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Results: 906
Cell cycle-coupled expansion of AR activity promotes cancer progression.
C McNair, A Urbanucci, CES Comstock, MA Augello, JF Goodwin, R Launchbury, SG Zhao, MJ Schiewer, A Ertel, J Karnes, E Davicioni, L Wang, Q Wang, IG Mills, FY Feng, W Li, JS Carroll, KE Knudsen
Apr 30, 2019
The androgen receptor (AR) is required for prostate cancer (PCa) survival and progression, and ablation of AR activity is the first line of therapeutic intervention for disseminated disease. While initially effective, recurrent...
Comparison of Light Field and Conventional Near-Eye AR Displays in Virtual-Real Integration Efficiency
Most existing wearable displays for augmented reality (AR) have only one fixed focal plane and hence can easily suffer from vergence-accommodation conflict (VAC). In contrast, light field displays allow users to focus at any...
Published by: IGI Global Scientific Publishing
Dendritic cells exposed to Human Immunodeficiency Virus-1 transmit a vigorous cytopathic infection to CD4+ T cells
Cameron, P.U., Freudenthal, P.S., Barker, J.M., Gezelter, S., Inaba, K., and Steinman, R.M. Dendritic cells exposed to Human Immunodeficiency Virus-1 transmit a vigorous cytopathic infection to CD4+ T cells. Science 257...
Published by: American Association for the Advancement of Science
Exploring the use of AR technology for co-creative product and packaging design
Gaetano Cascini, Jamie O'Hare, Elies Dekoninck, Niccolo Becattini, Jean François Boujut, Fatma Ben Guefrache, Iacopo Carli, Giandomenico Caruso, Lorenzo Giunta, Federico Morosi
Dec 31, 2020
Extended Reality technologies, including Virtual Reality (VR) and Augmented Reality (AR), are being applied in a wide variety of industrial applications, but their use within design practice remains very limited, despite some...
Co-Creation co-design Design representation Prototype Spatial augmented reality /dk/atira/pure/subjectarea/asjc/1700/1700 name=General Computer Science /dk/atira/pure/subjectarea/asjc/2200/2200 name=General Engineering /dk/atira/pure/sustainabledevelopmentgoals/industry_innovation_and_infrastructure name=SDG 9 - Industry, Innovation, and Infrastructure
Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer.
Meixia Che, Aashi Chaturvedi, Sarah A Munro, Samuel P Pitzen, Alex Ling, Weijie Zhang, Josh Mentzer, Sheng-Yu Ku, Loredana Puca, Yanyun Zhu, Andries M Bergman, Tesa M Severson, Colleen Forster, Yuzhen Liu, Jacob Hildebrand, Mark Daniel, Ting-You Wang, Luke A Selth, Theresa Hickey, Amina Zoubeidi, Martin Gleave, Rohan Bareja, Andrea Sboner, Wayne Tilley, Jason S Carroll, Winston Tan, Manish Kohli, Rendong Yang, Andrew C Hsieh, Paari Murugan, Wilbert Zwart, Himisha Beltran, R Stephanie Huang, Scott M Dehm
Jan 06, 2022
Endocrine therapies for prostate cancer inhibit the androgen receptor (AR) transcription factor. In most cases, AR activity resumes during therapy and drives progression to castration-resistant prostate cancer (CRPC). However...
Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer.
Meixia Che, Aashi Chaturvedi, Sarah A Munro, Samuel P Pitzen, Alex Ling, Weijie Zhang, Josh Mentzer, Sheng-Yu Ku, Loredana Puca, Yanyun Zhu, Andries M Bergman, Tesa M Severson, Colleen Forster, Yuzhen Liu, Jacob Hildebrand, Mark Daniel, Ting-You Wang, Luke A Selth, Theresa Hickey, Amina Zoubeidi, Martin Gleave, Rohan Bareja, Andrea Sboner, Wayne Tilley, Jason Carroll, Winston Tan, Manish Kohli, Rendong Yang, Andrew C Hsieh, Paari Murugan, Wilbert Zwart, Himisha Beltran, R Stephanie Huang, Scott M Dehm
Nov 04, 2021
Endocrine therapies for prostate cancer inhibit the androgen receptor (AR) transcription factor. In most cases, AR activity resumes during therapy and drives progression to castration-resistant prostate cancer (CRPC). However...
Exploring Enhancement of AR-HUD Visual Interaction Design Through Application of Intelligent Algorithms
This study aims to optimize the visual interaction design of AR-HUD and reduce cognitive load in complex driving situations. An immersive driving simulation incorporating eye-tracking technology was utilized to analyze objective...
Published by: IGI Global Scientific Publishing
Exploring the use of AR technology for co-creative product and packaging design
Gaetano Cascini, Jamie O'Hare, Elies Dekoninck, Niccolo Becattini, Jean François Boujut, Fatma Ben Guefrache, Iacopo Carli, Giandomenico Caruso, Lorenzo Giunta, Federico Morosi
Dec 31, 2020
Extended Reality technologies, including Virtual Reality (VR) and Augmented Reality (AR), are being applied in a wide variety of industrial applications, but their use within design practice remains very limited, despite some...
Co-Creation co-design Design representation Prototype Spatial augmented reality /dk/atira/pure/subjectarea/asjc/1700/1700 name=General Computer Science /dk/atira/pure/subjectarea/asjc/2200/2200 name=General Engineering /dk/atira/pure/sustainabledevelopmentgoals/industry_innovation_and_infrastructure name=SDG 9 - Industry, Innovation, and Infrastructure
Integration and Application of AR Technology in Augmented Reality Image Animation Within the Context of Lingnan Culture
With the maturity of AR technology, AR is more and more used in various industries. from the perspective of the application of AR technology at this stage, the emergence of AR technology improves the visual effect in image...
Published by: IGI Global Scientific Publishing
Blended English Teaching Model in Higher Education School Environment AR Constructive Technology
China's education modernization requirements clearly suggest exploring new teaching methods to improve teaching effectiveness. Based on this, this article investigates AR construction technology as a blended English teaching...
Published by: IGI Global Scientific Publishing
The Origin of Inequality. Origini 3, edited by Andrea Cardarelli, Alberto Cazzella and Marcella Frangipane
The article reviews The Origins of Inequality, a collection of essays brought together by Andrea Cardarelli, Alberto Cazzella and Marcella Frangipane following a series of seminars on this theme at the University of Roma La...
Localized quantitative estimates and potential blow-up rates for Navier-Stokes equations
Tobias Barker
Oct 31, 2023
We show that if v is a smooth suitable weak solution to the Navier-Stokes equations on B(0, 4) \times (0,T*), which possesses a singular point (x0,T*) \in B(0, 4) \times \{ T*\} , then for all \delta > 0 sufficiently...
Localized quantitative estimates and potential blow-up rates for Navier-Stokes equations
Tobias Barker
Oct 31, 2023
We show that if v is a smooth suitable weak solution to the Navier-Stokes equations on B(0, 4) \times (0,T*), which possesses a singular point (x0,T*) \in B(0, 4) \times \{ T*\} , then for all \delta > 0 sufficiently...
Perseveration and choice in Parkinson's disease
We have previously shown that patients with Parkinson's disease (PD) perseverate in their choice of action relative to healthy controls, and that this is affected by dopaminergic medication (Hughes LE, Barker RA, Owen AM, Rowe...
FORWARDS-1
LM Paterson, D Barker, S Cro, P Mozgunov, R Phillips, C Smith, L Nahar, S Paterson, AR Lingford-Hughes
Oct 24, 2022
BACKGROUND: Treatment of opiate addiction with opiate substitution treatment (e.g. methadone) is beneficial. However, some individuals desire or would benefit from abstinence but there are limited options to attenuate problems...
FORWARDS-1
LM Paterson, D Barker, S Cro, P Mozgunov, R Phillips, C Smith, L Nahar, S Paterson, AR Lingford-Hughes
Nov 18, 2022
BACKGROUND: Treatment of opiate addiction with opiate substitution treatment (e.g. methadone) is beneficial. However, some individuals desire or would benefit from abstinence but there are limited options to attenuate problems...
Adaptive Addiction Baclofen Bayesian dependence dose escalation GABA-B Methadone opiate phase I Humans Analgesics Opioid Baclofen Bayes Theorem Carbon Dioxide Cholecalciferol GABA-B Receptor Agonists Hypnotics and Sedatives Methadone Nicotine Opiate substitution treatment Opioid-Related Disorders Single-Blind Method vitamin D
Saying "No" to (the) Oxygen Capital? Amenity Migration, Counter-territorialization, and Uneven Rural Landscape Change in the Kaz Da?lar? (Ida Mountains) of Western Turkey
Diverse forms of conservation and development are transforming the material landscapes and related livelihoods of communities in rural places around the world. While many studies focus on changing protected area governance and...
amenity migration exurban political ecology reterritorialization counter-territorialization Kaz Da?? National Park Turkey Environmental Studies Nature and Society Relations Sociology of Culture tourism urban studies Urban Studies and Planning
Published by: Ursinus College
Towards a Better Understanding of Drone Forensics
Unmanned aerial vehicles (drones) have gained increased popularity as their innovative uses continue to expand across various fields. Despite their numerous beneficial uses, drones have unfortunately been misused, through many...
Published by: IGI Global Scientific Publishing
Birthweight, Type 2 Diabetes Mellitus, and Cardiovascular Disease
Daniela Zanetti, Emmi Tikkanen, Stefan Gustafsson, James R Priest, Stephen Burgess, Erik Ingelsson
Aug 16, 2018
BACKGROUND: Low birthweight has been associated with a higher risk of hypertension, type 2 diabetes mellitus (T2D), and cardiovascular disease. The Barker hypothesis posits that intrauterine growth restriction resulting in lower...
cardiovascular disease Diabetes mellitus Type 2 Genetics Hypertension obesity Adult Aged Birth Weight Blood Glucose blood pressure Body Mass Index Cardiovascular Diseases Diabetes mellitus Type 2 Female Genome-Wide Association Study Humans Incidence Male Mendelian Randomization Analysis Middle Aged Observational Studies as Topic Risk Factors United States
Impact of maternal obesity and diabetes on long-term health of the offspring.
The initial observations of David Barker, popularly known as the “Barker hypothesis” or “developmental origins of health and disease,” show that being born with low birth weight, as a result of intrauterine growth restriction...
Novel Androgen Receptor Coregulator GRHL2 Exerts Both Oncogenic and Antimetastatic Functions in Prostate Cancer.
Steve Paltoglou, Rajdeep Das, Scott L Townley, Theresa E Hickey, Gerard A Tarulli, Isabel Coutinho, Rayzel Fernandes, Adrienne R Hanson, Iza Denis, Jason S Carroll, Scott M Dehm, Ganesh V Raj, Stephen R Plymate, Wayne D Tilley, Luke A Selth
Jul 12, 2019
Alteration to the expression and activity of androgen receptor (AR) coregulators in prostate cancer is an important mechanism driving disease progression and therapy resistance. Using a novel proteomic technique, we identified a...
A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer.
Anne Y Warren, Charlie E Massie, Kate Watt, Katarina Luko, Folake Orafidiya, Luke A Selth, Hisham Mohammed, Brinder S Chohan, Suraj Menon, Ajoeb Baridi, Wanfeng Zhao, Carles Escriu, Thanakorn Pungsrinont, Clive D'Santos, Xiaoping Yang, Chris Taylor, Arham Qureshi, Vincent R Zecchini, Greg L Shaw, Scott M Dehm, Ian G Mills, Jason S Carroll, Wayne D Tilley, Iain J McEwan, Aria Baniahmad, David E Neal, Mohammad Asim
Nov 16, 2018
Elucidation of mechanisms underlying the increased androgen receptor (AR) activity and subsequent development of aggressive prostate cancer (PrCa) is pivotal in developing new therapies. Using a systems biology approach, we...
Current status of androgen receptor-splice variant 7 inhibitor niclosamide in castrate-resistant prostate-cancer
Navid Sobhani, Daniele Generali, Alberto D'Angelo, Michele Aieta, Giandomenico Roviello
Dec 31, 2018
Castrate-Resistant Prostate-Cancer (CRPC) is one of the most common malignancies occurring in men. Unfortunately, even if several recently approved agents clinically improved the outcome of CRPC patients, none of these is...
Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer.
RAC 3, one of the p160 family of co-activators is known to enhance the transcriptional activity of a number of steroid receptors. As co-activators are also known to enhance androgen receptor (AR) activity, we investigated the...
Adenocarcinoma Aged Aged 80 and over Androgens Biomarkers Tumor Disease Progression Epithelial Cells Gene Expression Regulation Neoplastic Humans In Situ Hybridization Male Middle Aged Neoplasm Proteins Neoplasm Staging Neoplasms Hormone-Dependent Nuclear Receptor Coactivator 3 Prostate-specific antigen Prostatic Hyperplasia Prostatic Neoplasms RNA Messenger RNA Neoplasm Receptors Androgen Trans-Activators Transcription Factors Transcription Genetic Transfection Tumor Cells Cultured
Association between perinatal factors, genetic susceptibility to obesity and age at adiposity rebound in children of the EDEN mother–child cohort
Aminata Hallimat Cissé, Sandrine Lioret, Blandine de Lauzon-Guillain, Anne Forhan, Ken K. Ong, Marie Aline Charles, Barbara Heude
Jul 28, 2021
Abstract: Background: Early adiposity rebound (AR) has been associated with increased risk of overweight or obesity in adulthood. However, little is known about early predictors of age at AR. We aimed to study the role of...
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