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Is the Dewlap an Honest Signal of Fighting Ability in the Male Green Anole (Anolis Carolinensis)?
Alexia Hughes
Jan 01, 0001
Signals are morphological or behavioral traits that an individual uses to influence the behavior or actions of another. These signals can be used in male-male competition, in which male secondary sexual traits act as a signal of...
Published by: Winthrop University
Surface-Sensitive NMR Detection of the Solid Electrolyte Interphase Layer on Reduced Graphene Oxide.
Michal Leskes, Gunwoo Kim, Tao Liu, Alison L Michan, Fabien Aussenac, Patrick Dorffer, Subhradip Paul, Clare P Grey
Jun 06, 2018
Forming a stable solid electrolyte interphase (SEI) is critical for rechargeable batteries' performance and lifetime. Understanding its formation requires analytical techniques that provide molecular-level insight. Here, dynamic...
Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice
H. James McQuillan, Jenny Clarkson, Alexia Kauff, Su Young Han, Siew Hoong Yip, Isaiah Cheong, Robert Porteous, Alison K. Heather, Allan E. Herbison
Dec 08, 2022
The mechanisms underlying the homeostatic estrogen negative feedback pathway central to mammalian fertility have remained unresolved. Direct measurement of gonadotropin-releasing hormone (GnRH) pulse generator activity in freely...
Published by: Nature Publishing Group UK
Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice
H. James McQuillan, Jenny Clarkson, Alexia Kauff, Su Young Han, Siew Hoong Yip, Isaiah Cheong, Robert Porteous, Alison K. Heather, Allan E. Herbison
Dec 22, 2022
The mechanisms underlying the homeostatic estrogen negative feedback pathway central to mammalian fertility have remained unresolved. Direct measurement of gonadotropin-releasing hormone (GnRH) pulse generator activity in freely...
Published by: Nature Publishing Group UK
Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice.
H James McQuillan, Jenny Clarkson, Alexia Kauff, Su Young Han, Siew Hoong Yip, Isaiah Cheong, Robert Porteous, Alison K Heather, Allan E Herbison
Jan 04, 2023
AAV9-mediated Schwann cell-targeted gene therapy rescues a model of demyelinating neuropathy
AAV9-mediated Schwann cell-targeted gene therapy rescues a model of demyelinating neuropathy.
Alexia Kagiava, Christos Karaiskos, Jan Richter, Christina Tryfonos, Matthew J Jennings, Amanda J Heslegrave, Irene Sargiannidou, Marina Stavrou, Henrik Zetterberg, Mary M Reilly, Christina Christodoulou, Rita Horvath, Kleopas A Kleopa
Mar 15, 2021
Mutations in the GJB1 gene, encoding the gap junction (GJ) protein connexin32 (Cx32), cause X-linked Charcot-Marie-Tooth disease (CMT1X), an inherited demyelinating neuropathy. We developed a gene therapy approach for CMT1X...
Reference exome data for Australian Aboriginal populations to support health-based research.
Alexia L Weeks, Heather A D'Antoine, Melita McKinnon, Genevieve Syn, Dawn Bessarab, Ngiare Brown, Steven YC Tong, Bo Reményi, Andrew Steer, Lesley-Ann Gray, Michael Inouye, Jonathan R Carapetis, Jenefer M Blackwell, Timo Lassmann
May 20, 2020
Whole exome sequencing (WES) is a popular and successful technology which is widely used in both research and clinical settings. However, there is a paucity of reference data for Aboriginal Australians to underpin the...
Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations.
Christina A Eichstaedt, Luca Pagani, Tiago Antao, Charlotte E Inchley, Alexia Cardona, Alexander Mörseburg, Florian J Clemente, Timothy J Sluckin, Ene Metspalu, Mario Mitt, Reedik Mägi, Georgi Hudjashov, Mait Metspalu, Maru Mormina, Guy S Jacobs, Toomas Kivisild
Mar 21, 2018
The aim of this study is to identify genetic variants that harbour signatures of recent positive selection and may facilitate physiological adaptations to hypobaric hypoxia. To achieve this, we conducted whole genome sequencing...
Reference exome data for Australian Aboriginal populations to support health-based research
Alexia L. Weeks, Heather A. D’Antoine, Melita McKinnon, Genevieve Syn, Dawn Bessarab, Ngiare Brown, Steven Y. C. Tong, Bo Reményi, Andrew Steer, Lesley-Ann Gray, Michael Inouye, Jonathan R. Carapetis, Jenefer M. Blackwell, Timo Lassmann
Feb 16, 2021
Abstract: Whole exome sequencing (WES) is a popular and successful technology which is widely used in both research and clinical settings. However, there is a paucity of reference data for Aboriginal Australians to underpin the...
Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes.
Rabab Nasrallah, Eva M Fast, Parham Solaimani, Kathy Knezevic, Alexia Eliades, Rahima Patel, Roshana Thambyrajah, Ashwin Unnikrishnan, Julie Thoms, Dominik Beck, Chris S Vink, Aileen Smith, Jason Wong, Mairi Shepherd, David Kent, Rahul Roychoudhuri, Fabian Paul, Julia Klippert, Annette Hammes, Thomas Willnow, Bertie Göttgens, Elaine Dzierzak, Leonard I Zon, George Lacaud, Valerie Kouskoff, John E Pimanda
Oct 12, 2016
Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation.
Konstantin Neukirch, Khaled Alsabil, Chau-Phi Dinh, Rossella Bilancia, Martin Raasch, Alexia Ville, Ida Cerqua, Guillaume Viault, Dimitri Bréard, Simona Pace, Veronika Temml, Elena Brunner, Paul M Jordan, Marta C Marques, Konstantin Loeser, André Gollowitzer, Stephan Permann, Jana Gerstmeier, Stefan Lorkowski, Hermann Stuppner, Ulrike Garscha, Tiago Rodrigues, Gonçalo J L Bernardes, Daniela Schuster, Denis Séraphin, Pascal Richomme, Antonietta Rossi, Alexander S Mosig, Fiorentina Roviezzo, Oliver Werz, Jean-Jacques Helesbeux, Andreas Koeberle
Aug 26, 2021
Endogenous long-chain metabolites of vitamin E (LCMs) mediate immune functions by targeting 5-lipoxygenase (5-LOX) and increasing the systemic concentrations of resolvin E3, a specialized proresolving lipid mediator. SAR studies...
Published by: Journal of medicinal chemistry
Reference exome data for Australian Aboriginal populations to support health-based research
Alexia L. Weeks, Heather A. D’Antoine, Melita McKinnon, Genevieve Syn, Dawn Bessarab, Ngiare Brown, Steven Y. C. Tong, Bo Reményi, Andrew Steer, Lesley-Ann Gray, Michael Inouye, Jonathan R. Carapetis, Jenefer M. Blackwell, Timo Lassmann
Apr 29, 2021
Abstract: Whole exome sequencing (WES) is a popular and successful technology which is widely used in both research and clinical settings. However, there is a paucity of reference data for Aboriginal Australians to underpin the...
A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations.
Florian J Clemente, Alexia Cardona, Charlotte E Inchley, Benjamin M Peter, Guy Jacobs, Luca Pagani, Daniel J Lawson, Tiago Antão, Mário Vicente, Mario Mitt, Michael DeGiorgio, Zuzana Faltyskova, Yali Xue, Qasim Ayub, Michal Szpak, Reedik Mägi, Anders Eriksson, Andrea Manica, Maanasa Raghavan, Morten Rasmussen, Simon Rasmussen, Eske Willerslev, Antonio Vidal-Puig, Chris Tyler-Smith, Richard Villems, Rasmus Nielsen, Mait Metspalu, Boris Malyarchuk, Miroslava Derenko, Toomas Kivisild
Nov 12, 2014
Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility.
Daniel J Wright, Felix R Day, Nicola D Kerrison, Florian Zink, Alexia Cardona, Patrick Sulem, Deborah J Thompson, Svanhvit Sigurjonsdottir, Daniel F Gudbjartsson, Agnar Helgason, J Ross Chapman, Steve P Jackson, Claudia Langenberg, Nicholas J Wareham, Robert A Scott, Unnur Thorsteindottir, Ken K Ong, Kari Stefansson, John RB Perry
Mar 06, 2017
Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation.
Konstantin Neukirch, Khaled Alsabil, Chau-Phi Dinh, Rossella Bilancia, Martin Raasch, Alexia Ville, Ida Cerqua, Guillaume Viault, Dimitri Bréard, Simona Pace, Veronika Temml, Elena Brunner, Paul M Jordan, Marta C Marques, Konstantin Loeser, André Gollowitzer, Stephan Permann, Jana Gerstmeier, Stefan Lorkowski, Hermann Stuppner, Ulrike Garscha, Tiago Rodrigues, Gonçalo JL Bernardes, Daniela Schuster, Denis Séraphin, Pascal Richomme, Antonietta Rossi, Alexander S Mosig, Fiorentina Roviezzo, Oliver Werz, Jean-Jacques Helesbeux, Andreas Koeberle
Jul 28, 2021
Endogenous long-chain metabolites of vitamin E (LCMs) mediate immune functions by targeting 5-lipoxygenase (5-LOX) and increasing the systemic concentrations of resolvin E3, a specialized proresolving lipid mediator. SAR studies...
Identifying and correcting epigenetics measurements for systematic sources of variation.
Flavie Perrier, Alexei Novoloaca, Srikant Ambatipudi, Laura Baglietto, Akram Ghantous, Vittorio Perduca, Myrto Barrdahl, Sophia Harlid, Ken K Ong, Alexia Cardona, Silvia Polidoro, Therese Haugdahl Nøst, Kim Overvad, Hanane Omichessan, Martijn Dollé, Christina Bamia, José Marìa Huerta, Paolo Vineis, Zdenko Herceg, Isabelle Romieu, Pietro Ferrari
Jul 23, 2018
BACKGROUND: Methylation measures quantified by microarray techniques can be affected by systematic variation due to the technical processing of samples, which may compromise the accuracy of the measurement process and contribute...
Systematic evaluation of high-level visual deficits and lesions in posterior cerebral artery stroke.
Knowledge about the consequences of stroke on high-level vision comes primarily from single case studies of patients selected based on their behavioural profiles, typically patients with specific stroke syndromes like pure...
Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population
Alexia Cardona, Felix R Day, John RB Perry, Marie Loh, Audrey Y Chu, Benjamin Lehne, Dirk S Paul, Luca A Lotta, Isobel D Stewart, Nicola D Kerrison, Robert A Scott, Kay-Tee Khaw, Nita G Forouhi, Claudia Langenberg, Chunyu Liu, Michael M Mendelson, Daniel Levy, Stephan Beck, R David Leslie, Josée Dupuis, James B Meigs, Jaspal S Kooner, Jussi Pihlajamäki, Allan Vaag, Alexander Perfilyev, Charlotte Ling, Marie-France Hivert, John C Chambers, Nicholas J Wareham, Ken K Ong
Sep 20, 2019
Epigenetic changes may contribute substantially to risks of diseases of aging. Previous studies reported seven methylation variable positions (MVPs) robustly associated with incident type 2 diabetes mellitus (T2DM). However...
GWAS of epigenetic aging rates in blood reveals a critical role for TERT.
Ake T Lu, Luting Xue, Elias L Salfati, Brian H Chen, Luigi Ferrucci, Daniel Levy, Roby Joehanes, Joanne M Murabito, Douglas P Kiel, Pei-Chien Tsai, Idil Yet, Jordana T Bell, Massimo Mangino, Toshiko Tanaka, Allan F McRae, Riccardo E Marioni, Peter M Visscher, Naomi R Wray, Ian J Deary, Morgan E Levine, Austin Quach, Themistocles Assimes, Philip S Tsao, Devin Absher, James D Stewart, Yun Li, Alex P Reiner, Lifang Hou, Andrea A Baccarelli, Eric A Whitsel, Abraham Aviv, Alexia Cardona, Felix R Day, Nicholas J Wareham, John RB Perry, Ken K Ong, Kenneth Raj, Kathryn L Lunetta, Steve Horvath
Apr 13, 2018
DNA methylation age is an accurate biomarker of chronological age and predicts lifespan, but its underlying molecular mechanisms are unknown. In this genome-wide association study of 9907 individuals, we find gene variants...
DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases.
Matthias Wielscher, Pooja R Mandaviya, Brigitte Kuehnel, Roby Joehanes, Rima Mustafa, Oliver Robinson, Yan Zhang, Barbara Bodinier, Esther Walton, Pashupati P Mishra, Pascal Schlosser, Rory Wilson, Pei-Chien Tsai, Saranya Palaniswamy, Riccardo E Marioni, Giovanni Fiorito, Giovanni Cugliari, Ville Karhunen, Mohsen Ghanbari, Bruce M Psaty, Marie Loh, Joshua C Bis, Benjamin Lehne, Nona Sotoodehnia, Ian J Deary, Marc Chadeau-Hyam, Jennifer A Brody, Alexia Cardona, Elizabeth Selvin, Alicia K Smith, Andrew H Miller, Mylin A Torres, Eirini Marouli, Xin Gào, Joyce BJ van Meurs, Johanna Graf-Schindler, Wolfgang Rathmann, Wolfgang Koenig, Annette Peters, Wolfgang Weninger, Matthias Farlik, Tao ZHANG, Wei Chen, Yujing Xia, Alexander Teumer, Matthias Nauck, Hans J Grabe, Macus Doerr, Terho Lehtimäki, Weihua Guan, Lili Milani, Toshiko Tanaka, Krista Fisher, Lindsay L Waite, Silva Kasela, Paolo Vineis, Niek Verweij, Pim van der Harst, Licia Iacoviello, Carlotta Sacerdote, Salvatore Panico, Vittorio Krogh, Rosario Tumino, Evangelia Tzala, Giuseppe Matullo, Mikko A Hurme, Olli T Raitakari, Elena Colicino, Andrea A Baccarelli, Mika Kähönen, Karl-Heinz Herzig, Shengxu Li, BIOS Consortium, Karen N Conneely, Jaspal S Kooner, Anna Köttgen, Bastiaan T Heijmans, Panos Deloukas, Caroline Relton, Kenneth Ong, Jordana T Bell, Eric Boerwinkle, Paul Elliott, Hermann Brenner, Marian Beekman, Daniel Levy, Melanie Waldenberger, John C Chambers, Abbas Dehghan, Marjo-Riitta Järvelin
May 09, 2022
We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to describe the DNA methylation signature of chronic low-grade inflammation as measured by C-Reactive protein (CRP). We find 1,511 independent...
Genomic analyses inform on migration events during the peopling of Eurasia.
Luca Pagani, Daniel John Lawson, Evelyn Jagoda, Alexander Mörseburg, Anders Eriksson, Mario Mitt, Florian Clemente, Georgi Hudjashov, Michael DeGiorgio, Lauri Saag, Jeffrey D Wall, Alexia Cardona, Reedik Mägi, Melissa A Wilson Sayres, Sarah Kaewert, Charlotte Inchley, Christiana L Scheib, Mari Järve, Monika Karmin, Guy S Jacobs, Tiago Antao, Florin Mircea Iliescu, Alena Kushniarevich, Qasim Ayub, Chris Tyler-Smith, Yali Xue, Bayazit Yunusbayev, Kristiina Tambets, Chandana Basu Mallick, Lehti Saag, Elvira Pocheshkhova, George Andriadze, Craig Muller, Michael C Westaway, David M Lambert, Grigor Zoraqi, Shahlo Turdikulova, Dilbar Dalimova, Zhaxylyk Sabitov, Gazi Nurun Nahar Sultana, Joseph Lachance, Sarah Tishkoff, Kuvat Momynaliev, Jainagul Isakova, Larisa D Damba, Marina Gubina, Pagbajabyn Nymadawa, Irina Evseeva, Lubov Atramentova, Olga Utevska, François-Xavier Ricaut, Nicolas Brucato, Herawati Sudoyo, Thierry Letellier, Murray P Cox, Nikolay A Barashkov, Vedrana Skaro, Lejla Mulahasanovic, Dragan Primorac, Hovhannes Sahakyan, Maru Mormina, Christina A Eichstaedt, Daria V Lichman, Syafiq Abdullah, Gyaneshwer Chaubey, Joseph TS Wee, Evelin Mihailov, Alexandra Karunas, Sergei Litvinov, Rita Khusainova, Natalya Ekomasova, Vita Akhmetova, Irina Khidiyatova, Damir Marjanović, Levon Yepiskoposyan, Doron M Behar, Elena Balanovska, Andres Metspalu, Miroslava Derenko, Boris Malyarchuk, Mikhail Voevoda, Sardana A Fedorova, Ludmila P Osipova, Marta Mirazón Lahr, Pascale Gerbault, Matthew Leavesley, Andrea Bamberg Migliano, Michael Petraglia, Oleg Balanovsky, Elza K Khusnutdinova, Ene Metspalu, Mark G Thomas, Andrea Manica, Rasmus Nielsen, Richard Villems, Eske Willerslev, Toomas Kivisild, Mait Metspalu
Aug 15, 2017
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