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Results: 89052
The association of mammographic density with risk of contralateral breast cancer and change in density with treatment in the WECARE study.
Julia A Knight, Kristina M Blackmore, Jing Fan, Kathleen E Malone, Esther M John, Charles F Lynch, Celine M Vachon, Leslie Bernstein, Jennifer D Brooks, Anne S Reiner, Xiaolin Liang, Meghan Woods, WECARE Study Collaborative Group, Jonine L Bernstein
Feb 07, 2020
BACKGROUND: Mammographic density (MD) is an established predictor of risk of a first breast cancer, but the relationship of MD to contralateral breast cancer (CBC) risk is not clear, including the roles of age, mammogram timing...
Breast Cancer Family History and Contralateral Breast Cancer Risk in Young Women
Anne S Reiner, Julia Sisti, Esther M John, Charles F Lynch, Jennifer D Brooks, Lene Mellemkjær, John D Boice, Julia A Knight, Patrick Concannon, Marinela Capanu, Marc Tischkowitz, Mark Robson, Xiaolin Liang, Meghan Woods, David V Conti, David Duggan, Roy Shore, Daniel O Stram, Duncan C Thomas, Kathleen E Malone, Leslie Bernstein, WECARE Study Collaborative Group, Jonine L Bernstein
Dec 07, 2020
Purpose The Women's Environmental Cancer and Radiation Epidemiology (WECARE) study demonstrated the importance of breast cancer family history on contralateral breast cancer (CBC) risk, even for noncarriers of deleterious...
Adolescent Adult Age Factors BRCA1 Protein BRCA2 Protein Breast Neoplasms Canada Case-Control Studies Checkpoint Kinase 2 Denmark Fanconi Anemia Complementation Group N Protein Female Genetic Predisposition to Disease Genotype Humans Middle Aged Neoplasm Invasiveness Polymorphism Single Nucleotide Risk Factors United States
CYP2D6 phenotype, tamoxifen, and risk of contralateral breast cancer in the WECARE Study.
Jennifer D Brooks, Elizabeth A Comen, Anne S Reiner, Irene Orlow, Siok F Leong, Xiaolin Liang, Lene Mellemkjær, Julia A Knight, Charles F Lynch, Esther M John, Leslie Bernstein, Meghan Woods, David R Doody, WECARE Study Collaborative Group, Kathleen E Malone, Jonine L Bernstein
Feb 18, 2019
BACKGROUND: Tamoxifen treatment greatly reduces a woman's risk of developing a second primary breast cancer. There is, however, substantial variability in treatment response, some of which may be attributed to germline genetic...
CYP2D6 Contralateral breast cancer Tamoxifen Adult Aged Antineoplastic Agents Hormonal Breast Neoplasms Case-Control Studies Cytochrome P-450 CYP2D6 Female Follow-Up Studies Humans Middle Aged Neoplasms Second Primary Pharmacogenomic Variants Polymorphism Single Nucleotide Tamoxifen Treatment Outcome
A case-control study of the joint effect of reproductive factors and radiation treatment for first breast cancer and risk of contralateral breast cancer in the WECARE study.
Jennifer D Brooks, John D Boice, Roy E Shore, Anne S Reiner, Susan A Smith, Leslie Bernstein, Julia A Knight, Charles F Lynch, Esther M John, Kathleen E Malone, Lene Mellemkjær, Rikke Langballe, Xiaolin Liang, Meghan Woods, Marc Tischkowitz, Patrick Concannon, Daniel O Stram, WECARE Study Collaborative Group
Oct 23, 2020
OBJECTIVE: To examined the impact of reproductive factors on the relationship between radiation treatment (RT) for a first breast cancer and risk of contralateral breast cancer (CBC). METHODS: The Women's Environmental Cancer...
The Contribution of Germline Pathogenic Variants in Breast Cancer Genes to Contralateral Breast Cancer Risk in BRCA1/BRCA2/PALB2-Negative Women.
Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.
Lourdes Ortiz-Fernández, Francisco David Carmona, Raquel López-Mejías, Maria Francisca González-Escribano, Paul A Lyons, Ann W Morgan, Amr H Sawalha, Peter A Merkel, Kenneth GC Smith, Miguel A González-Gay, Javier Martín, UK GCA Consortium, Turkish Takayasu Study Group, Vasculitis Clinical Research Consortium, IgAV Study Group, AAV Study group Spanish GCA Study Group
Apr 18, 2018
OBJETIVE: Systemic vasculitides represent a heterogeneous group of rare complex diseases of the blood vessels with a poorly understood aetiology. To investigate the shared genetic component underlying their predisposition, we...
Autoantibodies outcomes research systemic sclerosis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Case-Control Studies Epigenesis Genetic Female Genetic Loci Genetic Predisposition to Disease Giant Cell Arteritis HLA-DQ Antigens HLA-DQ beta-Chains Humans Jumonji Domain-Containing Histone Demethylases Linkage Disequilibrium Male Phenotype Polymorphism Single Nucleotide Protein Array Analysis Systemic Vasculitis Takayasu arteritis
The Contribution of Germline Pathogenic Variants in Breast Cancer Genes to Contralateral Breast Cancer Risk in BRCA1/BRCA2/PALB2 -Negative Women
Alexey Larionov, Eleanor Fewings, James Redman, Mae Goldgraben, Graeme Clark, John Boice, Patrick Concannon, Jonine Bernstein, David V. Conti, the WECARE Study Collaborative Group, Marc Tischkowitz
Feb 03, 2023
Published by: MDPI
Hormone receptor status of a first primary breast cancer predicts contralateral breast cancer risk in the WECARE study population.
Anne S Reiner, Charles F Lynch, Julia S Sisti, Esther M John, Jennifer D Brooks, Leslie Bernstein, Julia A Knight, Li Hsu, Patrick Concannon, Lene Mellemkjær, Marc Tischkowitz, Robert W Haile, Ronglai Shen, Kathleen E Malone, Meghan Woods, Xiaolin Liang, Monica Morrow, Jonine L Bernstein, WECARE Study Collaborative Group
Jul 20, 2017
BACKGROUND: Previous population-based studies have described first primary breast cancer tumor characteristics and their association with contralateral breast cancer (CBC) risk. However, information on influential covariates...
Contralateral breast cancer estrogen receptor Hormone receptor population-based Progesterone receptor Adult Aged BRCA1 Protein BRCA2 Protein Breast Neoplasms Case-Control Studies Female Humans Middle Aged Mutation Neoplasm Grading Neoplasm Staging Population Surveillance Receptors Estrogen Receptors Progesterone Risk Factors SEER Program Tumor Burden
Safety of blood donation by individuals over age 70 and their contribution to the blood supply in five developed countries
Mindy Goldman, Marc Germain, Yves Grégoire, Ralph R Vassallo, Hany Kamel, Marjorie Bravo, David O Irving, Emanuele Di Angelantonio, Whitney R Steele, Sheila F O'Brien, Biomedical Excellence for Safer Transfusion Collaborative (BEST) Investigators
Jan 29, 2019
BACKGROUND: Some countries impose an upper age limit on whole blood and double RBC donation while others do not. We evaluated the safety of blood donation in older individuals (≥71 years), and their contribution to the blood...
A Modified Progressive Supranuclear Palsy Rating Scale.
Marie-Therese Grötsch, Gesine Respondek, Carlo Colosimo, Yaroslau Compta, Jean Christophe Corvol, Joaquim Ferreira, Meret Koroni Huber, Martin Klietz, Lea FM Krey, Johannes Levin, Milica Jecmenica-Lukic, Daniel Macías-García, Wassilios G Meissner, Pablo Mir, Huw Morris, Christer Nilsson, James B Rowe, Klaus Seppi, Maria Stamelou, John C van Swieten, Gregor Wenning, Teodoro del Ser, Lawrence I Golbe, Günter U Höglinger, the ProPSP Study Group, and the Movement Disorder Society-Endorsed PSP Study Group Describe PSP Study Group
Jan 26, 2021
BACKGROUND: The Progressive Supranuclear Palsy Rating Scale is a prospectively validated physician-rated measure of disease severity for progressive supranuclear palsy. We hypothesized that, according to experts' opinion...
Investigation and Management of Apparently Sporadic Central Nervous System Haemangioblastoma for Evidence of Von Hippel–Lindau Disease
Hugh Furness, Louay Salfity, Johanna Devereux, Dorothy Halliday, Helen Hanson, Deborah M. Ruddy, UK VHL Study Group UK VHL Study Group, Neha Shah, George Sultana, Emma R. Woodward, Richard N. Sandford, Katie M. Snape, Eamonn R. Maher
Sep 17, 2021
Haemangioblastomas are rare, highly vascularised tumours that typically occur in the cerebellum, brain stem and spinal cord. Up to a third of individuals with a haemangioblastoma will have von Hippel–Lindau (VHL) disease....
The British Neurosurgical Trainee Research Collaborative
Aswin Chari, Aimun A Jamjoom, Ellie Edlmann, Aminul I Ahmed, Ian C Coulter, Ruichong Ma, Paul May, Paul M Brennan, Peter JA Hutchinson, Angelos G Kolias, British Neurosurgical Trainee Research Collaborative
Nov 28, 2018
Since its inception in 2012, the British Neurosurgical Trainee Research Collaborative (BNTRC) has established itself as a robust example of a trainee-led research collaborative. This article summarises the work of the...
Study protocol: baby-OSCAR trial
Samir Gupta, Edmund Juszczak, Pollyanna Hardy, Nimish Subhedar, Jonathan Wyllie, Wilf Kelsall, Sunil Sinha, Sam Johnson, Tracy Roberts, Elisabeth Hutchison, Justine Pepperell, Louise Linsell, Jennifer L Bell, Kayleigh Stanbury, Marketa Laube, Clare Edwards, David Field, ‘The Baby-OSCAR Collaborative Group’
Jul 30, 2021
BACKGROUND: The question of whether to treat patent ductus arteriosus (PDA) early or wait until symptoms appear remains high on the research agenda for neonatal medicine. Around 7000 extremely preterm babies under 29 weeks'...
bronchopulmonary dysplasia Echocardiography Ibuprofen Newborn PDA patent ductus arteriosus Preterm bronchopulmonary dysplasia Ductus Arteriosus Patent Humans Ibuprofen Infant Infant Low Birth Weight Infant Newborn Infant Premature Diseases Multicenter Studies as Topic Randomized Controlled Trials as Topic
New perspectives in eosinophilic granulomatosis with polyangiitis (EGPA)
Chiara Marvisi, Renato Alberto Sinico, Carlo Salvarani, David Jayne, Domenico Prisco, Benjamin Terrier, Giacomo Emmi, Augusto Vaglio, European EGPA Study Group
May 27, 2020
The European Eosinophilic Granulomatosis with Polyangiitis (EGPA) study group first gathered in Firenze in December 2018. The discussion was centred around the clinical and therapeutic needs in EGPA which still remain unmet....
Primary post-transplant lymphoproliferative disorder of the central nervous system
Mary M Taj, Britta Maecker-Kolhoff, Rebecca Ling, Simon Bomken, Birgit Burkhardt, Alan KS Chiang, Monika Csoka, Anna Füreder, Stéphanie Haouy, Jelena Lazic, Natalia Miakova, Veronique Minard-Colin, Suzanne D Turner, Anne Uyttebroeck, Andishe Attarbaschi, the international Berlin-Frankfurt-Münster (i-BFM) Study Group European Intergroup for Childhood Non-Hodgkin’s Lymphoma (EICNHL)
Feb 17, 2021
Primary central nervous system (CNS) post-transplant lymphoproliferative disorder (PTLD) in childhood is rare. Twenty-five patients were retrieved from nine European Intergroup for Childhood Non-Hodgkin's Lymphoma and/or...
Central Nervous System outcome post-transplant lymphoproliferative disorder transplant Treatment Adolescent Adult Allografts Brain Neoplasms Child Child Preschool Disease-Free Survival Female Hematopoietic Stem Cell Transplantation Humans Infant Injections Spinal Lymphoproliferative Disorders Male Organ Transplantation Rituximab Survival Rate
Teachers' Attitudes Towards the Effectiveness of Collaborative Reflection Support Method
This study aimed to explore how minute paper method (MPM) reconstructs the attitude towards the collaborative reflection among ten primary school English teachers with different levels of achievement goal (AG) and community...
Published by: IGI Global Scientific Publishing
Effectiveness of a quality improvement collaborative in reducing time to surgery for patients requiring emergency cholecystectomy.
JR Bamber, TJ Stephens, DA Cromwell, E Duncan, GP Martin, NF Quiney, JF Abercrombie, IJ Beckingham, Cholecystectomy Quality Improvement Collaborative
Oct 11, 2019
BACKGROUND: Acute gallstone disease is a high-volume emergency general surgery presentation with wide variations in the quality of care provided across the UK. This controlled cohort evaluation assessed whether participation in...
Variations in hemoglobin measurement and eligibility criteria across blood donation services are associated with differing low-hemoglobin deferral rates
Saurabh Zalpuri, Bas Romeijn, Elias Allara, Mindy Goldman, Hany Kamel, Jed Gorlin, Ralph Vassallo, Yves Grégoire, Naoko Goto, Peter Flanagan, Joanna Speedy, Andreas Buser, Jose Mauro Kutner, Karin Magnussen, Johanna Castrén, Liz Culler, Harry Sussmann, Femmeke J Prinsze, Kevin Belanger, Veerle Compernolle, Pierre Tiberghien, Jose Manuel Cardenas, Manish J Gandhi, Kamille A West, Cheuk-Kwong Lee, Sian James, Deanne Wells, Laurie J Sutor, Silvano Wendel, Matthew Coleman, Axel Seltsam, Kimberly Roden, Whitney R Steele, Milos Bohonek, Ramir Alcantara, Emanuele Di Angelantonio, Katja van den Hurk, BEST Collaborative Study Group
Jan 10, 2020
BACKGROUND: Determination of blood donor hemoglobin (Hb) levels is a pre-requisite to ensure donor safety and blood product quality. We aimed to identify Hb measurement practices across blood donation services and to what extent...
Collaborative Writing in the Intelligence Community
With new and evolving technology and ever-increasing remote collaboration, intelligence reporting processes are at a crossroads. Key questions about how best to collaboratively produce reports to get the right information to the...
Published by: IGI Global Scientific Publishing
Collaborative facilitation and collaborative inhibition in virtual environments
Worldwide, organizations and small and medium-sized enterprises have already disruptively changed in many ways their physiological inner mechanisms, because of information and communication technologies (ICT) revolution....
Collaborative creativity in instrumental group music learning as a site for enhancing pupil wellbeing
This study explores the nature of the elements that co-influence collaborative creativity in instrumental group music learning and the intrinsic potential for enhancing pupil wellbeing as evidenced in a particular...
Research in progress--LungSEARCH
UNLABELLED: Low-dose CT screening for lung cancer is effective but expensive. Therefore, cheaper or more focused screening strategies may be required. LungSEARCH is a randomised prospective trial of 1568 high-risk individuals...
A Study of the Motivation of Collaborative Consumption and the Moderating Effect of Perceived Social Distance
Youngkeun Choi
Jan 01, 2022
The purpose of the present study was to examine the relationships between motivation factors and collaborative consumption engagement and explore the moderating effect of perceived social distance on that relationship. For this...
Published by: IGI Global Scientific Publishing
Diffuse Intracranial Injury Patterns Are Associated with Impaired Cerebrovascular Reactivity in Adult Traumatic Brain Injury
Frederick A Zeiler, François Mathieu, Miguel Monteiro, Ben Glocker, Ari Ercole, Erta Beqiri, Manuel Cabeleira, Nino Stocchetti, Peter Smielewski, Marek Czosnyka, Virginia Newcombe, David K Menon, the CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Feb 28, 2020
Recent single-center retrospective analysis displayed the association between admission computed tomography (CT) markers of diffuse intracranial injury and worse cerebrovascular reactivity. The goal of this study was to further...
Emergency surgery for splenic flexure cancer
Nicola de'Angelis, Eloy Espin, Frederic Ris, Filippo Landi, Bertrand Le Roy, Federico Coccolini, Valerio Celentano, Angela Gurrado, Denis Pezet, Giorgio Bianchi, Riccardo Memeo, Giulio C Vitali, Alejandro Solis, Christine Denet, Salomone Di Saverio, Gian Luigi de'Angelis, Miquel Kraft, Paula Gonzálvez-Guardiola, Aine Stakelum, Fausto Catena, David Fuks, Des C Winter, Mario Testini, Aleix Martínez-Pérez, SFC Study Group
Apr 30, 2021
BACKGROUND: The effectiveness of surgical treatment for splenic flexure carcinomas (SFCs) in emergency settings remains unexplored. This study aims to compare the perioperative and long-term outcomes of different alternatives...
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