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The peroxisomal fatty acid transporter ABCD1/PMP-4 is required in the C. elegans hypodermis for axonal maintenance
Andrea Coppa, Sanjib Guha, Stéphane Fourcade, Janani Parameswaran, Montserrat Ruiz, Ann B Moser, Agatha Schlüter, Michael P Murphy, Jose Miguel Lizcano, Antonio Miranda-Vizuete, Esther Dalfó, Aurora Pujol
Feb 18, 2020
Adrenoleukodystrophy is a neurometabolic disorder caused by a defective peroxisomal ABCD1 transporter of very long-chain fatty acids (VLCFAs). Its pathogenesis is incompletely understood. Here we characterize a nematode model of...
Axonal degeneration Hypodermis Lipid Droplets Mitochondria redox imbalance Peroxisomes X-linked adrenoleukodystrophy ATP Binding Cassette Transporter Subfamily D Member 1 ATP-Binding Cassette Transporters Adrenoleukodystrophy Animals Caenorhabditis elegans Fatty Acids Mice Mice Knockout Subcutaneous Tissue
Guidelines for Data Collection to Measure SDG 4.7.4 and 4.7.5
In an effort to promote robust and comparable measurements of SDG 4 in this Decade of Action as nations strive to meet education targets, the UIS has spearheaded a methodological program on learning outcomes. Drawing from the...
SDGs global citizenship sustainability ICCS ILSA TIMSS measurement /dk/atira/pure/sustainabledevelopmentgoals/quality_education name=SDG 4 - Quality Education
Published by: UNESCO Institute for Statistics
Guidelines for Data Collection to Measure SDG 4.7.4 and 4.7.5
In an effort to promote robust and comparable measurements of SDG 4 in this Decade of Action as nations strive to meet education targets, the UIS has spearheaded a methodological program on learning outcomes. Drawing from the...
SDGs global citizenship sustainability ICCS ILSA TIMSS measurement /dk/atira/pure/sustainabledevelopmentgoals/quality_education name=SDG 4 - Quality Education
Published by: UNESCO Institute for Statistics
Poverty on a College Campus
Poverty is a reality for many individuals and families - including the college student. Unless you have experienced it yourself, it is difficult to understand. Join us for an interactive discussion on poverty: the complex and...
Published by: Winthrop University
Early identification of patients with Chagas disease at risk of developing cardiomyopathy using 2-D speckle tracking strain
Sithu Win, Monica Miranda-Schaeubinger, Ronald Gustavo Durán Saucedo, Paula Carballo Jimenez, Jorge Flores, Brandon Mercado-Saavedra, Lola Camila Telleria, Anne Raafs, Manuela Verastegui, Caryn Bern, Freddy Tinajeros, Stephane Heymans, Rachel Marcus, Robert H Gilman, Monica Mukherjee, Chagas Working Group
Jul 02, 2022
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Patient and practitioner views on a combined face-to-face and digital intervention to support medication adherence in hypertension
Miranda Van Emmenis, James Jamison, Aikaterini Kassavou, Wendy Hardeman, Felix Naughton, Charlotte A'Court, Stephen Sutton, Helen Eborall
Mar 04, 2022
OBJECTIVES: To explore patients' and healthcare practitioners' (HCPs) views about non-adherence to hypertension medication and potential content of a combined very brief face-to-face discussion (VBI) and digital intervention...
Impact of the geometry of inclusions at the micro-scale on the overall stochastic properties
In this contribution, the establishment of relationships between the microstructure of the material and the macroscopic properties is numerically investigated. The material under study is composed by inclusions randomly...
The Democracy to Come? An Enquiry Into the Vision of Blockchain-Powered E-Voting Start-Ups
This research sets out to analyze the message promoted by start-up enterprises that apply blockchain technologies for the purpose of e-voting [blockchain-powered e-voting (BPE)], and their perceived effects of this...
Miranda Imperial
Apr 23, 2021
Feedback from Outcome Measures and Treatment Effectiveness, Treatment Efficiency, and Collaborative Practice
Due to recent increases in the use of feedback from outcome measures in mental health settings, we systematically reviewed evidence regarding the impact of feedback from outcome measures on treatment effectiveness, treatment...
Impact of the geometry of inclusions at the micro-scale on the overall stochastic properties
In this contribution, the establishment of relationships between the microstructure of the material and the macroscopic properties is numerically investigated. The material under study is composed by inclusions randomly...
“Unusual Greenness”
Miranda Griffin
Nov 05, 2018
The books reviewed in this essay bring together various strands of thought that center on the material and the nonhuman in the Middle Ages: the things and landscapes that furnish, ground, and transmit medieval texts, but that...
Using family history information to promote healthy lifestyles and prevent diseases; a discussion of the evidence.
Liesbeth Claassen, Lidewij Henneman, A Cecile JW Janssens, Miranda Wijdenes-Pijl, Nadeem Qureshi, Fiona M Walter, Paula W Yoon, Danielle RM Timmermans
Jun 16, 2011
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Patient and practitioner views on a combined face-to-face and digital intervention to support medication adherence in hypertension
Miranda Van Emmenis, James Jamison, Aikaterini Kassavou, Wendy Hardeman, Felix Naughton, Charlotte A'Court, Stephen Sutton, Helen Eborall
Apr 01, 2022
OBJECTIVES: To explore patients' and healthcare practitioners' (HCPs) views about non-adherence to hypertension medication and potential content of a combined very brief face-to-face discussion (VBI) and digital intervention...
Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody.
Lu Tan, Juan Perez, Marianna Mela, Elena Miranda, Keith A Burling, Farshid N Rouhani, Dawn L DeMeo, Imran Haq, James A Irving, Adriana Ordóñez, Jennifer A Dickens, Mark Brantly, Stefan J Marciniak, Graeme JM Alexander, Bibek Gooptu, David A Lomas
May 18, 2018
α1-Antitrypsin is primarily synthesised in the liver, circulates to the lung and protects pulmonary tissues from proteolytic damage. The Z mutant (Glu342Lys) undergoes inactivating conformational change and polymerises. Polymers...
Emotional Competences in University and Teachers
Ana Cecilia Vásquez MIRANDA, Darién Barramedo Rodríguez GALAN, Johnny Félix Farfán PIMENTEL
Jul 31, 2021
The aim of the review is to analyze the impact of emotional competence in the context of the university curriculum and therefore on teachers. The study was developed under the parameters of the PRISMA declaration, the...
Emotional Competencies Development of Emotions Academic Learning and Training Educational Success No
Published by: Indonesia Strategic Sustainability
A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity.
Adriana Ordóñez, Juan Pérez, Lu Tan, Jennifer A Dickens, Neda Motamedi-Shad, James A Irving, Imran Haq, Ugo Ekeowa, Stefan J Marciniak, Elena Miranda, David A Lomas
May 18, 2018
Mutant Z α1-antitrypsin (E342K) accumulates as polymers within the endoplasmic reticulum (ER) of hepatocytes predisposing to liver disease, whereas low levels of circulating Z α1-antitrypsin lead to emphysema by loss of...
Liver Disease Monoclonal antibody scFv intrabody serpin polymer Animals Base Sequence COS Cells Chlorocebus aethiops Endoplasmic Reticulum Humans Immunoblotting Intracellular Space Kinetics Leukocyte Elastase Mice Inbred BALB C Molecular Sequence Data Mutation Polymerization Protease Inhibitors Single-Chain Antibodies alpha 1-Antitrypsin
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
Gait pattern alterations during walking, texting and walking and texting during cognitively distractive tasks while negotiating common pedestrian obstacles
Objectives Mobile phone texting is a common daily occurrence with a paucity of research examining corresponding gait characteristics. To date, most studies have participants walk in a straight line vs. overcoming barriers and...
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
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