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Results: 820
Lack of detectable neoantigen depletion signals in the untreated cancer genome.
Somatic mutations can result in the formation of neoantigens, immunogenic peptides that are presented on the tumor cell surface by HLA molecules. These mutations are expected to be under negative selection pressure, but the...
Mutational Analysis Identifies Therapeutic Biomarkers in Inflammatory Bowel Disease-Associated Colorectal Cancers.
Shahida Din, Kim Wong, Mike F Mueller, Anca Oniscu, James Hewinson, Catherine J Black, Martin L Miller, Alejandro Jiménez-Sánchez, Roy Rabbie, Mamunar Rashid, Jack Satsangi, David J Adams, Mark J Arends
Nov 06, 2018
Purpose: Inflammatory bowel disease-associated colorectal cancers (IBD-CRC) are associated with a higher mortality than sporadic colorectal cancers. The poorly defined molecular pathogenesis of IBD-CRCs limits development of...
Integrated Multi-Tumor Radio-Genomic Marker of Outcomes in Patients with High Serous Ovarian Carcinoma
Harini Veeraraghavan, Herbert Alberto Vargas, Alejandro-Jiménez Sánchez, Maura Micco, Eralda Mema, Yulia Lakhman, Mireia Crispin-Ortuzar, Erich P. Huang, Douglas A. Levine, Rachel N. Grisham, Nadeem Abu-Rustum, Joseph O. Deasy, Alexandra Snyder, Martin L. Miller, James D. Brenton, Evis Sala
Nov 19, 2020
Purpose: Develop an integrated intra-site and inter-site radiomics-clinical-genomic marker of high grade serous ovarian cancer (HGSOC) outcomes and explore the biological basis of radiomics with respect to molecular signaling...
Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient.
Alejandro Jiménez-Sánchez, Danish Memon, Stephane Pourpe, Harini Veeraraghavan, Yanyun Li, Hebert Alberto Vargas, Michael B Gill, Kay J Park, Oliver Zivanovic, Jason Konner, Jacob Ricca, Dmitriy Zamarin, Tyler Walther, Carol Aghajanian, Jedd D Wolchok, Evis Sala, Taha Merghoub, Alexandra Snyder, Martin L Miller
Jul 24, 2017
Developmental Ultrasound Characteristics in Guinea Pigs
Alejandro A Candia, Tamara Jiménez, Álvaro Navarrete, Felipe Beñaldo, Pablo Silva, Claudio García-Herrera, Amanda N Sferruzzi-Perri, Bernardo J Krause, Alejandro González-Candia, Emilio A Herrera
Mar 30, 2023
Background
Biometrical and blood flow examinations are fundamental for assessing fetoplacental development during pregnancy. Guinea pigs have been proposed as a good model to study fetal development and related...
Published by: Veterinary sciences
Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases
Roy Rabbie, Naser Ansari-Pour, Oliver Cast, Doreen Lau, Francis Scott, Sarah J. Welsh, Christine Parkinson, Leila Khoja, Luiza Moore, Mark Tullett, Kim Wong, Ingrid Ferreira, Julia M. Martínez Gómez, Mitchell Levesque, Ferdia A. Gallagher, Alejandro Jiménez-Sánchez, Laura Riva, Martin L. Miller, Kieren Allinson, Peter J. Campbell, Pippa Corrie, David C. Wedge, David J. Adams
Aug 27, 2020
Abstract: Metastatic melanoma carries a poor prognosis despite modern systemic therapies. Understanding the evolution of the disease could help inform patient management. Through whole-genome sequencing of 13 melanoma metastases...
Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases
Roy Rabbie, Naser Ansari-Pour, Oliver Cast, Doreen Lau, Francis Scott, Sarah J. Welsh, Christine Parkinson, Leila Khoja, Luiza Moore, Mark Tullett, Kim Wong, Ingrid Ferreira, Julia M. Martínez Gómez, Mitchell Levesque, Ferdia A. Gallagher, Alejandro Jiménez-Sánchez, Laura Riva, Martin L. Miller, Kieren Allinson, Peter J. Campbell, Pippa Corrie, David C. Wedge, David J. Adams
Aug 27, 2021
Abstract: Metastatic melanoma carries a poor prognosis despite modern systemic therapies. Understanding the evolution of the disease could help inform patient management. Through whole-genome sequencing of 13 melanoma metastases...
Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases.
Roy Rabbie, Naser Ansari-Pour, Oliver Cast, Doreen Lau, Francis Scott, Sarah J Welsh, Christine Parkinson, Leila Khoja, Luiza Moore, Mark Tullett, Kim Wong, Ingrid Ferreira, Julia M Martínez Gómez, Mitchell Levesque, Ferdia A Gallagher, Alejandro Jiménez-Sánchez, Laura Riva, Martin L Miller, Kieren Allinson, Peter J Campbell, Pippa Corrie, David C Wedge, David J Adams
Sep 25, 2020
Metastatic melanoma carries a poor prognosis despite modern systemic therapies. Understanding the evolution of the disease could help inform patient management. Through whole-genome sequencing of 13 melanoma metastases sampled...
Active Blended Learning
This chapter focuses on the joint implementation of blended learning and active learning. The authors analysed 152 institutional websites containing definitions of these concepts. Blended learning is commonly, though arguably...
Published by: IGI Global Scientific Publishing
Complement component 3 as biomarker of disease activity and cardiometabolic risk factor in rheumatoid arthritis and spondyloarthritis.
Iván Arias de la Rosa, Pilar Font, Alejandro Escudero-Contreras, María Dolores López-Montilla, Carlos Pérez-Sánchez, María Carmen Ábalos-Aguilera, Lourdes Ladehesa-Pineda, Alejandro Ibáñez-Costa, Carmen Torres-Granados, Yolanda Jimenez-Gomez, Alejandra Patiño-Trives, María Luque-Tévar, María Carmen Castro-Villegas, Jerusalem Calvo-Gutiérrez, Rafaela Ortega-Castro, Chary López-Pedrera, Eduardo Collantes-Estévez, Nuria Barbarroja
Oct 23, 2020
Interleukin-15 and interferon-gamma participate in the cross-talk between natural killer and monocytic cells required for tumour necrosis factor production.
Isidoro González-Alvaro, Carmen Domínguez-Jiménez, Ana M Ortiz, Vanessa Núñez-González, Pedro Roda-Navarro, Elena Fernández-Ruiz, David Sancho, Francisco Sánchez-Madrid
Jun 14, 2011
Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network.
Valérie Schreiber, Reuben Mercier, Sara Jiménez, Tao Ye, Emmanuel García-Sánchez, Annabelle Klein, Aline Meunier, Sabitri Ghimire, Catherine Birck, Bernard Jost, Kristian Honnens de Lichtenberg, Christian Honoré, Palle Serup, Gérard Gradwohl
Oct 19, 2021
OBJECTIVE: Mice lacking the bHLH transcription factor (TF) Neurog3 do not form pancreatic islet cells, including insulin-secreting beta cells, the absence of which leads to diabetes. In humans, homozygous mutations of NEUROG3...
Intravalley Spin-Flip Relaxation Dynamics in Single-Layer WS2.
Zilong Wang, Alejandro Molina-Sánchez, Patrick Altmann, Davide Sangalli, Domenico de Fazio, Giancarlo Soavi, Ugo Sassi, Federico Bottegoni, Franco Ciccacci, Marco Finazzi, Ludger Wirtz, Andrea C Ferrari, Andrea Marini, Giulio Cerullo, Stefano Dal Conte
Dec 10, 2018
In monolayer (1L) transition metal dichalcogenides (TMDs) the valence and conduction bands are spin-split because of the strong spin-orbit interaction. In tungsten-based TMDs the spin-ordering of the conduction band is such that...
Design Thinking and Compliance as Drivers for Decision Support System Adoption in Agriculture
To respond to increasing demands for good agricultural practices (GAP) and food safety, governments globally are introducing stringent regulations to govern agricultural compliance that affect production, storage, and sales...
Published by: IGI Global Scientific Publishing
Unraveling tumor-immune heterogeneity in advanced ovarian cancer uncovers immunogenic effect of chemotherapy.
Alejandro Jiménez-Sánchez, Paulina Cybulska, Katherine LaVigne Mager, Simon Koplev, Oliver Cast, Dominique-Laurent Couturier, Danish Memon, Pier Selenica, Ines Nikolovski, Yousef Mazaheri, Yonina Bykov, Felipe C Geyer, Geoff Macintyre, Lena Morrill Gavarró, Ruben M Drews, Michael B Gill, Anastasios D Papanastasiou, Ramon E Sosa, Robert A Soslow, Tyler Walther, Ronglai Shen, Dennis S Chi, Kay J Park, Travis Hollmann, Jorge S Reis-Filho, Florian Markowetz, Pedro Beltrao, Hebert Alberto Vargas, Dmitriy Zamarin, James D Brenton, Alexandra Snyder, Britta Weigelt, Evis Sala, Martin L Miller
May 20, 2020
In metastatic cancer, the degree of heterogeneity of the tumor microenvironment (TME) and its molecular underpinnings remain largely unstudied. To characterize the tumor-immune interface at baseline and during neoadjuvant...
Animals cisplatin Cohort Studies Cystadenocarcinoma Serous DNA Copy Number Variations Female Gene Expression Profiling Gene Expression Regulation Neoplastic Genes myc Humans Killer Cells Natural Lymphocytes Tumor-Infiltrating Mice Mutation Ovarian Neoplasms principal component analysis Tumor Microenvironment Wnt Signaling Pathway
COVID-19 Mitigation Measures and Their Impact on Subjective Wellbeing
This study assesses the actual magnitude and scope of the impacts of the COVID-19 mitigation measures at the individual level, with special interest in subjective well-being (SWB), its relevance and how these negative effects...
Published by: IGI Global Scientific Publishing
Neural Mechanisms that Control an Innate Foraging Behavior in Caenorhabditis Elegans
Alejandro Lopez-Cruz
Jan 01, 0001
The ability to efficiently locate food is critical for survival. Thus, animals modify their foraging patterns based on recent experience and current conditions to increase their likelihood of finding food. One highly conserved...
Published by: Rockefeller University
On the Interactions of Augmin with Microtubules and the Mechanics of the Cross-Linker PRC1
Alejandro Dottore
Jan 01, 0001
Cell division in eukaryotes requires the assembly and maintenance of a structure, the bipolar spindle, self-organized from microtubules and their associated proteins. A multitude of components have been identified to be involved...
Published by: Rockefeller University
The infrastructures of internal colonialism:
Alejandro De Coss-Corzo
May 01, 2023
This article explores the relation between infrastructures, labour and internal colonialism in Lerma, Mexico. Drawing on archival and ethnographic research of two hydraulic projects there, the article argues that infrastructures...
The infrastructures of internal colonialism:
Alejandro De Coss-Corzo
May 01, 2023
This article explores the relation between infrastructures, labour and internal colonialism in Lerma, Mexico. Drawing on archival and ethnographic research of two hydraulic projects there, the article argues that infrastructures...
Genetic diversity of Phytophthora infestans in the Northern Andean region.
Brain-to-Brain Coupling in the Gamma-Band as a Marker of Shared Intentionality
Cooperation and competition are two ways of social interaction keys to life in society. Recent EEG-based hyperscanning studies reveal that cooperative and competitive interactions induce an increase in interbrain coupling....
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