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Translational arrest due to cytoplasmic redox stress delays adaptation to growth on methanol and heterologous protein expression in a typical fed-batch culture of <i>Pichia pastoris</i>

Results: We have followed a typical fed-batch induction regime for heterologous protein production under the control of the AOX1 promoter using bothmicroarray and metabolomic analysis. The genetic constructs involved 1 and 3...

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High water vs. ad libitum water intake for autosomal dominant polycystic kidney disease
BACKGROUND: Vasopressin stimulates cyst growth in autosomal dominant polycystic kidney disease (ADPKD) and is a key therapeutic target. Evaluation of high water intake as an alternative to pharmacological vasopressin blockade is...
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Why does using personal strengths at work increase employee engagement; who makes the most out of it; and how?

Engaging in behaviors that take advantage of one's personal strengths at work can promote employee flourishing in the workplace and mental health. Personal strengths use has thus gained increasing attention within...

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Poetics Contra Psychoanalysis
AW Freer
May 18, 2017
This essay argues that psychoanalytic literary criticism has largely failed because it has assumed that literature and psychoanalysis share common analytical ground. I contend that psychoanalytic approaches necessarily deform...
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Shelley’s Vestimentary Poetics
AW Freer
May 19, 2017
The figures of veils in Shelley’s poetics have long been understood as an inconsistent and potentially confused contribution to a debate between representational and expressive accounts of language. However, Shelley’s veils are...
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Why does using personal strengths at work increase employee engagement; who makes the most out of it; and how?

Engaging in behaviors that take advantage of one's personal strengths at work can promote employee flourishing in the workplace and mental health. Personal strengths use has thus gained increasing attention within...

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BedMachine v3
Greenland's bed topography is a primary control on ice flow, grounding line migration, calving dynamics, and subglacial drainage. Moreover, fjord bathymetry regulates the penetration of warm Atlantic water (AW) that rapidly...
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Translational arrest due to cytoplasmic redox stress delays adaptation to growth on methanol and heterologous protein expression in a typical fed-batch culture of <i>Pichia pastoris</i>

Results: We have followed a typical fed-batch induction regime for heterologous protein production under the control of the AOX1 promoter using bothmicroarray and metabolomic analysis. The genetic constructs involved 1 and 3...

Published by:
Single-molecule analysis of genome rearrangements in cancer.
Rearrangements of the genome can be detected by microarray methods and massively parallel sequencing, which identify copy-number alterations and breakpoint junctions, but these techniques are poorly suited to reconstructing the...
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Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
MT Harper, AW Poole
May 28, 2020
Platelets enhance thrombin generation at sites of vascular injury by exposing phosphatidylserine during necrosis-like cell death. Anoctamin 6 (Ano6) is required for Ca(2+)-dependent phosphatidylserine exposure and is defective...
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Turning shame into creativity
H González, AW Richter
Sep 17, 2014
We draw on the functionalist perspective of emotions (Keltner & Gross, 1999) in order to propose that ashamed employees engage in creative activity as a way to restore their positive self-image. We also propose that the...
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On the Dynamics of Starting Plumes
N Bhamidipati, AW Woods
Feb 27, 2018
We explore the dynamics of starting plumes by analysis of a series of new small-scale laboratory experiments combined with a theoretical model for mass, momentum, and buoyancy conservation. We find that the head of the plume...
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