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Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
Interview with Gloria Mobley Brown - OH 780
This interview was conducted by Martin Jackson with Gloria Mobley Brown as part of Project 2020: A Collaborative Oral History. Mrs. Brown, 89, discusses her experiences as a Black student and educator, particularly during the...
2020 Black women Civil Rights Movement race Race Relations Black Lives Matter Education Rock Hill law
Published by: Winthrop University
Proximal femoral canal shape is more accurately assessed on AP hip radiographs than AP pelvis radiographs in primary hip osteoarthritis
Christian Merle, Wenzel Waldstein, Jennifer S Gregory, Simon R Goodyear, Richard M Aspden, Peter R Aldinger, David W Murray, Harinderjit S Gill
Jan 01, 0001
The objectives of the present study were to determine (1) whether differences in the radiographic appearance of the of the proximal femoral canal exist on corresponding AP pelvis and AP hip radiographs, and (2) whether...
AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A.
Alexandra K Davies, Daniel N Itzhak, James R Edgar, Tara L Archuleta, Jennifer Hirst, Lauren P Jackson, Margaret S Robinson, Georg HH Borner
Dec 13, 2018
Adaptor protein 4 (AP-4) is an ancient membrane trafficking complex, whose function has largely remained elusive. In humans, AP-4 deficiency causes a severe neurological disorder of unknown aetiology. We apply unbiased proteomic...
Proximal femoral canal shape is more accurately assessed on AP hip radiographs than AP pelvis radiographs in primary hip osteoarthritis
Christian Merle, Wenzel Waldstein, Jennifer S Gregory, Simon R Goodyear, Richard M Aspden, Peter R Aldinger, David W Murray, Harinderjit S Gill
Jan 01, 0001
The objectives of the present study were to determine (1) whether differences in the radiographic appearance of the of the proximal femoral canal exist on corresponding AP pelvis and AP hip radiographs, and (2) whether...
Brown and beige fat
Stefania Carobbio, Anne-Claire Guénantin, Isabella Samuelson, Myriam Bahri, Antonio Vidal-Puig
Nov 18, 2020
The adipose organ portrays adipocytes of diverse tones: white, brown and beige, each type with distinct functions. Adipocytes orchestrate their adaptation and expansion to provide storage to excess nutrients, the quick...
Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15.
Jennifer Hirst, Georg HH Borner, James Edgar, Marco Y Hein, Matthias Mann, Frank Buchholz, Robin Antrobus, Margaret S Robinson
Feb 13, 2019
The AP-5 complex is a recently identified but evolutionarily ancient member of the family of heterotetrameric adaptor proteins (AP complexes). It is associated with two proteins that are mutated in patients with hereditary...
Studying Brown Adipose Tissue in a Human in vitro Context.
New treatments for obesity and associated metabolic disease are increasingly warranted with the growth of the obesity pandemic. Brown adipose tissue (BAT) may represent a promising therapeutic target to treat obesity, as this...
Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex.
Adaptor protein complex 5 (AP-5) and its partners, SPG11 and SPG15, are recruited onto late endosomes and lysosomes. Here we show that recruitment of AP-5/SPG11/SPG15 is enhanced in starved cells and occurs by coincidence...
Adaptor Proteins Vesicular Transport Carrier Proteins Endosomes HEK293 Cells HeLa Cells Humans Lysosomes Mechanistic Target of Rapamycin Complex 1 Models Biological Monomeric GTP-Binding Proteins Multiprotein Complexes Nucleotides Phosphatidylinositol 3-Kinases Phosphatidylinositol Phosphates Protein Domains Proteins
Jean Carson Brown of Charlotte NC Jan. 14, 1947
Winthrop News Service
Jan 01, 0001
Jean Carson Brown of Charlotte, NC was named for Who's Who at Winthrop College. Miss Brown is a senior and editor of The Journal, Winthrop College's student literary publication.
Published by: Winthrop University
Prediction of three-dimensional femoral offset from AP pelvis radiographs in primary hip osteoarthritis
C Merle, W Waldstein, Elise Pegg, M R Streit, T Gotterbarm, P R Aldinger, D W Murray, H S Gill
Aug 01, 2013
BACKGROUND: In pre-operative planning for total hip arthroplasty (THA), femoral offset (FO) is frequently underestimated on AP pelvis radiographs as a result of inaccurate patient positioning, imprecise magnification, and...
Jean Carson Brown of Charlotte NC Jan. 8, 1947
Winthrop News Service
Jan 01, 0001
Jean Carson Brown, senior at Winthrop College, was selected for Who's Who among students in American colleges and universities. Miss Brown was active in campus affairs, serving as president of the campus poetry club, president...
Published by: Winthrop University
Prediction of three-dimensional femoral offset from AP pelvis radiographs in primary hip osteoarthritis
C Merle, W Waldstein, Elise Pegg, M R Streit, T Gotterbarm, P R Aldinger, D W Murray, H S Gill
Aug 01, 2013
BACKGROUND: In pre-operative planning for total hip arthroplasty (THA), femoral offset (FO) is frequently underestimated on AP pelvis radiographs as a result of inaccurate patient positioning, imprecise magnification, and...
The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma.
Nikolai Schleussner, Olaf Merkel, Mariantonia Costanza, Huan-Chang Liang, Franziska Hummel, Chiara Romagnani, Pawel Durek, Ioannis Anagnostopoulos, Michael Hummel, Korinna Jöhrens, Antonia Niedobitek, Patrick R Griffin, Roberto Piva, Henrike L Sczakiel, Wilhelm Woessmann, Christine Damm-Welk, Christian Hinze, Dagmar Stoiber, Bernd Gillissen, Suzanne D Turner, Eva Kaergel, Linda von Hoff, Michael Grau, Georg Lenz, Bernd Dörken, Claus Scheidereit, Lukas Kenner, Martin Janz, Stephan Mathas
Mar 20, 2018
Transcription factor AP-1 is constitutively activated and IRF4 drives growth and survival in ALK+ and ALK- anaplastic large cell lymphoma (ALCL). Here we demonstrate high-level BATF and BATF3 expression in ALCL. Both BATFs bind...
Basic-Leucine Zipper Transcription Factors Binding Sites CRISPR-Cas Systems Carrier Proteins Cell Death Cell Line Tumor Cell Survival Cytokines Gene Editing Gene Expression Regulation Neoplastic Gene Knockdown Techniques Humans Lymphoma Large-Cell Anaplastic Protein Binding Protein Kinase Inhibitors RNA Small Interfering T-Lymphocyte Subsets Th17 Cells Transcription Factor AP-1 Transcriptome
A BLOC-1-AP-3 super-complex sorts a cis-SNARE complex into endosome-derived tubular transport carriers.
Shanna L Bowman, Linh Le, Yueyao Zhu, Dawn C Harper, Anand Sitaram, Alexander C Theos, Elena V Sviderskaya, Dorothy C Bennett, Graça Raposo-Benedetti, David J Owen, Megan K Dennis, Michael S Marks
Apr 12, 2021
Membrane transport carriers fuse with target membranes through engagement of cognate vSNAREs and tSNAREs on each membrane. How vSNAREs are sorted into transport carriers is incompletely understood. Here we show that VAMP7, the...
A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2.
Panagiota Vardaka, Teresa Lozano, Christopher Bot, Jonathan Ellery, Sarah K Whiteside, Charlotte J Imianowski, Stuart Farrow, Simon Walker, Hanneke Okkenhaug, Jie Yang, Klaus Okkenhaug, Paula Kuo, Rahul Roychoudhuri
Oct 15, 2020
Whereas effector CD4+ and CD8+ T cells promote immune activation and can drive clearance of infections and cancer, CD4+ regulatory T (Treg) cells suppress their function, contributing to both immune homeostasis and cancer...
The WDR11 complex facilitates the tethering of AP-1-derived vesicles.
Paloma Navarro Negredo, James R Edgar, Paul T Manna, Robin Antrobus, Margaret S Robinson
Jul 20, 2018
Vesicluar transport of proteins from endosomes to the trans-Golgi network (TGN) is an essential cellular pathway, but much of its machinery is still unknown. A screen for genes involved in endosome-to-TGN trafficking produced...
Adaptor Protein Complex 1 Autoantigens CRISPR-Cas Systems Cytoplasmic Vesicles Endosomes GTPase-Activating Proteins HEK293 Cells HeLa Cells Humans Membrane Proteins Microscopy Fluorescence Multiprotein Complexes Protein Binding Protein Transport Proto-Oncogene Proteins RNA Interference trans-Golgi Network
Incarnate Quested Speaking
Patrick Brown
Jun 23, 2022
Patrick Brown is an independent scholar in Honolulu, Hawaii. Before moving to Hawaii, he taught in the philosophy department and the school of law at Seattle University. Brown received his Ph.D. in philosophy from Boston...
Published by: Memorial University of Newfoundland
Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome.
Matthew Van De Pette, Simon J Tunster, Grainne I McNamara, Tatyana Shelkovnikova, Steven Millership, Lindsay Benson, Stuart Peirson, Mark Christian, Antonio Vidal-Puig, Rosalind M John
Jun 24, 2019
The accurate diagnosis and clinical management of the growth restriction disorder Silver Russell Syndrome (SRS) has confounded researchers and clinicians for many years due to the myriad of genetic and epigenetic alterations...
Incarnate Quested Speaking
Patrick Brown
Jun 23, 2022
Patrick Brown is an independent scholar in Honolulu, Hawaii. Before moving to Hawaii, he taught in the philosophy department and the school of law at Seattle University. Brown received his Ph.D. in philosophy from Boston...
Published by: Memorial University of Newfoundland
Dietary (Poly)phenols, Brown Adipose Tissue Activation, and Energy Expenditure
Laura Mele, Guillaume Bidault, Pedro Mena, Alan Crozier, Furio Brighenti, Antonio Vidal-Puig, Daniele Del Rio
Nov 19, 2020
The incidence of overweight and obesity has reached epidemic proportions, making the control of body weight and its complications a primary health problem. Diet has long played a first-line role in preventing and managing...
brown adipose tissue dietary (poly)phenols energy expenditure Flavan-3-ols obesity resveratrol uncoupled protein 1 Adipose Tissue Brown Adrenergic Agonists Animals Anti-Obesity Agents Body Weight Diet Disease Models Animal Energy Metabolism Flavonoids Humans obesity Polyphenols resveratrol Stilbenes Tea Thermogenesis Uncoupling Protein 1
Myosin VI is required for sorting of AP-1B-dependent cargo to the basolateral domain in polarized MDCK cells.
In polarized epithelial cells, newly synthesized membrane proteins are delivered on specific pathways to either the apical or basolateral domains, depending on the sorting motifs present in these proteins. Because myosin VI has...
Adaptor Protein Complex 1 Amino Acid Motifs Animals Cell Cycle Proteins Cell Line Cell Polarity Dogs Endosomes Humans Membrane Glycoproteins Membrane Transport Proteins Mutagenesis Site-Directed Myosin Heavy Chains Protein Isoforms Protein Transport Transcription Factor TFIIIA Viral Envelope Proteins
Consistency in migration strategies and habitat preferences of brown skuas over two winters, a decade apart
At-sea movements and activity patterns of brown skuas Stercorarius antarcticus lonnbergi from South Georgia were analysed in 2 winters, a decade apart, to examine the degree of consistency in migration strategies and habitat...
A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2
Panagiota Vardaka, Teresa Lozano, Christopher Bot, Jonathan Ellery, Sarah K. Whiteside, Charlotte J. Imianowski, Stuart Farrow, Simon Walker, Hanneke Okkenhaug, Jie Yang, Klaus Okkenhaug, Paula Kuo, Rahul Roychoudhuri
Nov 03, 2020
Abstract: Whereas effector CD4+ and CD8+ T cells promote immune activation and can drive clearance of infections and cancer, CD4+ regulatory T (Treg) cells suppress their function, contributing to both immune homeostasis and...
The Gemini Planet Imager Exoplanet Survey
EL Nielsen, RJ De Rosa, B Macintosh, JJ Wang, JB Ruffio, E Chiang, MS Marley, D Saumon, D Savransky, S Mark Ammons, VP Bailey, T Barman, C Blain, J Bulger, A Burrows, J Chilcote, T Cotten, I Czekala, R Doyon, G Duchene, TM Esposito, D Fabrycky, MP Fitzgerald, KB Follette, JJ Fortney, BL Gerard, SJ Goodsell, JR Graham, AZ Greenbaum, P Hibon, S Hinkley, LA Hirsch, J Hom, LW Hung, R Ilene Dawson, P Ingraham, P Kalas, Q Konopacky, JE Larkin, EJ Lee, JW Lin, J Maire, F Marchis, C Marois, S Metchev, MA Millar-Blanchaer, KM Morzinski, R Oppenheimer, D Palmer, J Patience, M Perrin, L Poyneer, L Pueyo, RR Rafikov, A Rajan, J Rameau, FT Rantakyrö, B Ren, AC Schneider, A Sivaramakrishnan, I Song, R Soummer, M Tallis, S Thomas, K Ward-Duong, S Wolff
Apr 26, 2019
We present a statistical analysis of the first 300 stars observed by the
Gemini Planet Imager Exoplanet Survey (GPIES). This subsample includes six
detected planets and three brown dwarfs; from these detections and our...
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