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![Cover Image for [18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases.](https://coverimages.igi-global.com/images/search-article.png)
[18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases.
Elijah Mak, Antonina Kouli, Negin Holland, Nicolas Nicastro, George Savulich, Ajenthan Surendranathan, Maura Malpetti, Roido Manavaki, Young T Hong, Tim D Fryer, Franklin Aigbirhio, James B Rowe, John T O'Brien, Caroline H Williams-Gray
Sep 05, 2021
While [18F]-AV-1451 was developed as a PET radiotracer with high affinity for hyperphosphorylated tau, it has been proposed that loss of 'off-target' [18F]-AV-1451 binding to neuromelanin in the substantia nigra could be a...
[18F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion.
Richard W Bevan-Jones, Thomas E Cope, Simon P Jones, Luca Passamonti, Young T Hong, Tim Fryer, Robert Arnold, Jonathan P Coles, Franklin A Aigbirhio, Karalyn Patterson, John T O'Brien, James B Rowe
Nov 29, 2018
The PET ligand [18F]AV-1451 was developed to bind tau pathology in Alzheimer's disease, but increased binding has been shown in both genetic tauopathies and in semantic dementia, a disease strongly associated with TDP-43...
Rare Diseases Brain Disorders Dementia Acquired Cognitive Impairment aging Neurodegenerative Neurosciences Alzheimer's Disease Alzheimer's Disease Related Dementias (ADRD) Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) frontotemporal dementia (FTD) 2 Aetiology 2.1 Biological and endogenous factors Neurological
Monolayer Kagome metals AV<sub>3</sub>Sb<sub>5</sub>.
Recently, layered kagome metals AV3Sb5 (A = K, Rb, and Cs) have emerged as a fertile platform for exploring frustrated geometry, correlations, and topology. Here, using first-principles and mean-field...
Published by: Nature Communications
Stickler syndrome - lessons from a national cohort.
MP Snead, AJ Richards, AM McNinch, P Alexander, H Martin, TRW Nixon, P Bale, N Shenker, S Brown, AM Blackwell, AV Poulson
Nov 25, 2021
In 2011 NHS England commissioned a new national specialist MDT service for patients and families affected by Stickler syndrome. The Stickler syndromes form part of the spectrum of inherited vitreoretinopathies and are the most...
Systematic biases in determining dust attenuation curves through galaxy SED fitting
Jianbo Qin, Xian Zhong Zheng, Min Fang, Zhizheng Pan, Stijn Wuyts, Yong Shi, Yingjie Peng, Valentino Gonzalez, Fuyan Bian, Jia-Sheng Huang, Qiu-sheng Gu, Wenhao Liu, Qinghua Tan, Dong Dong Shi, Jian Ren, Yuheng Zhang, Man Qiao, Run Wen, Shuang Liu
Mar 31, 2022
While the slope of the dust attenuation curve (δ) is found to correlate with effective dust attenuation (AV) as obtained through spectral energy distribution (SED) fitting, it remains unknown how the fitting degeneracies shape...
Stickler syndrome - lessons from a national cohort.
MP Snead, AJ Richards, AM McNinch, P Alexander, H Martin, TRW Nixon, P Bale, N Shenker, S Brown, AM Blackwell, AV Poulson
Sep 23, 2022
In 2011 NHS England commissioned a new national specialist MDT service for patients and families affected by Stickler syndrome. The Stickler syndromes form part of the spectrum of inherited vitreoretinopathies and are the most...
Systematic biases in determining dust attenuation curves through galaxy SED fitting
Jianbo Qin, Xian Zhong Zheng, Min Fang, Zhizheng Pan, Stijn Wuyts, Yong Shi, Yingjie Peng, Valentino Gonzalez, Fuyan Bian, Jia-Sheng Huang, Qiu-sheng Gu, Wenhao Liu, Qinghua Tan, Dong Dong Shi, Jian Ren, Yuheng Zhang, Man Qiao, Run Wen, Shuang Liu
Mar 31, 2022
While the slope of the dust attenuation curve (δ) is found to correlate with effective dust attenuation (AV) as obtained through spectral energy distribution (SED) fitting, it remains unknown how the fitting degeneracies shape...
Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.
W Richard Bevan-Jones, Thomas E Cope, P Simon Jones, Sanne S Kaalund, Luca Passamonti, Kieren Allinson, Oliver Green, Young T Hong, Tim D Fryer, Robert Arnold, Jonathan P Coles, Franklin I Aigbirhio, Andrew J Larner, Karalyn Patterson, John T O'Brien, James B Rowe
Apr 17, 2020
The clinical syndromes of frontotemporal dementia are clinically and neuropathologically heterogeneous, but processes such as neuroinflammation may be common across the disease spectrum. We investigated how neuroinflammation...
Published by: Brain : a journal of neurology
Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia.
Edward A Hayter, Sophie MT Wehrens, Hans PA Van Dongen, Alessandra Stangherlin, Shobhan Gaddameedhi, Elena Crooks, Nichola J Barron, Luigi A Venetucci, John S O'Neill, Timothy M Brown, Debra J Skene, Andrew W Trafford, David A Bechtold
Jun 18, 2021
Electrical activity in the heart exhibits 24-hour rhythmicity, and potentially fatal arrhythmias are more likely to occur at specific times of day. Here, we demonstrate that circadian clocks within the brain and heart set daily...
Auditory dysfunction in type 2 Stickler Syndrome
Philip Alexander, Philip Gomersall, Jack Stancel-Lewis, Gregory Scott Fincham, Arabella Poulson, Allan Richards, Annie McNinch, David M. Baguley, Martin Snead
Sep 08, 2021
How unusual is the United Kingdom Coalition (and what are the chances of it happening again)?
Charles Lees
Jan 01, 0001
This article draws upon insights from theoretical and empirical studies of coalition behaviour in multiparty politics to examine the formation of the United Kingdom coalition following the general election of 6 May 2010. It...
The grammaticalization of epistemicity in Ibero-Romance
AV Corr
Aug 16, 2017
Typologically-unexpected overt expletives can be found in a restricted number of non-standard Ibero-Romance null-subject varieties. Historical data suggest that these overt expletives, which in today’s varieties show both...
Theory of radiation trapping by the accelerating solitons in optical fibers
We present a theory describing trapping of the normally dispersive radiation by the Raman solitons in optical fibers. Frequency of the radiation component is continuously blueshifting, while the soliton is redshifting....
Theory of radiation trapping by the accelerating solitons in optical fibers
We present a theory describing trapping of the normally dispersive radiation by the Raman solitons in optical fibers. Frequency of the radiation component is continuously blueshifting, while the soliton is redshifting....
How unusual is the United Kingdom Coalition (and what are the chances of it happening again)?
Charles Lees
Jan 01, 0001
This article draws upon insights from theoretical and empirical studies of coalition behaviour in multiparty politics to examine the formation of the United Kingdom coalition following the general election of 6 May 2010. It...
How to sabotage a secret society. The demise of Carl Friedrich Bahrdt’s German union in 1789
AV McKenzie-McHarg
Mar 17, 2017
In 1789 in Leipzig a slim pamphlet of 128 pages appeared that sent shock waves through the German republic of letters. The pamphlet, bearing the title Mehr Noten als Text (More Notes than Text), was an ‘exposure’ whose most...
Reverse Traceability Framework for Identifying Liability of Crashes for Self-Driving Vehicles Using Blockchains
Modern vehicles are increasingly having a higher level of technology and automation. Humans are increasingly becoming dependent on these modern technologies to take decisions related to their lives and safety. Such an increasing...
Published by: IGI Global Scientific Publishing
11C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies.
Nicolas Nicastro, Negin Holland, George Savulich, Stephen F Carter, Elijah Mak, Young T Hong, Selena Milicevic Sephton, Tim D Fryer, Franklin I Aigbirhio, James B Rowe, John T O'Brien
Nov 10, 2020
OBJECTIVE: Dementia with Lewy bodies (DLB) is a common cause of dementia, but atrophy is mild compared to Alzheimer's disease. We propose that DLB is associated instead with severe synaptic loss, and we test this hypothesis in...
Auditory dysfunction in type 2 Stickler Syndrome
Philip Alexander, Philip Gomersall, Jack Stancel-Lewis, Gregory Scott Fincham, Arabella Poulson, Allan Richards, Annie McNinch, David M. Baguley, Martin Snead
May 30, 2021
Therapeutic and diagnostic advances in Stickler syndrome
The Stickler syndromes are the leading cause of inherited retinal detachment and the most common cause of rhegmatogenous retinal detachment in childhood. The clinical and molecular genetic spectrum of this connective...
Martin Snead, Howard Martin, Peter Bale, Nick Shenker, David Baguley, Philip Alexander, Annie McNinch, Arabella Poulson
Dec 10, 2020
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