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Francis Bacon, the Advocate of Science
Lord Adrian
Jan 01, 0001
Lord Adrian, Master of Trinity College, Cambridge and Visiting Professor in The Rockefeller Institute, presented this lecture at the Institute on April 19, 1961, in honor of the four hundredth anniversary of the birth of Sir...
Published by: The Rockefeller Institute Press
Designs for adding a treatment arm to an ongoing clinical trial.
BACKGROUND:For many disease areas, there are often treatments in different stages of the development process. We consider the design of a two-arm parallel group trial where it is planned to add a new experimental treatment arm...
Optimal allocation multiple testing adaptive design Adding A Treatment Arm Family-wise Error Rate Control
Published by: Trials
Re-formulating Gehan's design as a flexible two-stage single-arm trial.
BACKGROUND: Gehan's two-stage design was historically the design of choice for phase II oncology trials. One of the reasons it is less frequently used today is that it does not allow for a formal test of treatment efficacy, and...
Sample size re-estimation in crossover trials
Abstract: Background: Crossover designs are commonly utilised in randomised controlled trials investigating treatments for long-term chronic illnesses. One problem with this design is its inherent repeated measures necessitate...
A product of independent beta probabilities dose escalation design for dual-agent phase I trials.
adaptive design dose escalation dual-agent trial nonparametric phase I clinical trial Antineoplastic Combined Chemotherapy Protocols Clinical Trials Phase I as Topic Computer Simulation Dose-Response Relationship Drug Humans Logistic Models Maximum Tolerated Dose Research Design statistics Nonparametric
Stepped wedge cluster randomized controlled trial designs
Abstract
Background
The stepped wedge (SW) cluster randomized controlled trial (CRCT) design is being used with increasing frequency. However, there is limited published research on...
Group sequential designs for stepped-wedge cluster randomised trials.
BACKGROUND/AIMS: The stepped-wedge cluster randomised trial design has received substantial attention in recent years. Although various extensions to the original design have been proposed, no guidance is available on the design...
Sample size re-estimation in crossover trials
BACKGROUND:Crossover designs are commonly utilised in randomised controlled trials investigating treatments for long-term chronic illnesses. One problem with this design is its inherent repeated measures necessitate the...
Admissible multiarm stepped-wedge cluster randomized trial designs.
Numerous publications have now addressed the principles of designing, analyzing, and reporting the results of stepped-wedge cluster randomized trials. In contrast, there is little research available pertaining to the design and...
An optimised multi-arm multi-stage clinical trial design for unknown variance.
Multi-arm multi-stage trial designs can bring notable gains in efficiency to the drug development process. However, for normally distributed endpoints, the determination of a design typically depends on the assumption that the...
Blinded and unblinded sample size reestimation in crossover trials balanced for period.
The determination of the sample size required by a crossover trial typically depends on the specification of one or more variance components. Uncertainty about the value of these parameters at the design stage means that there...
Group sequential crossover trial designs with strong control of the familywise error rate.
Crossover designs are an extremely useful tool to investigators, and group sequential methods have proven highly proficient at improving the efficiency of parallel group trials. Yet, group sequential methods and crossover...
Modelling semi-attributable toxicity in dual-agent phase I trials with non-concurrent drug administration.
Bayesian methods adaptive designs dose-toxicity modelling Drug Combinations phase I trials Algorithms Antineoplastic Agents Antineoplastic Combined Chemotherapy Protocols Biostatistics Clinical Trials Phase I as Topic Cohort Studies Computer Simulation Dose-Response Relationship Drug Drug Administration Schedule Humans Interatrial Block Models Statistical Neoplasms
Associate Professor, P-12 Colleagues Nab S.C. Association of Teacher Educators Awards
Winthrop University
Jan 01, 0001
Sue Spencer won the Exemplary Service to the Teaching Profession Award from the South Carolina Association of Teacher Educators. Local teachers Jennifer Gaston and Adrian Deese won the Cooperating Teacher of the Year Awards.
Published by: Winthrop University
Model selection and sample size adaptation
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display...
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