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Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke
Joanna M Wardlaw, Fergus Doubal, Rosalind Brown, Ellen Backhouse, Lisa Woodhouse, Philip Bath, Terence J Quinn, Thompson Robinson, Hugh S Markus, Richard McManus, John T O’Brien, David J Werring, Nikola Sprigg, Adrian Parry-Jones, Rhian M Touyz, Steven Williams, Yee-Haur Mah, Hedley Emsley, the R4VaD Investigators
Apr 09, 2021
Background: Stroke commonly affects cognition and, by definition, much vascular dementia follows stroke. However, there are fundamental limitations in our understanding of vascular cognitive impairment, restricting understanding...
The Rockefeller University Associates
The Rockefeller University
Jan 01, 0001
Few people have the opportunity to affect the well-being of others as profoundly as those who provide vital support for biomedical research which is essential to advances in medicine and health care. The Rockefeller University...
Published by: The Rockefeller University, Office of Development
New Initiatives in Biological and Medical Science
The Rockefeller University
Jan 01, 0001
In the early 1980s, The Rockefeller University launched a set of new initiatives in fields of biochemistry and molecular biology, which encompass genetics, cell biology, and neurobiology. Seven new research laboratories are...
Published by: The Rockefeller University
The United Kingdom Childhood Cancer Study
UK Childhood Cancer Study Investigators
Feb 21, 2020
An investigation into the possible causes of childhood cancer has been carried out throughout England, Scotland and Wales over the period 1991-1998. All children known to be suffering from one or other type of the disease over...
Factorial Structure and Validity of Depression (PHQ-9) and Anxiety (GAD-7) Scales after Traumatic Brain Injury
Ali Teymoori, Anastasia Gorbunova, Fardzadeh E. Haghish, Ruben Real, Marina Zeldovich, Yi-Jhen Wu, Suzanne Polinder, Thomas Asendorf, David Menon, CENTER-TBI Investigators and Participants CENTER-TBI Investigators and Participants, Nicole v. Steinbüchel
Mar 25, 2020
Background: The dimensionality of depression and anxiety instruments have recently been a source of controversy. Objectives and Design: In a European-wide sample of patients after Traumatic Brain Injury (TBI), we aim to examine...
Diffuse Intracranial Injury Patterns Are Associated with Impaired Cerebrovascular Reactivity in Adult Traumatic Brain Injury
Frederick A Zeiler, François Mathieu, Miguel Monteiro, Ben Glocker, Ari Ercole, Erta Beqiri, Manuel Cabeleira, Nino Stocchetti, Peter Smielewski, Marek Czosnyka, Virginia Newcombe, David K Menon, the CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Feb 28, 2020
Recent single-center retrospective analysis displayed the association between admission computed tomography (CT) markers of diffuse intracranial injury and worse cerebrovascular reactivity. The goal of this study was to further...
Blood Pressure Changes Following Antihypertensive Medication Reduction, by Drug Class and Dose Chosen for Withdrawal
James P. Sheppard, Mark Lown, Jenni Burt, Gary A. Ford, F. D. Richard Hobbs, Paul Little, Jonathan Mant, Rupert A. Payne, Richard J. McManus, On behalf of the OPTiMISE Investigators
May 04, 2021
Aims: Deprescribing of antihypertensive drugs is recommended for some older patients with polypharmacy, but there is little evidence to inform which drug (or dose) should be withdrawn. This study used data from the OPTiMISE...
Bridging Brain and Cognition
Ivan L. Simpson-Kent, Eiko I. Fried, Danyal Akarca, Silvana Mareva, Edward T. Bullmore, the CALM Team the CALM Team, Rogier A. Kievit
Jun 17, 2021
Network analytic methods that are ubiquitous in other areas, such as systems neuroscience, have recently been used to test network theories in psychology, including intelligence research. The network or mutualism theory of...
'Be on the TEAM' Study (Teenagers Against Meningitis)
Jeremy Carr, Emma Plested, Parvinder Aley, Susana Camara, Kimberly Davis, Jenny M MacLennan, Steve Gray, Saul N Faust, Ray Borrow, Hannah Christensen, Caroline Trotter, Martin CJ Maiden, Adam Finn, Matthew D Snape, ‘Be on the TEAM’ investigators
Oct 27, 2020
INTRODUCTION: Capsular group B Neisseria meningitidis (MenB) is the most common cause of invasive meningococcal disease (IMD) in many parts of the world. A MenB vaccine directed against the polysaccharide capsule remains elusive...
Paediatric infectious disease and immunisation paediatric intensive and critical care Infectious Diseases Paediatrics Adolescent Adult Humans Meningitis Meningococcal Infections Meningococcal Vaccines Neisseria meningitidis Neisseria meningitidis Serogroup B Randomized Controlled Trials as Topic State Medicine Vaccination Young Adult
The underlying etiology of infantile spasms (West syndrome)
John P. Osborne, Stuart W. Edwards, Fabienne Dietrich Alber, Eleanor Hancock, Anthony L. Johnson, Colin R. Kennedy, Marcus Likeman, Andrew L. Lux, Mark Mackay, Andrew Mallick, Richard W. Newton, Melinda Nolan, Ronit Pressler, Dietz Rating, Bernhard Schmitt, Christopher M. Verity, Finbar J. K. O'Callaghan, on behalf of the participating investigators
Sep 07, 2019
Objective
To determine the underlying etiologies in a contemporary cohort of infants with infantile spasms and to examine response to treatment.
Methods
Identification of the underlying etiology and...
To determine the underlying etiologies in a contemporary cohort of infants with infantile spasms and to examine response to treatment.
Methods
Identification of the underlying etiology and...
A randomised study of rituximab and belimumab sequential therapy in PR3 ANCA-associated vasculitis (COMBIVAS)
Mark E McClure, Seerapani Gopaluni, James Wason, Robert B Henderson, Andre van Maurik, Caroline CO Savage, Charles D Pusey, Alan D Salama, Paul A Lyons, Jacinta Lee, Kim Mynard, David R Jayne, Rachel B Jones, on behalf the COMBIVAS investigators
Mar 13, 2023
BACKGROUND: Sequential B cell-targeted immunotherapy with BAFF antagonism (belimumab) and B cell depletion (rituximab) may enhance B cell targeting in ANCA-associated vasculitis (AAV) through several mechanisms. METHODS: Study...
Brain death and postmortem organ donation
Ernest van Veen, Mathieu van der Jagt, Maryse C Cnossen, Andrew IR Maas, Inez D de Beaufort, David K Menon, Giuseppe Citerio, Nino Stocchetti, Wim JR Rietdijk, Jeroen TJM van Dijck, Erwin JO Kompanje, CENTER-TBI Investigators and Participants
Apr 14, 2020
BACKGROUND: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. METHODS: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic...
Psychometric Characteristics of the Patient-Reported Outcome Measures Applied in the CENTER-TBI Study.
Nicole von Steinbuechel, Katrin Rauen, Fabian Bockhop, Amra Covic, Ugne Krenz, Anne Marie Plass, Katrin Cunitz, Suzanne Polinder, Lindsay Wilson, Ewout W Steyerberg, Andrew IR Maas, David Menon, Yi-Jhen Wu, Marina Zeldovich, The Center-Tbi Participants And Investigators
Aug 19, 2021
Traumatic brain injury (TBI) may lead to impairments in various outcome domains. Since most instruments assessing these are only available in a limited number of languages, psychometrically validated translations are important...
The underlying etiology of infantile spasms (West syndrome)
John P. Osborne, Stuart W. Edwards, Fabienne Dietrich Alber, Eleanor Hancock, Anthony L. Johnson, Colin R. Kennedy, Marcus Likeman, Andrew L. Lux, Mark Mackay, Andrew Mallick, Richard W. Newton, Melinda Nolan, Ronit Pressler, Dietz Rating, Bernhard Schmitt, Christopher M. Verity, Finbar J. K. O'Callaghan, on behalf of the participating investigators
Sep 07, 2019
Objective
To determine the underlying etiologies in a contemporary cohort of infants with infantile spasms and to examine response to treatment.
Methods
Identification of the underlying etiology and...
To determine the underlying etiologies in a contemporary cohort of infants with infantile spasms and to examine response to treatment.
Methods
Identification of the underlying etiology and...
Psychometric Characteristics of the Patient-Reported Outcome Measures Applied in the CENTER-TBI Study
Nicole von Steinbuechel, Katrin Rauen, Fabian Bockhop, Amra Covic, Ugne Krenz, Anne Marie Plass, Katrin Cunitz, Suzanne Polinder, Lindsay Wilson, Ewout W. Steyerberg, Andrew I. R. Maas, David Menon, Yi-Jhen Wu, Marina Zeldovich, The Center-Tbi Participants And Investigators
May 30, 2021
Traumatic brain injury (TBI) may lead to impairments in various outcome domains. Since most instruments assessing these are only available in a limited number of languages, psychometrically validated translations are important...
The Gene Ontology Resource
The Gene Ontology Consortium
Feb 11, 2019
The Gene Ontology resource (GO; http://geneontology.org) provides structured, computable knowledge regarding the functions of genes and gene products. Founded in 1998, GO has become widely adopted in the life sciences, and its...
EmptyDrops
Aaron TL Lun, Samantha Riesenfeld, Tallulah Andrews, The Phuong Dao, Tomas Gomes, participants in the 1st Human Cell Atlas Jamboree, John C Marioni
May 28, 2019
Droplet-based single-cell RNA sequencing protocols have dramatically increased the throughput of single-cell transcriptomics studies. A key computational challenge when processing these data is to distinguish libraries for real...
Out of Asia
Shigella are ranked among the most prevalent aetiologies of diarrhoeal disease worldwide, disproportionately affecting young children in developing countries and high-risk communities in developed settings. Antimicrobial...
Association Between Toll-Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Genetic Variants and Clinical Progression of Huntington's Disease.
Imputation strategies for missing baseline neurological assessment covariates after traumatic brain injury
Ari Ercole, Abhishek Dixit, David W. Nelson, Shubhayu Bhattacharyay, Frederick A. Zeiler, Daan Nieboer, Omar Bouamra, David K. Menon, Andrew I. R. Maas, Simone A. Dijkland, Hester F. Lingsma, Lindsay Wilson, Fiona Lecky, Ewout W. Steyerberg, the CENTER-TBI Investigators and Participants
Aug 11, 2021
Characterization of the Cancer Spectrum in Men With Germline BRCA1 and BRCA2 Pathogenic Variants
Valentina Silvestri, Goska Leslie, Daniel R Barnes, CIMBA Group, Bjarni A Agnarsson, Kristiina Aittomäki, Elisa Alducci, Irene L Andrulis, Rosa B Barkardottir, Alicia Barroso, Daniel Barrowdale, Javier Benitez, Bernardo Bonanni, Ake Borg, Saundra S Buys, Trinidad Caldés, Maria A Caligo, Carlo Capalbo, Ian Campbell, Wendy K Chung, Kathleen BM Claes, Sarah V Colonna, Laura Cortesi, Fergus J Couch, Miguel de la Hoya, Orland Diez, Yuan Chun Ding, Susan Domchek, Douglas F Easton, Bent Ejlertsen, Christoph Engel, D Gareth Evans, Lidia Feliubadalò, Lenka Foretova, Florentia Fostira, Lajos Géczi, Anne-Marie Gerdes, Gord Glendon, Andrew K Godwin, David E Goldgar, Eric Hahnen, Frans BL Hogervorst, John L Hopper, Peter J Hulick, Claudine Isaacs, Angel Izquierdo, Paul A James, Ramunas Janavicius, Uffe Birk Jensen, Esther M John, Vijai Joseph, Irene Konstantopoulou, Allison W Kurian, Ava Kwong, Elisabetta Landucci, Fabienne Lesueur, Jennifer T Loud, Eva Machackova, Phuong L Mai, Keivan Majidzadeh-A, Siranoush Manoukian, Marco Montagna, Lidia Moserle, Anna Marie Mulligan, Katherine L Nathanson, Heli Nevanlinna, Joanne Ngeow, Liene Nikitina-Zake, Kenneth Offit, Edith Olah, Olufunmilayo I Olopade, Ana Osorio, Laura Papi, Sue K Park, Inge Sokilde Pedersen, Pedro Perez-Segura, Annabeth H Petersen, Pedro Pinto, Berardino Porfirio, Miquel Angel Pujana, Paolo Radice, Johanna Rantala, Muhammad U Rashid, Barak Rosenzweig, Maria Rossing, Marta Santamariña, Rita K Schmutzler, Leigha Senter, Jacques Simard, Christian F Singer, Angela R Solano, Melissa C Southey, Linda Steele, Zoe Steinsnyder, Dominique Stoppa-Lyonnet, Yen Yen Tan, Manuel R Teixeira, Soo H Teo, Mary Beth Terry, Mads Thomassen, Amanda E Toland, Sara Torres-Esquius, Nadine Tung, Christi J van Asperen, Ana Vega, Alessandra Viel, Jeroen Vierstraete, Barbara Wappenschmidt, Jeffrey N Weitzel, Greet Wieme, Sook-Yee Yoon, Kristin K Zorn, Lesley McGuffog, Michael T Parsons, Ute Hamann, Mark H Greene, Judy A Kirk, Susan L Neuhausen, Timothy R Rebbeck, Marc Tischkowitz, Georgia Chenevix-Trench, Antonis C Antoniou, Eitan Friedman, Laura Ottini
Sep 01, 2020
IMPORTANCE: The limited data on cancer phenotypes in men with germline BRCA1 and BRCA2 pathogenic variants (PVs) have hampered the development of evidence-based recommendations for early cancer detection and risk reduction in...
Value of risk scores in the decision to palliate patients with ruptured abdominal aortic aneurysm.
Impact of Sociodemographic, Premorbid, and Injury-Related Factors on Patient-Reported Outcome Trajectories after Traumatic Brain Injury (TBI).
Nicole von Steinbuechel, Stefanie Hahm, Holger Muehlan, Juan Carlos Arango-Lasprilla, Fabian Bockhop, Amra Covic, Silke Schmidt, Ewout W Steyerberg, Andrew I R Maas, David Menon, Nada Andelic, Marina Zeldovich, The Center-Tbi Participants And Investigators
Apr 17, 2023
Traumatic brain injury Mental Health LONG-TERM OUTCOMES Health-related quality of life (HRQoL) Multivariate Latent Class Mixed Models (Mlcmm) Recuperation Trajectories
Published by: Journal of clinical medicine
Impact of Sociodemographic, Premorbid, and Injury-Related Factors on Patient-Reported Outcome Trajectories after Traumatic Brain Injury (TBI).
Recent insights into Shigella.
PURPOSE OF REVIEW: Diarrhoea is a major global health problem, and recent studies have confirmed Shigella as a major contributor to this burden. Here, we review recent advances in Shigella research; focusing on their...
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