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Results: 473
Cell cycle-coupled expansion of AR activity promotes cancer progression.
C McNair, A Urbanucci, CES Comstock, MA Augello, JF Goodwin, R Launchbury, SG Zhao, MJ Schiewer, A Ertel, J Karnes, E Davicioni, L Wang, Q Wang, IG Mills, FY Feng, W Li, JS Carroll, KE Knudsen
Apr 30, 2019
The androgen receptor (AR) is required for prostate cancer (PCa) survival and progression, and ablation of AR activity is the first line of therapeutic intervention for disseminated disease. While initially effective, recurrent...
Comparison of Light Field and Conventional Near-Eye AR Displays in Virtual-Real Integration Efficiency
Most existing wearable displays for augmented reality (AR) have only one fixed focal plane and hence can easily suffer from vergence-accommodation conflict (VAC). In contrast, light field displays allow users to focus at any...
Published by: IGI Global Scientific Publishing
Exploring the use of AR technology for co-creative product and packaging design
Gaetano Cascini, Jamie O'Hare, Elies Dekoninck, Niccolo Becattini, Jean François Boujut, Fatma Ben Guefrache, Iacopo Carli, Giandomenico Caruso, Lorenzo Giunta, Federico Morosi
Dec 31, 2020
Extended Reality technologies, including Virtual Reality (VR) and Augmented Reality (AR), are being applied in a wide variety of industrial applications, but their use within design practice remains very limited, despite some...
Co-Creation co-design Design representation Prototype Spatial augmented reality /dk/atira/pure/subjectarea/asjc/1700/1700 name=General Computer Science /dk/atira/pure/subjectarea/asjc/2200/2200 name=General Engineering /dk/atira/pure/sustainabledevelopmentgoals/industry_innovation_and_infrastructure name=SDG 9 - Industry, Innovation, and Infrastructure
Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer.
Meixia Che, Aashi Chaturvedi, Sarah A Munro, Samuel P Pitzen, Alex Ling, Weijie Zhang, Josh Mentzer, Sheng-Yu Ku, Loredana Puca, Yanyun Zhu, Andries M Bergman, Tesa M Severson, Colleen Forster, Yuzhen Liu, Jacob Hildebrand, Mark Daniel, Ting-You Wang, Luke A Selth, Theresa Hickey, Amina Zoubeidi, Martin Gleave, Rohan Bareja, Andrea Sboner, Wayne Tilley, Jason S Carroll, Winston Tan, Manish Kohli, Rendong Yang, Andrew C Hsieh, Paari Murugan, Wilbert Zwart, Himisha Beltran, R Stephanie Huang, Scott M Dehm
Jan 06, 2022
Endocrine therapies for prostate cancer inhibit the androgen receptor (AR) transcription factor. In most cases, AR activity resumes during therapy and drives progression to castration-resistant prostate cancer (CRPC). However...
Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer.
Meixia Che, Aashi Chaturvedi, Sarah A Munro, Samuel P Pitzen, Alex Ling, Weijie Zhang, Josh Mentzer, Sheng-Yu Ku, Loredana Puca, Yanyun Zhu, Andries M Bergman, Tesa M Severson, Colleen Forster, Yuzhen Liu, Jacob Hildebrand, Mark Daniel, Ting-You Wang, Luke A Selth, Theresa Hickey, Amina Zoubeidi, Martin Gleave, Rohan Bareja, Andrea Sboner, Wayne Tilley, Jason Carroll, Winston Tan, Manish Kohli, Rendong Yang, Andrew C Hsieh, Paari Murugan, Wilbert Zwart, Himisha Beltran, R Stephanie Huang, Scott M Dehm
Nov 04, 2021
Endocrine therapies for prostate cancer inhibit the androgen receptor (AR) transcription factor. In most cases, AR activity resumes during therapy and drives progression to castration-resistant prostate cancer (CRPC). However...
Exploring the use of AR technology for co-creative product and packaging design
Gaetano Cascini, Jamie O'Hare, Elies Dekoninck, Niccolo Becattini, Jean François Boujut, Fatma Ben Guefrache, Iacopo Carli, Giandomenico Caruso, Lorenzo Giunta, Federico Morosi
Dec 31, 2020
Extended Reality technologies, including Virtual Reality (VR) and Augmented Reality (AR), are being applied in a wide variety of industrial applications, but their use within design practice remains very limited, despite some...
Co-Creation co-design Design representation Prototype Spatial augmented reality /dk/atira/pure/subjectarea/asjc/1700/1700 name=General Computer Science /dk/atira/pure/subjectarea/asjc/2200/2200 name=General Engineering /dk/atira/pure/sustainabledevelopmentgoals/industry_innovation_and_infrastructure name=SDG 9 - Industry, Innovation, and Infrastructure
Exploring Enhancement of AR-HUD Visual Interaction Design Through Application of Intelligent Algorithms
This study aims to optimize the visual interaction design of AR-HUD and reduce cognitive load in complex driving situations. An immersive driving simulation incorporating eye-tracking technology was utilized to analyze objective...
Published by: IGI Global Scientific Publishing
Integration and Application of AR Technology in Augmented Reality Image Animation Within the Context of Lingnan Culture
With the maturity of AR technology, AR is more and more used in various industries. from the perspective of the application of AR technology at this stage, the emergence of AR technology improves the visual effect in image...
Published by: IGI Global Scientific Publishing
Blended English Teaching Model in Higher Education School Environment AR Constructive Technology
China's education modernization requirements clearly suggest exploring new teaching methods to improve teaching effectiveness. Based on this, this article investigates AR construction technology as a blended English teaching...
Published by: IGI Global Scientific Publishing
Saying "No" to (the) Oxygen Capital? Amenity Migration, Counter-territorialization, and Uneven Rural Landscape Change in the Kaz Da?lar? (Ida Mountains) of Western Turkey
Diverse forms of conservation and development are transforming the material landscapes and related livelihoods of communities in rural places around the world. While many studies focus on changing protected area governance and...
amenity migration exurban political ecology reterritorialization counter-territorialization Kaz Da?? National Park Turkey Environmental Studies Nature and Society Relations Sociology of Culture tourism urban studies Urban Studies and Planning
Published by: Ursinus College
Towards a Better Understanding of Drone Forensics
Unmanned aerial vehicles (drones) have gained increased popularity as their innovative uses continue to expand across various fields. Despite their numerous beneficial uses, drones have unfortunately been misused, through many...
Published by: IGI Global Scientific Publishing
Novel Androgen Receptor Coregulator GRHL2 Exerts Both Oncogenic and Antimetastatic Functions in Prostate Cancer.
Steve Paltoglou, Rajdeep Das, Scott L Townley, Theresa E Hickey, Gerard A Tarulli, Isabel Coutinho, Rayzel Fernandes, Adrienne R Hanson, Iza Denis, Jason S Carroll, Scott M Dehm, Ganesh V Raj, Stephen R Plymate, Wayne D Tilley, Luke A Selth
Jul 12, 2019
Alteration to the expression and activity of androgen receptor (AR) coregulators in prostate cancer is an important mechanism driving disease progression and therapy resistance. Using a novel proteomic technique, we identified a...
A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer.
Anne Y Warren, Charlie E Massie, Kate Watt, Katarina Luko, Folake Orafidiya, Luke A Selth, Hisham Mohammed, Brinder S Chohan, Suraj Menon, Ajoeb Baridi, Wanfeng Zhao, Carles Escriu, Thanakorn Pungsrinont, Clive D'Santos, Xiaoping Yang, Chris Taylor, Arham Qureshi, Vincent R Zecchini, Greg L Shaw, Scott M Dehm, Ian G Mills, Jason S Carroll, Wayne D Tilley, Iain J McEwan, Aria Baniahmad, David E Neal, Mohammad Asim
Nov 16, 2018
Elucidation of mechanisms underlying the increased androgen receptor (AR) activity and subsequent development of aggressive prostate cancer (PrCa) is pivotal in developing new therapies. Using a systems biology approach, we...
Current status of androgen receptor-splice variant 7 inhibitor niclosamide in castrate-resistant prostate-cancer
Navid Sobhani, Daniele Generali, Alberto D'Angelo, Michele Aieta, Giandomenico Roviello
Dec 31, 2018
Castrate-Resistant Prostate-Cancer (CRPC) is one of the most common malignancies occurring in men. Unfortunately, even if several recently approved agents clinically improved the outcome of CRPC patients, none of these is...
Emergence of the London Millennium Bridge instability without synchronisation
Igor Belykh, Mateusz Bocian, Alan R. Champneys, Kevin Daley, Russell Jeter, John H. G. Macdonald, Allan McRobie
Jan 04, 2022
Abstract: The pedestrian-induced instability of the London Millennium Bridge is a widely used example of Kuramoto synchronisation. Yet, reviewing observational, experimental, and modelling evidence, we argue that increased...
Catastrophic sliding bifurcations and onset of oscillations in a superconducting resonator
This paper presents a general analysis and a concrete example of the catastrophic case of a discontinuity-induced bifurcation in so-called Filippov nonsmooth dynamical systems. Such systems are characterized by discontinuous...
Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer.
RAC 3, one of the p160 family of co-activators is known to enhance the transcriptional activity of a number of steroid receptors. As co-activators are also known to enhance androgen receptor (AR) activity, we investigated the...
Adenocarcinoma Aged Aged 80 and over Androgens Biomarkers Tumor Disease Progression Epithelial Cells Gene Expression Regulation Neoplastic Humans In Situ Hybridization Male Middle Aged Neoplasm Proteins Neoplasm Staging Neoplasms Hormone-Dependent Nuclear Receptor Coactivator 3 Prostate-specific antigen Prostatic Hyperplasia Prostatic Neoplasms RNA Messenger RNA Neoplasm Receptors Androgen Trans-Activators Transcription Factors Transcription Genetic Transfection Tumor Cells Cultured
Association between perinatal factors, genetic susceptibility to obesity and age at adiposity rebound in children of the EDEN mother–child cohort
Aminata Hallimat Cissé, Sandrine Lioret, Blandine de Lauzon-Guillain, Anne Forhan, Ken K. Ong, Marie Aline Charles, Barbara Heude
Jul 28, 2021
Abstract: Background: Early adiposity rebound (AR) has been associated with increased risk of overweight or obesity in adulthood. However, little is known about early predictors of age at AR. We aimed to study the role of...
Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotype.
JLL Robinson, TE Hickey, AY Warren, SL Vowler, T Carroll, AD Lamb, N Papoutsoglou, DE Neal, WD Tilley, JS Carroll
May 02, 2019
Castration-resistant prostate cancer (CRPC) continues to pose a significant clinical challenge with new generation second-line hormonal therapies affording limited improvement in disease outcome. As the androgen receptor (AR)...
Emergence of the London Millennium Bridge instability without synchronisation.
Igor Belykh, Mateusz Bocian, Alan R Champneys, Kevin Daley, Russell Jeter, John HG Macdonald, Allan McRobie
Jan 04, 2022
The pedestrian-induced instability of the London Millennium Bridge is a widely used example of Kuramoto synchronisation. Yet, reviewing observational, experimental, and modelling evidence, we argue that increased coherence of...
Reimagining the Audience-Dancer Relationship Through Mobile Augmented Reality
The research and development of an augmented reality (AR) application for Vancouver-based dance company Small Stage challenged a team of students at a graduate digital media program to understand how AR might reinvent the...
Published by: IGI Global Scientific Publishing
Effects of Volumetric Augmented Reality Displays on Human Depth Judgments
Many driving scenarios involve correctly perceiving road elements in depth and manually responding as appropriate. Of late, augmented reality (AR) head-up displays (HUDs) have been explored to assist drivers in identifying road...
Published by: IGI Global Scientific Publishing
Catastrophic sliding bifurcations and onset of oscillations in a superconducting resonator
This paper presents a general analysis and a concrete example of the catastrophic case of a discontinuity-induced bifurcation in so-called Filippov nonsmooth dynamical systems. Such systems are characterized by discontinuous...
FOXA1 mutations in hormone-dependent cancers.
The forkhead protein, FOXA1, is a critical interacting partner of the nuclear hormone receptors, oestrogen receptor-α (ER) and androgen receptor (AR), which are major drivers of the two most common cancers, namely breast and...
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