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Optimizing for High Resolution ADC Model With Combined Architecture
High resolution analog-digital conversion (ADC) is a key instrument to convert analog signals to digital signals, which is deployed in data acquisition system to match high resolution analog signals from seismometers systems. To...
Published by: IGI Global Scientific Publishing
Repeatability of diffusion-weighted MRI of the prostate using whole lesion ADC values, skew and histogram analysis.
Tristan Barrett, Edward M Lawrence, Andrew N Priest, Anne Y Warren, Vincent J Gnanapragasam, Ferdia A Gallagher, Evis Sala
Dec 14, 2018
PURPOSE: To investigate the repeatability of diffusion-weighted imaging parameter including ADC-derived histogram values in prostate cancer. METHODS: 10 patients with prostate cancer were prospectively recruited to a retest...
Evaluation of pretreatment ADC values as predictors of treatment response to neoadjuvant chemotherapy in patients with breast cancer - a multicenter study.
Alexey Surov, Maciej Pech, Hans-Jonas Meyer, Almir GV Bitencourt, Hiroshi Fujimoto, Gabrielle C Baxter, Gorane Santamaría, Fiona J Gilbert, Andreas Wienke
Jan 10, 2023
BACKGROUND: Magnetic resonance imaging (MRI) can be used to diagnose breast cancer. Diffusion weighted imaging (DWI) and the apparent diffusion coefficient (ADC) can reflect tumor microstructure in a non-invasive manner. The...
Evaluation of pretreatment ADC values as predictors of treatment response to neoadjuvant chemotherapy in patients with breast cancer - a multicenter study.
Alexey Surov, Maciej Pech, Hans-Jonas Meyer, Almir GV Bitencourt, Hiroshi Fujimoto, Gabrielle C Baxter, Gorane Santamaría, Fiona J Gilbert, Andreas Wienke
Dec 09, 2022
BACKGROUND: Magnetic resonance imaging (MRI) can be used to diagnose breast cancer. Diffusion weighted imaging (DWI) and the apparent diffusion coefficient (ADC) can reflect tumor microstructure in a non-invasive manner. The...
Precipitation drives global variation in natural selection
AM Siepielski, MB Morrissey, M Buoro, SM Carlson, CM Caruso, SM Clegg, T Coulson, J DiBattista, KM Gotanda, CD Francis, J Hereford, JG Kingsolver, KE Augustine, LEB Kruuk, RA Martin, BC Sheldon, N Sletvold, EI Svensson, MJ Wade, ADC MacColl
Apr 27, 2017
Climate change has the potential to affect the ecology and evolution of every species on Earth. Although the ecological consequences of climate change are increasingly well documented, the effects of climate on the key...
Sulfatase-cleavable linkers for antibody-drug conjugates.
Jonathan D Bargh, Stephen J Walsh, Albert Isidro-Llobet, Soleilmane Omarjee, Jason S Carroll, David R Spring
Jul 28, 2021
Antibody-drug conjugates (ADCs) are a class of targeted drug delivery agents combining the cell-selectivity of monoclonal antibodies (mAbs) and the cytotoxicity of small molecules. These two components are joined by a covalent...
Published by: Chemical science
Sulfatase-cleavable linkers for antibody-drug conjugates.
Jonathan D Bargh, Stephen J Walsh, Albert Isidro-Llobet, Soleilmane Omarjee, Jason S Carroll, David R Spring
Feb 05, 2020
Antibody-drug conjugates (ADCs) are a class of targeted drug delivery agents combining the cell-selectivity of monoclonal antibodies (mAbs) and the cytotoxicity of small molecules. These two components are joined by a covalent...
Serial changes in tumour measurements and apparent diffusion coefficients in prostate cancer patients on active surveillance with and without histopathological progression.
Nikita Sushentsev, Iztok Caglic, Leonardo Rundo, Vasily Kozlov, Evis Sala, Vincent J Gnanapragasam, Tristan Barrett
Sep 08, 2021
OBJECTIVE: To analyse serial changes in MRI-derived tumour measurements and apparent diffusion coefficient (ADC) values in prostate cancer (PCa) patients on active surveillance (AS) with and without histopathological disease...
Remembering Ewan MacColl
Owen Holland
May 05, 2013
In this article Owen Holland examines Ewan MacColl's early work in agit-prop theatre and his later activity as a songwriter, performer, and collector in the second British folk revival. He argues that his experience in the...
Theatre Workshop agit-prop theatre performance aesthetics second folk revival politically committed cultural production
Published by: New Theatre Quarterly Journal (published by CUP)
Diffusion kurtosis MRI as a predictive biomarker of response to neoadjuvant chemotherapy in high grade serous ovarian cancer.
Surrin S Deen, Andrew N Priest, Mary A McLean, Andrew B Gill, Cara Brodie, Robin Crawford, John Latimer, Peter Baldwin, Helena M Earl, Christine Parkinson, Sarah Smith, Charlotte Hodgkin, Ilse Patterson, Helen Addley, Susan Freeman, Penny Moyle, Mercedes Jimenez-Linan, Martin J Graves, Evis Sala, James D Brenton, Ferdia A Gallagher
Jul 15, 2019
This study assessed the feasibility of using diffusion kurtosis imaging (DKI) as a measure of tissue heterogeneity and proliferation to predict the response of high grade serous ovarian cancer (HGSOC) to neoadjuvant chemotherapy...
MRI features of the normal prostatic peripheral zone
Vlad Bura, Iztok Caglic, Ziga Snoj, Nikita Sushentsev, Alexandra S Berghe, Andrew N Priest, Tristan Barrett
Nov 16, 2020
OBJECTIVES: To assess the multiparametric MRI (mpMRI) appearances of normal peripheral zone (PZ) across age groups in a biopsy-naïve population, where prostate cancer (PCa) was subsequently excluded, and propose a scoring system...
Improving the image quality of DWI in breast cancer
Gabrielle C Baxter, Andrew J Patterson, Ramona Woitek, Iris Allajbeu, Martin J Graves, Fiona Gilbert
Sep 15, 2020
OBJECTIVE: To compare diffusion-weighted images (DWI) acquired using single-shot echo-planar imaging (ss-EPI) and multiplexed sensitivity encoding (MUSE) in breast cancer. METHODS: 20 females with pathologically confirmed breast...
Decoding the Interdependence of Multiparametric Magnetic Resonance Imaging to Reveal Patient Subgroups Correlated with Survivals.
Chao Li, Shuo Wang, Pan Liu, Turid Torheim, Natalie R Boonzaier, Bart RJ van Dijken, Carola-Bibiane Schönlieb, Florian Markowetz, Stephen J Price
Mar 21, 2019
Glioblastoma is highly heterogeneous in microstructure and vasculature, creating various tumor microenvironments among patients, which may lead to different phenotypes. The purpose was to interrogate the interdependence of...
Diazaborines Are a Versatile Platform to Develop ROS-Responsive Antibody Drug Conjugates*.
João PM António, Joana Inês Carvalho, Ana S André, Joana NR Dias, Sandra I Aguiar, Hélio Faustino, Ricardo MRM Lopes, Luis F Veiros, Gonçalo JL Bernardes, Frederico A da Silva, Pedro MP Gois
Oct 08, 2021
Antibody-drug conjugates (ADCs) are a new class of therapeutics that combine the lethality of potent cytotoxic drugs with the targeting ability of antibodies to selectively deliver drugs to cancer cells. In this study we show...
Diffusion kurtosis MRI as a predictive biomarker of response to neoadjuvant chemotherapy in high grade serous ovarian cancer
Surrin S. Deen, Andrew N. Priest, Mary A. McLean, Andrew B. Gill, Cara Brodie, Robin Crawford, John Latimer, Peter Baldwin, Helena M. Earl, Christine Parkinson, Sarah Smith, Charlotte Hodgkin, Ilse Patterson, Helen Addley, Susan Freeman, Penny Moyle, Mercedes Jimenez-Linan, Martin J. Graves, Evis Sala, James D. Brenton, Ferdia A. Gallagher
Jul 23, 2020
Abstract: This study assessed the feasibility of using diffusion kurtosis imaging (DKI) as a measure of tissue heterogeneity and proliferation to predict the response of high grade serous ovarian cancer (HGSOC) to neoadjuvant...
Diagnostic evaluation of magnetization transfer and diffusion kurtosis imaging for prostate cancer detection in a re-biopsy population.
Tristan Barrett, Mary McLean, Andrew N Priest, Edward M Lawrence, Andrew J Patterson, Brendan C Koo, Ilse Patterson, Anne Y Warren, Andrew Doble, Vincent J Gnanapragasam, Christof Kastner, Ferdia A Gallagher
Jun 04, 2018
OBJECTIVE: To evaluate diffusion kurtosis imaging (DKI) and magnetisation transfer imaging (MTI) compared to standard MRI for prostate cancer assessment in a re-biopsy population. METHODS: Thirty-patients were imaged at 3 T...
Diffusion kurtosis imaging Diffusion-weighted imaging MRI Magnetisation transfer imaging Prostate Aged Diffusion Magnetic Resonance Imaging Diffusion tensor imaging Humans Image Interpretation Computer-Assisted Image-guided biopsy Magnetic Resonance Imaging Male Middle Aged Prospective Studies Prostatic Neoplasms ROC Curve Retreatment
Can unenhanced MRI of the breast replace contrast-enhanced MRI in assessing response to neoadjuvant chemotherapy?
Beatrice Cavallo Marincola, Marianna Telesca, Fulvio Zaccagna, Frank Riemer, Michele Anzidei, Carlo Catalano, Federica Pediconi
Jul 31, 2018
BACKGROUND: The goals of neoadjuvant chemotherapy (NAC) are to reduce tumor volume and to offer a prognostic indicator in assessing treatment response. Contrast-enhanced magnetic resonance imaging (CE-MRI) is an established...
Breast Neoplasms MRI Chemotherapy Magnetic Resonance Imaging Adult Aged Breast Breast Neoplasms Chemotherapy Adjuvant Contrast Media Female Humans Image Enhancement Magnetic Resonance Imaging Meglumine Middle Aged Neoadjuvant Therapy Organometallic Compounds Reproducibility of Results Treatment Outcome
Low perfusion compartments in glioblastoma quantified by advanced magnetic resonance imaging and correlated with patient survival.
Chao Li, Jiun-Lin Yan, Turid Torheim, Mary A McLean, Natalie R Boonzaier, Jingjing Zou, Yuan Huang, Jianmin Yuan, Bart RJ van Dijken, Tomasz Matys, Florian Markowetz, Stephen J Price
Feb 25, 2019
BACKGROUND AND PURPOSE: Glioblastoma exhibits profound intratumoral heterogeneity in perfusion. Particularly, low perfusion may induce treatment resistance. Thus, imaging approaches that define low perfusion compartments are...
diffusion imaging Glioblastoma Heterogeneity Perfusion Imaging radioresistance Tumor habitat imaging Adult Aged Chemoradiotherapy Cohort Studies Diffusion Magnetic Resonance Imaging Female Glioblastoma Humans Kaplan-Meier Estimate Magnetic Resonance Imaging Male Middle Aged Neoplasm Invasiveness Supratentorial Neoplasms Survival Rate Temozolomide Young Adult
Standardisation of prostate multiparametric MRI across a hospital network
Marianthi-Vasiliki Papoutsaki, Clare Allen, Francesco Giganti, David Atkinson, Louise Dickinson, Jacob Goodman, Helen Saunders, Tristan Barrett, Shonit Punwani
May 11, 2021
OBJECTIVES: National guidelines recommend prostate multiparametric (mp) MRI in men with suspected prostate cancer before biopsy. In this study, we explore prostate mpMRI protocols across 14 London hospitals and determine whether...
Neoadjuvant chemotherapy in breast cancer
DJ Manton, A Chaturvedi, A Hubbard, MJ Lind, M Lowry, A Maraveyas, MD Pickles, DJ Tozer, LW Turnbull
Sep 01, 2021
A prospective study was undertaken in women undergoing neoadjuvant chemotherapy for locally advanced breast cancer in order to determine the ability of quantitative magnetic resonance imaging (MRI) and proton spectroscopy (MRS)...
Acceleration decoupling control of 6 degrees of freedom electro-hydraulic shaking table
Electro-hydraulic shaking tables are widely used for vibration testing where high force and displacement amplitudes are required. In particular, they are a vital tool in seismic testing, enabling the development of buildings...
acceleration control Electro-hydraulic shaking table modal control seismic testing three-variable-control /dk/atira/pure/subjectarea/asjc/2200/2203 name=Automotive Engineering /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/2200/2202 name=Aerospace Engineering /dk/atira/pure/subjectarea/asjc/2200/2211 name=Mechanics of Materials /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering
A survey by the European Society of Breast Imaging on the implementation of breast diffusion-weighted imaging in clinical practice.
Roberto Lo Gullo, Varadan Sevilimedu, Pascal Baltzer, Denis Le Bihan, Julia Camps-Herrero, Paola Clauser, Fiona J Gilbert, Mami Iima, Ritse M Mann, Savannah C Partridge, Andrew Patterson, Eric E Sigmund, Sunitha Thakur, Fabienne E Thibault, Laura Martincich, Katja Pinker, EUSOBI International Breast Diffusion-Weighted Imaging working group
Jun 07, 2022
OBJECTIVES: To perform a survey among all European Society of Breast Imaging (EUSOBI) radiologist members to gather representative data regarding the clinical use of breast DWI. METHODS: An online questionnaire was developed by...
A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis.
Paula MacGregor, Andrea L Gonzalez-Munoz, Fatoumatta Jobe, Martin C Taylor, Steven Rust, Alan M Sandercock, Olivia JS Macleod, Katrien Van Bocxlaer, Amanda F Francisco, Francois D'Hooge, Arnaud Tiberghien, Conor S Barry, Philip Howard, Matthew K Higgins, Tristan J Vaughan, Ralph Minter, Mark Carrington
May 03, 2019
Infections of humans and livestock with African trypanosomes are treated with drugs introduced decades ago that are not always fully effective and often have severe side effects. Here, the trypanosome haptoglobin-haemoglobin...
Rapid and robust cysteine bioconjugation with vinylheteroarenes.
Hikaru Seki, Stephen J Walsh, Jonathan D Bargh, Jeremy S Parker, Jason Carroll, David R Spring
Aug 19, 2021
Methods for residue-selective and stable modification of canonical amino acids enable the installation of distinct functionality which can aid in the interrogation of biological processes or the generation of new therapeutic...
Fetal diffusion tensor quantification of brainstem pathology in Chiari II malformation.
Ramona Woitek, Daniela Prayer, Michael Weber, Gabriele Amann, Rainer Seidl, Dieter Bettelheim, Veronika Schöpf, Peter C Brugger, Julia Furtner, Ulrika Asenbaum, Gregor Kasprian
Aug 05, 2019
OBJECTIVES: This prenatal MRI study evaluated the potential of diffusion tensor imaging (DTI) metrics to identify changes in the midbrain of fetuses with Chiari II malformations compared to fetuses with mild ventriculomegaly...
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