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Results: 281
Targeting integrin αvβ6 with gallium-68 tris (hydroxypyridinone) based PET probes
Giuseppe Floresta, Siham Memdouh, Truc Pham, Michelle T Ma, Philip J Blower, Robert C Hider, Vincenzo Abbate, Agostino Cilibrizzi
Aug 30, 2022
Expression of the cellular transmembrane receptor αvβ6 integrin is mostly restricted to malignant epithelial cells in a wide variety of carcinomas, including pancreatic and others derived from epithelial tissues. Thus, this...
Socioeconomic determinants of leprosy new case detection in the 100 Million Brazilian Cohort
Joilda Silva Nery, Anna Ramond, Julia Moreira Pescarini, André Alves, Agostino Strina, Maria Yury Ichihara, Maria Lucia Fernandes Penna, Liam Smeeth, Laura C Rodrigues, Mauricio L Barreto, Elizabeth B Brickley, Gerson Oliveira Penna
Sep 18, 2019
BACKGROUND: Although leprosy is recognised as a disease of poverty, there is little evidence on the specific socioeconomic factors associated with disease risk. To inform targeted strategies for disease elimination, we...
Targeting integrin αvβ6 with gallium-68 tris (hydroxypyridinone) based PET probes
Giuseppe Floresta, Siham Memdouh, Truc Pham, Michelle T Ma, Philip J Blower, Robert C Hider, Vincenzo Abbate, Agostino Cilibrizzi
Aug 30, 2022
Expression of the cellular transmembrane receptor αvβ6 integrin is mostly restricted to malignant epithelial cells in a wide variety of carcinomas, including pancreatic and others derived from epithelial tissues. Thus, this...
Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand-based drug design.
Joana Magalhães, Nina Franko, Giannamaria Annunziato, Martin Welch, Stephen K Dolan, Agostino Bruno, Andrea Mozzarelli, Stefano Armao, Aigars Jirgensons, Marco Pieroni, Gabriele Costantino, Barbara Campanini
Jan 08, 2019
Several bacteria rely on the reductive sulphur assimilation pathway, absent in mammals, to synthesise cysteine. Reduction of virulence and decrease in antibiotic resistance have already been associated with mutations on the...
O-acetylserine sulphhydrylase Scaffold hopping fragments ligand-based drug design medicinal chemistry Pyrazoles Anti-Bacterial Agents Bacteria Binding Sites Biological Assay Computer Simulation Cysteine Synthase DNA Recombinant Drug Design Ligands Models Molecular Small Molecule Libraries Structure-Activity Relationship
Uneven state distribution of homicides in Brazil and their effect on life expectancy, 2000-2015
José Manuel Aburto, Julia Calazans, Bernardo Lanza Queiroz, Shammi Luhar, Vladimir Canudas-Romo
Feb 17, 2021
OBJECTIVE: To determine cause-specific and age-specific contributions to life expectancy changes between 2000 and 2015, separately by state and sex in Brazil, with a focus on homicides. DESIGN: Retrospective cross-sectional...
The oxygen reduction reaction on palladium with low metal loadings
Guilherme V. Fortunato, Enrico Pizzutilo, Eduardo S.F. Cardoso, Marcos R.V. Lanza, Ioannis Katsounaros, Simon J. Freakley, Karl J.J. Mayrhofer, Gilberto Maia, Marc Ledendecker
Sep 01, 2020
Hydrogen peroxide is considered one of the most important commodity chemicals worldwide but its main production method, the anthraquinone process, poses serious logistical, environmental and safety challenges....
The oxygen reduction reaction on palladium with low metal loadings
Guilherme V. Fortunato, Enrico Pizzutilo, Eduardo S.F. Cardoso, Marcos R.V. Lanza, Ioannis Katsounaros, Simon J. Freakley, Karl J.J. Mayrhofer, Gilberto Maia, Marc Ledendecker
Sep 01, 2020
Hydrogen peroxide is considered one of the most important commodity chemicals worldwide but its main production method, the anthraquinone process, poses serious logistical, environmental and safety challenges....
RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways.
Victoria Gudiño, Sebastian Öther-Gee Pohl, Caroline V Billard, Patrizia Cammareri, Alfonso Bolado, Stuart Aitken, David Stevenson, Adam E Hall, Mark Agostino, John Cassidy, Colin Nixon, Alex Von Kriegsheim, Paz Freile, Linda Popplewell, George Dickson, Laura Murphy, Ann Wheeler, Malcolm Dunlop, Farhat Din, Douglas Strathdee, Owen J Sansom, Kevin B Myant
Apr 20, 2021
Current therapeutic options for treating colorectal cancer have little clinical efficacy and acquired resistance during treatment is common, even following patient stratification. Understanding the mechanisms that promote...
Animals Antineoplastic Agents Immunological Carcinogenesis Cell Line Tumor cetuximab Colorectal Neoplasms Drug Resistance Neoplasm ErbB Receptors Female Gene Expression Regulation Neoplastic Humans Male Mice Mice Inbred C57BL Mice Knockout Neuropeptides Signal Transduction Up-Regulation Wnt Signaling Pathway rac1 GTP-Binding Protein
Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era.
Anna K Pöntinen, Janetta Top, Sergio Arredondo-Alonso, Gerry Tonkin-Hill, Ana R Freitas, Carla Novais, Rebecca A Gladstone, Maiju Pesonen, Rodrigo Meneses, Henri Pesonen, John A Lees, Dorota Jamrozy, Stephen D Bentley, Val F Lanza, Carmen Torres, Luisa Peixe, Teresa M Coque, Julian Parkhill, Anita C Schürch, Rob JL Willems, Jukka Corander
Apr 26, 2021
Enterococcus faecalis is a commensal and nosocomial pathogen, which is also ubiquitous in animals and insects, representing a classical generalist microorganism. Here, we study E. faecalis isolates ranging from the...
Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era
Anna K. Pöntinen, Janetta Top, Sergio Arredondo-Alonso, Gerry Tonkin-Hill, Ana R. Freitas, Carla Novais, Rebecca A. Gladstone, Maiju Pesonen, Rodrigo Meneses, Henri Pesonen, John A. Lees, Dorota Jamrozy, Stephen D. Bentley, Val F. Lanza, Carmen Torres, Luisa Peixe, Teresa M. Coque, Julian Parkhill, Anita C. Schürch, Rob J. L. Willems, Jukka Corander
Mar 09, 2021
The role of clinical and neuroimaging features in the diagnosis of CADASIL.
Anna Bersano, Gloria Bedini, Hugh Stephen Markus, Paolo Vitali, Enrico Colli-Tibaldi, Franco Taroni, Cinzia Gellera, Silvia Baratta, Lorena Mosca, Paola Carrera, Maurizio Ferrari, Cristina Cereda, Gaetano Grieco, Silvia Lanfranconi, Franca Mazucchelli, Davide Zarcone, Maria Luisa De Lodovici, Giorgio Bono, Giorgio Battista Boncoraglio, Eugenio Agostino Parati, Maria Vittoria Calloni, Patrizia Perrone, Bianca Maria Bordo, Cristina Motto, Elio Agostoni, Alessandro Pezzini, Alessandro Padovani, Giuseppe Micieli, Anna Cavallini, Graziella Molini, Francesco Sasanelli, Maria Sessa, Giancarlo Comi, Nicoletta Checcarelli, Massimo Carmerlingo, Manuel Corato, Simona Marcheselli, Laura Fusi, Giampiero Grampa, Davide Uccellini, Simone Beretta, Carlo Ferrarese, Barbara Incorvaia, Carlo Sebastiano Tadeo, Laura Adobbati, Vincenzo Silani, Giuseppe Faragò, Nadia Trobia, Caspar Grond-Ginsbach, Livia Candelise, Lombardia GENS-group
Mar 29, 2019
2022 roadmap on neuromorphic computing and engineering
Dennis V Christensen, Regina Dittmann, Bernabe Linares-Barranco, Abu Sebastian, Manuel Le Gallo, Andrea Redaelli, Stefan Slesazeck, Thomas Mikolajick, Sabina Spiga, Stephan Menzel, Ilia Valov, Gianluca Milano, Carlo Ricciardi, Shi-Jun Liang, Feng Miao, Mario Lanza, Tyler J Quill, Scott Keene, Alberto Salleo, Julie Grollier, Danijela Marković, Alice Mizrahi, Peng Yao, J Joshua Yang, Giacomo Indiveri, John Paul Strachan, Suman Datta, Elisa Vianello, Alexandre Valentian, Johannes Feldmann, Xuan Li, Wolfram HP Pernice, Harish Bhaskaran, Steve Furber, Emre Neftci, Franz Scherr, Wolfgang Maass, Srikanth Ramaswamy, Jonathan Tapson, Priyadarshini Panda, Youngeun Kim, Gouhei Tanaka, Simon Thorpe, Chiara Bartolozzi, Thomas A Cleland, Christoph Posch, ShihChii Liu, Gabriella Panuccio, Mufti Mahmud, Arnab Neelim Mazumder, Morteza Hosseini, Tinoosh Mohsenin, Elisa Donati, Silvia Tolu, Roberto Galeazzi, Martin Ejsing Christensen, Sune Holm, Daniele Ielmini, N Pryds
Jun 07, 2022
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity.
Emma C Thomson, Laura E Rosen, James G Shepherd, Roberto Spreafico, Ana da Silva Filipe, Jason A Wojcechowskyj, Chris Davis, Luca Piccoli, David J Pascall, Josh Dillen, Spyros Lytras, Nadine Czudnochowski, Rajiv Shah, Marcel Meury, Natasha Jesudason, Anna de Marco, Kathy Li, Jessica Bassi, Aine O'Toole, Dora Pinto, Rachel M Colquhoun, Katja Culap, Ben Jackson, Fabrizia Zatta, Andrew Rambaut, Stefano Jaconi, Vattipally B Sreenu, Jay Nix, Ivy Zhang, Ruth F Jarrett, William G Glass, Martina Beltramello, Kyriaki Nomikou, Matteo Pizzuto, Lily Tong, Elisabetta Cameroni, Tristan I Croll, Natasha Johnson, Julia Di Iulio, Arthur Wickenhagen, Alessandro Ceschi, Aoife M Harbison, Daniel Mair, Paolo Ferrari, Katherine Smollett, Federica Sallusto, Stephen Carmichael, Christian Garzoni, Jenna Nichols, Massimo Galli, Joseph Hughes, Agostino Riva, Antonia Ho, Marco Schiuma, Malcolm G Semple, Peter JM Openshaw, Elisa Fadda, J Kenneth Baillie, John D Chodera, ISARIC4C investigators, COVID-19 Genomics UK (COG-UK) Consortium, Suzannah J Rihn, Samantha J Lycett, Herbert W Virgin, Amalio Telenti, Davide Corti, David L Robertson, Gyorgy Snell
Feb 05, 2021
covid-19 N439K SARS-CoV-2 spike monoclonal antibody escape Mutation Protein Structure receptor binding motif variant Angiotensin-Converting Enzyme 2 Antibodies Neutralizing Antibodies Viral covid-19 Genetic Fitness Humans Immune Evasion Mutation Phylogeny SARS-CoV-2 Spike Glycoprotein Coronavirus Virulence
Determinants of diet and physical activity (DEDIPAC)
Johannes Brug, Hidde P van der Ploeg, Anne Loyen, Wolfgang Ahrens, Oliver Allais, Lene F Andersen, Greet Cardon, Laura Capranica, Sebastien Chastin, Ilse De Bourdeaudhuij, Marieke De Craemer, Alan Donnelly, Ulf Ekelund, Paul Finglas, Marion Flechtner-Mors, Antje Hebestreit, Thomas Kubiak, Massimo Lanza, Nanna Lien, Ciaran MacDonncha, Mario Mazzocchi, Pablo Monsivais, Marie Murphy, Mary Nicolaou, Ute Nöthlings, Donal J O'Gorman, Britta Renner, Gun Roos, Matthijs van den Berg, Matthias B Schulze, Jürgen M Steinacker, Karien Stronks, Dorothee Volkert, Jeroen Lakerveld, DEDIPAC consortium
Feb 13, 2018
The establishment of the Determinants of Diet and Physical Activity (DEDIPAC) Knowledge Hub, 2013–2016, was the first action taken by the ‘Healthy Diet for a Healthy Life’ European Joint Programming Initiative. DEDIPAC aimed to...
Human and mouse essentiality screens as a resource for disease gene discovery.
Pilar Cacheiro, Violeta Muñoz-Fuentes, Stephen A Murray, Mary E Dickinson, Maja Bucan, Lauryl MJ Nutter, Kevin A Peterson, Hamed Haselimashhadi, Ann M Flenniken, Hugh Morgan, Henrik Westerberg, Tomasz Konopka, Chih-Wei Hsu, Audrey Christiansen, Denise G Lanza, Arthur L Beaudet, Jason D Heaney, Helmut Fuchs, Valerie Gailus-Durner, Tania Sorg, Jan Prochazka, Vendula Novosadova, Christopher J Lelliott, Hannah Wardle-Jones, Sara Wells, Lydia Teboul, Heather Cater, Michelle Stewart, Tertius Hough, Wolfgang Wurst, Radislav Sedlacek, David J Adams, John R Seavitt, Glauco Tocchini-Valentini, Fabio Mammano, Robert E Braun, Colin McKerlie, Yann Herault, Martin Hrabě de Angelis, Ann-Marie Mallon, KC Kent Lloyd, Steve DM Brown, Helen Parkinson, Terrence F Meehan, Damian Smedley, Genomics England Research Consortium, International Mouse Phenotyping Consortium
Mar 02, 2020
The identification of causal variants in sequencing studies remains a considerable challenge that can be partially addressed by new gene-specific knowledge. Here, we integrate measures of how essential a gene is to supporting...
2022 roadmap on neuromorphic computing and engineering
Dennis V Christensen, Regina Dittmann, Bernabe Linares-Barranco, Abu Sebastian, Manuel Le Gallo, Andrea Redaelli, Stefan Slesazeck, Thomas Mikolajick, Sabina Spiga, Stephan Menzel, Ilia Valov, Gianluca Milano, Carlo Ricciardi, Shi-Jun Liang, Feng Miao, Mario Lanza, Tyler J Quill, Scott T Keene, Alberto Salleo, Julie Grollier, Danijela Marković, Alice Mizrahi, Peng Yao, J Joshua Yang, Giacomo Indiveri, John Paul Strachan, Suman Datta, Elisa Vianello, Alexandre Valentian, Johannes Feldmann, Xuan Li, Wolfram HP Pernice, Harish Bhaskaran, Steve Furber, Emre Neftci, Franz Scherr, Wolfgang Maass, Srikanth Ramaswamy, Jonathan Tapson, Priyadarshini Panda, Youngeun Kim, Gouhei Tanaka, Simon Thorpe, Chiara Bartolozzi, Thomas A Cleland, Christoph Posch, ShihChii Liu, Gabriella Panuccio, Mufti Mahmud, Arnab Neelim Mazumder, Morteza Hosseini, Tinoosh Mohsenin, Elisa Donati, Silvia Tolu, Roberto Galeazzi, Martin Ejsing Christensen, Sune Holm, Daniele Ielmini, N Pryds
Jun 29, 2022
Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer.
Andrea Strakova, Máire Ní Leathlobhair, Guo-Dong Wang, Ting-Ting Yin, Ilona Airikkala-Otter, Janice L Allen, Karen M Allum, Leontine Bansse-Issa, Jocelyn L Bisson, Artemio Castillo Domracheva, Karina F de Castro, Anne M Corrigan, Hugh R Cran, Jane T Crawford, Stephen M Cutter, Laura Delgadillo Keenan, Edward M Donelan, Ibikunle A Faramade, Erika Flores Reynoso, Eleni Fotopoulou, Skye N Fruean, Fanny Gallardo-Arrieta, Olga Glebova, Rodrigo F Häfelin Manrique, Joaquim Jgp Henriques, Natalia Ignatenko, Debbie Koenig, Marta Lanza-Perea, Remo Lobetti, Adriana M Lopez Quintana, Thibault Losfelt, Gabriele Marino, Inigo Martincorena, Simón Martínez Castañeda, Mayra F Martínez-López, Michael Meyer, Berna Nakanwagi, Andrigo B De Nardi, Winifred Neunzig, Sally J Nixon, Marsden M Onsare, Antonio Ortega-Pacheco, Maria C Peleteiro, Ruth J Pye, John F Reece, Jose Rojas Gutierrez, Haleema Sadia, Sheila K Schmeling, Olga Shamanova, Richard K Ssuna, Audrey E Steenland-Smit, Alla Svitich, Ismail Thoya Ngoka, Bogdan A Vițălaru, Anna P de Vos, Johan P de Vos, Oliver Walkinton, David C Wedge, Alvaro S Wehrle-Martinez, Mirjam G van der Wel, Sophie Ae Widdowson, Elizabeth P Murchison
Apr 26, 2016
Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer
Andrea Strakova, Thomas J. Nicholls, Adrian Baez-Ortega, Máire Ní Leathlobhair, Alexander T. Sampson, Katherine Hughes, Isobelle A. G. Bolton, Kevin Gori, Jinhong Wang, Ilona Airikkala-Otter, Janice L. Allen, Karen M. Allum, Clara L. Arnold, Leontine Bansse-Issa, Thinlay N. Bhutia, Jocelyn L. Bisson, Kelli Blank, Cristóbal Briceño, Artemio Castillo Domracheva, Anne M. Corrigan, Hugh R. Cran, Jane T. Crawford, Stephen M. Cutter, Eric Davis, Karina F. de Castro, Andrigo B. De Nardi, Anna P. de Vos, Laura Delgadillo Keenan, Edward M. Donelan, Adela R. Espinoza Huerta, Ibikunle A. Faramade, Mohammed Fazil, Eleni Fotopoulou, Skye N. Fruean, Fanny Gallardo-Arrieta, Olga Glebova, Pagona G. Gouletsou, Rodrigo F. Häfelin Manrique, Joaquim J. G. P. Henriques, Rodrigo S. Horta, Natalia Ignatenko, Yaghouba Kane, Cathy King, Debbie Koenig, Ada Krupa, Steven J. Kruzeniski, Marta Lanza-Perea, Mihran Lazyan, Adriana M. Lopez Quintana, Thibault Losfelt, Gabriele Marino, Simón Martínez Castañeda, Mayra F. Martínez-López, Bedan M. Masuruli, Michael Meyer, Edward J. Migneco, Berna Nakanwagi, Karter B. Neal, Winifred Neunzig, Sally J. Nixon, Antonio Ortega-Pacheco, Francisco Pedraza-Ordoñez, Maria C. Peleteiro, Katherine Polak, Ruth J. Pye, Juan C. Ramirez-Ante, John F. Reece, Jose Rojas Gutierrez, Haleema Sadia, Sheila K. Schmeling, Olga Shamanova, Alan G. Sherlock, Audrey E. Steenland-Smit, Alla Svitich, Lester J. Tapia Martínez, Ismail Thoya Ngoka, Cristian G. Torres, Elizabeth M. Tudor, Mirjam G. van der Wel, Bogdan A. Vițălaru, Sevil A. Vural, Oliver Walkinton, Alvaro S. Wehrle-Martinez, Sophie A. E. Widdowson, Irina Zvarich, Patrick F. Chinnery, Maria Falkenberg, Claes M. Gustafsson, Elizabeth P. Murchison
Jun 17, 2021
Abstract: Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for ‘selfish’ traits, such as replicative...
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