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Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death
Fergus W Hamilton, Matt Thomas, David Arnold, Tom Palmer, Ed Moran, Alexander J Mentzer, Nick Maskell, Kenneth Baillie, Charlotte Summers, Aroon Hingorani, Alasdair MacGowan, Golam M Khandaker, Ruth Mitchell, George Davey Smith, Peter Ghazal, Nicholas J Timpson
Feb 13, 2023
Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death
Fergus W Hamilton, Matt Thomas, David Arnold, Tom Palmer, Ed Moran, Alexander J Mentzer, Nick Maskell, Kenneth Baillie, Charlotte Summers, Aroon Hingorani, Alasdair MacGowan, Golam M Khandaker, Ruth Mitchell, George Davey Smith, Peter Ghazal, Nicholas J Timpson
Mar 02, 2023
Alemtuzumab as Treatment for Multiple Sclerosis.
Alemtuzumab, the first monoclonal antibody to be used as a therapy and the first to be humanized, was introduced into the treatment of multiple sclerosis in 1991 after its successful use in hematology, oncology, and...
The Hidden Perils of Affirmative Action
Contests are ubiquitous in economic, organizational and political settings. Contest designers often use tools to make a contest among asymmetric contestants more even, in order to either elicit higher effort levels, or for...
Promoting remyelination in multiple sclerosis
Abstract: The greatest unmet need in multiple sclerosis (MS) are treatments that delay, prevent or reverse progression. One of the most tractable strategies to achieve this is to therapeutically enhance endogenous remyelination;...
The Hidden Perils of Affirmative Action
Contests are ubiquitous in economic, organizational and political settings. Contest designers often use tools to make a contest among asymmetric contestants more even, in order to either elicit higher effort levels, or for...
Activity-dependent regulation of NMDA receptors in substantia nigra dopaminergic neurones.
N-Methyl-d-aspartate receptors (NMDARs) are Ca(2+)-permeable glutamate receptors that play a critical role in synaptic plasticity and promoting cell survival. However, overactive NMDARs can trigger cell death signalling pathways...
Mammary stem cells have myoepithelial cell properties.
Michael D Prater, Valérie Petit, I Alasdair Russell, Rajshekhar R Giraddi, Mona Shehata, Suraj Menon, Reiner Schulte, Ivo Kalajzic, Nicola Rath, Michael F Olson, Daniel Metzger, Marisa M Faraldo, Marie-Ange Deugnier, Marina A Glukhova, John Stingl
Jul 16, 2014
Actins Animals Benzamides Cell Proliferation Cells Cultured Dioxoles Epithelial Cells Female Flow Cytometry Gene Expression Profiling Green Fluorescent Proteins Interleukin Receptor Common gamma Subunit Mammary Glands Animal Mice Inbred C57BL Mice Inbred CBA Mice Inbred NOD Mice SCID Mice Transgenic Microscopy Fluorescence Myocytes Smooth Muscle Oligonucleotide Array Sequence Analysis Receptors Transforming Growth Factor beta Reverse Transcriptase Polymerase Chain Reaction Stem Cells
Acute posterior multifocal placoid pigment epitheliopathy after alemtuzumab treatment for relapsing-remitting multiple sclerosis.
Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci.
Glucocorticoids act by binding to the glucocorticoid receptor (GR), which binds to specific motifs within enhancers of target genes to activate transcription. Previous studies have suggested that GRs can promote interactions...
chromatin remodeling ENHANCER fluorescence in situ hybridization glucocorticoid receptor macrophage Animals Binding Sites Chromatin Chromatin Assembly and Disassembly DNA-Binding Proteins Dexamethasone Gene Expression Regulation Humans In Situ Hybridization Fluorescence Kinetics Kruppel-Like Factor 4 Kruppel-Like Transcription Factors MACROPHAGES Male Mice Mice Inbred C57BL Nuclear Receptor Coactivators Primary Cell Culture Promoter Regions Genetic Protein Binding Proto-Oncogene Proteins c-fos Receptors Glucocorticoid Signal Transduction Transcription Factors
Targets downstream of Cdk8 in Dictyostelium development.
A novel cardiac output response to stress test developed to improve diagnosis and monitoring of heart failure in primary care.
Sarah J Charman, Nduka C Okwose, Renae J Stefanetti, Kristian Bailey, Jane Skinner, Arsen Ristic, Petar M Seferovic, Mike Scott, Stephen Turley, Ahmet Fuat, Jonathan Mant, Richard FD Hobbs, Guy A MacGowan, Djordje G Jakovljevic
Jun 22, 2018
Diminished seroconversion following a single SARS-COV-2 vaccine in ocrelizumab-treated relapsing-remitting multiple sclerosis patients.
Zoya Georgieva, Rainer Dӧffinger, Dinakantha Kumararatne, Alasdair Coles, Claire McCarthy
Oct 08, 2021
BACKGROUND: Despite impressive efficacy in immunocompetent individuals, the immunogenicity of a single dose of COVID-19 vaccine in B-cell-deplete patients remains unknown. OBJECTIVES: We aimed to quantify real-world vaccine...
Association of Smoking, Alcohol Consumption, Blood Pressure, Body Mass Index, and Glycemic Risk Factors With Age-Related Macular Degeneration
Valerie Kuan, Alasdair Warwick, Aroon Hingorani, Adnan Tufail, Valentina Cipriani, Stephen Burgess, Reecha Sofat, International AMD Genomics Consortium (IAMDGC)
Nov 05, 2021
IMPORTANCE: Advanced age-related macular degeneration (AMD) is a leading cause of blindness in Western countries. Causal, modifiable risk factors need to be identified to develop preventive measures for advanced AMD. OBJECTIVE...
Diminished seroconversion following a single SARS-COV-2 vaccine in ocrelizumab-treated relapsing-remitting multiple sclerosis patients.
Zoya G Georgieva, Rainer Dӧffinger, Dinakantha Kumararatne, Alasdair J Coles, Claire McCarthy
May 25, 2022
BACKGROUND: Despite impressive efficacy in immunocompetent individuals, the immunogenicity of a single dose of COVID-19 vaccine in B-cell-deplete patients remains unknown. OBJECTIVES: We aimed to quantify real-world vaccine...
Immune reconstitution after alemtuzumab therapy for multiple sclerosis triggering Graves' orbitopathy
Jonathan CP Roos, Carla Moran, V Krishna Chatterjee, Joanne Jones, Alasdair Coles, Rachna Murthy
Dec 20, 2018
Alemtuzumab-a monoclonal antibody targeting the CD52 glycoprotein expressed by most mature leucocytes-effectively decreases relapse rate and disability progression in early, relapsing-remitting multiple sclerosis (MS). However...
Adolescent Adult Alemtuzumab Antineoplastic Agents Immunological Autoantibodies Disease Progression Enzyme-Linked Immunosorbent Assay Female Graves Ophthalmopathy Humans Immune Reconstitution Magnetic Resonance Imaging Male Middle Aged Multiple Sclerosis Receptors Thyrotropin Recurrence Retrospective Studies Risk Factors
Alemtuzumab improves neurological functional systems in treatment-naive relapsing-remitting multiple sclerosis patients.
Edward J Fox, Daniel Wynn, Alasdair J Coles, Jeffrey Palmer, David H Margolin, CAMMS223 Investigators
Apr 13, 2016
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