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Vascular Interstitial Cells in Retinal Arteriolar Annuli Are Altered During Hypertension.
David Ramos, Joana Catita, Mariana López-Luppo, Andreia Valença, Aina Bonet, Ana Carretero, Marc Navarro, Victor Nacher, Simon Mendez-Ferrer, Anna Meseguer, Alba Casellas, Luísa Mendes-Jorge, Jesús Ruberte
Aug 09, 2019
Purpose: It has been suggested that arteriolar annuli localized in retinal arterioles regulate retinal blood flow acting as sphincters. Here, the morphology and protein expression profile of arteriolar annuli have been analyzed...
Actins Animals Anoctamin-1 Arterial Pressure Arterioles Endothelial Cells Green Fluorescent Proteins Histocytochemistry Hyaluronan Receptors Hypertension Hypertensive Retinopathy Interstitial Cells of Cajal Mice Mice Inbred ICR Mice Transgenic Microscopy Electron Transmission Microscopy Fluorescence NADPH Dehydrogenase Nestin Retinal Artery
Management of Pediatric Distal Fingertip Injuries
UNLABELLED: Nail bed and fingertip injuries are the commonest hand injuries in children and can lead to profound functional and cosmetic impairments if not appropriately managed. Fingertip injuries can present with subungual...
In vivo structural modification of type II arabinogalactans with fungal endo-β-1, 6-galactanase in Arabidopsis.
Aina Kikuchi, Katsuya Hara, Yoshihisa Yoshimi, Kouichi Soga, Daisuke Takahashi, Toshihisa Kotake
Nov 23, 2022
The double-edged sword of industry collaboration
This paper studies the impact of university-industry collaboration on academic research output. We analyze the channels through which the degree of industry collaboration may be affecting research output. We exploit a unique...
Basic vs. applied research Industry-science links Research collaboration /dk/atira/pure/subjectarea/asjc/2200/2200 name=General Engineering /dk/atira/pure/subjectarea/asjc/1400/1405 name=Management of Technology and Innovation /dk/atira/pure/subjectarea/asjc/1400/1408 name=Strategy and Management /dk/atira/pure/subjectarea/asjc/1800/1803 name=Management Science and Operations Research
In vivo structural modification of type II arabinogalactans with fungal endo-β-1, 6-galactanase in Arabidopsis.
Aina Kikuchi, Katsuya Hara, Yoshihisa Yoshimi, Kouichi Soga, Daisuke Takahashi, Toshihisa Kotake
Jan 04, 2023
Arabinogalactan-proteins (AGPs) are mysterious extracellular glycoproteins in plants. Although AGPs are highly conserved, their molecular functions remain obscure. The physiological importance of AGPs has been extensively...
Recognising Colorectal Cancer in Primary Care
Natalia Calanzani, Aina Chang, Marije van Melle, Merel M. Pannebakker, Garth Funston, Fiona M. Walter
May 10, 2021
Abstract: Colorectal cancer (CRC) is the third most common cancer worldwide. Primary care professionals can play an important role in both prevention and early detection of CRC. Most CRCs are attributed to modifiable lifestyle...
Recognising Colorectal Cancer in Primary Care.
Natalia Calanzani, Aina Chang, Marije van Melle, Merel M Pannebakker, Garth Funston, Fiona M Walter
Mar 25, 2021
The double-edged sword of industry collaboration
This paper studies the impact of university-industry collaboration on academic research output. We analyze the channels through which the degree of industry collaboration may be affecting research output. We exploit a unique...
Basic vs. applied research Industry-science links Research collaboration /dk/atira/pure/subjectarea/asjc/2200/2200 name=General Engineering /dk/atira/pure/subjectarea/asjc/1400/1405 name=Management of Technology and Innovation /dk/atira/pure/subjectarea/asjc/1400/1408 name=Strategy and Management /dk/atira/pure/subjectarea/asjc/1800/1803 name=Management Science and Operations Research
Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity.
Lindsay E Wu, Dorit Samocha-Bonet, P Tess Whitworth, Daniel J Fazakerley, Nigel Turner, Trevor J Biden, David E James, James Cantley
Aug 28, 2020
A critical feature of obesity is enhanced insulin secretion from pancreatic β-cells, enabling the majority of individuals to maintain glycaemic control despite adiposity and insulin resistance. Surprisingly, the factors...
adipocyte adipokine BMI body mass index Beta-cell ELISA enzyme-linked immunosorbant assay FABP4 GSIS glucose-stimulated insulin secretion IBMX 3-Isobutyl-1-methylxanthine Insulin Secretion NEFA non-esterified fatty acid obesity SILAC stable-isotope labelling by amino acids in cell culture T2D type 2 diabetes cAMP cyclic-AMP
The homeostatic dynamics of feeding behaviour identify novel mechanisms of anorectic agents.
Thomas M McGrath, Eleanor Spreckley, Aina Fernandez Rodriguez, Carlo Viscomi, Amin Alamshah, Elina Akalestou, Kevin G Murphy, Nick S Jones
Jan 06, 2020
Better understanding of feeding behaviour will be vital in reducing obesity and metabolic syndrome, but we lack a standard model that captures the complexity of feeding behaviour. We construct an accurate stochastic model of...
Glycemic effects and safety of L-Glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study.
Dorit Samocha-Bonet, Donald J Chisholm, Fiona M Gribble, Adelle CF Coster, Kevin H Carpenter, Graham RD Jones, Jens J Holst, Jerry R Greenfield
Feb 04, 2020
BACKGROUND AND AIMS: L-glutamine is an efficacious glucagon-like peptide (GLP)-1 secretagogue in vitro. When administered with a meal, glutamine increases GLP-1 and insulin excursions and reduces postprandial glycaemia in type 2...
The homeostatic dynamics of feeding behaviour identify novel mechanisms of anorectic agents
Thomas M. McGrath, Eleanor Spreckley, Aina Fernandez Rodriguez, Carlo Viscomi, Amin Alamshah, Elina Akalestou, Kevin G. Murphy, Nick S. Jones
Dec 05, 2019
Better understanding of feeding behaviour will be vital in reducing obesity and metabolic syndrome, but we lack a standard model that captures the complexity of feeding behaviour. We construct an accurate stochastic model of...
Genomes reveal marked differences in the adaptive evolution between orangutan species.
Maja P Mattle-Greminger, Tugce Bilgin Sonay, Alexander Nater, Marc Pybus, Tariq Desai, Guillem de Valles, Ferran Casals, Aylwyn Scally, Jaume Bertranpetit, Tomas Marques-Bonet, Carel P van Schaik, Maria Anisimova, Michael Krützen
Apr 12, 2019
BACKGROUND: Integrating demography and adaptive evolution is pivotal to understanding the evolutionary history and conservation of great apes. However, little is known about the adaptive evolution of our closest relatives, in...
The fall of the summer truffle
Brian S Steidinger, Ulf Büntgen, Uli Stobbe, Willy Tegel, Ludger Sproll, Matthias Haeni, Barbara Moser, István Bagi, José-Antonio Bonet, Marc Buée, Benjamin Dauphin, Fernando Martínez-Peña, Virginie Molinier, Roman Zweifel, Simon Egli, Martina Peter
Oct 06, 2022
Global warming is pushing populations outside their range of physiological tolerance. According to the environmental envelope framework, the most vulnerable populations occur near the climatic edge of their species'...
Alien Voices under the Bean Arbor
H Wu
Aug 08, 2017
This article examines an eighteenth-century French Jesuit’s translation of the final chapter of the early Qing collection of vernacular stories Doupeng xianhua 豆棚閒話 (Idle Talks under the Bean Arbor), which became a...
Inference of natural selection from ancient DNA.
Marianne Dehasque, María C Ávila-Arcos, David Díez-Del-Molino, Matteo Fumagalli, Katerina Guschanski, Eline D Lorenzen, Anna-Sapfo Malaspinas, Tomas Marques-Bonet, Michael D Martin, Gemma GR Murray, Alexander ST Papadopulos, Nina Overgaard Therkildsen, Daniel Wegmann, Love Dalén, Andrew D Foote
May 22, 2020
Evolutionary processes, including selection, can be indirectly inferred based on patterns of genomic variation among contemporary populations or species. However, this often requires unrealistic assumptions of ancestral...
Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
Adamantios Mamais, Jillian H Kluss, Luis Bonet-Ponce, Natalie Landeck, Rebekah G Langston, Nathan Smith, Alexandra Beilina, Alice Kaganovich, Manik C Ghosh, Laura Pellegrini, Ravindran Kumaran, Ioannis Papazoglou, George R Heaton, Rina Bandopadhyay, Nunziata Maio, Changyoun Kim, Matthew J LaVoie, David Gershlick, Mark R Cookson
Jan 05, 2022
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant Parkinson disease (PD), while polymorphic LRRK2 variants are associated with sporadic PD. PD-linked mutations increase LRRK2 kinase activity and induce...
Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
Adamantios Mamais, Jillian H Kluss, Luis Bonet-Ponce, Natalie Landeck, Rebekah G Langston, Nathan Smith, Alexandra Beilina, Alice Kaganovich, Manik C Ghosh, Laura Pellegrini, Ravindran Kumaran, Ioannis Papazoglou, George R Heaton, Rina Bandopadhyay, Nunziata Maio, Changyoun Kim, Matthew J LaVoie, David C Gershlick, Mark R Cookson
Jan 28, 2022
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant Parkinson disease (PD), while polymorphic LRRK2 variants are associated with sporadic PD. PD-linked mutations increase LRRK2 kinase activity and induce...
Aged Animals Biological Transport Corpus Striatum Gain of Function Mutation HEK293 Cells Humans Iron Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Lysosomes Male Mice Mice Inbred C57BL Microglia Middle Aged Mutation Parkinson Disease Protein Serine-Threonine Kinases Transferrin Transferrins rab GTP-Binding Proteins
Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians
Yang Luo, Sara Suliman, Samira Asgari, Tiffany Amariuta, Yuriy Baglaenko, Marta Martínez-Bonet, Kazuyoshi Ishigaki, Maria Gutierrez-Arcelus, Roger Calderon, Leonid Lecca, Segundo R. León, Judith Jimenez, Rosa Yataco, Carmen Contreras, Jerome T. Galea, Mercedes Becerra, Sergey Nejentsev, Peter A. Nigrovic, D. Branch Moody, Megan B. Murray, Soumya Raychaudhuri
Aug 20, 2020
Abstract: Of the 1.8 billion people worldwide infected with Mycobacterium tuberculosis, 5–15% will develop active tuberculosis (TB). Approximately half will progress to active TB within the first 18 months after infection...
Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians.
Yang Luo, Sara Suliman, Samira Asgari, Tiffany Amariuta, Yuriy Baglaenko, Marta Martínez-Bonet, Kazuyoshi Ishigaki, Maria Gutierrez-Arcelus, Roger Calderon, Leonid Lecca, Segundo R León, Judith Jimenez, Rosa Yataco, Carmen Contreras, Jerome T Galea, Mercedes Becerra, Sergey Nejentsev, Peter A Nigrovic, D Branch Moody, Megan B Murray, Soumya Raychaudhuri
Oct 22, 2019
Of the 1.8 billion people worldwide infected with Mycobacterium tuberculosis, 5-15% will develop active tuberculosis (TB). Approximately half will progress to active TB within the first 18 months after infection, presumably...
Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans.
Magdalena Stepien, David J Hughes, Sandra Hybsier, Christina Bamia, Anne Tjønneland, Kim Overvad, Aurélie Affret, Mathilde His, Marie-Christine Boutron-Ruault, Verena Katzke, Tilman Kühn, Krasimira Aleksandrova, Antonia Trichopoulou, Pagona Lagiou, Phlippos Orfanos, Domenico Palli, Sabina Sieri, Rosario Tumino, Fulvio Ricceri, Salvatore Panico, HB As Bueno-de-Mesquita, Petra H Peeters, Elisabete Weiderpass, Cristina Lasheras, Catalina Bonet Bonet, Elena Molina-Portillo, Miren Dorronsoro, José María Huerta, Aurelio Barricarte, Bodil Ohlsson, Klas Sjöberg, Mårten Werner, Dmitry Shungin, Nick Wareham, Kay-Tee Khaw, Ruth C Travis, Heinz Freisling, Amanda J Cross, Lutz Schomburg, Mazda Jenab
Aug 17, 2017
BACKGROUND: Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their...
Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance.
Daniel J Fazakerley, Rima Chaudhuri, Pengyi Yang, Ghassan J Maghzal, Kristen C Thomas, James R Krycer, Sean J Humphrey, Benjamin L Parker, Kelsey H Fisher-Wellman, Christopher C Meoli, Nolan J Hoffman, Ciana Diskin, James G Burchfield, Mark J Cowley, Warren Kaplan, Zora Modrusan, Ganesh Kolumam, Jean Yh Yang, Daniel L Chen, Dorit Samocha-Bonet, Jerry R Greenfield, Kyle L Hoehn, Roland Stocker, David E James
Aug 28, 2020
Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic diseases. Here, we show a selective deficiency in mitochondrial coenzyme Q (CoQ) in insulin-resistant adipose and muscle tissue. This...
Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study.
Lina Cai, Eleanor Wheeler, Nicola D Kerrison, Jian'an Luan, Panos Deloukas, Paul W Franks, Pilar Amiano, Eva Ardanaz, Catalina Bonet, Guy Fagherazzi, Leif C Groop, Rudolf Kaaks, José María Huerta, Giovanna Masala, Peter M Nilsson, Kim Overvad, Valeria Pala, Salvatore Panico, Miguel Rodriguez-Barranco, Olov Rolandsson, Carlotta Sacerdote, Matthias B Schulze, Annemieke MW Spijkerman, Anne Tjonneland, Rosario Tumino, Yvonne T van der Schouw, Stephen J Sharp, Nita G Forouhi, Elio Riboli, Mark I McCarthy, Inês Barroso, Claudia Langenberg, Nicholas J Wareham
Sep 17, 2020
The dental proteome of Homo antecessor.
Frido Welker, Jazmín Ramos-Madrigal, Petra Gutenbrunner, Meaghan Mackie, Shivani Tiwary, Rosa Rakownikow Jersie-Christensen, Cristina Chiva, Marc R Dickinson, Martin Kuhlwilm, Marc de Manuel, Pere Gelabert, María Martinón-Torres, Ann Margvelashvili, Juan Luis Arsuaga, Eudald Carbonell, Tomas Marques-Bonet, Kirsty Penkman, Eduard Sabidó, Jürgen Cox, Jesper V Olsen, David Lordkipanidze, Fernando Racimo, Carles Lalueza-Fox, José María Bermúdez de Castro, Eske Willerslev, Enrico Cappellini
Nov 05, 2020
The phylogenetic relationships between hominins of the Early Pleistocene epoch in Eurasia, such as Homo antecessor, and hominins that appear later in the fossil record during the Middle Pleistocene epoch, such as Homo sapiens...
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