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Sphingolipid, fatty acid and phospholipid metabolites are associated with disease severity and mTOR inhibition in lymphangioleiomyomatosis.
BACKGROUND: Lymphangioleiomyomatosis (LAM) is a rare multisystem disease almost exclusively affecting women which causes loss of lung function, lymphatic abnormalities and angiomyolipomas. LAM occurs sporadically and in people...
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Research on Monitoring Method of Stock Market Systematic Crash Based on Market Transaction Data
Yan Li, Zhan Li
Jan 01, 2023
Sharp rises and falls in stock prices have become increasingly frequent in recent years. Stock market crashes bring great risks to the stability of the securities markets. Using recurrence plot theory and a heuristic...
“Judging a book by its cover”
Objectives. Diagnosis is ubiquitous in Psychiatry, and whilst it can bring benefits; adverse effects of “labelling” may also be possible. The present study aimed to evaluate experimentally whether clinicians’ judgements about a...
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Spatial Dynamics and Fine-Scale Vertical Behaviour of Immature Eastern Australasian White Sharks (Carcharodon carcharias).
Knowledge of the 3-dimensional space use of large marine predators is central to our understanding of ecosystem dynamics and for the development of management recommendations. Horizontal movements of white sharks, Carcharodon...
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Brain glucose sensors play a significant role in the regulation of pancreatic glucose-stimulated insulin secretion.
As patients decline from health to type 2 diabetes, glucose-stimulated insulin secretion (GSIS) typically becomes impaired. Although GSIS is driven predominantly by direct sensing of a rise in blood glucose by pancreatic...
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Direct Amination of Fluorescein Esters to Produce a Library of Novel Rhodols
Rebecca Lam
Jan 01, 0001
A direct amination of fluorescein derivatives was prepared through a one-pot method that avoids palladium catalysis and prefunctionalization of the hydroxyl group. The method was optimized, and a series of N-aryl rhodamines were...
Published by: Ursinus College
“Judging a book by its cover”
Objectives. Diagnosis is ubiquitous in Psychiatry, and whilst it can bring benefits; adverse effects of “labelling” may also be possible. The present study aimed to evaluate experimentally whether clinicians’ judgements about a...
Published by:
FPGA-aware techniques for rapid generation of profitable custom instructions
Instruction set extension of FPGA based reconfigurable processors provides an effective means to meet the increasingly strict design constraints of embedded systems. We have shown in our previous works [20,21] that the usage of...
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Pyrolysis using microwave absorbents as reaction bed
Used frying oil (UFO), a waste produced in large volume each year worldwide, represents a potential resource for biofuel production rather than a disposal problem for modern society. Pyrolysis technique using microwave heating...
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FPGA-aware techniques for rapid generation of profitable custom instructions
Instruction set extension of FPGA based reconfigurable processors provides an effective means to meet the increasingly strict design constraints of embedded systems. We have shown in our previous works [20,21] that the usage of...
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Development and validation of a driving simulator for traffic control using field data
This paper presents the development and validation of a driving simulator for ramp traffic control on expressways using a traffic simulator and control (TSC). The TSC consists of two main components: car-following model (CFM)...
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Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
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A counterintuitive stereochemical outcome from a chelation-controlled vinylmetal aldehyde addition leads to the configurational reassignment of phormidolide A.
As part of our ongoing studies towards the total synthesis of phormidolide A (1), we explored the chelation-controlled vinylmetal addition of iodide 2 to aldehyde 3 to install the reported 17S configuration. While the...
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