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Diffuse Intracranial Injury Patterns Are Associated with Impaired Cerebrovascular Reactivity in Adult Traumatic Brain Injury
Frederick A Zeiler, François Mathieu, Miguel Monteiro, Ben Glocker, Ari Ercole, Erta Beqiri, Manuel Cabeleira, Nino Stocchetti, Peter Smielewski, Marek Czosnyka, Virginia Newcombe, David K Menon, the CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Feb 28, 2020
Recent single-center retrospective analysis displayed the association between admission computed tomography (CT) markers of diffuse intracranial injury and worse cerebrovascular reactivity. The goal of this study was to further...
Evaluation of the relationship between slow-waves of intracranial pressure, mean arterial pressure and brain tissue oxygen in TBI
Frederick A Zeiler, Manuel Cabeleira, Peter J Hutchinson, Nino Stocchetti, Marek Czosnyka, Peter Smielewski, Ari Ercole, CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
May 11, 2020
Brain tissue oxygen (PbtO2) monitoring in traumatic brain injury (TBI) has demonstrated strong associations with global outcome. Additionally, PbtO2 signals have been used to derive indices thought to be associated with...
Association between Cerebrovascular Reactivity Monitoring and Mortality Is Preserved When Adjusting for Baseline Admission Characteristics in Adult Traumatic Brain Injury
Frederick A Zeiler, Ari Ercole, Erta Beqiri, Manuel Cabeleira, Eric P Thelin, Nino Stocchetti, Ewout W Steyerberg, Andrew IR Maas, David K Menon, Marek Czosnyka, Peter Smielewski, CENTER-TBI High Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Nov 25, 2019
Cerebral autoregulation, as measured using the pressure reactivity index (PRx), has been related to global patient outcome in adult patients with traumatic brain injury (TBI). To date, this has been documented without accounting...
Descriptive analysis of low versus elevated intracranial pressure on cerebral physiology in adult traumatic brain injury
Frederick A Zeiler, Ari Ercole, Manuel Cabeleira, Nino Stocchetti, Peter J Hutchinson, Peter Smielewski, Marek Czosnyka, CENTER-TBI High Resolution (HR ICU) Sub-Study Participants and Investigators
Nov 11, 2020
BACKGROUND: To date, the cerebral physiologic consequences of persistently elevated intracranial pressure (ICP) have been based on either low-resolution physiologic data or retrospective high-frequency data from single centers....
Association between Physiological Signal Complexity and Outcomes in Moderate and Severe Traumatic Brain Injury
Frederick A Zeiler, Ari Ercole, Michal M Placek, Peter J Hutchinson, Nino Stocchetti, Marek Czosnyka, Peter Smielewski, CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Jul 27, 2020
In traumatic brain injury (TBI), preliminary retrospective work on signal entropy suggests an association with global outcome. The goal of this study was to provide multi-center validation of the association between multi-scale...
Impact of duration and magnitude of raised intracranial pressure on outcome after severe traumatic brain injury
Cecilia AI Åkerlund, Joseph Donnelly, Frederick A. Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W. Nelson, the CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators
Dec 22, 2020
Magnitude of intracranial pressure (ICP) elevations and their duration have been associated with worse outcomes in patients with traumatic brain injuries (TBI), however published thresholds for injury vary and uncertainty about...
Relationship between Measures of Cerebrovascular Reactivity and Intracranial Lesion Progression in Acute Traumatic Brain Injury Patients
François Mathieu, Frederick A Zeiler, Ari Ercole, Miguel Monteiro, Konstantinos Kamnitsas, Ben Glocker, Daniel P Whitehouse, Tilak Das, Peter Smielewski, Marek Czosnyka, Peter J Hutchinson, Virginia FJ Newcombe, David K Menon, CENTER-TBI High Resolution Sub-Study Participants and Investigators
May 05, 2020
Failure of cerebral autoregulation has been linked to unfavorable outcome after traumatic brain injury (TBI). Preliminary evidence from a small, retrospective, single-center analysis suggests that autoregulatory dysfunction may...
cerebral autoregulation Intracranial hemorrhage Traumatic brain injury Adult Brain Injuries Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Disease Progression Europe Female Humans Intensive Care Units Intersectoral Collaboration Male Middle Aged Tomography X-Ray Computed Treatment Outcome
Statistical Cerebrovascular Reactivity Signal Properties after Secondary Decompressive Craniectomy in Traumatic Brain Injury
Frederick A Zeiler, Marcel Aries, Manuel Cabeleira, Thomas A van Essen, Nino Stocchetti, David K Menon, Ivan Timofeev, Marek Czosnyka, Peter Smielewski, Peter Hutchinson, Ari Ercole, CENTER-TBI High Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Dec 20, 2019
Decompressive craniectomy (DC) in traumatic brain injury (TBI) has been suggested to influence cerebrovascular reactivity. We aimed to determine if the statistical properties of vascular reactivity metrics and slow-wave...
DC PRx TBI cerebrovascular reactivity Decompressive Craniectomy Adolescent Adult Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Decompressive Craniectomy Female Humans Intensive Care Units Intracranial Pressure Male Middle Aged Pilot Projects Prospective Studies Tomography X-Ray Computed Young Adult
Factorial Structure and Validity of Depression (PHQ-9) and Anxiety (GAD-7) Scales after Traumatic Brain Injury
Ali Teymoori, Anastasia Gorbunova, Fardzadeh E. Haghish, Ruben Real, Marina Zeldovich, Yi-Jhen Wu, Suzanne Polinder, Thomas Asendorf, David Menon, CENTER-TBI Investigators and Participants CENTER-TBI Investigators and Participants, Nicole v. Steinbüchel
Mar 25, 2020
Background: The dimensionality of depression and anxiety instruments have recently been a source of controversy. Objectives and Design: In a European-wide sample of patients after Traumatic Brain Injury (TBI), we aim to examine...
Low-resolution pressure reactivity index and its derived optimal cerebral perfusion pressure in adult traumatic brain injury
Lennart Riemann, Erta Beqiri, Peter Smielewski, Marek Czosnyka, Nino Stocchetti, Oliver Sakowitz, Klaus Zweckberger, Andreas Unterberg, Alexander Younsi, CENTER-TBI High Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Aug 07, 2020
BACKGROUND: After traumatic brain injury (TBI), brain tissue can be further damaged when cerebral autoregulation is impaired. Managing cerebral perfusion pressure (CPP) according to computed "optimal CPP" values based on...
Impact of duration and magnitude of raised intracranial pressure on outcome after severe traumatic brain injury
Cecilia AI Åkerlund, Joseph Donnelly, Frederick A Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W Nelson, CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators
Nov 25, 2020
Magnitude of intracranial pressure (ICP) elevations and their duration have been associated with worse outcomes in patients with traumatic brain injuries (TBI), however published thresholds for injury vary and uncertainty about...
Univariate comparison of performance of different cerebrovascular reactivity indices for outcome association in adult TBI
Cerebrovascular reactivity is not associated with therapeutic intensity in adult traumatic brain injury
Quality indicators for patients with traumatic brain injury in European intensive care units
Jilske A Huijben, Eveline JA Wiegers, Ari Ercole, Nicolette F de Keizer, Andrew IR Maas, Ewout W Steyerberg, Giuseppe Citerio, Lindsay Wilson, Suzanne Polinder, Daan Nieboer, David Menon, Hester F Lingsma, Mathieu van der Jagt, CENTER-TBI investigators and participants for the ICU stratum
Feb 17, 2020
BACKGROUND: The aim of this study is to validate a previously published consensus-based quality indicator set for the management of patients with traumatic brain injury (TBI) at intensive care units (ICUs) in Europe and to study...
Compensatory-reserve-weighted intracranial pressure versus intracranial pressure for outcome association in adult traumatic brain injury
Comparison of Performance of Different Optimal Cerebral Perfusion Pressure Parameters for Outcome Prediction in Adult Traumatic Brain Injury
Systemic Markers of Injury and Injury Response Are Not Associated with Impaired Cerebrovascular Reactivity in Adult Traumatic Brain Injury
Frederick A Zeiler, François Mathieu, Miguel Monteiro, Ben Glocker, Ari Ercole, Manuel Cabeleira, Nino Stocchetti, Peter Smielewski, Marek Czosnyka, Virginia Newcombe, David K Menon, Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Sep 15, 2020
The role of extra-cranial injury burden and systemic injury response on cerebrovascular response in traumatic brain injury (TBI) is poorly documented. This study preliminarily assesses the association between admission features...
TBI autoregulation cerebrovascular reactivity extra-cranial injury injury burden Adult Biomarkers Biomedical Research Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Europe Female Humans Intersectoral Collaboration Male Middle Aged Patient Admission Prospective Studies Treatment Outcome
Analysis of Cardio-Cerebral Crosstalk Events in an Adult Cohort from the CENTER-TBI Study.
Giovanna Maria Dimitri, Erta Beqiri, Marek Czosnyka, Ari Ercole, Peter Smielewski, Pietro Lio, CENTER-TBI High Resolution Substudy Participants and Investigators
Apr 17, 2020
OBJECTIVE: In a previous study, we observed the presence of simultaneous increases in intracranial pressure (ICP) and the heart rate (HR), which we denominated cardio-cerebral crosstalk (CC), and we related the number of such...
Brain Tissue Oxygen and Cerebrovascular Reactivity in Traumatic Brain Injury
Frederick A Zeiler, Erta Beqiri, Manuel Cabeleira, Peter J Hutchinson, Nino Stocchetti, David K Menon, Marek Czosnyka, Peter Smielewski, Ari Ercole, Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Mar 31, 2020
Pressure reactivity index (PRx) and brain tissue oxygen (PbtO2) are associated with outcome in traumatic brain injury (TBI). This study explores the relationship between PRx and PbtO2 in adult moderate/severe TBI. Using the...
ICP autoregulation brain tissue oxygen physiological burden Adult Aged Biomedical Research Brain Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Cost of Illness Europe Female Glasgow Outcome Scale Humans Intersectoral Collaboration Male Middle Aged Oxygen Consumption Prospective Studies Treatment Outcome
Variation in Structure and Process of Care in Traumatic Brain Injury
Maryse C Cnossen, Suzanne Polinder, Hester F Lingsma, Andrew IR Maas, David Menon, Ewout W Steyerberg, CENTER-TBI Investigators and Participants
Jun 19, 2018
INTRODUCTION: The strength of evidence underpinning care and treatment recommendations in traumatic brain injury (TBI) is low. Comparative effectiveness research (CER) has been proposed as a framework to provide evidence for...
Primary versus early secondary referral to a specialized neurotrauma center in patients with moderate/severe traumatic brain injury
Charlie Aletta Sewalt, Benjamin Yaël Gravesteijn, David Menon, Hester Floor Lingsma, Andrew IR Maas, Nino Stocchetti, Esmee Venema, Fiona E Lecky, CENTER TBI Participants and Investigators
Aug 26, 2021
BACKGROUND: Prehospital care for patients with traumatic brain injury (TBI) varies with some emergency medical systems recommending direct transport of patients with moderate to severe TBI to hospitals with specialist...
Frequency of fatigue and its changes in the first 6 months after traumatic brain injury
Nada Andelic, Cecilie Røe, Cathrine Brunborg, Marina Zeldovich, Marianne Løvstad, Daniel Løke, Ida M Borgen, Daphne C Voormolen, Emilie I Howe, Marit V Forslund, Hilde M Dahl, Nicole von Steinbuechel, CENTER-TBI participants investigators
Feb 05, 2021
BACKGROUND: Fatigue is one of the most commonly reported subjective symptoms following traumatic brain injury (TBI). The aims were to assess frequency of fatigue over the first 6 months after TBI, and examine whether fatigue...
Use and impact of high intensity treatments in patients with traumatic brain injury across Europe
Jilske A Huijben, Abhishek Dixit, Nino Stocchetti, Andrew IR Maas, Hester F Lingsma, Mathieu van der Jagt, David Nelson, Giuseppe Citerio, Lindsay Wilson, David K Menon, Ari Ercole, CENTER-TBI Investigators and Participants
Nov 03, 2020
PURPOSE: To study variation in, and clinical impact of high Therapy Intensity Level (TIL) treatments for elevated intracranial pressure (ICP) in patients with traumatic brain injury (TBI) across European Intensive Care Units...
Changing care pathways and between-center practice variations in intensive care for traumatic brain injury across Europe
Jilske A Huijben, Eveline JA Wiegers, Hester F Lingsma, Giuseppe Citerio, Andrew IR Maas, David K Menon, Ari Ercole, David Nelson, Mathieu van der Jagt, Ewout W Steyerberg, Raimund Helbok, Fiona Lecky, Wilco Peul, Tatiana Birg, Tommaso Zoerle, Marco Carbonara, Nino Stocchetti, CENTER-TBI Investigators and Participants
Feb 12, 2020
PURPOSE: To describe ICU stay, selected management aspects, and outcome of Intensive Care Unit (ICU) patients with traumatic brain injury (TBI) in Europe, and to quantify variation across centers. METHODS: This is a prospective...
Occurrence and timing of withdrawal of life-sustaining measures in traumatic brain injury patients
Ernest van Veen, Mathieu van der Jagt, Giuseppe Citerio, Nino Stocchetti, Diederik Gommers, Alex Burdorf, David K Menon, Andrew IR Maas, Erwin JO Kompanje, Hester F Lingsma, CENTER-TBI Investigators and Participants
Nov 05, 2021
BACKGROUND: In patients with severe brain injury, withdrawal of life-sustaining measures (WLSM) is common in intensive care units (ICU). WLSM constitutes a dilemma: instituting WLSM too early could result in death despite the...
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