, Georgia Chenevix-Trench, Antonis C Antoniou, Mark Robson, Marjanka K Schmidt
Jul 08, 2021
PURPOSE: To evaluate the association between a previously published 313 variant-based breast cancer (BC) polygenic risk score (PRS313) and contralateral breast cancer (CBC) risk, in BRCA1 and BRCA2 pathogenic variant...
Brain death and postmortem organ donation
Ernest van Veen, Mathieu van der Jagt, Maryse C Cnossen, Andrew IR Maas, Inez D de Beaufort, David K Menon, Giuseppe Citerio, Nino Stocchetti, Wim JR Rietdijk, Jeroen TJM van Dijck, Erwin JO Kompanje, CENTER-TBI Investigators and Participants
Apr 14, 2020
BACKGROUND: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. METHODS: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic...
Age-specific breast cancer risk by body mass index and familial risk
John L Hopper, Gillian S Dite, Robert J Macinnis, Yuyan Liao, Nur Zeinomar, Julia A Knight, Melissa C Southey, Roger L Milne, Wendy K Chung, Graham G Giles, Jeanine M Genkinger, Sue-Anne McLachlan, Michael L Friedlander, Antonis C Antoniou, Prue C Weideman, Gord Glendon, Stephanie Nesci, kConFab Investigators, Irene L Andrulis, Saundra S Buys, Mary B Daly, Esther M John, Kelly Anne Phillips, Mary Beth Terry
Dec 04, 2018
BACKGROUND: The association between body mass index (BMI) and risk of breast cancer depends on time of life, but it is unknown whether this association depends on a woman's familial risk. METHODS: We conducted a prospective...
Body Mass Index Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm Breast Cancer familial risk Gene–environment interaction Adult Age Factors Aged Australia Body Mass Index Breast Neoplasms Canada Female Follow-Up Studies Humans Incidence Medical History Taking Middle Aged New Zealand Postmenopause Premenopause Prospective Studies Registries Risk Factors United States Young Adult
Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers.
Frank Qian, Matti A Rookus, Goska Leslie, Harvey A Risch, Mark H Greene, Cora M Aalfs, Muriel A Adank, Julian Adlard, Bjarni A Agnarsson, Munaza Ahmed, Kristiina Aittomäki, Irene L Andrulis, Norbert Arnold, Banu K Arun, Margreet Gem Ausems, Jacopo Azzollini, Daniel Barrowdale, Julian Barwell, Javier Benitez, Katarzyna Białkowska, Valérie Bonadona, Julika Borde, Ake Borg, Angela R Bradbury, Joan Brunet, Saundra S Buys, Trinidad Caldés, Maria A Caligo, Ian Campbell, Jonathan Carter, Jocelyne Chiquette, Wendy K Chung, Kathleen BM Claes, J Margriet Collée, Marie-Agnès Collonge-Rame, Fergus J Couch, Mary B Daly, Capucine Delnatte, Orland Diez, Susan M Domchek, Cecilia M Dorfling, Jacqueline Eason, Douglas F Easton, Ros Eeles, Christoph Engel, D Gareth Evans, Laurence Faivre, Lidia Feliubadaló, Lenka Foretova, Eitan Friedman, Debra Frost, Patricia A Ganz, Judy Garber, Vanesa Garcia-Barberan, Andrea Gehrig, Gord Glendon, Andrew K Godwin, Encarna B Gómez Garcia, Ute Hamann, Jan Hauke, John L Hopper, Peter J Hulick, Evgeny N Imyanitov, Claudine Isaacs, Louise Izatt, Anna Jakubowska, Ramunas Janavicius, Esther M John, Beth Y Karlan, Carolien M Kets, Yael Laitman, Conxi Lázaro, Dominique Leroux, Jenny Lester, Fabienne Lesueur, Jennifer T Loud, Jan Lubiński, Alicja Łukomska, Lesley McGuffog, Noura Mebirouk, Hanne EJ Meijers-Heijboer, Alfons Meindl, Austin Miller, Marco Montagna, Thea M Mooij, Emmanuelle Mouret-Fourme, Katherine L Nathanson, Bita Nehoray, Susan L Neuhausen, Heli Nevanlinna, Finn C Nielsen, Kenneth Offit, Edith Olah, Kai-Ren Ong, Jan C Oosterwijk, Laura Ottini, Michael T Parsons, Paolo Peterlongo, Georg Pfeiler, Nisha Pradhan, Paolo Radice, Susan J Ramus, Johanna Rantala, Gad Rennert, Mark Robson, Gustavo C Rodriguez, Ritu Salani, Maren T Scheuner, Rita K Schmutzler, Payal D Shah, Lucy E Side, Jacques Simard, Christian F Singer, Doris Steinemann, Dominique Stoppa-Lyonnet, Yen Yen Tan, Manuel R Teixeira, Mary Beth Terry, Mads Thomassen, Marc Tischkowitz, Silvia Tognazzo, Amanda E Toland, Nadine Tung, Christi J van Asperen, Klaartje van Engelen, Elizabeth J van Rensburg, Laurence Venat-Bouvet, Jeroen Vierstraete, Gabriel Wagner, Lisa Walker, Jeffrey N Weitzel, Drakoulis Yannoukakos, kConFab Investigators, HEBON Investigators, GEMO Study Collaborators, EMBRACE Collaborators, Antonis C Antoniou, David E Goldgar, Olufunmilayo I Olopade, Georgia Chenevix-Trench, Timothy R Rebbeck, Dezheng Huo, CIMBA
Jun 17, 2019
BACKGROUND: Height and body mass index (BMI) are associated with higher ovarian cancer risk in the general population, but whether such associations exist among BRCA1/2 mutation carriers is unknown. METHODS: We applied a...
TP53-based interaction analysis identifies cis-eQTL variants for TP53BP2, FBXO28, and FAM53A that associate with survival and treatment outcome in breast cancer.
R Fagerholm, S Khan, MK Schmidt, M García-Closas, P Heikkilä, J Saarela, J Beesley, M Jamshidi, K Aittomäki, J Liu, HR Ali, IL Andrulis, MW Beckmann, S Behrens, FM Blows, H Brenner, J Chang-Claude, FJ Couch, K Czene, PA Fasching, J Figueroa, G Floris, G Glendon, Q Guo, P Hall, E Hallberg, U Hamann, B Holleczek, MJ Hooning, JL Hopper, A Jager, M Kabisch, kConFab/AOCS Investigators, R Keeman, V-M Kosma, D Lambrechts, A Lindblom, A Mannermaa, S Margolin, E Provenzano, M Shah, MC Southey, J Dennis, M Lush, K Michailidou, Q Wang, MK Bolla, AM Dunning, DF Easton, PDP Pharoah, G Chenevix-Trench, C Blomqvist, H Nevanlinna
Mar 16, 2017
Value of risk scores in the decision to palliate patients with ruptured abdominal aortic aneurysm.
Hall Fire at Owens Put Out After 24 Hours
Winthrop University
Jan 01, 0001
Fire investigators have been able to gain access to the building to begin their investigation. Winthrop officials are working to begin restoration to Bancroft Hall, Kinard Hall and the area outside the buildings.
Published by: Winthrop University
Association of germline variation with the survival of women with BRCA1/2 pathogenic variants and breast cancer.
Taru A Muranen, Sofia Khan, Rainer Fagerholm, Kristiina Aittomäki, Julie M Cunningham, Joe Dennis, Goska Leslie, Lesley McGuffog, Michael T Parsons, Jacques Simard, Susan Slager, Penny Soucy, Douglas F Easton, Marc Tischkowitz, Amanda B Spurdle, kConFab Investigators, Rita K Schmutzler, Barbara Wappenschmidt, Eric Hahnen, Maartje J Hooning, HEBON Investigators, Christian F Singer, Gabriel Wagner, Mads Thomassen, Inge Sokilde Pedersen, Susan M Domchek, Katherine L Nathanson, Conxi Lazaro, Caroline Maria Rossing, Irene L Andrulis, Manuel R Teixeira, Paul James, Judy Garber, Jeffrey N Weitzel, SWE-BRCA Investigators, Anna Jakubowska, Drakoulis Yannoukakos, Esther M John, Melissa C Southey, Marjanka K Schmidt, Antonis C Antoniou, Georgia Chenevix-Trench, Carl Blomqvist, Heli Nevanlinna
Aug 28, 2020
Germline genetic variation has been suggested to influence the survival of breast cancer patients independently of tumor pathology. We have studied survival associations of genetic variants in two etiologically unique groups of...
XVIIth Little Brain Big Brain
Little Brain Big Brain is a biannual meeting organized and attended by young investigators. Since its inception in 1989, this meeting has brought together promising junior researchers in neurogastroenterology. The XVIIth meeting...
Rock Hill Fire Department Provides Update on Owens Hall Fire
Winthrop University
Jan 01, 0001
The fire started outside the building on a small section of flat roof located where Owens Hall and Bancroft Annex join. Fire investigators reviewed and ruled out the mechanical room, HVAC and elevator systems.
Published by: Winthrop University
Shared genetic contribution to Ischaemic Stroke and Alzheimer's Disease.
Matthew Traylor, Poneh Adib-Samii, Denise Harold, Alzheimer's Disease Neuroimaging Initiative, UK Young Lacunar Stroke DNA resource International Stroke Genetics Consortium (ISGC), Martin Dichgans, Julie Williams, Cathryn M Lewis, Hugh S Markus, METASTROKE, investigators International Genomics of Alzheimer's Project (IGAP)
Feb 23, 2016
The Landscape of Somatic Genetic Alterations in Breast Cancers From ATM Germline Mutation Carriers.
Britta Weigelt, Rui Bi, Rahul Kumar, Pedro Blecua, Diana L Mandelker, Felipe C Geyer, Fresia Pareja, Paul A James, kConFab Investigators, Fergus J Couch, Diana M Eccles, Fiona Blows, Paul Pharoah, Anqi Li, Pier Selenica, Raymond S Lim, Gowtham Jayakumaran, Nic Waddell, Ronglai Shen, Larry Norton, Hannah Y Wen, Simon N Powell, Nadeem Riaz, Mark E Robson, Jorge S Reis-Filho, Georgia Chenevix-Trench
Jul 26, 2018
Alleles Phenotype Mutation ataxia-telangiectasia hormone receptors brcal protein DNA DNA Damage Genes brcal gene tp53 gene Germ-Line Mutation Loss of Heterozygosity protein p53 Recombination Genetic Genetics Neoplasms Breast Cancer Somatic mutation biopharmaceutics classification system infiltrates cell cycle checkpoint Exome datasets
Characterization of the Cancer Spectrum in Men With Germline BRCA1 and BRCA2 Pathogenic Variants
Valentina Silvestri, Goska Leslie, Daniel R Barnes, CIMBA Group, Bjarni A Agnarsson, Kristiina Aittomäki, Elisa Alducci, Irene L Andrulis, Rosa B Barkardottir, Alicia Barroso, Daniel Barrowdale, Javier Benitez, Bernardo Bonanni, Ake Borg, Saundra S Buys, Trinidad Caldés, Maria A Caligo, Carlo Capalbo, Ian Campbell, Wendy K Chung, Kathleen BM Claes, Sarah V Colonna, Laura Cortesi, Fergus J Couch, Miguel de la Hoya, Orland Diez, Yuan Chun Ding, Susan Domchek, Douglas F Easton, Bent Ejlertsen, Christoph Engel, D Gareth Evans, Lidia Feliubadalò, Lenka Foretova, Florentia Fostira, Lajos Géczi, Anne-Marie Gerdes, Gord Glendon, Andrew K Godwin, David E Goldgar, Eric Hahnen, Frans BL Hogervorst, John L Hopper, Peter J Hulick, Claudine Isaacs, Angel Izquierdo, Paul A James, Ramunas Janavicius, Uffe Birk Jensen, Esther M John, Vijai Joseph, Irene Konstantopoulou, Allison W Kurian, Ava Kwong, Elisabetta Landucci, Fabienne Lesueur, Jennifer T Loud, Eva Machackova, Phuong L Mai, Keivan Majidzadeh-A, Siranoush Manoukian, Marco Montagna, Lidia Moserle, Anna Marie Mulligan, Katherine L Nathanson, Heli Nevanlinna, Joanne Ngeow, Liene Nikitina-Zake, Kenneth Offit, Edith Olah, Olufunmilayo I Olopade, Ana Osorio, Laura Papi, Sue K Park, Inge Sokilde Pedersen, Pedro Perez-Segura, Annabeth H Petersen, Pedro Pinto, Berardino Porfirio, Miquel Angel Pujana, Paolo Radice, Johanna Rantala, Muhammad U Rashid, Barak Rosenzweig, Maria Rossing, Marta Santamariña, Rita K Schmutzler, Leigha Senter, Jacques Simard, Christian F Singer, Angela R Solano, Melissa C Southey, Linda Steele, Zoe Steinsnyder, Dominique Stoppa-Lyonnet, Yen Yen Tan, Manuel R Teixeira, Soo H Teo, Mary Beth Terry, Mads Thomassen, Amanda E Toland, Sara Torres-Esquius, Nadine Tung, Christi J van Asperen, Ana Vega, Alessandra Viel, Jeroen Vierstraete, Barbara Wappenschmidt, Jeffrey N Weitzel, Greet Wieme, Sook-Yee Yoon, Kristin K Zorn, Lesley McGuffog, Michael T Parsons, Ute Hamann, Mark H Greene, Judy A Kirk, Susan L Neuhausen, Timothy R Rebbeck, Marc Tischkowitz, Georgia Chenevix-Trench, Antonis C Antoniou, Eitan Friedman, Laura Ottini
Sep 01, 2020
IMPORTANCE: The limited data on cancer phenotypes in men with germline BRCA1 and BRCA2 pathogenic variants (PVs) have hampered the development of evidence-based recommendations for early cancer detection and risk reduction in...
A fresh approach to evidence synthesis.
For most conservation interventions, insufficient evidence exists for investigators to be able to conduct a meta-analysis for each species or genus. However, by being apprised of studies that examine how a particular...
Towards a Better Understanding of Drone Forensics
Unmanned aerial vehicles (drones) have gained increased popularity as their innovative uses continue to expand across various fields. Despite their numerous beneficial uses, drones have unfortunately been misused, through many...
Published by: IGI Global Scientific Publishing
Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn's disease
Evangelos Stournaras, Wendi Qian, Apostolos Pappas, You Yi Hong, Rasha Shawky, UK IBD BioResource Investigators, Tim Raine, Miles Parkes, UK IBD Bioresource Investigators
Jul 20, 2020
OBJECTIVE: Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date...
Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medication (TASMINH4)
Richard J McManus, Jonathan Mant, Marloes Franssen, Alecia Nickless, Claire Schwartz, James Hodgkinson, Peter Bradburn, Andrew Farmer, Sabrina Grant, Sheila M Greenfield, Carl Heneghan, Susan Jowett, Una Martin, Siobhan Milner, Mark Monahan, Sam Mort, Emma Ogburn, Rafael Perera-Salazar, Syed Ahmar Shah, Ly-Mee Yu, Lionel Tarassenko, FD Richard Hobbs, TASMINH4 investigators
May 18, 2018
BACKGROUND: Studies evaluating titration of antihypertensive medication using self-monitoring give contradictory findings and the precise place of telemonitoring over self-monitoring alone is unclear. The TASMINH4 trial aimed to...
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