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Capturing the systemic immune signature of a norovirus infection
A J. Cutler, J Oliveira, R C. Ferreira, B Challis, N M. Walker, S Caddy, J Lu, H E. Stevens, D J. Smyth, M L. Pekalski, J Kennet, K M.D. Hunter, I Goodfellow, L S. Wicker, J A. Todd, F Waldron-Lynch
Jun 30, 2017
Recovery of genetically defined murine norovirus in tissue culture by using a fowlpox virus expressing T7 RNA polymerase.
Despite the significant disease burden caused by human norovirus infection, an efficient tissue-culture system for these viruses remains elusive. Murine norovirus (MNV) is an ideal surrogate for the study of norovirus biology...
Norovirus Polymerase Fidelity Contributes to Viral Transmission In Vivo.
Intrahost genetic diversity and replication error rates are intricately linked to RNA virus pathogenesis, with alterations in viral polymerase fidelity typically leading to attenuation during infections in vivo. We have...
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Capturing the systemic immune signature of a norovirus infection
Antony J Cutler, Joao Oliveira, Ricardo C Ferreira, Ben Challis, Neil M Walker, Sarah Caddy, Jia Lu, Helen E Stevens, Deborah J Smyth, Marcin L Pekalski, Jane Kennet, Kara MD Hunter, Ian Goodfellow, Linda S Wicker, John A Todd, Frank Waldron-Lynch
Sep 05, 2018
BACKGROUND: The infection of a participant with norovirus during the adaptive study of interleukin-2 dose on regulatory T cells in type 1 diabetes (DILT1D) allowed a detailed insight into the cellular and cytokine immune...
Design, development, and validation of a strand-specific RT-qPCR assay for GI and GII human Noroviruses.
Katja Marie Kjara König, Aminu S Jahun, Komal Nayak, Lydia N Drumright, Matthias Zibauer, Ian Goodfellow, Myra Hosmillo
Jan 06, 2022
Human noroviruses (HuNoV) are the major cause of viral gastroenteritis worldwide. Similar to other positive-sense single-stranded RNA viruses, norovirus RNA replication requires the formation of a negative strand RNA...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
miR-155 induction is a marker of murine norovirus infection but does not contribute to control of replication in vivo.
Background: Due to their role in fine-tuning cellular protein expression, microRNAs both promote viral replication and contribute to antiviral responses, for a range of viruses. The interactions between norovirus and the...
A Cell-based Fluorescence Resonance Energy Transfer (FRET) Sensor Reveals Inter- and Intragenogroup Variations in Norovirus Protease Activity and Polyprotein Cleavage.
FRET RNA virus calicivirus Norovirus polyprotein Protease Substrate Specificity Virus Amino Acid Sequence Amino Acid Substitution Animals Cell Line Fluorescence Resonance Energy Transfer Humans Mice Molecular Sequence Data Norovirus Peptide Hydrolases Polyproteins Proteolysis Viral Nonstructural Proteins
Complete genome sequence of canine astrovirus with molecular and epidemiological characterisation of UK strains.
Canine astrovirus Complete genome Gastroenteritis Amino Acid Sequence Animals Astroviridae Astroviridae Infections Base Sequence Capsid Proteins Dog Diseases Dogs Feces Gastroenteritis Genome Viral Molecular Sequence Data Pets Polymerase Chain Reaction Sequence Analysis DNA Sequence Homology Species Specificity United Kingdom
The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2.
Omer Ziv, Jonathan Price, Lyudmila Shalamova, Tsveta Kamenova, Ian Goodfellow, Friedemann Weber, Eric A Miska
Nov 03, 2020
COMRADES covid-19 FSE-arch RNA structure RNA-RNA interaction SARS-CoV-2 coronavirus discontinuous transcription host-virus Ribosomal frameshifting Animals covid-19 Chlorocebus aethiops Frameshifting Ribosomal Genome Viral Humans Protein Biosynthesis RNA Viral SARS-CoV-2 Transcription Genetic Vero Cells Virus Replication
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
Interferon responses to norovirus infections
Human noroviruses (HuNoVs) are increasingly becoming the main cause of transmissible gastroenteritis worldwide, with hundreds of thousands of deaths recorded annually. Yet, decades after their discovery, there is still no...
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells In Vitro.
Human norovirus (HuNoV) is a major cause of nonbacterial gastroenteritis worldwide, yet despite its impact on society, vaccines and antivirals are currently lacking. A HuNoV replicon system has been widely applied to the...
Antiviral Agents drug resistance mechanisms noroviruses Protease Inhibitors proteases 3C Viral Proteases Amino Acid Sequence Antiviral Agents Cell Line Tumor Cysteine Endopeptidases Fluorescence Resonance Energy Transfer Humans Isoxazoles Mutation Norwalk virus Phenylalanine Pyrrolidinones Valine Viral Proteins Virus Replication
Sentiment Analysis on Movie Reviews Dataset Using Support Vector Machines and Ensemble Learning
The internet makes it easier for people to connect to each other and has become a platform to express ideas and share information with the world. The growth of the internet has indirectly led to the development of social...
Published by: IGI Global Scientific Publishing
Right sided eventration of diaphragm with clinodactyly
A. Sareen and K. Mahajan
Apr 21, 2015
Diaphragmatic hernia can be of two types-absence or deficiency of the diaphragm, or eventration resulting in elevation of a portion of the diaphragm as a result of incomplete muscularization. Complete eventration almost...
Published by: IJHS Medical Association
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
Targeting macrophage- and intestinal epithelial cell-specific microRNAs against norovirus restricts replication in vivo.
Until recently, our understanding of the cellular tropism of human norovirus (HuNoV), a major cause of viral gastroenteritis, has been limited. Immune cells and intestinal epithelial cells (IECs) have been proposed as targets of...
Pathology caused by persistent murine norovirus infection.
Amita Shortland, James Chettle, Joy Archer, Kathryn Wood, Dalan Bailey, Ian Goodfellow, Barbara A Blacklaws, Jonathan L Heeney
Mar 13, 2020
Subclinical infection of murine norovirus (MNV) was detected in a mixed breeding group of WT and Stat1(-/-) mice with no outward evidence of morbidity or mortality. Investigations revealed the presence of an attenuated MNV...
Design, development, and validation of a strand-specific RT-qPCR assay for GI and GII human Noroviruses.
Katja Marie Kjara König, Aminu Jahun, Komal Nayak, Lydia N Drumright, Matthias Zibauer, Ian Goodfellow, Myra Hosmillo
Nov 03, 2021
Human noroviruses (HuNoV) are the major cause of viral gastroenteritis worldwide. Similar to other positive-sense single-stranded RNA viruses, norovirus RNA replication requires the formation of a negative strand RNA...
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