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Synthesis, Suzuki Couplings, and Small-molecule Inhibitors
Patrick Gray
Jan 01, 0001
The goal of this research project was to design and synthesize small-molecule inhibitors using reductive amination, Suzuki coupling, and the addition of protecting groups.
small molecules INHIBITORS reductive amination Suzuki coupling Organic chemistry Physical Sciences and Mathematics
Published by: Ursinus College
Copper(i)-catalyzed sulfonylative Suzuki-Miyaura cross-coupling.
Using a simple copper(i) catalyst has allowed a high yielding sulfonylative-Suzuki-Miyaura cross-coupling reaction to be developed. The process provides a single step route to diaryl sulfones from the direct combination of aryl...
Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck-Suzuki reaction.
Esther Alza, Luca Laraia, Brett M Ibbeson, Súil Collins, Warren RJD Galloway, Jamie E Stokes, Ashok R Venkitaraman, David R Spring
Jan 23, 2018
The synthesis of a previously undescribed sp3-rich 6-5-5-6 tetracyclic ring scaffold using a palladium catalysed domino Heck-Suzuki reaction is reported. This reaction is high-yielding, selective for the domino process over the...
Confined diffusion of transmembrane proteins and lipids induced by the same actin meshwork lining the plasma membrane.
Takahiro K Fujiwara, Kokoro Iwasawa, Ziya Kalay, Taka A Tsunoyama, Yusuke Watanabe, Yasuhiro M Umemura, Hideji Murakoshi, Kenichi GN Suzuki, Yuri L Nemoto, Nobuhiro Morone, Akihiro Kusumi
May 28, 2019
The mechanisms by which the diffusion rate in the plasma membrane (PM) is regulated remain unresolved, despite their importance in spatially regulating the reaction rates in the PM. Proposed models include entrapment in...
An Explanatory Comparison of Japanese Secondary English Textbooks and IB English Textbooks
Akihiro Yasuda
Feb 19, 2021
Fifty percent of IB schools in Japan use both the national and IB-authorized English textbooks. This chapter will explore the issue of how these differ. Books used for the study came from MYP Phase 3, MYP Phase 4, DP English B...
Teacher Education Education Educational Administration and Leadership Social Sciences and Humanities
Published by: IGI Global Scientific Publishing
Chelate stabilized metal oxides for visible light photocatalyzed water oxidations
Dominic Walsh, Noelia M. Sanchez-Ballester, Katsuhiko Ariga, Akihiro Tanaka, Mark Weller
Feb 01, 2015
Visible light driven photocatalytic water oxidations were undertaken that compared lactate stabilized molecular and nanoparticle cobalt complexes and calcium manganese oxides as simple mimics of the PSII CaMn4O5 catalyst....
Robust and reusable supported palladium catalysts for cross-coupling reactions in flow
Two novel polymer encapsulated silica supported palladium catalysts have been prepared and shown to be highly active, robust and recyclable catalysts for Heck and Suzuki–Miyaura cross coupling reactions under continuous flow...
Post-synthetic modification of zinc metal-organic frameworks through palladium-catalysed carbon-carbon bond formation
Andrew D. Burrows, Laura C. Fisher, Timothy J. Mays, Sean P. Rigby, Sharon E. Ashbrook, Daniel M. Dawson
Sep 01, 2015
Post-synthetic Suzuki coupling reactions have been undertaken on the halide-functionalised metal-organic frameworks (MOFs) [Zn4O(bdc-Br)3] (bdc-Br = 2-bromo-1,4-benzenedicarboxylate, IRMOF-2) and...
Robust and reusable supported palladium catalysts for cross-coupling reactions in flow
Two novel polymer encapsulated silica supported palladium catalysts have been prepared and shown to be highly active, robust and recyclable catalysts for Heck and Suzuki–Miyaura cross coupling reactions under continuous flow...
Direct core functionalisation of naphthalenediimides by iridium catalysed C–H borylation
Catherine L. Lyall, Camilla C. Shotton, Monserrat Pérez-salvia, Dan Pantos, Simon E. Lewis
Nov 18, 2014
We report the first boron-substituted naphthalenediimides (NDIs), prepared by iridium catalysed C–H activation. When the NDI substrates bear N-benzyl substituents, the naphthyl NDI core is borylated in preference, suggestive of...
Post-synthetic modification of zinc metal-organic frameworks through palladium-catalysed carbon-carbon bond formation
Andrew D. Burrows, Laura C. Fisher, Timothy J. Mays, Sean P. Rigby, Sharon E. Ashbrook, Daniel M. Dawson
Sep 01, 2015
Post-synthetic Suzuki coupling reactions have been undertaken on the halide-functionalised metal-organic frameworks (MOFs) [Zn4O(bdc-Br)3] (bdc-Br = 2-bromo-1,4-benzenedicarboxylate, IRMOF-2) and...
Direct core functionalisation of naphthalenediimides by iridium catalysed C–H borylation
Catherine L. Lyall, Camilla C. Shotton, Monserrat Pérez-salvia, Dan Pantos, Simon E. Lewis
Nov 18, 2014
We report the first boron-substituted naphthalenediimides (NDIs), prepared by iridium catalysed C–H activation. When the NDI substrates bear N-benzyl substituents, the naphthyl NDI core is borylated in preference, suggestive of...
Connectivity Gradient in the Human Left Inferior Frontal Gyrus
Takuro Nakae, Riki Matsumoto, Takeharu Kunieda, Yoshiki Arakawa, Katsuya Kobayashi, Akihiro Shimotake, Yukihiro Yamao, Takayuki Kikuchi, Toshihiko Aso, Masao Matsuhashi, Kazumichi Yoshida, Akio Ikeda, Ryosuke Takahashi, Matthew A Lambon Ralph, Susumu Miyamoto
Mar 11, 2020
In the dual-stream model of language processing, the exact connectivity of the ventral stream to the anterior temporal lobe remains elusive. To investigate the connectivity between the inferior frontal gyrus (IFG) and the...
Chelate stabilized metal oxides for visible light photocatalyzed water oxidations
Dominic Walsh, Noelia M. Sanchez-Ballester, Katsuhiko Ariga, Akihiro Tanaka, Mark Weller
Feb 01, 2015
Visible light driven photocatalytic water oxidations were undertaken that compared lactate stabilized molecular and nanoparticle cobalt complexes and calcium manganese oxides as simple mimics of the PSII CaMn4O5 catalyst....
Benzoyl side-chains push the open-circuit voltage of PCDTBT/PCBM solar cells beyond 1 V
F Lombeck, S Müllers, H Komber, SM Menke, AJ Pearson, PJ Conaghan, CR McNeill, RH Friend, M Sommer
Sep 07, 2017
The synthesis, characterization and solar cell performance of PCDTBT and its highly soluble analogue hexyl-PCDTBT with cross-conjugated benzoyl moieties at the carbazole comonomer are presented. Through the use of both model...
Metabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes.
Vijesh J Bhute, Xiaoping Bao, Kaitlin K Dunn, Kylie R Knutson, Eric C McCurry, Gyuhyung Jin, Wei-Hua Lee, Sarah Lewis, Akihiro Ikeda, Sean P Palecek
Jun 20, 2018
Cardiovascular disease is a leading cause of death worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) hold immense clinical potential and recent studies have enabled generation of virtually pure hPSC-CMs...
Differential Regulation of the Melanoma Proteome by eIF4A1 and eIF4E.
Cailin E Joyce, Adrienne G Yanez, Akihiro Mori, Akinori Yoda, Johanna S Carroll, Carl D Novina
Aug 20, 2019
Small molecules and antisense oligonucleotides that inhibit the translation initiation factors eIF4A1 and eIF4E have been explored as broad-based therapeutic agents for cancer treatment, based on the frequent upregulation of...
Evidence for a deep, distributed and dynamic code for animacy in human ventral anterior temporal cortex.
Timothy T Rogers, Christopher R Cox, Qihong Lu, Akihiro Shimotake, Takayuki Kikuchi, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda, Riki Matsumoto, Matthew Lambon Ralph
Oct 28, 2021
Asymmetric parental genome engineering by Cas9 during mouse meiotic exit
Mammalian genomes can be edited by injecting pronuclear embryos with Cas9 cRNA and guide RNA (gRNA) but it is unknown whether editing can also occur during the onset of embryonic development, prior to pronuclear embryogenesis....
Serum BDNF levels before and after the development of mood disorders
K Ihara, H Yoshida, PB Jones, M Hashizume, Y Suzuki, H Ishijima, HK Kim, T Suzuki, M Hachisu
Feb 17, 2016
Asymmetric parental genome engineering by Cas9 during mouse meiotic exit
Mammalian genomes can be edited by injecting pronuclear embryos with Cas9 cRNA and guide RNA (gRNA) but it is unknown whether editing can also occur during the onset of embryonic development, prior to pronuclear embryogenesis....
Economic Value of Cultural Ecosystem Services from Recreation in Popa Mountain National Park, Myanmar
Protected areas offer diverse ecosystem services, including cultural services related to recreation, which contribute manifold to human wellbeing and the economy. However, multiple pressures from other human activities...
The Expression of TALEN before Fertilization Provides a Rapid Knock-Out Phenotype in Xenopus laevis Founder Embryos.
Kei Miyamoto, Ken-Ichi T Suzuki, Miyuki Suzuki, Yuto Sakane, Tetsushi Sakuma, Sarah Herberg, Angela Simeone, David Simpson, Jerome Jullien, Takashi Yamamoto, JB Gurdon
Nov 04, 2015
Animals Base Sequence Deoxyribonucleases Embryo Nonmammalian Eye Proteins Female Fertilization Founder Effect Gene Expression Regulation Developmental Gene Knockout Techniques Genes Lethal Homeodomain Proteins Male Microinjections Molecular Sequence Data Monophenol Monooxygenase Oocytes PAX6 Transcription Factor Paired Box Transcription Factors Phenotype RNA Messenger Repressor Proteins Sequence Alignment Sperm Injections Intracytoplasmic Transcriptional Activation Xenopus laevis
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