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Serum amyloid P component promotes formation of distinct aggregated lysozyme morphologies and reduces toxicity in Drosophila flies expressing F57I lysozyme.
Liza Bergkvist, Daniel R Richards, Ana Bernardo-Gancedo, Janet R Kumita, Peter R Nilsson, Ann-Christin Brorsson
Feb 24, 2020
Many conflicting reports about the involvement of serum amyloid P component (SAP) in amyloid diseases have been presented over the years; SAP is known to be a universal component of amyloid aggregates but it has been suggested...
Published by: PLOS ONE
Serum amyloid P component promotes formation of distinct aggregated lysozyme morphologies and reduces toxicity in Drosophila flies expressing F57I lysozyme.
Liza Bergkvist, Daniel R Richards, Ana Bernardo-Gancedo, Janet R Kumita, Peter R Nilsson, Ann-Christin Brorsson
Mar 09, 2020
Many conflicting reports about the involvement of serum amyloid P component (SAP) in amyloid diseases have been presented over the years; SAP is known to be a universal component of amyloid aggregates but it has been suggested...
Serum amyloid P component promotes formation of distinct aggregated lysozyme morphologies and reduces toxicity in Drosophila flies expressing F57I lysozyme
Liza Bergkvist, Daniel R. Richards, Ana Bernardo-Gancedo, Janet R. Kumita, Peter R. Nilsson, Ann-Christin Brorsson
Jan 24, 2020
The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme
M Ahn, CL Hagan, A Bernardo-Gancedo, E De Genst, FN Newby, J Christodoulou, A Dhulesia, M Dumoulin, CV Robinson, CM Dobson, JR Kumita
Jan 10, 2017
Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation.
Minkoo Ahn, Christopher A Waudby, Ana Bernardo-Gancedo, Erwin De Genst, Anne Dhulesia, Xavier Salvatella, John Christodoulou, Christopher M Dobson, Janet R Kumita
Jun 04, 2018
Populating transient and partially unfolded species is a crucial step in the formation and accumulation of amyloid fibrils formed from pathogenic variants of human lysozyme linked with a rare but fatal hereditary systemic...
Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer's-associated amyloid beta peptide.
Jordan H Cater, Janet R Kumita, Rafaa Zeineddine Abdallah, Guomao Zhao, Ana Bernardo-Gancedo, Amanda Henry, Wendy Winata, Mengna Chi, Brin SF Grenyer, Michelle L Townsend, Marie Ranson, Catalin S Buhimschi, D Stephen Charnock-Jones, Christopher M Dobson, Mark R Wilson, Irina A Buhimschi, Amy R Wyatt
Mar 11, 2019
Molecular Chaperones Preeclampsia Pregnancy protein misfolding Proteostasis Alzheimer Disease Amyloid beta-Peptides Female Humans Microscopy Electron Transmission Molecular Chaperones Peptide Fragments pre-eclampsia Pregnancy Pregnancy Proteins protein aggregation Pathological Protein Folding Protein Stability Proteostasis Deficiencies
The Effect of Jet Flow Impingement on the Corrosion Products formed on a Pipeline Steel in Naturally Aerated Sour Brine
Corrosion was generated by the action of a jet impingement flow of sour brine on pipeline steel samples of X70. Flow-assisted corrosion affected nature, number and peak intensity of the chemical species formed as corrosion...
The Effect of Jet Flow Impingement on the Corrosion Products formed on a Pipeline Steel in Naturally Aerated Sour Brine
Corrosion was generated by the action of a jet impingement flow of sour brine on pipeline steel samples of X70. Flow-assisted corrosion affected nature, number and peak intensity of the chemical species formed as corrosion...
Catastrophic sliding bifurcations and onset of oscillations in a superconducting resonator
This paper presents a general analysis and a concrete example of the catastrophic case of a discontinuity-induced bifurcation in so-called Filippov nonsmooth dynamical systems. Such systems are characterized by discontinuous...
Teixeira singularities in 3D switched feedback control systems
This paper is concerned with the analysis of a singularity that can occur in three-dimensional discontinuous feedback control systems. The singularity is the two-fold — a tangency of orbits to both sides of a switching manifold....
Catastrophic sliding bifurcations and onset of oscillations in a superconducting resonator
This paper presents a general analysis and a concrete example of the catastrophic case of a discontinuity-induced bifurcation in so-called Filippov nonsmooth dynamical systems. Such systems are characterized by discontinuous...
Analysis of endothelial-to-haematopoietic transition at the single cell level identifies cell cycle regulation as a driver of differentiation
Teixeira singularities in 3D switched feedback control systems
This paper is concerned with the analysis of a singularity that can occur in three-dimensional discontinuous feedback control systems. The singularity is the two-fold — a tangency of orbits to both sides of a switching manifold....
The mechanics of solid-state nanofoaming.
Solid-state nanofoaming experiments are conducted on two polymethyl methacrylate (PMMA) grades of markedly different molecular weight using CO2 as the blowing agent. The sensitivity of porosity to foaming time and foaming...
A Case Study of Clozapine and Cognition
George Savulich, Gisela Mezquida, Samuel Atkinson, Miguel bernardo, Emilio Fernandez-Egea
Mar 27, 2018
Cognitive dysfunction is a hallmark feature of schizophrenia, often presenting in patients with psychotic disorders since the first episode (1) or earlier (2). Antipsychotic medication is effective for treating the positive...
Analysis of endothelial-to-haematopoietic transition at the single cell level identifies cell cycle regulation as a driver of differentiation.
Giovanni Canu, Emmanouil Athanasiadis, Rodrigo A Grandy, Jose Garcia-Bernardo, Paulina M Strzelecka, Ludovic Vallier, Daniel Ortmann, Ana Cvejic
May 18, 2020
Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility.
Christine Cheung, Andreia S Bernardo, Matthew WB Trotter, Roger A Pedersen, Sanjay Sinha
Jan 23, 2018
Heterogeneity of embryological origins is a hallmark of vascular smooth muscle cells (SMCs) and may influence the development of vascular disease. Differentiation of human pluripotent stem cells (hPSCs) into developmental...
Analysis of endothelial-to-haematopoietic transition at the single cell level identifies cell cycle regulation as a driver of differentiation
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
An evaluation of the Johanson model for roller compaction process development for a high dose API
Kevin M. Moroney, Patrick Cronin, Opeyemi A. Adeleye, Barbara E. Schaller, Matthew A. Howard, Bernardo Castro-Dominguez, Rohit Ramachandran, Gavin M. Walker
Apr 15, 2020
Roller compaction (RC) is a dry granulation technique applied to improve the flow and compressibility of drug formulations. RC implementation for high drug load formulations can be challenging due to flow issues and a high...
An evaluation of the Johanson model for roller compaction process development for a high dose API
Kevin M. Moroney, Patrick Cronin, Opeyemi A. Adeleye, Barbara E. Schaller, Matthew A. Howard, Bernardo Castro-Dominguez, Rohit Ramachandran, Gavin M. Walker
Apr 15, 2020
Roller compaction (RC) is a dry granulation technique applied to improve the flow and compressibility of drug formulations. RC implementation for high drug load formulations can be challenging due to flow issues and a high...
A comparative study of oxygen diffusion in PET and PEF using molecular modelling
Bio-derived polyethylene furanoate (PEF) has recently gained attention as a sustainable alternative to polyethylene terephthalate (PET), amidst environmental concerns over fossil fuel depletion. Herein, we outline a...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
A comparative study of oxygen diffusion in PET and PEF using molecular modelling
Bio-derived polyethylene furanoate (PEF) has recently gained attention as a sustainable alternative to polyethylene terephthalate (PET), amidst environmental concerns over fossil fuel depletion. Herein, we outline a...
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