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E-commerce shipping through a third-party supply chain
We consider an e-commerce retailer who must ship orders from a warehouse to a set of customers with delivery deadlines. As is often the case, the retailer uses a third-party service provider to ensure its distribution. The...
E-commerce shipping through a third-party supply chain
We consider an e-commerce retailer who must ship orders from a warehouse to a set of customers with delivery deadlines. As is often the case, the retailer uses a third-party service provider to ensure its distribution. The...
Dynamic Notch signalling regulates neural stem cell state progression in the Drosophila optic lobe.
BACKGROUND: Neural stem cells generate all of the neurons and glial cells in the central nervous system, both during development and in the adult to maintain homeostasis. In the Drosophila optic lobe, neuroepithelial cells...
neural stem cell Neuralized Notch Optic Lobe Animals Animals Genetically Modified Drosophila Drosophila Proteins Gene Expression Regulation Developmental Intracellular Signaling Peptides and Proteins Membrane Proteins Neural Stem Cells Neuroepithelial Cells Neurogenesis Neurons Optic Lobe Nonmammalian Receptors Notch Signal Transduction
The Serine Protease Homolog, Scarface, Is Sensitive to Nutrient Availability and Modulates the Development of the Drosophila Blood-Brain Barrier.
Imaging drug delivery to skin with stimulated Raman scattering microscopy
Efficient drug delivery to the skin is essential for the treatment of major dermatologic diseases, such as eczema, psoriasis and acne. However, many compounds penetrate the skin barrier poorly and require optimized formulations...
The Serine Protease Homolog, Scarface, Is Sensitive to Nutrient Availability and Modulates the Development of the <i>Drosophila</i> Blood-Brain Barrier.
The adaptable transcriptional response to changes in food availability not only ensures animal survival but also lets embryonic development progress. Interestingly, the CNS is preferentially protected from periods of...
The transcription factor SoxD controls neuronal guidance in the Drosophila visual system.
Esteban G Contreras, Tomás Palominos, Álvaro Glavic, Andrea H Brand, Jimena Sierralta, Carlos Oliva
Nov 13, 2018
Precise control of neurite guidance during development is essential to ensure proper formation of neuronal networks and correct function of the central nervous system (CNS). How neuronal projections find their targets to...
Imaging drug delivery to skin with stimulated Raman scattering microscopy
Efficient drug delivery to the skin is essential for the treatment of major dermatologic diseases, such as eczema, psoriasis and acne. However, many compounds penetrate the skin barrier poorly and require optimized formulations...
Objective assessment of nanoparticle disposition in mammalian skin after topical exposure
Christopher S. J. Campbell, L. Rodrigo Contreras-Rojas, Begona Delgado-Charro, Richard H. Guy
Aug 20, 2012
The use of nanoparticles as formulation components of topical drug delivery systems for the skin has been widely investigated in the literature. Because of the conflicting conclusions resulting from these studies concerning the...
The proneural wave in the Drosophila optic lobe is driven by an excitable reaction-diffusion mechanism.
David J Jörg, Elizabeth E Caygill, Anna E Hakes, Esteban G Contreras, Andrea H Brand, Benjamin D Simons
Feb 15, 2019
D. melanogaster developmental biology Optic Lobe physics of living systems proneural wave reaction-diffusion system sequential patterning Animals Cell Differentiation Drosophila Drosophila Proteins ErbB Receptors Gene Expression Regulation Developmental Neuroepithelial Cells Neurons Optic Lobe Nonmammalian Receptors Invertebrate Peptide Signal Transduction
Evaluation of drug delivery to intact and porated skin by coherent Raman scattering and fluorescence microscopies
Natalie A. Belsey, Natalie L. Garrett, L. Rodrigo Contreras-Rojas, Adam J. Pickup-Gerlaugh, Gareth J. Price, Julian Moger, Richard H. Guy
Jan 28, 2014
Stimulated Raman scattering microscopy was used to assess the permeation of topically applied drugs and formulation excipients into porcine skin. This chemically selective technique generates high-resolution 3D images, from...
Genes and lipids that impact uptake and assimilation of exogenous coenzyme Q in Saccharomyces cerevisiae.
Lucía Fernández-Del-Río, Miranda E Kelly, Jaime Contreras, Michelle C Bradley, Andrew M James, Michael P Murphy, Gregory S Payne, Catherine F Clarke
May 14, 2020
Coenzyme Q (CoQ) is an essential player in the respiratory electron transport chain and is the only lipid-soluble antioxidant synthesized endogenously in mammalian and yeast cells. In humans, genetic mutations, pathologies...
CoQ(6) rescue coenzyme Q Endocytosis Saccharomyces cerevisiae transport Ubiquinone Uptake Animals GTP-Binding Proteins Humans Lipids Microfilament Proteins Mitochondrial Diseases N-Terminal Acetyltransferase B Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Ubiquinone Vesicular Transport Proteins
Objective assessment of nanoparticle disposition in mammalian skin after topical exposure
Christopher S. J. Campbell, L. Rodrigo Contreras-Rojas, Begona Delgado-Charro, Richard H. Guy
Aug 20, 2012
The use of nanoparticles as formulation components of topical drug delivery systems for the skin has been widely investigated in the literature. Because of the conflicting conclusions resulting from these studies concerning the...
Neural and Cognitive Signatures of Guilt Predict Hypocritical Blame
Hongbo Yu, Luis Sebastian Contreras-Huerta, Annayah Prosser, Matthew Apps, Wilhelm Hofmann, Walter Sinnott-Armstrong, Molly J. Crockett
Nov 30, 2022
A common form of moral hypocrisy occurs when people blame others for moral violations that they themselves commit. It is assumed that hypocritical blamers act in this manner to falsely signal that they hold moral standards that...
Neural and Cognitive Signatures of Guilt Predict Hypocritical Blame
Hongbo Yu, Luis Sebastian Contreras-Huerta, Annayah Prosser, Matthew Apps, Wilhelm Hofmann, Walter Sinnott-Armstrong, Molly J. Crockett
Nov 30, 2022
A common form of moral hypocrisy occurs when people blame others for moral violations that they themselves commit. It is assumed that hypocritical blamers act in this manner to falsely signal that they hold moral standards that...
Disrupted functional connectivity in adolescent obesity.
Laura Moreno-Lopez, Oren Contreras-Rodriguez, Carles Soriano-Mas, Emmanuel A Stamatakis, Antonio Verdejo-Garcia
Aug 15, 2017
BACKGROUND/OBJECTIVE: Obesity has been associated with brain alterations characterised by poorer interaction between a hypersensitive reward system and a comparatively weaker prefrontal-cognitive control system. These...
Evaluation of drug delivery to intact and porated skin by coherent Raman scattering and fluorescence microscopies
Natalie A. Belsey, Natalie L. Garrett, L. Rodrigo Contreras-Rojas, Adam J. Pickup-Gerlaugh, Gareth J. Price, Julian Moger, Richard H. Guy
Jan 28, 2014
Stimulated Raman scattering microscopy was used to assess the permeation of topically applied drugs and formulation excipients into porcine skin. This chemically selective technique generates high-resolution 3D images, from...
Influence of race/ethnicity on response to lupus nephritis treatment
David Isenberg, Gerald B Appel, Gabriel Contreras, Mary A Dooley, Ellen M Ginzler, David Jayne, Jorge Sánchez-Guerrero, David Wofsy, Xueqing Yu, Neil Solomons
Nov 24, 2020
OBJECTIVE: To compare the efficacy and safety of mycophenolate mofetil (MMF) and intravenous cyclophosphamide (IVC) as induction treatment for lupus nephritis (LN), by race, ethnicity and geographical region. METHODS: A total of...
A combination of computational and experimental approaches identifies DNA sequence constraints associated with target site binding specificity of the transcription factor CSL.
Rubben Torella, Jinghua Li, Eddie Kinrade, Gustavo Cerda-Moya, Ashley N Contreras, Robert Foy, Robert Stojnic, Robert C Glen, Rhett A Kovall, Boris Adryan, Sarah J Bray
Aug 22, 2014
Principles of early human development and germ cell program from observed model systems
T Kobayashi, H Zhang, WC Tang, N Irie, S Withey, D Klisch, A Sybirna, S Dietmann, DA Contreras, R Webb, C Allegrucci, R Alberio, MA Surani, A Surani
Aug 01, 2017
Animals Bone Morphogenetic Proteins Cell Differentiation Cell Lineage Embryoid Bodies Embryonic Development Epigenesis Genetic Female Gastrulation Gene Dosage Germ Cells Germ Layers Humans In Vitro Techniques Macaca fascicularis Male Models Animal Models Biological Pluripotent Stem Cells Positive Regulatory Domain I-Binding Factor 1 Primitive Streak Repressor Proteins SOXF Transcription Factors Swine Wnt Signaling Pathway
The Role of Surface Recombination on the Performance of Perovskite Solar Cells
Jesús Idígoras, Lidia Contreras-Bernal, James M. Cave, Nicola E. Courtier, Ángel Barranco, Ana Borras, Juan R. Sánchez-Valencia, Juan A. Anta, Alison B. Walker
Nov 09, 2018
Herein, the preparation of 1D TiO2 nanocolumnar films grown by plasma-enhanced chemical vapor deposition is reported as the electron selective layer (ESL) for perovskite solar devices. The impact of the ESL...
The Role of Surface Recombination on the Performance of Perovskite Solar Cells
Jesús Idígoras, Lidia Contreras-Bernal, James M. Cave, Nicola E. Courtier, Ángel Barranco, Ana Borras, Juan R. Sánchez-Valencia, Juan A. Anta, Alison B. Walker
Nov 09, 2018
Herein, the preparation of 1D TiO2 nanocolumnar films grown by plasma-enhanced chemical vapor deposition is reported as the electron selective layer (ESL) for perovskite solar devices. The impact of the ESL...
Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens.
Mauricio P Contreras, Hsuan Pai, Yasin Tumtas, Cian Duggan, Enoch Lok Him Yuen, Angel Vergara Cruces, Jiorgos Kourelis, Hee-Kyung Ahn, Kim-Teng Lee, Chih-Hang Wu, Tolga O Bozkurt, Lida Derevnina, Sophien Kamoun
Jan 04, 2023
Photorhabdus adhesion modification protein (Pam) binds extracellular polysaccharide and alters bacterial attachment
Robert T. Jones, Maria Sanchez-Contreras, Isabella Vlisidou, Matthew R. Amos, Guowei Yang, Xavier Munoz-Berbel, Abhishek Upadhyay, Ursula J. Potter, Susan A. Joyce, Todd A. Ciche, A. Toby A. Jenkins, Stefan Bagby, Richard H ffrench-Constant, Nicholas R Waterfield
May 12, 2010
Background: Photorhabdus are Gram-negative nematode-symbiotic and insect-pathogenic bacteria. The species Photorhabdus asymbiotica is able to infect humans as well as insects. We investigated the secreted proteome of a...
Photorhabdus adhesion modification protein (Pam) binds extracellular polysaccharide and alters bacterial attachment
Robert T. Jones, Maria Sanchez-Contreras, Isabella Vlisidou, Matthew R. Amos, Guowei Yang, Xavier Munoz-Berbel, Abhishek Upadhyay, Ursula J. Potter, Susan A. Joyce, Todd A. Ciche, A. Toby A. Jenkins, Stefan Bagby, Richard H ffrench-Constant, Nicholas R Waterfield
May 12, 2010
Background: Photorhabdus are Gram-negative nematode-symbiotic and insect-pathogenic bacteria. The species Photorhabdus asymbiotica is able to infect humans as well as insects. We investigated the secreted proteome of a...
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