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When bats go viral
The recent upsurge in bat-borne virus research has attracted substantial news coverage worldwide. A systematic review of virological literature revealed that most studies portrayed bats as a major concern for public health (51%)...
New law puts Bolivian biodiversity hotspot on road to deforestation.
Álvaro Fernández-Llamazares, Joose Helle, Johanna Eklund, Andrew Balmford, R Mónica Moraes, Victoria Reyes-García, Mar Cabeza
Jan 23, 2018
In August 2017, the Bolivian government passed a contentious law downgrading the legal protection of the Isiboro-Sécure National Park and Indigenous Territory (TIPNIS, for its Spanish acronym), the ancestral homeland of four...
Mauve/LYST limits fusion of lysosome-related organelles and promotes centrosomal recruitment of microtubule nucleating proteins.
Lysosome-related organelles (LROs) are endosomal compartments carrying tissue-specific proteins, which become enlarged in Chediak-Higashi syndrome (CHS) due to mutations in LYST. Here, we show that Drosophila Mauve, a...
Chediak-Higashi syndrome Drosophila LYST centrosomes endosomal vesicle trafficking lysosome-related organelles mauve microtubule nucleation minispindles/Ch-TOG Animals Cell Line Centrosome Chediak-Higashi Syndrome Cytoplasmic Granules Drosophila Drosophila Proteins Female Humans Lysosomes Microtubule-Associated Proteins Microtubules Mutation Oocytes Spindle Apparatus Vesicular Transport Proteins
Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice.
Ralf Salzer, Jordan J Clark, Marina Vaysburd, Veronica T Chang, Anna Albecka, Leo Kiss, Parul Sharma, Andres Gonzalez Llamazares, Anja Kipar, Julian A Hiscox, Andrew Owen, A Radu Aricescu, James P Stewart, Leo C James, Jan Löwe
Aug 26, 2021
The COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, has triggered a worldwide health emergency. Here, we show that ferritin-like Dps from hyperthermophilic Sulfolobus islandicus, covalently coupled with SARS-CoV-2...
covid-19 Dps RBD SARS-CoV-2 coronavirus Subunit vaccine Angiotensin-Converting Enzyme 2 Animals Antibodies Neutralizing Antibodies Viral Bacterial Proteins covid-19 COVID-19 Vaccines DNA-Binding Proteins Ferritins Humans Immunization Mice Nanoparticles Protein Domains Protein Multimerization Receptors Virus Spike Glycoprotein Coronavirus Sulfolobus
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Folding of cohesin's coiled coil is important for Scc2/4-induced association with chromosomes.
Naomi J Petela, Andres Gonzalez Llamazares, Sarah Dixon, Bin Hu, Byung-Gil Lee, Jean Metson, Heekyo Seo, Antonio Ferrer-Harding, Menelaos Voulgaris, Thomas Gligoris, James Collier, Byung-Ha Oh, Jan Löwe, Kim A Nasmyth
Jul 28, 2021
Cohesin's association with and translocation along chromosomal DNAs depend on an ATP hydrolysis cycle driving the association and subsequent release of DNA. This involves DNA being 'clamped' by Scc2 and ATP-dependent engagement...
S. cerevisiae Chromosomes cryo-EM Folding Gene Expression molecular biophysics sister chromatid cohesion structural biology Adenosine Triphosphatases Cell Cycle Proteins Chromatids Chromosomal Proteins Non-Histone Chromosomes Cryoelectron Microscopy DNA Dimerization Gene Expression Regulation Fungal Hydrolysis Protein Domains Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins
Silencing of StRIK in potato suggests a role in periderm related to RNA processing and stress
Pau Boher, Marçal Soler, Sandra Fernández-Piñán, Xènia Torrent, Sebastian Y. Müller, Krystyna A. Kelly, Olga Serra, Mercè Figueras
Sep 08, 2021
Abstract: Background: The periderm is a protective barrier crucial for land plant survival, but little is known about genetic factors involved in its development and regulation. Using a transcriptomic approach in the cork oak...
Transport of DNA within cohesin involves clamping on top of engaged heads by Scc2 and entrapment within the ring by Scc3.
James E Collier, Byung-Gil Lee, Maurici Brunet Roig, Stanislav Yatskevich, Naomi J Petela, Jean Metson, Menelaos Voulgaris, Andres Gonzalez Llamazares, Jan Löwe, Kim A Nasmyth
Sep 16, 2020
In addition to extruding DNA loops, cohesin entraps within its SMC-kleisin ring (S-K) individual DNAs during G1 and sister DNAs during S-phase. All three activities require related hook-shaped proteins called Scc2 and Scc3....
Modeling sapling distribution over time using a functional predictor in a generalized additive model
Daniel Moreno-Fernández, Nicole H. Augustin, Fernando Montes, Isabel Cañellas, Mariola Sánchez-González
Mar 01, 2018
Key message: The effect of adult trees on sapling density distribution during the regeneration fellings is determined in aPinus sylvestrisL. Mediterranean forest using generalized additive models. Context: Spatial pattern of...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Silencing of StRIK in potato suggests a role in periderm related to RNA processing and stress.
Pau Boher, Marçal Soler, Sandra Fernández-Piñán, Xènia Torrent, Sebastian Y Müller, Krystyna A Kelly, Olga Serra, Mercè Figueras
Oct 08, 2021
BACKGROUND: The periderm is a protective barrier crucial for land plant survival, but little is known about genetic factors involved in its development and regulation. Using a transcriptomic approach in the cork oak (Q. suber)...
flowering Rna Regulation Kh-domain Rna-binding Protein Potato Tuber Periderm Rs2-interacting Kh Protein Cell Nucleus Plants Genetically Modified Arabidopsis Flowers Plant Tubers Plant Proteins DNA Transposable Elements RNA Plant Gene Expression Regulation Plant Gene Silencing Solanum tuberosum Gene Regulatory Networks Stress Physiological
Genomic Analysis of Staphylococcus aureus of the Lineage CC130, Including mecC-Carrying MRSA and MSSA Isolates Recovered of Animal, Human, and Environmental Origins.
Paula Gómez, Laura Ruiz-Ripa, Rosa Fernández-Fernández, Haythem Gharsa, Karim Ben Slama, Ursula Höfle, Myriam Zarazaga, Mark A Holmes, Carmen Torres
Mar 04, 2021
Most methicillin resistant Staphylococcus aureus (MRSA) isolates harboring mecC gene belong to clonal complex CC130. This lineage has traditionally been regarded as animal-associated as it lacks the human specific immune evasion...
Short-Term Response of Cytosolic N O 3 - to Inorganic Carbon Increase in Posidonia oceanica Leaf Cells.
The concentration of CO2 in the atmosphere has increased over the past 200 years and is expected to continue rising in the next 50 years at a rate of 3 ppm·year-1. This increase has led to a decrease in seawater pH that has...
Neural correlates of the severity of cocaine, heroin, alcohol, MDMA and cannabis use in polysubstance abusers
Laura Moreno-López, Emmanuel A Stamatakis, Maria José Fernández-Serrano, Manuel Gómez-Río, Antonio Rodríguez-Fernández, Miguel Pérez-García, Antonio Verdejo-García
Aug 08, 2017
INTRODUCTION: Functional imaging studies of addiction following protracted abstinence have not been systematically conducted to look at the associations between severity of use of different drugs and brain dysfunction. Findings...
Silencing of StRIK in potato suggests a role in periderm related to RNA processing and stress.
Pau Boher, Marçal Soler, Sandra Fernández-Piñán, Xènia Torrent, Sebastian Y Müller, Krystyna A Kelly, Olga Serra, Mercè Figueras
Dec 24, 2022
BACKGROUND: The periderm is a protective barrier crucial for land plant survival, but little is known about genetic factors involved in its development and regulation. Using a transcriptomic approach in the cork oak (Q. suber)...
flowering Kh-domain Rna-binding Protein Potato Tuber Periderm Rna Regulation Rs2-interacting Kh Protein Arabidopsis Cell Nucleus DNA Transposable Elements Flowers Gene Expression Regulation Plant Gene Regulatory Networks Gene Silencing Plant Proteins Plant Tubers Plants Genetically Modified RNA Plant Solanum tuberosum Stress Physiological
Short-Term Response of Cytosolic N O 3 − to Inorganic Carbon Increase in Posidonia oceanica Leaf Cells
The concentration of CO2 in the atmosphere has increased over the past 200 years and is expected to continue rising in the next 50 years at a rate of 3 ppm·year−1. This increase has led to a decrease in seawater pH that has...
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
Evolution of nectar spur length in a clade of Linaria reflects changes in cell division rather than in cell expansion.
BACKGROUND AND AIMS: Nectar spurs (tubular outgrowths of a floral organ which contain, or give the appearance of containing, nectar) are hypothesized to be a 'key innovation' which can lead to rapid speciation within a lineage...
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