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Results: 39
4D imaging reveals stage dependent random and directed cell motion during somite morphogenesis.
James McColl, Gi Fay Mok, Anna H Lippert, Aleks Ponjavic, Leila Muresan, Andrea Münsterberg
Nov 16, 2018
Somites are paired embryonic segments that form in a regular sequence from unsegmented mesoderm during vertebrate development. Although transient structures they are of fundamental importance as they generate cell lineages of...
Single-Molecule Light-Sheet Imaging of Suspended T Cells.
Aleks Ponjavic, James McColl, Alexander R Carr, Ana Mafalda Santos, Klara Kulenkampff, Anna Lippert, Simon J Davis, David Klenerman, Steven F Lee
Apr 11, 2019
Adaptive immune responses are initiated by triggering of the T cell receptor. Single-molecule imaging based on total internal reflection fluorescence microscopy at coverslip/basal cell interfaces is commonly used to study this...
resPAINT
Edward W Sanders, Alexander R Carr, Ezra Bruggeman, Markus Körbel, Sarah I Benaissa, Robert F Donat, Ana M Santos, James McColl, Kevin O'Holleran, David Klenerman, Simon J Davis, Steven F Lee, Aleks Ponjavic
Aug 23, 2022
Points for accumulation in nanoscale topography (PAINT) allows practically unlimited measurements in localisation microscopy but is limited by background fluorescence at high probe concentrations, especially in volumetric...
resPAINT
Edward W Sanders, Alexander R Carr, Ezra Bruggeman, Markus Körbel, Sarah I Benaissa, Robert F Donat, Ana M Santos, James McColl, Kevin O'Holleran, David Klenerman, Simon J Davis, Steven F Lee, Aleks Ponjavic
Aug 23, 2022
Abstract: Points for accumulation in nanoscale topography (PAINT) allows practically unlimited measurements in localisation microscopy but is limited by background fluorescence at high probe concentrations, especially in...
A cell topography-based mechanism for ligand discrimination by the T cell receptor.
Ricardo A Fernandes, Kristina A Ganzinger, Justin C Tzou, Peter Jönsson, Steven F Lee, Matthieu Palayret, Ana Mafalda Santos, Alexander R Carr, Aleks Ponjavic, Veronica T Chang, Charlotte Macleod, B Christoffer Lagerholm, Alan E Lindsay, Omer Dushek, Andreas Tilevik, Simon J Davis, David Klenerman
May 24, 2019
T cell receptor dwell time microvilli receptor triggering single-molecule imaging Animals Antigen-Presenting Cells Host-Pathogen Interactions Humans Immunity Innate Kinetics Ligands Lymphocyte Activation Major Histocompatibility Complex Microvilli Models Theoretical Peptides Phosphorylation Receptors Antigen T-Cell Signal Transduction single molecule imaging T-Lymphocytes
Capturing resting T cells
Ana Mafalda Santos, Aleks Ponjavic, Marco Fritzsche, Ricardo A Fernandes, Jorge Bernardino de la Serna, Martin J Wilcock, Falk Schneider, Iztok Urbančič, James McColl, Consuelo Anzilotti, Kristina A Ganzinger, Meike Aßmann, David Depoil, Richard J Cornall, Michael L Dustin, David Klenerman, Simon J Davis, Christian Eggeling, Steven F Lee
Mar 12, 2018
Thermodynamics of high-pressure ice phases explored with atomistic simulations
Aleks Reinhardt, Mandy Bethkenhagen, Federica Coppari, Marius Millot, Sebastien Hamel, Bingqing Cheng
Aug 11, 2022
Most experimentally known high-pressure ice phases have a body-centred cubic (bcc) oxygen lattice. Our large-scale molecular-dynamics simulations with a machine-learning potential indicate that, amongst these bcc ice phases...
Targeted modulation of protein liquid-liquid phase separation by evolution of amino-acid sequence.
Rationally and efficiently modifying the amino-acid sequence of proteins to control their ability to undergo liquid-liquid phase separation (LLPS) on demand is not only highly desirable, but can also help to elucidate which...
Targeted modulation of protein liquid-liquid phase separation by evolution of amino-acid sequence.
Rationally and efficiently modifying the amino-acid sequence of proteins to control their ability to undergo liquid-liquid phase separation (LLPS) on demand is not only highly desirable, but can also help to elucidate which...
Published by: PLoS computational biology
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