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Results: 376
Increased cardiac Pi/PCr in the diabetic heart observed using phosphorus magnetic resonance spectroscopy at 7T.
Ladislav Valkovič, Andrew Apps, Jane Ellis, Stefan Neubauer, Damian J Tyler, Albrecht Ingo Schmid, Oliver J Rider, Christopher Rodgers
Jun 16, 2022
Phosphorus magnetic resonance spectroscopy (31P-MRS) has previously demonstrated decreased energy reserves in the form of phosphocreatine to adenosine-tri-phosphate ratio (PCr/ATP) in the hearts of patients with type 2 diabetes...
Increased cardiac Pi/PCr in the diabetic heart observed using phosphorus magnetic resonance spectroscopy at 7T.
Ladislav Valkovič, Andrew Apps, Jane Ellis, Stefan Neubauer, Damian J Tyler, Albrecht Ingo Schmid, Oliver J Rider, Christopher T Rodgers
Jul 17, 2022
Phosphorus magnetic resonance spectroscopy (31P-MRS) has previously demonstrated decreased energy reserves in the form of phosphocreatine to adenosine-tri-phosphate ratio (PCr/ATP) in the hearts of patients with type 2 diabetes...
Understanding contemporary challenges to INGO legitimacy
In recent years, INGO legitimacy has been subject to growing scrutiny from analysts and practitioners alike. Critics have highlighted a backlash against INGOs in the Global South, a growing mismatch between INGO capacities and...
Understanding contemporary challenges to INGO legitimacy
In recent years, INGO legitimacy has been subject to growing scrutiny from analysts and practitioners alike. Critics have highlighted a backlash against INGOs in the Global South, a growing mismatch between INGO capacities and...
Quantifying the effect of dobutamine stress on myocardial Pi and pH in healthy volunteers
Andrew Apps, Ladislav Valkovič, Mark Peterzan, Justin Yc Lau, Moritz Hundertmark, William Clarke, Elizabeth M Tunnicliffe, Jane Ellis, Damian J Tyler, Stefan Neubauer, Oliver J Rider, Christopher T Rodgers, Albrecht Ingo Schmid
Aug 04, 2020
Measuring inorganic phosphate and intracellular pH in the healthy and hypertrophic cardiomyopathy hearts by in vivo 7T 31P-cardiovascular magnetic resonance spectroscopy.
Ladislav Valkovič, William T Clarke, Albrecht I Schmid, Betty Raman, Jane Ellis, Hugh Watkins, Matthew D Robson, Stefan Neubauer, Christopher T Rodgers
Feb 19, 2019
31P CMRS 3D-CSI 7T Cardiac Pi Cardiac intracellular pH Adenosine Triphosphate Adult Aged Biomarkers Cardiomyopathy Hypertrophic Case-Control Studies Energy Metabolism Female Humans Hydrogen-Ion Concentration Hydrolysis Magnetic Resonance Spectroscopy Male Middle Aged Myocardium Phosphates Phosphocreatine Phosphorus Isotopes Reproducibility of Results Young Adult
Self-Interest or Altruism: Why do Some INGOs Engage in Conflict Settings While Others Leave?
Rachel Arthur
Jan 01, 0001
Why do some international non-governmental organizations (INGOs) continue work in conflict settings while others leave? Understanding the motivations influencing INGO behavior in fragile and conflict settings is important for...
NGO INGO Conflict Fragility Behavior peacekeeping interventions Financial Support International Relations Peace and Conflict Studies Political Science Social and Behavioral Sciences
Published by: Ursinus College
Autophagy Delivers Viral Antigens for MHC Class II Presentation and is Regulated by Viral Infection
Dorothee Schmid
Jan 01, 0001
MHC class II molecules generally present peptides derived from exogenous antigens after endocytosis. However, biochemical studies have revealed that MHC class II ligands are frequently derived from intracellular proteins after...
Published by: Rockefeller University
Correlation-Adjusted Regression Survival Scores for High-Dimensional Variable Selection
biomarker discovery Breast Cancer multigene signature personalized medicine prostate cancer survival modeling Aged Aged 80 and over Biomarkers Tumor Breast Neoplasms Computer Simulation Female Genetic Markers Humans Male Middle Aged Proportional Hazards Models Prostatic Neoplasms Regression Analysis Survival Analysis Watchful Waiting
Ordo-responsibility in the sharing economy
Can private companies legitimately regulate sharing markets, and if yes, how? Whereas scholars have either criticized sharing platforms for expanding into private and public arenas or welcomed them to counterbalance...
corporate citizenship legitimacy ordo-responsibility sharing economy social contract /dk/atira/pure/subjectarea/asjc/1400/1400 name=General Business,Management and Accounting /dk/atira/pure/subjectarea/asjc/1200/1211 name=Philosophy /dk/atira/pure/subjectarea/asjc/2000/2002 name=Economics and Econometrics
Emergence
The paper reconstructs Niklas Luhmann’s diagnosis of the dysfunctional character of moral communication in the modern society by emphasizing the emergent character of today’s moral problems. In the systems-theoretic...
Using adjoint-based optimization to enhance ignition in non-premixed jets.
Gradient-based optimization is used to reliably and optimally induce ignition in three examples of laminar non-premixed mixture configurations. Using time-integrated heat release as a cost functional, the non-convex optimization...
Two-year outcomes of minimally invasive XEN Gel Stent implantation in primary open-angle and pseudoexfoliation glaucoma.
PURPOSE: The aim of this study was to evaluate the efficacy of XEN® Gel Stent implantation in the treatment of primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (XFG) regarding the reduction of intraocular...
Ab interno XEN Gel Stent Glaucoma minimally invasive glaucoma surgery Exfoliation syndrome Female Follow-Up Studies glaucoma drainage implants Glaucoma Open-Angle Humans Intraocular Pressure Male Minimally Invasive Surgical Procedures Prosthesis Design Retrospective Studies Stents Time Factors Tonometry Ocular Treatment Outcome
Bone Marrow Stromal Cells Drive Key Hallmarks of B Cell Malignancies
All B cell leukaemias and a substantial fraction of lymphomas display a natural niche residency in the bone marrow. While the bone marrow compartment may only be one of several sites of disease manifestations, the strong...
ZAP-70 Shapes the Immune Microenvironment in B Cell Malignancies
Zeta-chain-associated protein kinase-70 (ZAP-70) is a tyrosine kinase mainly expressed in T cells, NK cells and a subset of B cells. Primarily it functions in T cell receptor (TCR) activation through its tyrosine kinase...
Transforming Growth Factor-Beta Orchestrates Tumour and Bystander Cells in B-Cell Non-Hodgkin Lymphoma.
Transforming growth factor-beta (TGFB) is a critical regulator of normal haematopoiesis. Dysregulation of the TGFB pathway is associated with numerous haematological malignancies including myelofibrosis, acute myeloid leukaemia...
Bone Marrow Stromal Cells Drive Key Hallmarks of B Cell Malignancies.
All B cell leukaemias and a substantial fraction of lymphomas display a natural niche residency in the bone marrow. While the bone marrow compartment may only be one of several sites of disease manifestations, the strong...
Bone Marrow Stromal Cells Drive Key Hallmarks of B Cell Malignancies.
All B cell leukaemias and a substantial fraction of lymphomas display a natural niche residency in the bone marrow. While the bone marrow compartment may only be one of several sites of disease manifestations, the strong...
Published by: International journal of molecular sciences
Do hybrids impede sustainability?:How semantic reorientations and governance reforms can produce and preserve sustainability in sharing business models (ABS 2018
The sharing economy is a hotbed of hybridity and sustainability owing to the reduction in transactions costs that create information, trust, and trade. However, the hybridization also challenges the sustainability of sharing...
Saving the moral capital of NGOs
The literature on nonprofit management has embraced the concept of “accountability” to target urgent challenges related to NGO probity and integrity, and there have been attempts in the literature to use rational-choice-based...
The anti-GMO advocacy
Purpose: Public debates on the use of genetically modified organisms (GMOs) are strongly influenced by the nongovernmental organization (NGO)-led advocacy, most of which is harshly critical of genetic engineering. This...
American institutionalism Complexity reduction Discourse failure GMO NGO /dk/atira/pure/subjectarea/asjc/2200/2207 name=Control and Systems Engineering /dk/atira/pure/subjectarea/asjc/1700/1701 name=Computer Science (miscellaneous) /dk/atira/pure/subjectarea/asjc/2600/2614 name=Theoretical Computer Science /dk/atira/pure/subjectarea/asjc/3300/3301 name=Social Sciences (miscellaneous) /dk/atira/pure/subjectarea/asjc/2200/2201 name=Engineering (miscellaneous)
Emergence
The paper reconstructs Niklas Luhmann’s diagnosis of the dysfunctional character of moral communication in the modern society by emphasizing the emergent character of today’s moral problems. In the systems-theoretic...
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