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Vascular Effects of Four-Week Functional and Resistance Exercise Training Programs
Allyson K Getty
Jan 01, 0001
The purpose of this study is to examine how two four-week self-report exercise interventions modify cardiovascular health measures; including BP, blood glucose and cholesterol levels, body fat percentage, brachial artery FMD...
Cardiovascular health IMT FMD Body composition Exercise intervention Exercise Physiology Medicine and Health Sciences PREVENTIVE MEDICINE
Published by: Ursinus College
Effects of a Short-Term Functional Exercise Program on Cardiac and Vascular Health
Allyson K. Getty
Jan 01, 0001
Cardiovascular (CV) disease is the leading cause of death in the United States. Research consistently shows that those at the highest risk for CV disease are those who are overweight and have low fitness and activity levels....
Cardiovascular Exercise Intervention vascular HEALTH short-term blood pressure Blood Glucose Cholesterol artery wall Cardiology Cardiovascular Diseases Exercise Physiology Medicine and Health Sciences
Published by: Ursinus College
The Lantern Vol. 35, No. 2, Spring 1969
Ritchie Davis, Janie Lancey, Linda DiMauro, Mary Ellen McFadden, Pam Grant, Beth Bland, Richard Dixon
Jan 01, 0001
My Steps Alone He Said He Hated Time Communication Evolution Morning Almost Faded Today I Looked Gloucester Have You Ever Tried It's Contact The Galloping Camel Life's Flight Haiku Today is Monday At...
Ursinus College Collegeville Pennsylvania Lantern Literary Magazine poetry fiction Creative Nonfiction Arts and Humanities Creative Writing fiction illustration Nonfiction poetry
Published by: Ursinus College
Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals
Xulin Liu, Maria-Eleni Dounavi, Karen Ritchie, Katie Wells, Craig W. Ritchie, Li Su, Graciela Muniz-Terrera, John T. O’Brien
Apr 24, 2021
Abstract: Background: Structural brain changes associated with Alzheimer’s disease (AD) can occur decades before the onset of symptoms. The Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) score has been suggested to be...
Midlife alcohol consumption and longitudinal brain atrophy
Michael J. Firbank, John T. O’Brien, Karen Ritchie, Katie Wells, Guy Williams, Li Su, Craig W. Ritchie
Oct 22, 2020
Abstract: Background and aims: Consensus is lacking on whether light to moderate consumption of alcohol compared to abstinence is neuroprotective. In this study, we investigated the relationship between self-reported alcohol use...
Midlife alcohol consumption and longitudinal brain atrophy
Michael J. Firbank, John T. O’Brien, Karen Ritchie, Katie Wells, Guy Williams, Li Su, Craig W. Ritchie
Jun 21, 2021
Abstract: Background and aims: Consensus is lacking on whether light to moderate consumption of alcohol compared to abstinence is neuroprotective. In this study, we investigated the relationship between self-reported alcohol use...
Association between midlife dementia risk factors and longitudinal brain atrophy
John T O'Brien, Michael J Firbank, Karen Ritchie, Katie Wells, Guy B Williams, Craig W Ritchie, Li Su
Dec 11, 2019
Background: Increased rates of brain atrophy on serial MRI are frequently used as a surrogate marker of disease progression in Alzheimer’s disease and other dementias. However, the extent to which they are associated with future...
Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer's disease.
James D Stefaniak, Li Su, Elijah Mak, Nasim Sheikh-Bahaei, Katie Wells, Karen Ritchie, Adam Waldman, Craig W Ritchie, John T O'Brien
Jan 25, 2018
INTRODUCTION: Cerebral small vessel disease (CSVD) is associated with late-onset Alzheimer's disease (LOAD) and might contribute to the relationship between apolipoprotein E ε4 (APOE ε4) and LOAD, in older people. However, it is...
Cerebral microbleed cerebral small vessel disease Dementia MRI Middle age Risk Factors White matter hyperintensity Adult Alzheimer Disease Apolipoprotein E4 cerebral small vessel diseases Cross-Sectional Studies Family Health Female Genetic Predisposition to Disease Humans Image Processing Computer-Assisted Magnetic Resonance Imaging Male Middle Aged prevalence Regression Analysis statistics Nonparametric white matter
Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia.
Maria-Eleni Dounavi, Elijah Mak, Katie Wells, Karen Ritchie, Craig W Ritchie, Li Su, John T O' Brien
Mar 16, 2020
The hippocampus is one of the first regions to demonstrate atrophy during the prodromal stage of Alzheimer's disease. Volumetric analysis of its individual subfields could provide biomarkers with higher sensitivity than whole...
Midlife alcohol consumption and longitudinal brain atrophy
Michael J Firbank, John T O'Brien, Karen Ritchie, Katie Wells, Guy Williams, Li Su, Craig W Ritchie
Jun 15, 2020
BACKGROUND AND AIMS: Consensus is lacking on whether light to moderate consumption of alcohol compared to abstinence is neuroprotective. In this study, we investigated the relationship between self-reported alcohol use and brain...
Trauma and depressive symptomatology in middle-aged persons at high risk of dementia
Karen Ritchie, Isabelle Carrière, Sarah Gregory, Tam Watermeyer, Samuel Danso, Li Su, Craig W Ritchie, John T O'Brien
Sep 28, 2020
OBJECTIVE: Depression and trauma are associated with changes in brain regions implicated in Alzheimer's disease. The present study examined associations between childhood trauma, depression, adult cognitive functioning and risk...
Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals.
Xulin Liu, Maria-Eleni Dounavi, Karen Ritchie, Katie Wells, Craig W Ritchie, Li Su, Graciela Muniz-Terrera, John T O'Brien
Dec 23, 2020
BACKGROUND: Structural brain changes associated with Alzheimer's disease (AD) can occur decades before the onset of symptoms. The Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) score has been suggested to be associated...
Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients
Dami A Collier, Sonny M Assennato, Ben Warne, Nyarie Sithole, Katherine Sharrocks, Allyson Ritchie, Pooja Ravji, Matthew Routledge, Dominic Sparkes, Jordan Skittrall, Anna Smielewska, Isobel Ramsey, Neha Goel, Martin Curran, David Enoch, Rhys Tassell, Michelle Lineham, Devan Vaghela, Clare Leong, Hoi Ping Mok, John Bradley, Kenneth GC Smith, Vivienne Mendoza, Nikos Demiris, Martin Besser, Gordon Dougan, Paul J Lehner, Mark J Siedner, Hongyi Zhang, Claire S Waddington, Helen Lee, Ravindra K Gupta, CITIID-NIHR COVID BioResource Collaboration
Aug 10, 2020
There is an urgent need for rapid SARS-CoV-2 testing in hospitals to limit nosocomial spread. We report an evaluation of point of care (POC) nucleic acid amplification testing (NAAT) in 149 participants with parallel combined...
Functional neuroimaging findings in healthy middle-aged adults at risk of Alzheimer's disease.
Mirette Habib, Elijah Mak, Silvy Gabel, Li Su, Guy Williams, Adam Waldman, Katie Wells, Karen Ritchie, Craig Ritchie, John T O'Brien
Jun 05, 2017
Alzheimer’s disease COGNITIVE IMPAIRMENT Functional Magnetic Resonance Imaging neurodegeneration Neuroimaging positron emission tomography Preclinical dementia Adult Alzheimer Disease Apolipoprotein E4 Brain Cognitive Dysfunction Functional Neuroimaging Gray Matter health status Humans Middle Aged Risk Factors
Trauma and depressive symptomatology in middle-aged persons at high risk of dementia
Karen Ritchie, Isabelle Carrière, Sarah Gregory, Tam Watermeyer, Samuel Danso, Li Su, Craig W Ritchie, John T O'Brien
Oct 23, 2020
Objective: Depression and trauma are associated with changes in brain regions implicated in Alzheimer’s disease. The present study examined associations between childhood trauma, depression, adult cognitive functioning and risk...
Published by: BMJ Publishing Group
Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers
Maria-Eleni Dounavi, Audrey Low, Elizabeth F McKiernan, Elijah Mak, Graciela Muniz-Terrera, Karen Ritchie, Craig W Ritchie, Li Su, John T O'Brien
Oct 23, 2021
Accumulating evidence suggests vascular dysregulation in preclinical Alzheimer's disease. In this study, cerebral hemodynamics and their coupling with cognition in middle-aged apolipoprotein ε4 carriers (APOEε4+) were...
APOE arterial spin labelling cerebral blood flow Dementia Perfusion Adult Alzheimer Disease Apolipoprotein E4 Atrophy Case-Control Studies Cerebral Arteries Cerebrovascular Circulation Cognition Female Follow-Up Studies Hematocrit Heterozygote Humans Linear Models Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Neurovascular Coupling
Allocentric and Egocentric Spatial Processing in Middle-Aged Adults at High Risk of Late-Onset Alzheimer's Disease
Karen Ritchie, Isabelle Carrière, David Howett, Li Su, Michael Hornberger, John T O'Brien, Craig W Ritchie, Dennis Chan
Nov 12, 2018
Impairments in spatial processing due to hippocampal degeneration have been observed in the years immediately preceding the diagnosis of Alzheimer's disease (AD) dementia. The demonstration of changes in spatial processing in...
Alzheimer’s disease Cognition Diagnosis Magnetic Resonance Imaging neuropsychology Preclinical Prognosis Spatial Memory Age of Onset Alzheimer Disease Brain Cross-Sectional Studies Female Genetic Predisposition to Disease Humans Male Middle Aged Neuropsychological Tests Parents Prospective Studies Risk Factors Self Concept Space Perception Spatial Navigation
Power, false discovery rate and Winner's Curse in eQTL studies.
Investigation of the genetic architecture of gene expression traits has aided interpretation of disease and trait-associated genetic variants; however, key aspects of expression quantitative trait loci (eQTL) study design and...
Improving outcomes in high-risk, nonmetastatic renal cancer
High-risk, localized renal cancer is associated with recurrence rates of up to 75% at 10 years. The outcomes of patients at this disease stage depend on optimal patient stratification, surgical management and systemic therapy...
Disease Modelling of Cognitive Outcomes and Biomarkers in the European Prevention of Alzheimer’s Dementia Longitudinal Cohort
A key challenge for the secondary prevention of Alzheimer’s dementia is the need to identify individuals early on in the disease process through sensitive cognitive tests and biomarkers. The European Prevention of Alzheimer’s...
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