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Results: 78778
Computational analysis of GAL pathway pinpoints mechanisms underlying natural variation.
Quantitative traits are measurable phenotypes that show continuous variation over a wide phenotypic range. Enormous effort has recently been put into determining the genetic influences on a variety of quantitative traits with...
Computational Biology Computer Simulation Galactose Gene Expression Regulation Fungal genetic variation Metabolic Networks and Pathways Models Biological Monosaccharide Transport Proteins Mutation Phenotype Quantitative Trait Heritable Repressor Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Transcription Factors
Spatial Multivariate Cluster Analysis for Defining Target Population of Environments in West Africa for Yam Breeding
Tunrayo Alabi, Patrick Adebola, Asrat Asfaw, David De Koeyer, Antonio Lopez-Montes, Robert Asiedu
Jul 01, 2019
Yam (Dioscorea spp.) is a major staple crop with high agricultural and cultural significance for over 300 million people in West Africa. Despite its importance, productivity is miserably low. A better understanding of the...
Published by: IGI Global Scientific Publishing
A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface.
Sarah E Stewart, Sam A Menzies, Stephanie J Popa, Natalia Savinykh, Anna Petrunkina Harrison, Paul J Lehner, Kevin Moreau
Dec 07, 2017
Galectins are a family of lectin binding proteins expressed both intracellularly and extracellularly. Galectin-3 (Gal-3, also known as LGALS3) is expressed at the cell surface; however, Gal-3 lacks a signal sequence, and the...
Complexity in the light curves and spectra of slow-evolving superluminous supernovae
C Inserra, M Nicholl, T-W Chen, A Jerkstrand, SJ Smartt, T Krühler, JP Anderson, C Baltay, M Della Valle, M Fraser, A Gal-Yam, L Galbany, E Kankare, K Maguire, D Rabinowitz, K Smith, S Valenti, DR Young
Jul 10, 2017
Long-Duration Superluminous Supernovae at Late Times
A Jerkstrand, SJ Smartt, C Inserra, M Nicholl, T-W Chen, T Krühler, J Sollerman, S Taubenberger, A Gal-Yam, E Kankare, K Maguire, M Fraser, S Valenti, M Sullivan, R Cartier, DR Young
Apr 11, 2017
Charcot-Leyden crystal protein/galectin-10 interacts with cationic ribonucleases and is required for eosinophil granulogenesis
Milica Grozdanovic, Christine Doyle, Li Lu, Brian Maybruck, Mark Kwatia, Nethaji Thiyagarajan, Ravi Acharya, Steven Ackerman
Aug 31, 2020
Background
The human eosinophil Charcot-Leyden Crystal (CLC) protein is a member of the Galectin superfamily and is also known as Galectin-10 (Gal-10). CLC/Gal-10 forms the distinctive hexagonal bipyramidal crystals...
The human eosinophil Charcot-Leyden Crystal (CLC) protein is a member of the Galectin superfamily and is also known as Galectin-10 (Gal-10). CLC/Gal-10 forms the distinctive hexagonal bipyramidal crystals...
A versatile drug delivery system targeting senescent cells.
Daniel Muñoz-Espín, Miguel Rovira, Irene Galiana, Cristina Giménez, Beatriz Lozano-Torres, Marta Paez-Ribes, Susana Llanos, Selim Chaib, Maribel Muñoz-Martín, Alvaro C Ucero, Guillermo Garaulet, Francisca Mulero, Stephen G Dann, Todd VanArsdale, David J Shields, Andrea Bernardos, José Ramón Murguía, Ramón Martínez-Máñez, Manuel Serrano
Sep 20, 2018
Senescent cells accumulate in multiple aging-associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β-galactosidase activity of...
Chemotherapy Fibrosis nanomedicine palbociclib Senescence Animals Cell Survival Cellular Senescence Cytotoxins Disease Models Animal Drug Compounding Drug Delivery Systems Fluorescent Dyes Galactose Heterografts Lysosomes Mice Neoplasm Transplantation Neoplasms Oligosaccharides Piperazines Pyridines Staining and Labeling beta-Galactosidase
Real-time tracking and in vivo visualization of β-galactosidase activity in colorectal tumor with a ratiometric near-infrared fluorescent probe
Kaizhi Gu, Yisheng Xu, Hui Li, Zhiqian Guo, Shaojia Zhu, Shiqin Zhu, Ping Shi, Tony D. James, He Tian, Wei-Hong Zhu
Apr 27, 2016
Development of “smart” noninvasive bioimaging probes for trapping specific enzyme activities is highly desirable for cancer therapy in vivo. Given that β-galactosidase (β-gal) is an important biomarker for cell senescence and...
Real-time tracking and in vivo visualization of β-galactosidase activity in colorectal tumor with a ratiometric near-infrared fluorescent probe
Kaizhi Gu, Yisheng Xu, Hui Li, Zhiqian Guo, Shaojia Zhu, Shiqin Zhu, Ping Shi, Tony D. James, He Tian, Wei-Hong Zhu
Apr 27, 2016
Development of “smart” noninvasive bioimaging probes for trapping specific enzyme activities is highly desirable for cancer therapy in vivo. Given that β-galactosidase (β-gal) is an important biomarker for cell senescence and...
A Self-Determination Theory Approach to Work Motivation of Autistic Adults
The study explores work motivation of autistic adults through the lens of Self-Determination Theory (SDT). Twelve autistic employees (ages 28-47; 3 females) participated in semi-structured qualitative interviews about their work...
Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity.
Estela González-Gualda, Marta Pàez-Ribes, Beatriz Lozano-Torres, David Macias, Joseph R Wilson, Cristina González-López, Hui-Ling Ou, Sofía Mirón-Barroso, Zhenguang Zhang, Araceli Lérida-Viso, Juan F Blandez, Andrea Bernardos, Félix Sancenón, Miguel Rovira, Ljiljana Fruk, Carla P Martins, Manuel Serrano, Gary J Doherty, Ramón Martínez-Máñez, Daniel Muñoz-Espín
Mar 24, 2020
Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse disease...
Navitoclax (ABT-263) Cellular Senescence chemotherapy-induced senescence Lung cancer prodrug senolytics Thrombocytopenia Aniline Compounds Animals Antineoplastic Agents Apoptosis Blood Platelets Cell Survival Cellular Senescence Drug Screening Assays Antitumor Female Galactose Humans Mice Mice Inbred C57BL Mice SCID Molecular Structure Neoplasms Experimental prodrugs Sulfonamides Tumor Cells Cultured
PTF12os and iPTF13bvn
C Fremling, J Sollerman, F Taddia, M Ergon, M Fraser, E Karamehmetoglu, S Valenti, A Jerkstrand, I Arcavi, F Bufano, N Elias Rosa, AV Filippenko, D Fox, A Gal-Yam, DA Howell, R Kotak, P Mazzali, D Milisavljevic, PE Nugent, A Nyholm, E Pian, S Smartt
Aug 15, 2016
Two‐Dimensional Design Strategy to Construct Smart Fluorescent Probes for the Precise Tracking of Senescence
The tracking of cellular senescence usually depends on the detection of senescence‐associated β‐galactosidase (SA‐β‐gal). Previous probes for SA‐β‐gal with this purpose only cover a single dimension: the accumulation...
Yuan Guo, Ying Gao, Yulu Hu, Qimeng Liu, Xiaokang Li, Xinming Li, Chu-Young Kim, Tony D. James, Jian Li, Xi Chen
May 03, 2021
The tracking of cellular senescence usually depends on the detection of senescence‐associated β‐galactosidase (SA‐β‐gal). Previous probes for SA‐β‐gal with this purpose only cover a single dimension: the accumulation...
The Patterned Structure of Galactoglucomannan Suggests It May Bind to Cellulose in Seed Mucilage.
Li Yu, Jan J Lyczakowski, Caroline S Pereira, Toshihisa Kotake, Xiaolan Yu, An Li, Soren Mogelsvang, Munir S Skaf, Paul Dupree
Nov 13, 2018
The interaction between mannan polysaccharides and cellulose microfibrils contributes to cell wall properties in some vascular plants, but the molecular arrangement of mannan in the cell wall and the nature of the molecular...
SN 2020jgb
Abstract
The detonation of a thin (≲0.03 M
⊙ ) helium shell (He-shell) atop a ∼1...
C Liu, AA Miller, A Polin, AE Nugent, K De, PE Nugent, S Schulze, A Gal-Yam, C Fremling, S Anand, I Andreoni, P Blanchard, TG Brink, S Dhawan, AV Filippenko, K Maguire, T Schweyer, H Sears, Y Sharma, MJ Graham, SL Groom, D Hale, MM Kasliwal, FJ Masci, J Purdum, B Racine, J Sollerman, SR Kulkarni
Apr 03, 2023
Charcot-Leyden crystal protein/galectin-10 interacts with cationic ribonucleases and is required for eosinophil granulogenesis
Milica Grozdanovic, Christine Doyle, Li Lu, Brian Maybruck, Mark Kwatia, Nethaji Thiyagarajan, Ravi Acharya, Steven Ackerman
Aug 31, 2020
Background
The human eosinophil Charcot-Leyden Crystal (CLC) protein is a member of the Galectin superfamily and is also known as Galectin-10 (Gal-10). CLC/Gal-10 forms the distinctive hexagonal bipyramidal crystals...
The human eosinophil Charcot-Leyden Crystal (CLC) protein is a member of the Galectin superfamily and is also known as Galectin-10 (Gal-10). CLC/Gal-10 forms the distinctive hexagonal bipyramidal crystals...
LSQ13fn
J Polshaw, R Kotak, L Dessart, M Fraser, A Gal-Yam, C Inserra, SA Sim, SJ Smartt, J Sollerman, C Baltay, D Rabinowitz, S Benetti, MT Botticella, H Campbell, TW Chen, L Galbany, R McKinnon, M Nicholl, KW Smith, M Sullivan, K Takáts, S Valenti, DR Young
Jul 19, 2016
Ratiometric electrochemical detection of β-galactosidase
A novel ferrocene-based substrate for the ratiometric electrochemical detection of β-galactosidase was designed and synthesised. It was demonstrated to be an excellent electrochemical substrate for β-Gal detection with...
The type Iax supernova, SN 2015H
MR Magee, R Kotak, SA Sim, M Kromer, D Rabinowitz, SJ Smartt, C Baltay, HC Campbell, T-W Chen, M Fink, A Gal-Yam, L Galbany, W Hillebrandt, C Inserra, E Kankare, L Le Guillou, JD Lyman, K Maguire, R Pakmor, FK Röpke, AJ Ruiter, IR Seitenzahl, M Sullivan, S Valenti, DR Young
Jul 20, 2016
Two‐Dimensional Design Strategy to Construct Smart Fluorescent Probes for the Precise Tracking of Senescence
The tracking of cellular senescence usually depends on the detection of senescence‐associated β‐galactosidase (SA‐β‐gal). Previous probes for SA‐β‐gal with this purpose only cover a single dimension: the accumulation...
Yuan Guo, Ying Gao, Yulu Hu, Qimeng Liu, Xiaokang Li, Xinming Li, Chu-Young Kim, Tony D. James, Jian Li, Xi Chen
May 03, 2021
The tracking of cellular senescence usually depends on the detection of senescence‐associated β‐galactosidase (SA‐β‐gal). Previous probes for SA‐β‐gal with this purpose only cover a single dimension: the accumulation...
Effective cylindrical cell decompositions for restricted sub-Pfaffian sets
The o-minimal structure generated by the restricted Pfaffian functions, known as restricted sub-Pfaffian sets, admits a natural measure of complexity in terms of a format F, recording information like the number of variables...
Ratiometric electrochemical detection of β-galactosidase
A novel ferrocene-based substrate for the ratiometric electrochemical detection of β-galactosidase was designed and synthesised. It was demonstrated to be an excellent electrochemical substrate for β-Gal detection with...
A transformerless three‐level three‐phase boost PWM inverter for PV applications
Aswin Palanisamy, Yam P. Siwakoti, Akshay Mahajan, Teng Long, Omid Forati Kashani, Frede Blaabjerg
Jul 28, 2021
Abstract: Multilevel converters have seen rising demands in the past decades, due to their increased power ratings, enhanced power quality, low switching losses and reduced electromagnetic interference. Prominent among them are...
Published by: IET Power Electronics
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