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Studying Brown Adipose Tissue in a Human in vitro Context.
New treatments for obesity and associated metabolic disease are increasingly warranted with the growth of the obesity pandemic. Brown adipose tissue (BAT) may represent a promising therapeutic target to treat obesity, as this...
Carbon-nanoparticle-triggered acute lung inflammation and its resolution are not altered in PPARγ-defective (P465L) mice.
Alexander A Götz, Antonio Vidal-Puig, Heiko G Rödel, Martin Hrabé de Angelis, Tobias Stoeger
Oct 20, 2011
No metabolic effects of mustard allyl-isothiocyanate compared with placebo in men.
Mirjam Langeveld, Chong Yew Tan, Maarten R Soeters, Samuel Virtue, Laura PE Watson, Peter R Murgatroyd, Graeme K Ambler, Santiago Vidal-Puig, Krishna V Chatterjee, Antonio Vidal-Puig
Apr 11, 2018
Background: Induction of nonshivering thermogenesis can be used to influence energy balance to prevent or even treat obesity. The pungent component of mustard, allyl-isothiocyanate (AITC), activates the extreme cold receptor...
allyl-isothiocyanate energy expenditure mustard Thermogenesis thermogenic food Adolescent Adult Aged Animals Blood Glucose Body Temperature Cross-Over Studies Energy Intake Energy Metabolism Female Humans Hunger Isothiocyanates Male Mice Middle Aged Mustard Plant Norepinephrine Oxygen Consumption Thermogenesis Young Adult
PPARs and Metabolic Disorders Associated with Challenged Adipose Tissue Plasticity.
Peroxisome proliferator-activated receptors (PPARs) are members of a family of nuclear hormone receptors that exert their transcriptional control on genes harboring PPAR-responsive regulatory elements (PPRE) in partnership with...
Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans.
S Virtue, M Masoodi, BAM de Weijer, M van Eijk, CYL Mok, M Eiden, M Dale, A Pirraco, MJ Serlie, JL Griffin, A Vidal-Puig
May 20, 2015
Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons.
Mark A Smith, Loukia Katsouri, Samuel Virtue, Agharul I Choudhury, Antonio Vidal-Puig, Michael LJ Ashford, Dominic J Withers
Oct 09, 2020
Leptin acts on hypothalamic pro-opiomelanocortin (POMC) neurons to regulate glucose homeostasis, but the precise mechanisms remain unclear. Here, we demonstrate that leptin-induced depolarization of POMC neurons is associated...
SGBS cells as a model of human adipocyte browning
Chia Rou Yeo, Madhur Agrawal, Shawn Hoon, Asim Shabbir, Manu Kunaal Shrivastava, Shiqi Huang, Chin Meng Khoo, Vanna Chhay, M Shabeer Yassin, E Shyong Tai, Antonio Vidal-Puig, Sue-Anne Toh
Oct 09, 2020
The Simpson Golabi Behmel Syndrome (SGBS) pre-adipocyte cell strain is widely considered to be a representative in vitro model of human white pre-adipocytes. A recent study suggested that SGBS adipocytes exhibit an unexpected...
A pipeline for making 31P NMR accessible for small- and large-scale lipidomics studies.
Samuel Furse, Huw EL Williams, Adam J Watkins, Samuel Virtue, Antonio Vidal-Puig, Risha Amarsi, Marika Charalambous, Albert Koulman
Jun 03, 2021
Dietary (Poly)phenols, Brown Adipose Tissue Activation, and Energy Expenditure
Laura Mele, Guillaume Bidault, Pedro Mena, Alan Crozier, Furio Brighenti, Antonio Vidal-Puig, Daniele Del Rio
Nov 19, 2020
The incidence of overweight and obesity has reached epidemic proportions, making the control of body weight and its complications a primary health problem. Diet has long played a first-line role in preventing and managing...
brown adipose tissue dietary (poly)phenols energy expenditure Flavan-3-ols obesity resveratrol uncoupled protein 1 Adipose Tissue Brown Adrenergic Agonists Animals Anti-Obesity Agents Body Weight Diet Disease Models Animal Energy Metabolism Flavonoids Humans obesity Polyphenols resveratrol Stilbenes Tea Thermogenesis Uncoupling Protein 1
A pipeline for making 31 P NMR accessible for small- and large-scale lipidomics studies
Samuel Furse, Huw E. L. Williams, Adam J. Watkins, Samuel Virtue, Antonio Vidal-Puig, Risha Amarsi, Marika Charalambous, Albert Koulman
Jul 28, 2021
Abstract: Detailed molecular analysis is of increasing importance in research into the regulation of biochemical pathways, organismal growth and disease. Lipidomics in particular is increasingly sought after as it provides...
Brown and beige fat
Stefania Carobbio, Anne-Claire Guénantin, Isabella Samuelson, Myriam Bahri, Antonio Vidal-Puig
Nov 18, 2020
The adipose organ portrays adipocytes of diverse tones: white, brown and beige, each type with distinct functions. Adipocytes orchestrate their adaptation and expansion to provide storage to excess nutrients, the quick...
Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism
Adipose tissue and the liver play significant roles in the regulation of whole-body energy homeostasis, but they have not evolved to cope with the continuous, chronic, nutrient surplus seen in obesity. In this review, we detail...
Adipose Tissue Fatty Acid Flux metabolism Nonalcoholic fatty liver disease adipokines Adipose Tissue Adiposity Animals Blood Glucose Energy Metabolism Humans Hyperglycemia Inflammation Mediators Insulin Resistance Liver non-alcoholic fatty liver disease obesity Prognosis Risk Factors Signal Transduction
Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function.
Kasparas Petkevicius, Guillaume Bidault, Sam Virtue, Stephen A Newland, Martin Dale, Aurelien Dugourd, Julio Saez-Rodriguez, Ziad Mallat, Antonio Vidal-Puig
Mar 24, 2021
OBJECTIVE: Neuroimmune interactions between the sympathetic nervous system (SNS) and macrophages are required for the homeostasis of multiple tissues, including the adipose tissue. It has been proposed that the SNS maintains...
Atherosclerosis immunometabolism Neuroimmune Norepinephrine Sympathetic adrb2 Adipocytes Adipose Tissue White Animals Atherosclerosis Bone Marrow Transplantation Cells Cultured Diet High-Fat Diet Western Disease Models Animal Female Insulin Resistance MACROPHAGES Male Mice Mice Inbred C57BL Mice Knockout obesity Panniculitis Phenotype Receptors Adrenergic beta-2 Signal Transduction sympathetic nervous system
SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation
G Bidault, S Virtue, K Petkevicius, HE Jolin, A Dugourd, AC Guenantin, J Leggat, B Mahler-Araujo, BYH Lam, MK Ma, M Dale, S Carobbio, A Kaser, PG Fallon, J Saez Rodriguez, ANJ McKenzie, A Vidal-Puig
Oct 18, 2021
Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue.
Caroline Araiz, Anqi Yan, Lucia Bettedi, Isabella Samuelson, Sam Virtue, Anne K McGavigan, Christian Dani, Antonio Vidal-Puig, Lazaros C Foukas
Jun 20, 2019
The insulin/IGF-1 signalling pathway is a key regulator of metabolism and the rate of ageing. We previously documented that systemic inactivation of phosphoinositide 3-kinase (PI3K) p110α, the principal PI3K isoform that...
Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice.
Amandine Girousse, Samuel Virtue, Dan Hart, Antonio Vidal-Puig, Peter R Murgatroyd, Etienne Mouisel, Coralie Sengenès, David B Savage
Sep 05, 2018
OBJECTIVE: Surplus dietary fat cannot be converted into other macronutrient forms or excreted, so has to be stored or oxidized. Healthy mammals store excess energy in the form of triacylgycerol (TAG) in lipid droplets within...
Energy partitioning fatty acid oxidation Insulin Resistance lipodystrophy Substrate competition Adipocytes Adipose Tissue Adiposity Animals Diet High-Fat Dietary Fats Energy Intake Energy Metabolism Fatty Liver Glucose Hyperinsulinism Insulin Resistance Lipids lipodystrophy Liver Mice obesity Oxidation-Reduction Weight Gain
Dietary stearic acid regulates mitochondria in vivo in humans.
Deniz Senyilmaz-Tiebe, Daniel H Pfaff, Sam Virtue, Kathrin V Schwarz, Thomas Fleming, Sandro Altamura, Martina U Muckenthaler, Jürgen G Okun, Antonio Vidal-Puig, Peter Nawroth, Aurelio A Teleman
Mar 28, 2019
Since modern foods are unnaturally enriched in single metabolites, it is important to understand which metabolites are sensed by the human body and which are not. We previously showed that the fatty acid stearic acid (C18:0)...
Bioinformatics strategies for lipidomics analysis
Laxman Yetukuri, Mikko Katajamaa, Gema Medina-Gomez, Tuulikki Seppänen-Laakso, Antonio Vidal-Puig, Matej Oresic
Jun 14, 2011
Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice.
Valentina Sanghez, Cankut Cubuk, Patricia Sebastián-Leon, Stefania Carobbio, Joaquin Dopazo, Antonio Vidal-Puig, Alessandro Bartolomucci
Mar 15, 2016
Adipose Tissue IRS1 IRS2 Insulin Metabolic Syndrome obesity Adipose Tissue White Animals Diet High-Fat Dominance-Subordination Down-Regulation Glucose Insulin Insulin Resistance Liver Male Mice Mice Inbred C57BL Muscle Skeletal obesity Real-Time Polymerase Chain Reaction Signal Transduction Stress Psychological
Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6.
Chong Yew Tan, Samuel Virtue, Guillaume Bidault, Martin Dale, Rachel Hagen, Julian L Griffin, Antonio Vidal-Puig
Oct 13, 2015
Elovl6 adaptive thermogenesis brown adipose tissue elongase energy expenditure fatty acid acyl chain length Acetyltransferases Adipose Tissue Brown Animals Blotting Western Fatty Acid Elongases Fatty Acids Mice Mice Inbred C57BL Mice Knockout Mitochondrial Proteins Real-Time Polymerase Chain Reaction Thermogenesis
Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome.
Matthew Van De Pette, Simon J Tunster, Grainne I McNamara, Tatyana Shelkovnikova, Steven Millership, Lindsay Benson, Stuart Peirson, Mark Christian, Antonio Vidal-Puig, Rosalind M John
Jun 24, 2019
The accurate diagnosis and clinical management of the growth restriction disorder Silver Russell Syndrome (SRS) has confounded researchers and clinicians for many years due to the myriad of genetic and epigenetic alterations...
GPER and ERα mediate estradiol enhancement of mitochondrial function in inflamed adipocytes through a PKA dependent mechanism.
Marco Bauzá-Thorbrügge, Sergio Rodríguez-Cuenca, Antonio Vidal-Puig, Bel M Galmés-Pascual, Miquel Sbert-Roig, Magdalena Gianotti, Isabel Lladó, Ana M Proenza
Dec 10, 2018
Obesity is associated with inflammation, dysregulated adipokine secretion, and disrupted adipose tissue mitochondrial function. Estradiol (E2) has been previously reported to increase mitochondrial function and biogenesis in...
17beta-estradiol G protein-coupled oestrogen receptor adipocyte Mitochondrial function Oestrogen receptor alpha PKA 3T3 Cells Adipocytes Animals Cell Line Cyclic AMP-Dependent Protein Kinases Estradiol Estrogen Receptor alpha Estrogen Receptor beta Female Inflammation Interleukin-6 Male Mice Mice Inbred C57BL Mitochondria obesity Rats Rats Wistar Receptors G-Protein-Coupled
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