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Results: 15
Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.
Alisa F Zyryanova, Félix Weis, Alexandre Faille, Akeel Abo Alard, Ana Crespillo-Casado, Yusuke Sekine, Heather P Harding, Felicity Allen, Leopold Parts, Christophe Fromont, Peter M Fischer, Alan J Warren, David Ron
Apr 04, 2018
A prototype low-carbon segmented concrete shell building floor system
Robin Oval, Mishael Nuh, Eduardo Castro e Costa, Omar Abo Madyan, John Orr, Paul Shepherd
Jan 31, 2023
Concrete shell structures offer a mechanically efficient solution as a building floor system to reduce the environmental impact of our buildings. Although the curved geometry of shells can be an obstacle to their fabrication and...
A prototype low-carbon segmented concrete shell building floor system
Robin Oval, Mishael Nuh, Eduardo Castro e Costa, Omar Abo Madyan, John Orr, Paul Shepherd
Jan 31, 2023
Concrete shell structures offer a mechanically efficient solution as a building floor system to reduce the environmental impact of our buildings. Although the curved geometry of shells can be an obstacle to their fabrication and...
The ADAMTS13-VWF axis is dysregulated in chronic thromboembolic pulmonary hypertension.
Michael Newnham, Kieron South, Marta Bleda, William R Auger, Joan A Barberà, Harm Bogaard, Katherine Bunclark, John E Cannon, Marion Delcroix, Charaka Hadinnapola, Luke S Howard, David Jenkins, Eckhard Mayer, Choo Ng, Christopher J Rhodes, Nicholas Screaton, Karen Sheares, Michael A Simpson, Mark Southwood, Li Su, Dolores Taboada, Matthew Traylor, Richard C Trembath, Sofia S Villar, Martin R Wilkins, John Wharton, Stefan Gräf, Joanna Pepke-Zaba, Michael Laffan, David A Lane, Nicholas W Morrell, Mark Toshner
Jan 31, 2019
Chronic thromboembolic pulmonary hypertension (CTEPH) is an important consequence of pulmonary embolism that is associated with abnormalities in haemostasis. We investigated the ADAMTS13-von Willebrand factor (VWF) axis in...
GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression.
Yeda Wu, Graham K Murray, Enda M Byrne, Julia Sidorenko, Peter M Visscher, Naomi R Wray
Mar 30, 2021
Genetic factors are recognized to contribute to peptic ulcer disease (PUD) and other gastrointestinal diseases, such as gastro-oesophageal reflux disease (GORD), irritable bowel syndrome (IBS) and inflammatory bowel disease...
ABO Blood-Group System Antigens Neoplasm CDX2 Transcription Factor Depression Duodenal Ulcer Female Fucosyltransferases GPI-Linked Proteins Galactosyltransferases Gastroesophageal Reflux Gastrointestinal Diseases Genetic Predisposition to Disease Genome-Wide Association Study Helicobacter Infections Helicobacter pylori Humans Inflammatory Bowel Diseases Male Mucin-1 Mucin-6 Neoplasm Proteins Peptic ulcer
GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression
Yeda Wu, Graham K. Murray, Enda M. Byrne, Julia Sidorenko, Peter M. Visscher, Naomi R. Wray
Feb 19, 2021
Abstract: Genetic factors are recognized to contribute to peptic ulcer disease (PUD) and other gastrointestinal diseases, such as gastro-oesophageal reflux disease (GORD), irritable bowel syndrome (IBS) and inflammatory bowel...
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.
Sílvia Bonàs-Guarch, Marta Guindo-Martínez, Irene Miguel-Escalada, Niels Grarup, David Sebastian, Elias Rodriguez-Fos, Friman Sánchez, Mercè Planas-Fèlix, Paula Cortes-Sánchez, Santi González, Pascal Timshel, Tune H Pers, Claire C Morgan, Ignasi Moran, Goutham Atla, Juan R González, Montserrat Puiggros, Jonathan Martí, Ehm A Andersson, Carlos Díaz, Rosa M Badia, Miriam Udler, Aaron Leong, Varindepal Kaur, Jason Flannick, Torben Jørgensen, Allan Linneberg, Marit E Jørgensen, Daniel R Witte, Cramer Christensen, Ivan Brandslund, Emil V Appel, Robert A Scott, Jian'an Luan, Claudia Langenberg, Nicholas J Wareham, Oluf Pedersen, Antonio Zorzano, Jose C Florez, Torben Hansen, Jorge Ferrer, Josep Maria Mercader, David Torrents
Apr 11, 2018
The reanalysis of existing GWAS data represents a powerful and cost-effective opportunity to gain insights into the genetics of complex diseases. By reanalyzing publicly available type 2 diabetes (T2D) genome-wide association...
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.
Beben Benyamin, Tonu Esko, Janina S Ried, Aparna Radhakrishnan, Sita H Vermeulen, Michela Traglia, Martin Gögele, Denise Anderson, Linda Broer, Clara Podmore, Jian'an Luan, Zoltan Kutalik, Serena Sanna, Peter van der Meer, Toshiko Tanaka, Fudi Wang, Harm-Jan Westra, Lude Franke, Evelin Mihailov, Lili Milani, Jonas Hälldin, Juliane Winkelmann, Thomas Meitinger, Joachim Thiery, Annette Peters, Melanie Waldenberger, Augusto Rendon, Jennifer Jolley, Jennifer Sambrook, Lambertus A Kiemeney, Fred C Sweep, Cinzia F Sala, Christine Schwienbacher, Irene Pichler, Jennie Hui, Ayse Demirkan, Aaron Isaacs, Najaf Amin, Maristella Steri, Gérard Waeber, Niek Verweij, Joseph E Powell, Dale R Nyholt, Andrew C Heath, Pamela AF Madden, Peter M Visscher, Margaret J Wright, Grant W Montgomery, Nicholas G Martin, Dena Hernandez, Stefania Bandinelli, Pim van der Harst, Manuela Uda, Peter Vollenweider, Robert A Scott, Claudia Langenberg, Nicholas J Wareham, InterAct Consortium, Cornelia van Duijn, John Beilby, Peter P Pramstaller, Andrew A Hicks, Willem H Ouwehand, Konrad Oexle, Christian Gieger, Andres Metspalu, Clara Camaschella, Daniela Toniolo, Dorine W Swinkels, John B Whitfield
Jan 23, 2018
Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with...
Enaminone-based carboxylic acids as novel non-classical carbonic anhydrases inhibitors
Mahmoud F Abo-Ashour, Hadia Almahli, Alessandro Bonardia, Amira Khalil, Tarfah Al-Warhi, Sara T Al-Rashood, Hatem A Abdel-Aziz, Alessio Nocentini, Claudiu T Supuran, Wagdy M Eldehna
Sep 23, 2022
The First Norovirus Longitudinal Seroepidemiological Study From Sub-Saharan Africa Reveals High Seroprevalence of Diverse Genotypes Associated With Host Susceptibility Factors.
Lucy Thorne, Angela Nalwoga, Alexander J Mentzer, Alexis de Rougemont, Myra Hosmillo, Emily Webb, Margaret Nampiija, Allan Muhwezi, Tommy Carstensen, Deepti Gurdasani, Adrian V Hill, Manj S Sandhu, Alison Elliott, Ian Goodfellow
Jul 25, 2018
BACKGROUND: Human noroviruses (HuNoVs) are a prominent cause of gastroenteritis, yet fundamental questions remain regarding epidemiology, diversity, and immunity in sub-Saharan African children. We investigated HuNoV...
Antibodies Viral Blood Group Antigens Caliciviridae Infections Child Preschool Cross-Sectional Studies Demography Disease Susceptibility Enzyme-Linked Immunosorbent Assay Female Fucosyltransferases Gastroenteritis genetic variation Genotype Humans Infant Infant Newborn Longitudinal Studies Male Norovirus Polymorphism Single Nucleotide Pregnancy Risk Factors Seroepidemiologic Studies Socioeconomic Factors Uganda
The use of third-party packed red blood cells during ex situ normothermic machine perfusion of organs for transplantation
Chris J Callaghan, Benedict L Phillips, Theodora Foukaneli, Susan Robinson, Christopher JE Watson
Oct 05, 2020
Ex situ normothermic machine perfusion (NMP) is being used increasingly in the assessment of higher risk deceased donor organs and to facilitate prolonged organ storage. Third-party packed red blood cells (pRBCs) are often used...
Replication and Characterization of Association between ABO SNPs and Red Blood Cell Traits by Meta-Analysis in Europeans.
Stela McLachlan, Claudia Giambartolomei, Jon White, Pimphen Charoen, Andrew Wong, Chris Finan, Jorgen Engmann, Tina Shah, Micha Hersch, Clara Podmore, Alana Cavadino, Barbara J Jefferis, Caroline E Dale, Elina Hypponen, Richard W Morris, Juan P Casas, Meena Kumari, Yoav Ben-Shlomo, Tom R Gaunt, Fotios Drenos, Claudia Langenberg, Diana Kuh, Mika Kivimaki, Rico Rueedi, Gerard Waeber, Aroon D Hingorani, Jacqueline F Price, Ann P Walker, UCLEB Consortium
Jun 28, 2016
From lipid locus to drug target through human genomics.
Sander W van der Laan, Eric L Harshfield, Daiane Hemerich, David Stacey, Angela M Wood, Folkert W Asselbergs
Aug 08, 2018
In the last decade, over 175 genetic loci have robustly been associated to levels of major circulating blood lipids. Most loci are specific to one or two lipids, whereas some (SUGP1, ZPR1, TRIB1, HERPUD1, and FADS1) are...
Automated typing of red blood cell and platelet antigens
William J Lane, Connie M Westhoff, Nicholas S Gleadall, Maria Aguad, Robin Smeland-Wagman, Sunitha Vege, Daimon P Simmons, Helen H Mah, Matthew S Lebo, Klaudia Walter, Nicole Soranzo, Emanuele Di Angelantonio, John Danesh, David J Roberts, Nick A Watkins, Willem H Ouwehand, Adam S Butterworth, Richard M Kaufman, Heidi L Rehm, Leslie E Silberstein, Robert C Green, MedSeq Project
Oct 10, 2018
BACKGROUND: There are more than 300 known red blood cell (RBC) antigens and 33 platelet antigens that differ between individuals. Sensitisation to antigens is a serious complication that can occur in prenatal medicine and after...
ABO Blood-Group System Adolescent Adult Aged Aged 80 and over Algorithms Antigens Human Platelet Blood Grouping and Crossmatching Blood Platelets Databases Genetic Erythrocytes Genome Human Humans Middle Aged Randomized Controlled Trials as Topic Rh-Hr Blood-Group System whole genome sequencing Young Adult