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Results: 8
Connecting gene expression data from connectivity map and in silico target predictions for small molecule mechanism-of-action analysis.
Aakash Chavan Ravindranath, Nolen Perualila-Tan, Adetayo Kasim, Georgios Drakakis, Sonia Liggi, Suzanne C Brewerton, Daniel Mason, Michael J Bodkin, David A Evans, Aditya Bhagwat, Willem Talloen, Hinrich WH Göhlmann, Ziv Shkedy, Andreas Bender, QSTAR Consortium
Apr 14, 2015
Cryo-EM Structure of the Rhodobacter sphaeroides Light-Harvesting 2 Complex at 2.1 Å
Pu Qian, David JK Swainsbury, Tristan I Croll, Pablo Castro-Hartmann, Giorgio Divitini, Kasim Sader, C Neil Hunter
Oct 29, 2021
Light-harvesting 2 (LH2) antenna complexes augment the collection of solar energy in many phototrophic bacteria. Despite its frequent role as a model for such complexes, there has been no three-dimensional (3D) structure...
Cryo-EM structure of the Rhodospirillum rubrum RC-LH1 complex at 2.5 Å.
Pu Qian, Tristan I Croll, David JK Swainsbury, Pablo Castro-Hartmann, Nigel W Moriarty, Kasim Sader, C Neil Hunter
Nov 10, 2021
The reaction centre light-harvesting 1 (RC-LH1) complex is the core functional component of bacterial photosynthesis. We determined the cryo-electron microscopy (cryo-EM) structure of the RC-LH1 complex from Rhodospirillum...
Carotenoids cryo-electron microscopy light-harvesting Photosynthesis Quinone reaction centre Bacterial Proteins Bacteriochlorophylls Benzoquinones Binding Sites Cryoelectron Microscopy Crystallization Electron Transport Complex III Hydrogen Bonding Hydroquinones Ligands Light-Harvesting Protein Complexes Phospholipids Protein Conformation alpha-Helical Rhodospirillum rubrum
Cryo-EM structures of light-harvesting 2 complexes from Rhodopseudomonas palustris reveal the molecular origin of absorption tuning.
Pu Qian, Cam T Nguyen-Phan, Alastair T Gardiner, Tristan I Croll, Aleksander W Roszak, June Southall, Philip J Jackson, Cvetelin Vasilev, Pablo Castro-Hartmann, Kasim Sader, C Neil Hunter, Richard J Cogdell
Nov 17, 2022
Light Responsiveness and Assembly of Arylazopyrazole-Based Surfactants in Neat and Mixed CTAB Micelles.
Gunjan Tyagi, Jake L Greenfield, Beatrice E Jones, William N Sharratt, Kasim Khan, Dale Seddon, Lorna A Malone, Nathan Cowieson, Rachel C Evans, Matthew J Fuchter, João T Cabral
Feb 01, 2023
The self-assembly of an arylazopyrazole-based photosurfactant (PS), based on cetyltrimethylammonium bromide (CTAB), and its mixed micelle formation with CTAB in aqueous solution was investigated by small angle neutron and X-ray...
Polymeric nanobiotics as a novel treatment for mycobacterial infections.
Iris L Batalha, Audrey Bernut, Mark Schiebler, Myriam M Ouberai, Charlotte Passemar, Catherine Klapholz, Sonja Kinna, Sarah Michel, Kasim Sader, Pablo Castro-Hartmann, Stephen A Renshaw, Mark E Welland, R Andres Floto
Oct 28, 2019
antibiotic clofazimine Isoniazid Mycobacterium tuberculosis Nanoparticles Polymer-drug conjugate Zebrafish Animals Antitubercular Agents clofazimine Delayed-Action Preparations Disease Models Animal Drug Combinations Drug Delivery Systems Humans Isoniazid MACROPHAGES Mycobacterium tuberculosis Nanoparticles Polymers Tuberculosis Zebrafish
2.4-Å structure of the double-ring Gemmatimonas phototrophica photosystem.
Pu Qian, Alastair T Gardiner, Ivana Šímová, Katerina Naydenova, Tristan I Croll, Philip J Jackson, Nupur, Miroslav Kloz, Petra Čubáková, Marek Kuzma, Yonghui Zeng, Pablo Castro-Hartmann, Bart van Knippenberg, Kenneth N Goldie, David Kaftan, Pavel Hrouzek, Jan Hájek, Jon Agirre, C Alistair Siebert, David Bína, Kasim Sader, Henning Stahlberg, Roman Sobotka, Christopher J Russo, Tomáš Polívka, C Neil Hunter, Michal Koblížek
Mar 19, 2022
Phototrophic Gemmatimonadetes evolved the ability to use solar energy following horizontal transfer of photosynthesis-related genes from an ancient phototrophic proteobacterium. The electron cryo-microscopy structure of the...
Stepwise pathogenic evolution of Mycobacterium abscessus.
Josephine M Bryant, Karen P Brown, Sophie Burbaud, Isobel Everall, Juan M Belardinelli, Daniela Rodriguez-Rincon, Dorothy M Grogono, Chelsea M Peterson, Deepshikha Verma, Ieuan E Evans, Christopher Ruis, Aaron Weimann, Divya Arora, Sony Malhotra, Bridget Bannerman, Charlotte Passemar, Kerra Templeton, Gordon MacGregor, Kasim Jiwa, Andrew J Fisher, Tom L Blundell, Diane J Ordway, Mary Jackson, Julian Parkhill, R Andres Floto
May 05, 2021
Although almost all mycobacterial species are saprophytic environmental organisms, a few, such as Mycobacterium tuberculosis, have evolved to cause transmissible human infection. By analyzing the recent emergence and spread of...