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Results: 78787
Whole-genome analysis of animal A- and B-type cyclins.
Transcriptome Sequence of the Bloodstream Form of Trypanoplasma borreli, a Hematozoic Parasite of Fish Transmitted by Leeches.
Here, we report a transcriptome sequence of Trypanoplasma borreli isolated from its natural host, the common carp, Cyprinus carpio The transcriptome allows an analysis of abundant cell surface proteins and acts as a comparator...
Black-necked spitting cobra ( Naja nigricollis) phospholipases A 2 may cause Trypanosoma brucei death by blocking endocytosis through the flagellar pocket
Andrea Martos-Esteban, Olivia JS Macleod, Isabella Maudlin, Konstantinos Kalogeropoulos, Jonas A Jürgensen, Mark Carrington, Andreas H Laustsen
Apr 19, 2022
Abstract: African trypanosomes, such as Trypanosoma brucei, are flagellated protozoa which proliferate in mammals and cause a variety of diseases in people and animals. In a mammalian host, the external face of the African...
A new generation of T7 RNA polymerase-independent inducible expression plasmids for Trypanosoma brucei.
Expression of transgenes is central to forward and reverse genetic analysis in Trypanosoma brucei. The inducible expression of transgenes in trypanosomes is based on the tetracycline repressor binding to a tetracycline operator...
Phosphorylation of eIF2α on Threonine 169 is not required for Trypanosoma brucei cell cycle arrest during differentiation.
Carla Cristi DC Avila, Lori Peacock, Fabricio Castro Machado, Wendy Gibson, Sergio Schenkman, Mark Carrington, Beatriz A Castilho
Mar 24, 2016
Proteomic selection of immunodiagnostic antigens for human African trypanosomiasis and generation of a prototype lateral flow immunodiagnostic device.
BACKGROUND: The diagnosis of Human African Trypanosomiasis relies mainly on the Card Agglutination Test for Trypanosomiasis (CATT). While this test is successful, it is acknowledged that there may be room for improvement. Our...
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
A new reporter cell line for studies with proteasome inhibitors in Trypanosoma brucei.
A Trypanosoma brucei cell line is described that produces a visual readout of proteasome activity. The cell line contains an integrated transgene encoding an ubiquitin-green fluorescent protein (GFP) fusion polypeptide...
Charge density waves and Fermi surface reconstruction in the clean overdoped cuprate superconductor Tl2Ba2CuO6+δ.
Hall effect and quantum oscillation measurements on high temperature cuprate superconductors show that underdoped compositions have small Fermi surface pockets whereas when heavily overdoped, a single much larger pocket is...
Developmentally regulated instability of the GPI-PLC mRNA is dependent on a short-lived protein factor.
The expression of the vast majority of protein coding genes in trypanosomes is regulated exclusively at the post-transcriptional level. Developmentally regulated mRNAs that vary in levels of expression have provided an insight...
Establishing a Research Agenda on Mobile Health Technologies and Later-Life Pain Using an Evidence-Based Consensus Workshop Approach
Elaine Wethington, Christopher Eccleston, Geri Gay, Rachael Gooberman-Hill, Patricia Schofield, Elizabeth Bacon, Wen Dombrowski, Robert Jamison, Max Rothman, Lauren Meador, Cara Kenien, Karl Pillemer, Corinna Löckenhoff, M. Carrington Reid
Dec 31, 2018
The rapid growth of mHealth devices holds substantial potential for improving care and care outcomes in all patient populations, including older adults with pain. However, existing research reflects a substantial gap in...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Black-necked spitting cobra (Naja nigricollis) phospholipases A2 may cause Trypanosoma brucei death by blocking endocytosis through the flagellar pocket.
Andrea Martos-Esteban, Olivia JS Macleod, Isabella Maudlin, Konstantinos Kalogeropoulos, Jonas A Jürgensen, Mark Carrington, Andreas H Laustsen
May 18, 2022
African trypanosomes, such as Trypanosoma brucei, are flagellated protozoa which proliferate in mammals and cause a variety of diseases in people and animals. In a mammalian host, the external face of the African trypanosome...
Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications.
Amy Cording, Michael Gormally, Peter J Bond, Mark Carrington, Shankar Balasubramanian, Eric A Miska, Beth Thomas
Jan 22, 2016
AFRICAN TRYPANOSOMIASIS RET1 RNA modifications TUTase drug-discovery Non-coding RNA post-transcriptional modification trypanosome uridylylation Drug Discovery Humans Nucleic Acid Synthesis Inhibitors Protozoan Proteins RNA Editing RNA Nucleotidyltransferases RNA Untranslated Trypanocidal Agents Trypanosoma brucei brucei Trypanosomiasis African Uridine Triphosphate
Establishing a Research Agenda on Mobile Health Technologies and Later-Life Pain Using an Evidence-Based Consensus Workshop Approach
Elaine Wethington, Christopher Eccleston, Geri Gay, Rachael Gooberman-Hill, Patricia Schofield, Elizabeth Bacon, Wen Dombrowski, Robert Jamison, Max Rothman, Lauren Meador, Cara Kenien, Karl Pillemer, Corinna Löckenhoff, M. Carrington Reid
Dec 31, 2018
The rapid growth of mHealth devices holds substantial potential for improving care and care outcomes in all patient populations, including older adults with pain. However, existing research reflects a substantial gap in...
Multispecies reconstructions uncover widespread conservation, and lineage-specific elaborations in eukaryotic mRNA metabolism.
The degree of conservation and evolution of cytoplasmic mRNA metabolism pathways across the eukaryotes remains incompletely resolved. In this study, we describe a comprehensive genome and transcriptome-wide analysis of proteins...
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
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