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Current Therapies for Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer Patients.
Alexey A Larionov
Sep 05, 2018
The median survival of patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) has more than doubled, since the discovery of HER2-targeted treatments: it rose from less than 2 years...
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Management Problems in Global Crowdsourcing
The study aimed to develop recommendations for the optimization of settings in which the crowdsourcing project takes place. Findings show that crowdfunding projects are hybrid and include the elements of crowdsourcing...
On Equilibrium in Monopolistic Competition with Endogenous Labor
We consider a model of monopolistic competition with several heterogeneous sectors and endogenous labor supply. For low (high) values of the labor supply elasticity, we show that there is always a unique equilibrium. For medium...
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Hierarchical machine learning of potential energy surfaces.
We present hierarchical machine learning (hML) of highly accurate potential energy surfaces (PESs). Our scheme is based on adding predictions of multiple Δ-machine learning models trained on energies and energy corrections...
Assessing Stability in the Relationship Between Parties in Crowdfunding and Crowdsourcing Projects During the COVID-19 Crisis
This research reviews challenges in building sustainable relationships between the parties involved in the crowdfunding and crowdsourcing projects, which are running in extreme situations, such as the COVID-19 pandemic. This...
On Equilibrium in Monopolistic Competition with Endogenous Labor
We consider a model of monopolistic competition with several heterogeneous sectors and endogenous labor supply. For low (high) values of the labor supply elasticity, we show that there is always a unique equilibrium. For medium...
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Modelling drug flux through microporated skin

A simple mathematical equation has been developed to predict drug flux through microporated skin. The theoretical model is based on an approach applied previously to water evaporation through leaf stomata. Pore density, pore...

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Modelling drug flux through microporated skin

A simple mathematical equation has been developed to predict drug flux through microporated skin. The theoretical model is based on an approach applied previously to water evaporation through leaf stomata. Pore density, pore...

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The hitting time of zero for a stable process
For any two-sided jumping α-stable process, where 1<α<2, we find an explicit identity for the law of the first hitting time of the origin. This complements existing work in the symmetric case and the spectrally one-sided...
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Quantum-Limited Directional Amplifiers with Optomechanics.
Directional amplifiers are an important resource in quantum-information processing, as they protect sensitive quantum systems from excess noise. Here, we propose an implementation of phase-preserving and phase-sensitive...
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The hitting time of zero for a stable process
For any two-sided jumping α-stable process, where 1<α<2, we find an explicit identity for the law of the first hitting time of the origin. This complements existing work in the symmetric case and the spectrally one-sided...
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Photovoltage spectroscopy of dipolar spin waves in Dy micromagnets
We report on a sensitive spectroscopic technique for probing the spin excitations of individual submicron magnets. This technique uses a high mobility two dimensional electron gas (2DEG) confined in a GaAs/AlGaAs heterojunction...
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Photovoltage spectroscopy of dipolar spin waves in Dy micromagnets
We report on a sensitive spectroscopic technique for probing the spin excitations of individual submicron magnets. This technique uses a high mobility two dimensional electron gas (2DEG) confined in a GaAs/AlGaAs heterojunction...
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New immunological potential markers for triple negative breast cancer
Breast cancer (BC) is the second leading cause of cancer death in women worldwide, and settings of specific prognostic factors and efficacious therapies are made difficult by phenotypic heterogeneity of BC subtypes. Therefore...
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New immunological potential markers for triple negative breast cancer
Abstract: Breast cancer (BC) is the second leading cause of cancer death in women worldwide, and settings of specific prognostic factors and efficacious therapies are made difficult by phenotypic heterogeneity of BC subtypes....
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Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy.
Abundant filamentous inclusions of tau are characteristic of more than 20 neurodegenerative diseases that are collectively termed tauopathies. Electron cryo-microscopy (cryo-EM) structures of tau amyloid filaments from human...
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New immunological potential markers for triple negative breast cancer
Breast cancer (BC) is the second leading cause of cancer death in women worldwide, and settings of specific prognostic factors and efficacious therapies are made difficult by phenotypic heterogeneity of BC subtypes. Therefore...
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dia-PASEF data analysis using FragPipe and DIA-NN for deep proteomics of low sample amounts.
The dia-PASEF technology uses ion mobility separation to reduce signal interferences and increase sensitivity in proteomic experiments. Here we present a two-dimensional peak-picking algorithm and generation of optimized...
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Big Data and Internet of Things (IoT) Technologies' Influence on Higher Education
To respond to the needs of digital transformation, universities must continue to play their role as proving ground for educating the future generation and innovation. The article is devoted to overview, discussion, and...

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