Involvement of G-quadruplex regions in mammalian replication origin activity.
Paulina Prorok,
Marie Artufel,
Antoine Aze,
Philippe Coulombe,
Isabelle Peiffer,
Laurent Lacroix,
Aurore Guédin,
Jean-Louis Mergny,
Julia Damaschke,
Aloys Schepers,
Christelle Cayrou,
Marie-Paule Teulade-Fichou,
Benoit Ballester,
Marcel Méchali
Jul 21, 2020
Genome-wide studies of DNA replication origins revealed that origins preferentially associate with an Origin G-rich Repeated Element (OGRE), potentially forming G-quadruplexes (G4). Here, we functionally address their...