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Tumour Necrosis Factor Inhibitor monotherapy versus combination therapy for the treatment of psoriatic arthritis
Matthew Thomas, Gavin Shaddick, Rachel Charlton, Charlotte Cavill, Richard Holland, Florenzo Iannone, Giovanni Lapadula, Simona Lopriore, Jakub Zavada, Michal Uher, Karel Pavelka, Lenka Szczukova, Prodromos Sidiropolous, Irini Flouri, Alexandros Drosos, Burkhard Möller, Michael Nissen, Rüdiger Müller, Almut Scherer, Neil McHugh, Alison Nightingale
Jan 01, 2021
Objective
To investigate whether tumour necrosis factor inhibitor (TNFi) combination therapy with conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) is more effective for psoriatic arthritis (PsA)...
To investigate whether tumour necrosis factor inhibitor (TNFi) combination therapy with conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) is more effective for psoriatic arthritis (PsA)...
Balancing glycolytic flux
The increased glucose metabolism in cancer cells is required to fulfill their high energetic and biosynthetic demands. Changes in the metabolic activity of cancer cells are caused by the activation of oncogenes or loss of tumor...
Tumour Necrosis Factor Inhibitor monotherapy versus combination therapy for the treatment of psoriatic arthritis
Matthew Thomas, Gavin Shaddick, Rachel Charlton, Charlotte Cavill, Richard Holland, Florenzo Iannone, Giovanni Lapadula, Simona Lopriore, Jakub Zavada, Michal Uher, Karel Pavelka, Lenka Szczukova, Prodromos Sidiropolous, Irini Flouri, Alexandros Drosos, Burkhard Möller, Michael Nissen, Rüdiger Müller, Almut Scherer, Neil McHugh, Alison Nightingale
Jan 01, 2021
Objective
To investigate whether tumour necrosis factor inhibitor (TNFi) combination therapy with conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) is more effective for psoriatic arthritis (PsA)...
To investigate whether tumour necrosis factor inhibitor (TNFi) combination therapy with conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) is more effective for psoriatic arthritis (PsA)...
Near-native state imaging by cryo-soft-X-ray tomography reveals remodelling of multiple cellular organelles during HSV-1 infection.
Kamal L Nahas, Viv Connor, Katharina M Scherer, Clemens F Kaminski, Maria Harkiolaki, Colin M Crump, Stephen C Graham
Aug 07, 2022
Combining sample expansion and light sheet microscopy for the volumetric imaging of virus-infected cells with super-resolution.
Luca Mascheroni, Katharina M Scherer, James D Manton, Edward Ward, Oliver Dibben, Clemens F Kaminski
Jul 29, 2020
Expansion microscopy is a sample preparation technique that enables the optical imaging of biological specimens at super-resolution owing to their physical magnification, which is achieved through water-absorbing polymers. The...
Flat-Field Super-Resolution Localization Microscopy with a Low-Cost Refractive Beam-Shaping Element.
Christopher J Rowlands, Florian Ströhl, Pedro P Vallejo Ramirez, Katharina M Scherer, Clemens F Kaminski
Sep 05, 2018
Super-resolution single-molecule localization microscopy, often referred to as PALM/STORM, works by ensuring that fewer than one fluorophore in a diffraction-limited volume is emitting at any one time, allowing the observer to...
Variational Autoencoders for Cancer Data Integration
Nikola Simidjievski, Cristian Bodnar, Ifrah Tariq, Paul Scherer, Helena Andres Terre, Zohreh Shams, Mateja Jamnik, Pietro Liò
Feb 10, 2020
International initiatives such as the Molecular Taxonomy of Breast Cancer International Consortium are collecting multiple data sets at different genome-scales with the aim to identify novel cancer bio-markers and predict...
Artificial Intelligence Machine Learning Deep learning multi-omic analysis variational autoencoder bioinformactics cancer–breast cancer integrative data analyses
Published by: Frontiers in genetics
A fluorescent reporter system enables spatiotemporal analysis of host cell modification during herpes simplex virus-1 replication.
Katharina M Scherer, James D Manton, Timothy K Soh, Luca Mascheroni, Vivienne Connor, Colin M Crump, Clemens F Kaminski
Jan 07, 2021
Herpesviruses are large and complex viruses that have a long history of coevolution with their host species. One important factor in the virus-host interaction is the alteration of intracellular morphology during viral...
Cytoskeleton Fluorescence herpesvirus host–pathogen interaction microscopic imaging Microscopy Organelle Animals Capsid Chlorocebus aethiops Cytoplasm Genes Reporter Golgi Apparatus Herpesvirus 1 Human Humans Microscopy Fluorescence Single-Cell Analysis Spatio-Temporal Analysis Vero Cells Virus Assembly Virus Replication
Near-native state imaging by cryo-soft-X-ray tomography reveals remodelling of multiple cellular organelles during HSV-1 infection
Kamal L Nahas, Viv Connor, Katharina M Scherer, Clemens F Kaminski, Maria Harkiolaki, Colin M Crump, Stephen C Graham
Jul 07, 2022
Variational Autoencoders for Cancer Data Integration
Nikola Simidjievski, Cristian Bodnar, Ifrah Tariq, Paul Scherer, Helena Andres Terre, Zohreh Shams, Mateja Jamnik, Pietro Liò
Jan 17, 2020
International initiatives such as the Molecular Taxonomy of Breast Cancer International Consortium are collecting multiple data sets at different genome-scales with the aim to identify novel cancer bio-markers and predict...
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.
Beatrice Griffiths, Caroline A Lewis, Karim Bensaad, Susana Ros, Qifeng Zhang, Emma C Ferber, Sofia Konisti, Barrie Peck, Heike Miess, Philip East, Michael Wakelam, Adrian L Harris, Almut Schulze
Nov 26, 2020
BACKGROUND: Regulation of lipid metabolism via activation of sterol regulatory element binding proteins (SREBPs) has emerged as an important function of the Akt/mTORC1 signaling axis. Although the contribution of dysregulated...
Variational Autoencoders for Cancer Data Integration
Nikola Simidjievski, Cristian Bodnar, Ifrah Tariq, Paul Scherer, Helena Andres Terre, Zohreh Shams, Mateja Jamnik, Pietro Liò
Dec 25, 2019
International initiatives such as the Molecular Taxonomy of Breast Cancer International Consortium are collecting multiple data sets at different genome-scales with the aim to identify novel cancer bio-markers and predict...
EAP45 association with budding HIV-1
Bo Meng, Pedro P Vallejo Ramirez, Katharina M Scherer, Ezra Bruggeman, Julia C Kenyon, Clemens F Kaminski, Andrew M Lever
Sep 28, 2021
The Grizzly, September 20, 2001
Cornota Harkins, Anne Antanavage, '04, Katie Leham, Christine Ginty, Susan Goll, Sarah Ewald, Tammy Scherer, Julia Campbell, Joe Petsko, Meghan Beck, Kate Juliano, Eric Fiero, Fallon Szarko, Sarah Napolitan, Katie Lambert, Becky Borbidge
Jan 01, 0001
American Heartache: The Destruction of the World Trade Center Freshman Lauren Melton Helps Save Lives Ursinus in London Gets Off the Ground Air Quality Jeopardized by Proposed Power Plant Truth About Ecstasy: Students...
Ursinus College Collegeville Pennsylvania newspaper field hockey Rugby Soccer cross country Volleyball Football yoga fringe festival Campus Activities Board September 11 Nuclear power plants career planning Ecstasy Lauren Melton cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR.
Michael Scherer, Gilles Gasparoni, Souad Rahmouni, Tatiana Shashkova, Marion Arnoux, Edouard Louis, Arina Nostaeva, Diana Avalos, Emmanouil T Dermitzakis, Yurii S Aulchenko, Thomas Lengauer, Paul A Lyons, Michel Georges, Jörn Walter
Oct 18, 2021
Background
Understanding the influence of genetic variants on DNA methylation is fundamental for the interpretation of epigenomic data in the context of disease. There is a need for systematic approaches not only for...
Published by: Epigenetics & chromatin
Chong Yew Tan, Samuel Virtue, Steven Murfitt, Lee D Roberts, Yi Hui Phua, Martin Dale, Julian L Griffin, Francisco Tinahones, Philipp E Scherer, Antonio Vidal-Puig
Nov 19, 2015
Meta-analysis and multidisciplinary consensus statement
Siddharth Srivastava, Jamie A. Love-Nichols, Kira A. Dies, David H. Ledbetter, Christa L. Martin, Wendy K. Chung, Helen V. Firth, Thomas Frazier, Robin L. Hansen, Lisa Prock, Han Brunner, Ny Hoang, Stephen W. Scherer, Mustafa Sahin, David T. Miller
Jul 29, 2020
Abstract: Purpose: For neurodevelopmental disorders (NDDs), etiological evaluation can be a diagnostic odyssey involving numerous genetic tests, underscoring the need to develop a streamlined algorithm maximizing molecular...
Meta-analysis and multidisciplinary consensus statement
Siddharth Srivastava, Jamie A. Love-Nichols, Kira A. Dies, David H. Ledbetter, Christa L. Martin, Wendy K. Chung, Helen V. Firth, Thomas Frazier, Robin L. Hansen, Lisa Prock, Han Brunner, Ny Hoang, Stephen W. Scherer, Mustafa Sahin, David T. Miller
Sep 25, 2020
Abstract: Purpose: For neurodevelopmental disorders (NDDs), etiological evaluation can be a diagnostic odyssey involving numerous genetic tests, underscoring the need to develop a streamlined algorithm maximizing molecular...
Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR.
Michael Scherer, Gilles Gasparoni, Souad Rahmouni, Tatiana Shashkova, Marion Arnoux, Edouard Louis, Arina Nostaeva, Diana Avalos, Emmanouil T Dermitzakis, Yurii S Aulchenko, Thomas Lengauer, Paul A Lyons, Michel Georges, Jörn Walter
Sep 27, 2021
BACKGROUND: Understanding the influence of genetic variants on DNA methylation is fundamental for the interpretation of epigenomic data in the context of disease. There is a need for systematic approaches not only for...
The Grizzly, February 1, 2001
Lauren Cyrsky, Dan Reimold, Tammy Scherer, Susan Patton, Quinn Dinsmore, Brian Berg, Sarah Napolitan, Chuck Pulsfort, Jeff Church, Padraic Maroney, Kate Gallagher, Amit Podhurst
Jan 01, 0001
Fight to Save Collegeville dam Reaches Critical Point UC to Honor Black History Duryea, Maples in Need of Repairs, Students Say Biology Majors Spend Break in Costa Rica Opinions: Absolut Pathetic: Student Alcohol Abuse on...
Ursinus College Collegeville Pennsylvania newspaper Swimming gymnastics Basketball Eleanor Snell Jen Shillingford Berman Art Museum Shawn Witt Mike Keeper Alcohol Costa Rica Black History Month Duryea Hall Maples Hall Amanda Helwig Collegeville Dam cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The Grizzly, October 5, 1999
Stephanie Restine, Erny Hoke, Megan Restine, Tammy Scherer, Dan Reimold, Ann Van Buren, Susan Fialkowski, Kelly Tessena, Tim Noone, Andy Maynard, Aaron Hampton, Cory Braiterman, Fran Shaughnessy
Jan 01, 0001
Bears Clobber Swarthmore During Family Day Game Family Day A Success Admission Rumor Proves False Sophomore Week Set 811 Main Street Forget MTV: Career Services Offering UC Seniors Opportunity to Star in "Real World" ...
Ursinus College Collegeville Pennsylvania newspaper cheerleading Soccer Football Volleyball Family Day career planning Cloake House admissions Sophomore Week cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Pathogen genomics study of an early medieval community in Germany reveals extensive co-infections.
Joanna H Bonczarowska, Julian Susat, Barbara Mühlemann, Isabelle Jasch-Boley, Sebastian Brather, Benjamin Höke, Susanne Brather-Walter, Valerie Schoenenberg, Jonathan Scheschkewitz, Gabriele Graenert, Dirk Krausse, Michael Francken, Terry C Jones, Joachim Wahl, Almut Nebel, Ben Krause-Kyora
Dec 13, 2022
Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson's Disease.
Johannes Hertel, Amy C Harms, Almut Heinken, Federico Baldini, Cyrille C Thinnes, Enrico Glaab, Daniel A Vasco, Maik Pietzner, Isobel D Stewart, Nicholas J Wareham, Claudia Langenberg, Claudia Trenkwalder, Rejko Krüger, Thomas Hankemeier, Ronan MT Fleming, Brit Mollenhauer, Ines Thiele
Nov 25, 2019
Parkinson's disease (PD) exhibits systemic effects on the human metabolism, with emerging roles for the gut microbiome. Here, we integrate longitudinal metabolome data from 30 drug-naive, de novo PD patients and 30 matched...
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