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Early Detection of Alzheimer's Disease Using Bottleneck Transformers
Early detection of Alzheimer's disease (AD) and its prodromal state, mild cognitive impairment (MCI), is crucial for providing suitable treatment and preventing the disease from progressing. It can also aid researchers and...
QoS-Aware Web Services Recommendations Using Dynamic Clustering Algorithms
Service-oriented computing (SOC) activates communication through web services to provide computing as a service for business applications in the service-oriented architecture (SOA). To make SOC successful, finding a needed...
Agricultural Recommendation System for Crops Using Different Machine Learning Regression Methods
Agriculture is a foremost field within the world, and it's the backbone in the Republic of India. Agriculture has been in poor condition. The impact of temperature variations and its uncertainty has engendered the bulk of the...
Novel Clustering-Based Web Service Recommendation Framework
Normally web services are classified originate in on the quality of service, wherever the term quality is not absolute and it is a relative term. The quality of web services is measured or derived using various parameters like...
Association Between Entrepreneurship Ecosystem and Entrepreneurial Behavior & Attitudes
Entrepreneurship ecosystem and entrepreneurial behaviour & attitudes are significantly associated with several variables associated with social development, economic development, science & technological development, intellectual...
Mitigating Risks in the Cloud-Based Metaverse Access Control Strategies and Techniques
The advent of the metaverse has revolutionized virtual interactions and navigation, introducing intricate access control challenges. This paper addresses the need for effective access control models in the cloud-based metaverse....
Cyberbullying in the Metaverse
The emergence of the metaverse, a virtual reality space, has ushered in a new era of digital experiences and interactions in global information systems. With its unique social norms and behaviors, this new world presents...
Optimal Placement of Micro Distribution Generator in Micro-Grid for Loss Minimization Using PSO
The major aim of DG optimal placement is obtaining the best DGs units sizes and locations so as to have optimum operation and planning of the distribution network system while considering DG capacity constraint. This paper...
How Do Digital Market Platform Hosts Exercise Control Over Sellers?
High speed connectivity, smart mobile devices, social media, and rapidly-proliferating end-user applications have given rise to digital markets. This paper investigates how digital market hosts exercise control over sellers. The...
Global Development on LCA Research
Research on life cycle assessment (LCA) has been conducted over three decades. According to ISO 14040, LCA is an international standard that provides a methodology for assessing the environmental impact of products and...
Deep Learning-Based Object Detection in Diverse Weather Conditions
The number of different types of composite images has grown very rapidly in current years, making object detection an extremely critical task that requires a deeper understanding of various deep learning strategies that help to...
Critical assessment of protein intrinsic disorder prediction
Marco Necci, Damiano Piovesan, Silvio C. E. Tosatto, Md Tamjidul Hoque, Ian Walsh, Sumaiya Iqbal, Michele Vendruscolo, Pietro Sormanni, Chen Wang, Daniele Raimondi, Ronesh Sharma, Yaoqi Zhou, Thomas Litfin, Oxana Valerianovna Galzitskaya, Michail Yu. Lobanov, Wim Vranken, Björn Wallner, Claudio Mirabello, Nawar Malhis, Zsuzsanna Dosztányi, Gábor Erdős, Bálint Mészáros, Jianzhao Gao, Kui Wang, Gang Hu, Zhonghua Wu, Alok Sharma, Jack Hanson, Kuldip Paliwal, Isabelle Callebaut, Tristan Bitard-Feildel, Gabriele Orlando, Zhenling Peng, Jinbo Xu, Sheng Wang, David T. Jones, Domenico Cozzetto, Fanchi Meng, Jing Yan, Jörg Gsponer, Jianlin Cheng, Tianqi Wu, Lukasz Kurgan, Vasilis J. Promponas, Stella Tamana, Cristina Marino-Buslje, Elizabeth Martínez-Pérez, Anastasia Chasapi, Christos Ouzounis, A. Keith Dunker, Andrey V. Kajava, Jeremy Y. Leclercq, Burcu Aykac-Fas, Matteo Lambrughi, Emiliano Maiani, Elena Papaleo, Lucia Beatriz Chemes, Lucía Álvarez, Nicolás S. González-Foutel, Valentin Iglesias, Jordi Pujols, Salvador Ventura, Nicolás Palopoli, Guillermo Ignacio Benítez, Gustavo Parisi, Claudio Bassot, Arne Elofsson, Sudha Govindarajan, John Lamb, Marco Salvatore, András Hatos, Alexander Miguel Monzon, Martina Bevilacqua, Ivan Mičetić, Giovanni Minervini, Lisanna Paladin, Federica Quaglia, Emanuela Leonardi, Norman Davey, Tamas Horvath, Orsolya Panna Kovacs, Nikoletta Murvai, Rita Pancsa, Eva Schad, Beata Szabo, Agnes Tantos, Sandra Macedo-Ribeiro, Jose Antonio Manso, Pedro José Barbosa Pereira, Radoslav Davidović, Nevena Veljkovic, Borbála Hajdu-Soltész, Mátyás Pajkos, Tamás Szaniszló, Mainak Guharoy, Tamas Lazar, Mauricio Macossay-Castillo, Peter Tompa
May 08, 2021
Abstract: Intrinsically disordered proteins, defying the traditional protein structure–function paradigm, are a challenge to study experimentally. Because a large part of our knowledge rests on computational predictions, it is...
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Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential.
Tetsushi Nakao, Alexander G Bick, Margaret A Taub, Seyedeh M Zekavat, Md M Uddin, Abhishek Niroula, Cara L Carty, John Lane, Michael C Honigberg, Joshua S Weinstock, Akhil Pampana, Christopher J Gibson, Gabriel K Griffin, Shoa L Clarke, Romit Bhattacharya, Themistocles L Assimes, Leslie S Emery, Adrienne M Stilp, Quenna Wong, Jai Broome, Cecelia A Laurie, Alyna T Khan, Albert V Smith, Thomas W Blackwell, Veryan Codd, Christopher P Nelson, Zachary T Yoneda, Juan M Peralta, Donald W Bowden, Marguerite R Irvin, Meher Boorgula, Wei Zhao, Lisa R Yanek, Kerri L Wiggins, James E Hixson, C Charles Gu, Gina M Peloso, Dan M Roden, Muagututi'a S Reupena, Chii-Min Hwu, Dawn L DeMeo, Kari E North, Shannon Kelly, Solomon K Musani, Joshua C Bis, Donald M Lloyd-Jones, Jill M Johnsen, Michael Preuss, Russell P Tracy, Patricia A Peyser, Dandi Qiao, Pinkal Desai, Joanne E Curran, Barry I Freedman, Hemant K Tiwari, Sameer Chavan, Jennifer A Smith, Nicholas L Smith, Tanika N Kelly, Bertha Hidalgo, L Adrienne Cupples, Daniel E Weeks, Nicola L Hawley, Ryan L Minster, Lifestyle and Genetic Adaptations Study (OLaGA) Group Samoan Obesity, Ranjan Deka, Take T Naseri, Lisa de Las Fuentes, Laura M Raffield, Alanna C Morrison, Paul S Vries, Christie M Ballantyne, Eimear E Kenny, Stephen S Rich, Eric A Whitsel, Michael H Cho, M Benjamin Shoemaker, Betty S Pace, John Blangero, Nicholette D Palmer, Braxton D Mitchell, Alan R Shuldiner, Kathleen C Barnes, Susan Redline, Sharon LR Kardia, Gonçalo R Abecasis, Lewis C Becker, Susan R Heckbert, Jiang He, Wendy Post, Donna K Arnett, Ramachandran S Vasan, Dawood Darbar, Scott T Weiss, Stephen T McGarvey, Mariza de Andrade, Yii-Der Ida Chen, Robert C Kaplan, Deborah A Meyers, Brian S Custer, Adolfo Correa, Bruce M Psaty, Myriam Fornage, JoAnn E Manson, Eric Boerwinkle, Barbara A Konkle, Ruth JF Loos, Jerome I Rotter, Edwin K Silverman, Charles Kooperberg, John Danesh, Nilesh J Samani, Siddhartha Jaiswal, Peter Libby, Patrick T Ellinor, Nathan Pankratz, Benjamin L Ebert, Alexander P Reiner, Rasika A Mathias, Ron Do, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Pradeep Natarajan
May 09, 2022
Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and diverse malignancies. Clonal hematopoiesis of...
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Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
Michael P. Menden, Dennis Wang, Mike J. Mason, Bence Szalai, Krishna C. Bulusu, Yuanfang Guan, Thomas Yu, Jaewoo Kang, Minji Jeon, Russ Wolfinger, Tin Nguyen, Mikhail Zaslavskiy, In Sock Jang, Zara Ghazoui, Mehmet Eren Ahsen, Robert Vogel, Elias Chaibub Neto, Thea Norman, Eric K. Y. Tang, Mathew J. Garnett, Giovanni Y. Di Veroli, Stephen Fawell, Gustavo Stolovitzky, Justin Guinney, Jonathan R. Dry, Julio Saez-Rodriguez, Jordi Abante, Barbara Schmitz Abecassis, Nanne Aben, Delasa Aghamirzaie, Tero Aittokallio, Farida S. Akhtari, Bissan Al-Lazikani, Tanvir Alam, Amin Allam, Chad Allen, Mariana Pelicano de Almeida, Doaa Altarawy, Vinicius Alves, Alicia Amadoz, Benedict Anchang, Albert A. Antolin, Jeremy R. Ash, Victoria Romeo Aznar, Wail Ba-alawi, Moeen Bagheri, Vladimir Bajic, Gordon Ball, Pedro J. Ballester, Delora Baptista, Christopher Bare, Mathilde Bateson, Andreas Bender, Denis Bertrand, Bhagya Wijayawardena, Keith A. Boroevich, Evert Bosdriesz, Salim Bougouffa, Gergana Bounova, Thomas Brouwer, Barbara Bryant, Manuel Calaza, Alberto Calderone, Stefano Calza, Stephen Capuzzi, Jose Carbonell-Caballero, Daniel Carlin, Hannah Carter, Luisa Castagnoli, Remzi Celebi, Gianni Cesareni, Hyeokyoon Chang, Guocai Chen, Haoran Chen, Huiyuan Chen, Lijun Cheng, Ariel Chernomoretz, Davide Chicco, Kwang-Hyun Cho, Sunghwan Cho, Daeseon Choi, Jaejoon Choi, Kwanghun Choi, Minsoo Choi, Martine De Cock, Elizabeth Coker, Isidro Cortes-Ciriano, Miklós Cserzö, Cankut Cubuk, Christina Curtis, Dries Van Daele, Cuong C. Dang, Tjeerd Dijkstra, Joaquin Dopazo, Sorin Draghici, Anastasios Drosou, Michel Dumontier, Friederike Ehrhart, Fatma-Elzahraa Eid, Mahmoud ElHefnawi, Haitham Elmarakeby, Bo van Engelen, Hatice Billur Engin, Iwan de Esch, Chris Evelo, Andre O. Falcao, Sherif Farag, Carlos Fernandez-Lozano, Kathleen Fisch, Asmund Flobak, Chiara Fornari, Amir B. K. Foroushani, Donatien Chedom Fotso, Denis Fourches, Stephen Friend, Arnoldo Frigessi, Feng Gao, Xiaoting Gao, Jeffrey M. Gerold, Pierre Gestraud, Samik Ghosh, Jussi Gillberg, Antonia Godoy-Lorite, Lizzy Godynyuk, Adam Godzik, Anna Goldenberg, David Gomez-Cabrero, Mehmet Gonen, Chris de Graaf, Harry Gray, Maxim Grechkin, Roger Guimera, Emre Guney, Benjamin Haibe-Kains, Younghyun Han, Takeshi Hase, Di He, Liye He, Lenwood S. Heath, Kristoffer H. Hellton, Manuela Helmer-Citterich, Marta R. Hidalgo, Daniel Hidru, Steven M. Hill, Sepp Hochreiter, Seungpyo Hong, Eivind Hovig, Ya-Chih Hsueh, Zhiyuan Hu, Justin K Huang, R. Stephanie Huang, László Hunyady, Jinseub Hwang, Tae Hyun Hwang, Woochang Hwang, Yongdeuk Hwang, Olexandr Isayev, Oliver Bear Don’t Walk, John Jack, Samad Jahandideh, Jiadong Ji, Yousang Jo, Piotr J. Kamola, Georgi K. Kanev, Loukia Karacosta, Mostafa Karimi, Samuel Kaski, Marat Kazanov, Abdullah M Khamis, Suleiman Ali Khan, Narsis A. Kiani, Allen Kim, Jinhan Kim, Juntae Kim, Kiseong Kim, Kyung Kim, Sunkyu Kim, Yongsoo Kim, Yunseong Kim, Paul D. W. Kirk, Hiroaki Kitano, Gunter Klambauer, David Knowles, Melissa Ko, Alvaro Kohn-Luque, Albert J. Kooistra, Melaine A. Kuenemann, Martin Kuiper, Christoph Kurz, Mijin Kwon, Twan van Laarhoven, Astrid Laegreid, Simone Lederer, Heewon Lee, Jeon Lee, Yun Woo Lee, Eemeli Lepp_aho, Richard Lewis, Jing Li, Lang Li, James Liley, Weng Khong Lim, Chieh Lin, Yiyi Liu, Yosvany Lopez, Joshua Low, Artem Lysenko, Daniel Machado, Neel Madhukar, Dries De Maeyer, Ana Belen Malpartida, Hiroshi Mamitsuka, Francesco Marabita, Kathleen Marchal, Pekka Marttinen, Daniel Mason, Alireza Mazaheri, Arfa Mehmood, Ali Mehreen, Magali Michaut, Ryan A. Miller, Costas Mitsopoulos, Dezso Modos, Marijke Van Moerbeke, Keagan Moo, Alison Motsinger-Reif, Rajiv Movva, Sebastian Muraru, Eugene Muratov, Mushthofa Mushthofa, Niranjan Nagarajan, Sigve Nakken, Aritro Nath, Pierre Neuvial, Richard Newton, Zheng Ning, Carlos De Niz, Baldo Oliva, Catharina Olsen, Antonio Palmeri, Bhawan Panesar, Stavros Papadopoulos, Jaesub Park, Seonyeong Park, Sungjoon Park, Yudi Pawitan, Daniele Peluso, Sriram Pendyala, Jian Peng, Livia Perfetto, Stefano Pirro, Sylvia Plevritis, Regina Politi, Hoifung Poon, Eduard Porta, Isak Prellner, Kristina Preuer, Miguel Angel Pujana, Ricardo Ramnarine, John E. Reid, Fabien Reyal, Sylvia Richardson, Camir Ricketts, Linda Rieswijk, Miguel Rocha, Carmen Rodriguez-Gonzalvez, Kyle Roell, Daniel Rotroff, Julian R. de Ruiter, Ploy Rukawa, Benjamin Sadacca, Zhaleh Safikhani, Fita Safitri, Marta Sales-Pardo, Sebastian Sauer, Moritz Schlichting, Jose A. Seoane, Jordi Serra, Ming-Mei Shang, Alok Sharma, Hari Sharma, Yang Shen, Motoki Shiga, Moonshik Shin, Ziv Shkedy, Kevin Shopsowitz, Sam Sinai, Dylan Skola, Petr Smirnov, Izel Fourie Soerensen, Peter Soerensen, Je-Hoon Song, Sang Ok Song, Othman Soufan, Andreas Spitzmueller, Boris Steipe, Chayaporn Suphavilai, Sergio Pulido Tamayo, David Tamborero, Jing Tang, Zia-ur-Rehman Tanoli, Marc Tarres-Deulofeu, Jesper Tegner, Liv Thommesen, Seyed Ali Madani Tonekaboni, Hong Tran, Ewoud De Troyer, Amy Truong, Tatsuhiko Tsunoda, Gábor Turu, Guang-Yo Tzeng, Lieven Verbeke, Santiago Videla, Daniel Vis, Andrey Voronkov, Konstantinos Votis, Ashley Wang, Hong-Qiang Horace Wang, Po-Wei Wang, Sheng Wang, Wei Wang, Xiaochen Wang, Xin Wang, Krister Wennerberg, Lorenz Wernisch, Lodewyk Wessels, Gerard J. P. van Westen, Bart A. Westerman, Simon Richard White, Egon Willighagen, Tom Wurdinger, Lei Xie, Shuilian Xie, Hua Xu, Bhagwan Yadav, Christopher Yau, Huwate Yeerna, Jia Wei Yin, Michael Yu, MinHwan Yu, So Jeong Yun, Alexey Zakharov, Alexandros Zamichos, Massimiliano Zanin, Li Zeng, Hector Zenil, Frederick Zhang, Pengyue Zhang, Wei Zhang, Hongyu Zhao, Lan Zhao, Wenjin Zheng, AZEDINE Zoufir, Manuela Zucknick
Jun 16, 2020
Abstract: The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating...
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